메뉴 건너뛰기




Volumn 5, Issue , 2011, Pages 435-443

Future prospects in the treatment of erectile dysfunction: Focus on avanafil

Author keywords

PDE5; Pharmacokinetics; Sexual performance

Indexed keywords

2 (4 AMINOPHENYL) 1,2 DIHYDRO 1 OXO 7 (2 PYRIDINYLMETHOXY) 4 (3,4,5 TRIMETHOXYPHENYL) 3 ISOQUINOLINECARBOXYLIC ACID METHYL ESTER; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; APOMORPHINE; AVANAFIL; BREMELANOTIDE; FR 226807; GISADENAFIL; GLUTAMIC ACID; HEXARELIN; JNJ 10280205; JNJ 10287069; KF 31327; M VIX; MIRODENAFIL; PAPAVERINE; PHENTOLAMINE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROSTAGLANDIN E1; SEROTONIN 2C AGONIST; SILDENAFIL; SLX 2101; TADALAFIL; TRAZODONE; UDENAFIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARDENAFIL; VASOACTIVE INTESTINAL POLYPEPTIDE; YM 348;

EID: 84859112058     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S15852     Document Type: Review
Times cited : (34)

References (79)
  • 1
    • 20144378083 scopus 로고    scopus 로고
    • Summary of the recommendations on sexual dysfunctions in men
    • Lue TF, Giuliano F, Montorsi F, et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med. 2004;1(1):6-23.
    • (2004) J Sex Med , vol.1 , Issue.1 , pp. 6-23
    • Lue, T.F.1    Giuliano, F.2    Montorsi, F.3
  • 2
    • 0033776081 scopus 로고    scopus 로고
    • Impact of erectile dysfunction on quality of life: Patient and partner perspectives
    • Wagner G, Fugl-Meyer KS, Fugl-Meyer AR. Impact of erectile dysfunction on quality of life: patient and partner perspectives. Int J Impot Res. Oct 2000;12 Suppl 4:S144-S146.
    • (2000) Int J Impot Res , vol.12 , Issue.SUPPL. 4
    • Wagner, G.1    Fugl-Meyer, K.S.2    Fugl-Meyer, A.R.3
  • 3
    • 0028036149 scopus 로고
    • Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study
    • Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994;151:54-61.
    • (1994) J Urol , vol.151 , pp. 54-61
    • Feldman, H.A.1    Goldstein, I.2    Hatzichristou, D.G.3    Krane, R.J.4    McKinlay, J.B.5
  • 4
    • 27744607670 scopus 로고    scopus 로고
    • Physiology of penile erection and pathophysiology of erectile dysfunction
    • Dean RC, Lue TF. Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am. Nov 2005;32(4):379-395, v.
    • (2005) Urol Clin North Am , vol.32 , Issue.4 , pp. 379-395
    • Dean, R.C.1    Lue, T.F.2
  • 5
    • 0033030739 scopus 로고    scopus 로고
    • Definition and classification of erectile dysfunction: Report of the Nomenclature Committee of the International Society of Impotence Research
    • Lizza EF, Rosen RC. Definition and classification of erectile dysfunction: report of the Nomenclature Committee of the International Society of Impotence Research. Int J Impot Res. 1999;11(3):141-143.
    • (1999) Int J Impot Res , vol.11 , Issue.3 , pp. 141-143
    • Lizza, E.F.1    Rosen, R.C.2
  • 6
    • 0030898317 scopus 로고    scopus 로고
    • Comparative results of goal oriented therapy for erectile dysfunction
    • Hanash KA. Comparative results of goal oriented therapy for erectile dysfunction. J Urol. 1997;157(6):2135-2138.
    • (1997) J Urol , vol.157 , Issue.6 , pp. 2135-2138
    • Hanash, K.A.1
  • 7
    • 22244468054 scopus 로고    scopus 로고
    • Chapter 1: The management of erectile dysfunction: An AUA update
    • Montague DK, Jarow JP, Broderick GA, et al. Chapter 1: The management of erectile dysfunction: an AUA update. J Urol. 2005;174(1):230-239.
    • (2005) J Urol , vol.174 , Issue.1 , pp. 230-239
    • Montague, D.K.1    Jarow, J.P.2    Broderick, G.A.3
  • 8
    • 23944512775 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction
    • Gupta M, Kovar A, Meibohm B. The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction. J Clin Pharmacol. 2005;45(9):987-1003.
    • (2005) J Clin Pharmacol , vol.45 , Issue.9 , pp. 987-1003
    • Gupta, M.1    Kovar, A.2    Meibohm, B.3
  • 9
    • 0036121963 scopus 로고    scopus 로고
    • Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: Absolute bioavailability, food effects and dose proportionality
    • Nichols DJ, Muirhead GJ, Harness JA. Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. Br J Clin Pharmacol. 2002;53: 5S-12S.
    • (2002) Br J Clin Pharmacol , vol.53
    • Nichols, D.J.1    Muirhead, G.J.2    Harness, J.A.3
  • 10
    • 15844430082 scopus 로고    scopus 로고
    • Duration of action of sildenafil citrate in men with erectile dysfunction
    • Gingell C, Sultana SR, Wulff MB, Gepi-Attee S. Duration of action of sildenafil citrate in men with erectile dysfunction. J Sex Med. 2004;1(2): 179-184.
    • (2004) J Sex Med , vol.1 , Issue.2 , pp. 179-184
    • Gingell, C.1    Sultana, S.R.2    Wulff, M.B.3    Gepi-Attee, S.4
  • 11
    • 0033547738 scopus 로고    scopus 로고
    • Use of sildenafil (Viagra) in patients with cardiovascular disease
    • Cheitlin MD, Hutter AM Jr, Brindis RG, et al. Use of sildenafil (Viagra) in patients with cardiovascular disease. Circulation. 1999;99(1): 168-177.
    • (1999) Circulation , vol.99 , Issue.1 , pp. 168-177
    • Cheitlin, M.D.1    Hutter Jr., A.M.2    Brindis, R.G.3
  • 12
    • 0030154874 scopus 로고    scopus 로고
    • Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
    • Boolell M, Allen MJ, Ballard SA, et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 1996;8(2):47-52.
    • (1996) Int J Impot Res , vol.8 , Issue.2 , pp. 47-52
    • Boolell, M.1    Allen, M.J.2    Ballard, S.A.3
  • 13
    • 0035258442 scopus 로고    scopus 로고
    • Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: A RigiScan and pharmacokinetic study
    • Klotz T, Sachse R, Heidrich A, et al. Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: a RigiScan and pharmacokinetic study. World J Urol. 2001;19(1):32-39.
    • (2001) World J Urol , vol.19 , Issue.1 , pp. 32-39
    • Klotz, T.1    Sachse, R.2    Heidrich, A.3
  • 14
    • 17944364288 scopus 로고    scopus 로고
    • Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose
    • Stark S, Sachse R, Liedl T, et al. Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose. Eur Urol. 2001;40(2):181-188.
    • (2001) Eur Urol , vol.40 , Issue.2 , pp. 181-188
    • Stark, S.1    Sachse, R.2    Liedl, T.3
  • 15
    • 0037370684 scopus 로고    scopus 로고
    • Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction
    • Rajagopalan P, Mazzu A, Xia C, Dawkins R, Sundaresan P. Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction. J Clin Pharmacol. 2003;43(3):260-267.
    • (2003) J Clin Pharmacol , vol.43 , Issue.3 , pp. 260-267
    • Rajagopalan, P.1    Mazzu, A.2    Xia, C.3    Dawkins, R.4    Sundaresan, P.5
  • 16
    • 0037195229 scopus 로고    scopus 로고
    • Erectile dysfunction: Comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil-review of the literature
    • Gresser U, Gleiter CH. Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil-review of the literature. Eur J Med Res. 2002;7(10):435-446.
    • (2002) Eur J Med Res , vol.7 , Issue.10 , pp. 435-446
    • Gresser, U.1    Gleiter, C.H.2
  • 17
    • 0035983115 scopus 로고    scopus 로고
    • Tadalafil (Cialis) for men with erectile dysfunction
    • Eardley I, Cartledge J. Tadalafil (Cialis) for men with erectile dysfunction. Int J Clin Pract. 2002;56(4):300-304.
    • (2002) Int J Clin Pract , vol.56 , Issue.4 , pp. 300-304
    • Eardley, I.1    Cartledge, J.2
  • 18
    • 0038204487 scopus 로고    scopus 로고
    • Tadalafil: A new agent for erectile dysfunction
    • Brock G. Tadalafil: a new agent for erectile dysfunction. Can J Urol. 2003;10(Suppl 1):17-22.
    • (2003) Can J Urol , vol.10 , Issue.SUPPL. 1 , pp. 17-22
    • Brock, G.1
  • 19
    • 0042236843 scopus 로고    scopus 로고
    • Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones
    • Hellstrom WJG, Overstreet JW, Yu A, et al. Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones. J Urol. 2003;170(3):887-891.
    • (2003) J Urol , vol.170 , Issue.3 , pp. 887-891
    • Hellstrom, W.J.G.1    Overstreet, J.W.2    Yu, A.3
  • 20
    • 23744435642 scopus 로고    scopus 로고
    • A comparative review of the options for treatment of erectile dysfunction: Which treatment for which patient?
    • Hatzimouratidis K, Hatzichristou DG. A comparative review of the options for treatment of erectile dysfunction: which treatment for which patient? Drugs. 2005;65(12):1621-1650.
    • (2005) Drugs , vol.65 , Issue.12 , pp. 1621-1650
    • Hatzimouratidis, K.1    Hatzichristou, D.G.2
  • 21
    • 61649110304 scopus 로고    scopus 로고
    • Cardiovascular effects of phosphodiesterase type 5 inhibitors
    • Vlachopoulos C, Ioakeimidis N, Rokkas K, Stefanadis C. Cardiovascular effects of phosphodiesterase type 5 inhibitors. J Sex Med. 2009;6(3): 658-674.
    • (2009) J Sex Med , vol.6 , Issue.3 , pp. 658-674
    • Vlachopoulos, C.1    Ioakeimidis, N.2    Rokkas, K.3    Stefanadis, C.4
  • 22
    • 29544435476 scopus 로고    scopus 로고
    • Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: Focus on alpha-blocker interactions
    • Kloner RA. Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions. Am J Cardiol. 2005;96(12B):42M-46M.
    • (2005) Am J Cardiol , vol.96 , Issue.12 B
    • Kloner, R.A.1
  • 23
    • 38149136418 scopus 로고    scopus 로고
    • Looking to the future for erectile dysfunction therapies
    • Hatzimouratidis K, Hatzichristou DG. Looking to the future for erectile dysfunction therapies. Drugs. 2008;68(2):231-250.
    • (2008) Drugs , vol.68 , Issue.2 , pp. 231-250
    • Hatzimouratidis, K.1    Hatzichristou, D.G.2
  • 24
    • 33645794792 scopus 로고    scopus 로고
    • EAU guidelines on erectile dysfunction: An update
    • Wespes E, Amar E, Hatzichristou D, et al. EAU guidelines on erectile dysfunction: an update. Eur Urol. 2006;49(5):806-815.
    • (2006) Eur Urol , vol.49 , Issue.5 , pp. 806-815
    • Wespes, E.1    Amar, E.2    Hatzichristou, D.3
  • 25
    • 28444498797 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibitors and nonarteritic anterior ischemic optic neuropathy (NAION): Coincidence or causality?
    • Hatzichristou D. Phosphodiesterase 5 inhibitors and nonarteritic anterior ischemic optic neuropathy (NAION): coincidence or causality? J Sex Med. 2005;2(6):751-758.
    • (2005) J Sex Med , vol.2 , Issue.6 , pp. 751-758
    • Hatzichristou, D.1
  • 26
    • 0029919229 scopus 로고    scopus 로고
    • Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction
    • Linet OI, Ogrinc FG. Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. N Engl J Med. 1996;334(14):873-877.
    • (1996) N Engl J Med , vol.334 , Issue.14 , pp. 873-877
    • Linet, O.I.1    Ogrinc, F.G.2
  • 27
    • 0031795784 scopus 로고    scopus 로고
    • Combination therapy using oral alpha-blockers and intracavernosal injection in men with erectile dysfunction
    • Kaplan SA, Reis RB, Kohn IJ, Shabsigh R, Te AE. Combination therapy using oral alpha-blockers and intracavernosal injection in men with erectile dysfunction. Urology. 1998;52(5):739-743.
    • (1998) Urology , vol.52 , Issue.5 , pp. 739-743
    • Kaplan, S.A.1    Reis, R.B.2    Kohn, I.J.3    Shabsigh, R.4    Te, A.E.5
  • 28
    • 0026342799 scopus 로고
    • An improved vasoactive drug combination for a pharmacological erection program
    • Bennett AH, Carpenter AJ, Barada JH. An improved vasoactive drug combination for a pharmacological erection program. J Urol. 1991; 146(6):1564-1565.
    • (1991) J Urol , vol.146 , Issue.6 , pp. 1564-1565
    • Bennett, A.H.1    Carpenter, A.J.2    Barada, J.H.3
  • 29
    • 2342508518 scopus 로고    scopus 로고
    • Clinical and sonographic assessment of the side effects of intracavernous injection of vasoactive substances
    • Moemen MN, Hamed HA, Kamel II, Shamloul RM, Ghanem HM. Clinical and sonographic assessment of the side effects of intracavernous injection of vasoactive substances. Int J Impot Res. 2004;16(2): 143-145.
    • (2004) Int J Impot Res , vol.16 , Issue.2 , pp. 143-145
    • Moemen, M.N.1    Hamed, H.A.2    Kamel, I.I.3    Shamloul, R.M.4    Ghanem, H.M.5
  • 30
    • 0032956973 scopus 로고    scopus 로고
    • Intracavernosal versus intraurethral alprostadil: A prospective randomized study
    • Shokeir AA, Alserafi MA, Mutabagani H. Intracavernosal versus intraurethral alprostadil: a prospective randomized study. BJU Int. 1999;83(7):812-815.
    • (1999) BJU Int , vol.83 , Issue.7 , pp. 812-815
    • Shokeir, A.A.1    Alserafi, M.A.2    Mutabagani, H.3
  • 31
    • 0031792318 scopus 로고    scopus 로고
    • Vacuum devices in erectile dysfunction: Indications and efficacy
    • Oakley N, Moore KT. Vacuum devices in erectile dysfunction: indications and efficacy. Br J Urol. 1998;82(5):673-681.
    • (1998) Br J Urol , vol.82 , Issue.5 , pp. 673-681
    • Oakley, N.1    Moore, K.T.2
  • 32
    • 33644812682 scopus 로고    scopus 로고
    • Outcome of penile prosthesis implantation for treating erectile dysfunction: Experience with 504 procedures
    • Minervini A, Ralph DJ, Pryor JP. Outcome of penile prosthesis implantation for treating erectile dysfunction: experience with 504 procedures. BJU Int. 2006;97(1):129-133.
    • (2006) BJU Int , vol.97 , Issue.1 , pp. 129-133
    • Minervini, A.1    Ralph, D.J.2    Pryor, J.P.3
  • 34
    • 41549146877 scopus 로고    scopus 로고
    • The efficacy and safety of udenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction
    • Paick J-S, Kim SW, Yang DY, et al. The efficacy and safety of udenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction. J Sex Med. 2008;5(4):946-953.
    • (2008) J Sex Med , vol.5 , Issue.4 , pp. 946-953
    • Paick, J.-S.1    Kim, S.W.2    Yang, D.Y.3
  • 35
    • 38149008399 scopus 로고    scopus 로고
    • SLx-2101, a new long-acting PDE5 inhibitor: Preliminary safety, tolerability, PK and endothelial function effects in healthy subjects
    • Prince W, Campbell AS, Tong W, et al. SLx-2101, a new long-acting PDE5 inhibitor: preliminary safety, tolerability, PK and endothelial function effects in healthy subjects. J Sex Med. 2006;3(Suppl 1):29-30.
    • (2006) J Sex Med , vol.3 , Issue.SUPPL. 1 , pp. 29-30
    • Prince, W.1    Campbell, A.S.2    Tong, W.3
  • 36
    • 55849098428 scopus 로고    scopus 로고
    • Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction
    • Paick JS, Ahn TY, Choi HK, et al. Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction. J Sex Med. 2008;5(11):2672-2680.
    • (2008) J Sex Med , vol.5 , Issue.11 , pp. 2672-2680
    • Paick, J.S.1    Ahn, T.Y.2    Choi, H.K.3
  • 37
    • 0035812664 scopus 로고    scopus 로고
    • FR226807: A potent and selective phosphodiesterase type 5 inhibitor
    • Hosogai N, Hamada K, Tomita M, et al. FR226807: a potent and selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol. 2001;428(2): 295-302.
    • (2001) Eur J Pharmacol , vol.428 , Issue.2 , pp. 295-302
    • Hosogai, N.1    Hamada, K.2    Tomita, M.3
  • 38
    • 0035184939 scopus 로고    scopus 로고
    • Pharmacological profile of T-1032, a novel specific phosphodiesterase type 5 inhibitor, in isolated rat aorta and rabbit corpus cavernosum
    • Takagi M, Mochida H, Noto T, et al. Pharmacological profile of T-1032, a novel specific phosphodiesterase type 5 inhibitor, in isolated rat aorta and rabbit corpus cavernosum. Eur J Pharmacol. 2001;411(1-2):161-168.
    • (2001) Eur J Pharmacol , vol.411 , Issue.1-2 , pp. 161-168
    • Takagi, M.1    Mochida, H.2    Noto, T.3
  • 39
    • 0035834482 scopus 로고    scopus 로고
    • KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5
    • Hirose R, Okumura H, Yoshimatsu A, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001;431(1):17-24.
    • (2001) Eur J Pharmacol , vol.431 , Issue.1 , pp. 17-24
    • Hirose, R.1    Okumura, H.2    Yoshimatsu, A.3
  • 40
    • 33748309156 scopus 로고    scopus 로고
    • JNJ-10280205 and JNJ-10287069: Novel PDE5 inhibitors as clinical candidates for erectile dysfunction
    • Qiu Y, Bhattacharjee S, Kraft P, et al. JNJ-10280205 and JNJ-10287069: novel PDE5 inhibitors as clinical candidates for erectile dysfunction. Int J Impot Res. 2006;18:477-483.
    • (2006) Int J Impot Res , vol.18 , pp. 477-483
    • Qiu, Y.1    Bhattacharjee, S.2    Kraft, P.3
  • 41
    • 2342470807 scopus 로고    scopus 로고
    • NCX-911, a novel nitric oxide-releasing PDE5 inhibitor relaxes rabbit corpus cavernosum in the absence of endogenous nitric oxide
    • Kalsi JS, Kell PD, Cellek S, Ralph DJ. NCX-911, a novel nitric oxide-releasing PDE5 inhibitor relaxes rabbit corpus cavernosum in the absence of endogenous nitric oxide. Int J Impot Res. 2004;16:195-200.
    • (2004) Int J Impot Res , vol.16 , pp. 195-200
    • Kalsi, J.S.1    Kell, P.D.2    Cellek, S.3    Ralph, D.J.4
  • 42
    • 0033829159 scopus 로고    scopus 로고
    • Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction
    • Wessells H, Gralnek D, Dorr R, Hruby VJ, Hadley ME, Levine N. Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology. 2000;56(4):641-646.
    • (2000) Urology , vol.56 , Issue.4 , pp. 641-646
    • Wessells, H.1    Gralnek, D.2    Dorr, R.3    Hruby, V.J.4    Hadley, M.E.5    Levine, N.6
  • 44
    • 2342453337 scopus 로고    scopus 로고
    • Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra
    • Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004;16:135-142.
    • (2004) Int J Impot Res , vol.16 , pp. 135-142
    • Rosen, R.C.1    Diamond, L.E.2    Earle, D.C.3    Shadiack, A.M.4    Molinoff, P.B.5
  • 45
    • 39149106751 scopus 로고    scopus 로고
    • Salvage of sildenafil failures with bremelanotide: A randomized, double-blind, placebo controlled study
    • Safarinejad MR, Hosseini SY. Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study. J Urol. 2008;179(3):1066-1071.
    • (2008) J Urol , vol.179 , Issue.3 , pp. 1066-1071
    • Safarinejad, M.R.1    Hosseini, S.Y.2
  • 46
    • 0035123243 scopus 로고    scopus 로고
    • A double-blind, placebocontrolled, efficacy and safety study of topical gel formulation of 1% alprostadil (Topiglan) for the in-office treatment of erectile dysfunction
    • Goldstein I, Payton TR, Schechter PJ. A double-blind, placebocontrolled, efficacy and safety study of topical gel formulation of 1% alprostadil (Topiglan) for the in-office treatment of erectile dysfunction. Urology. 2001;57(2):301-305.
    • (2001) Urology , vol.57 , Issue.2 , pp. 301-305
    • Goldstein, I.1    Payton, T.R.2    Schechter, P.J.3
  • 47
    • 35648997466 scopus 로고    scopus 로고
    • Injection therapy for the treatment of erectile dysfunction: A comparison between alprostadil and a combination of vasoactive intestinal polypeptide and phentolamine mesilate
    • Shah PJ, Dinsmore W, Oakes RA, Hackett G. Injection therapy for the treatment of erectile dysfunction: a comparison between alprostadil and a combination of vasoactive intestinal polypeptide and phentolamine mesilate. Curr Med Res Opin. 2007;23(10):2577-2583.
    • (2007) Curr Med Res Opin , vol.23 , Issue.10 , pp. 2577-2583
    • Shah, P.J.1    Dinsmore, W.2    Oakes, R.A.3    Hackett, G.4
  • 48
    • 2942754237 scopus 로고    scopus 로고
    • An open-label, randomized, flexible-dose, crossover study to assess the comparative efficacy and safety of sildenafil citrate and apomorphine hydrochloride in men with erectile dysfunction
    • Eardley I, Wright P, MacDonagh R, Hole J, Edwards A. An open-label, randomized, flexible-dose, crossover study to assess the comparative efficacy and safety of sildenafil citrate and apomorphine hydrochloride in men with erectile dysfunction. BJU International. 2004;93(9):1271-1275.
    • (2004) BJU International , vol.93 , Issue.9 , pp. 1271-1275
    • Eardley, I.1    Wright, P.2    Macdonagh, R.3    Hole, J.4    Edwards, A.5
  • 49
    • 77955260510 scopus 로고    scopus 로고
    • Inhalation device allows novel administration of apomorphine in men with erectile dysfunction-efficacy and safety findings
    • Riley A, Main M, Morgan F. Inhalation device allows novel administration of apomorphine in men with erectile dysfunction-efficacy and safety findings. J Sex Med. 2010;7(4 Pt 1):1508-1517.
    • (2010) J Sex Med , vol.7 , Issue.4 PART. 1 , pp. 1508-1517
    • Riley, A.1    Main, M.2    Morgan, F.3
  • 50
    • 2342509138 scopus 로고    scopus 로고
    • Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats
    • Brioni JD, Moreland RB, Cowart M, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004;101(17):6758-6763.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.17 , pp. 6758-6763
    • Brioni, J.D.1    Moreland, R.B.2    Cowart, M.3
  • 51
    • 10644239822 scopus 로고    scopus 로고
    • Effect of excitatory amino acid receptor agonists on penile erection after administration into the CA3 hippocampal region in the rat
    • Song Y, Rajasekaran M. Effect of excitatory amino acid receptor agonists on penile erection after administration into the CA3 hippocampal region in the rat. Urology. 2004;64(6):1250-1254.
    • (2004) Urology , vol.64 , Issue.6 , pp. 1250-1254
    • Song, Y.1    Rajasekaran, M.2
  • 52
    • 0034849563 scopus 로고    scopus 로고
    • Pharmacology of penile erection
    • Andersson KE. Pharmacology of penile erection. Pharmacol Rev. 2001; 53(3):417-450.
    • (2001) Pharmacol Rev , vol.53 , Issue.3 , pp. 417-450
    • Andersson, K.E.1
  • 53
    • 0028846701 scopus 로고
    • Oral trazodone as empirical therapy for erectile dysfunction: A retrospective review
    • Lance R, Albo M, Costabile RA, Steers WD. Oral trazodone as empirical therapy for erectile dysfunction: a retrospective review. Urology. 1995;46(1):117-120.
    • (1995) Urology , vol.46 , Issue.1 , pp. 117-120
    • Lance, R.1    Albo, M.2    Costabile, R.A.3    Steers, W.D.4
  • 54
    • 0032586675 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine 2C receptors on spinal neurons controlling penile erection in the rat
    • Bancila M, Vergé D, Rampin O, et al. 5-Hydroxytryptamine 2C receptors on spinal neurons controlling penile erection in the rat. Neuroscience. 1999;92(4):1523-1537.
    • (1999) Neuroscience , vol.92 , Issue.4 , pp. 1523-1537
    • Bancila, M.1    Vergé, D.2    Rampin, O.3
  • 55
    • 0347987923 scopus 로고    scopus 로고
    • Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist
    • Kimura Y, Hatanaka K, Naitou Y, et al. Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. Eur J Pharmacol. 2004;483(1):37-43.
    • (2004) Eur J Pharmacol , vol.483 , Issue.1 , pp. 37-43
    • Kimura, Y.1    Hatanaka, K.2    Naitou, Y.3
  • 56
    • 0037304589 scopus 로고    scopus 로고
    • BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro
    • Kalsi JS, Rees RW, Hobbs AJ, et al. BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. J Urol. 2003;169(2):761-766.
    • (2003) J Urol , vol.169 , Issue.2 , pp. 761-766
    • Kalsi, J.S.1    Rees, R.W.2    Hobbs, A.J.3
  • 57
    • 0035826261 scopus 로고    scopus 로고
    • NO-independent regulatory site on soluble guanylate cyclase
    • Stasch JP, Becker EM, Alonso-Alija C, et al. NO-independent regulatory site on soluble guanylate cyclase. Nature. 2001;410:212-215.
    • (2001) Nature , vol.410 , pp. 212-215
    • Stasch, J.P.1    Becker, E.M.2    Alonso-Alija, C.3
  • 58
    • 0034650714 scopus 로고    scopus 로고
    • Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
    • Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol. 2000;522(2):177-185.
    • (2000) J Physiol , vol.522 , Issue.2 , pp. 177-185
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 59
    • 0035134310 scopus 로고    scopus 로고
    • Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway
    • Chitaley K, Wingard CJ, Clinton Webb R, et al. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med. 2001;7:119-122.
    • (2001) Nat Med , vol.7 , pp. 119-122
    • Chitaley, K.1    Wingard, C.J.2    Clinton Webb, R.3
  • 60
    • 3042702873 scopus 로고    scopus 로고
    • Topical application of a Rho-kinase inhibitor in rats causes penile erection
    • Dai Y, Chitaley K, Webb RC, Lewis RW, Mills TM. Topical application of a Rho-kinase inhibitor in rats causes penile erection. Int J Impot Res. 2004;16:294-298.
    • (2004) Int J Impot Res , vol.16 , pp. 294-298
    • Dai, Y.1    Chitaley, K.2    Webb, R.C.3    Lewis, R.W.4    Mills, T.M.5
  • 61
    • 22744455938 scopus 로고    scopus 로고
    • Pro-VGF-derived peptides induce penile erection in male rats: Involvement of paraventricular nitric oxide
    • Succu S, Mascia MS, Melis T, et al. Pro-VGF-derived peptides induce penile erection in male rats: involvement of paraventricular nitric oxide. Neuropharmacology. 2005;49(7):1017-1025.
    • (2005) Neuropharmacology , vol.49 , Issue.7 , pp. 1017-1025
    • Succu, S.1    Mascia, M.S.2    Melis, T.3
  • 62
    • 0034905771 scopus 로고    scopus 로고
    • EP 91073 prevents EP 80661-induced penile erection: New evidence for the existence of specific EP peptide receptors mediating penile erection
    • Melis MR, Succu S, Spano MS, Deghenghi R, Argiolas A. EP 91073 prevents EP 80661-induced penile erection: new evidence for the existence of specific EP peptide receptors mediating penile erection. Neuropharmacology. 2001;41:254-262.
    • (2001) Neuropharmacology , vol.41 , pp. 254-262
    • Melis, M.R.1    Succu, S.2    Spano, M.S.3    Deghenghi, R.4    Argiolas, A.5
  • 63
    • 0034666561 scopus 로고    scopus 로고
    • EP 60761 and EP 50885, two hexarelin analogues, induce penile erection in rats
    • Melis MR, Succu S, Spano MS, et al. EP 60761 and EP 50885, two hexarelin analogues, induce penile erection in rats. Eur J Pharmacol. 2000;404(1-2):137-143.
    • (2000) Eur J Pharmacol , vol.404 , Issue.1-2 , pp. 137-143
    • Melis, M.R.1    Succu, S.2    Spano, M.S.3
  • 64
    • 0029963477 scopus 로고    scopus 로고
    • Dopamine agonists increase nitric oxide production in the paraventricular nucleus of the hypothalamus: Correlation with penile erection and yawning
    • Melis MR, Succu S, Argiolas A. Dopamine agonists increase nitric oxide production in the paraventricular nucleus of the hypothalamus: correlation with penile erection and yawning. Eur J Neurosci. 1996; 8(10):2056-2063.
    • (1996) Eur J Neurosci , vol.8 , Issue.10 , pp. 2056-2063
    • Melis, M.R.1    Succu, S.2    Argiolas, A.3
  • 65
    • 33846879393 scopus 로고    scopus 로고
    • Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin
    • Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR. Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: involvement of central oxytocin. Neuropharmacology. 2007;52(3):1034-1043.
    • (2007) Neuropharmacology , vol.52 , Issue.3 , pp. 1034-1043
    • Succu, S.1    Sanna, F.2    Melis, T.3    Boi, A.4    Argiolas, A.5    Melis, M.R.6
  • 66
    • 33845774784 scopus 로고    scopus 로고
    • Christ G. hMaxi-K gene transfer in males with erectile dysfunction: Results of the first human trial
    • Melman A, Bar-Chama N, McCullough A, Davies K, Christ G. hMaxi-K gene transfer in males with erectile dysfunction: results of the first human trial. Hum Gene Ther. 2006;17(12):1165-1176.
    • (2006) Hum Gene Ther , vol.17 , Issue.12 , pp. 1165-1176
    • Melman, A.1    Bar-Chama, N.2    McCullough, A.3    Davies, K.4
  • 67
    • 0032877382 scopus 로고    scopus 로고
    • Interposition of sural nerve restores function of cavernous nerves resected during radical prostatectomy
    • Kim ED, Scardino PT, Hampel ORI, Mills NL, Wheeler TM, Nath RK. Interposition of sural nerve restores function of cavernous nerves resected during radical prostatectomy. J Urol. 1999;161(1): 188-192.
    • (1999) J Urol , vol.161 , Issue.1 , pp. 188-192
    • Kim, E.D.1    Scardino, P.T.2    Hampel, O.R.I.3    Mills, N.L.4    Wheeler, T.M.5    Nath, R.K.6
  • 68
    • 0036019368 scopus 로고    scopus 로고
    • Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo
    • Kershen RT, Yoo JJ, Moreland RB, Krane RJ, Atala A. Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo. Tissue Eng. 2002;8(3):515-524.
    • (2002) Tissue Eng , vol.8 , Issue.3 , pp. 515-524
    • Kershen, R.T.1    Yoo, J.J.2    Moreland, R.B.3    Krane, R.J.4    Atala, A.5
  • 69
    • 0142062593 scopus 로고    scopus 로고
    • Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices
    • Falke G, Yoo JJ, Kwon TG, Moreland R, Atala A. Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices. Tissue Eng. 2003;9(5): 871-879.
    • (2003) Tissue Eng , vol.9 , Issue.5 , pp. 871-879
    • Falke, G.1    Yoo, J.J.2    Kwon, T.G.3    Moreland, R.4    Atala, A.5
  • 70
    • 17144427696 scopus 로고    scopus 로고
    • Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering
    • Pilatz A, Schultheiss D, Gabouev AI, et al. Isolation of primary endothelial and stromal cell cultures of the corpus cavernosum penis for basic research and tissue engineering. Eur Urol. 2005;47(5):710-719.
    • (2005) Eur Urol , vol.47 , Issue.5 , pp. 710-719
    • Pilatz, A.1    Schultheiss, D.2    Gabouev, A.I.3
  • 71
    • 77958507849 scopus 로고    scopus 로고
    • Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction
    • Limin M, Johnsen N, Hellstrom WJG. Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction. Expert Opin Investig Drugs. 2010;19(11):1427-1437.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.11 , pp. 1427-1437
    • Limin, M.1    Johnsen, N.2    Hellstrom, W.J.G.3
  • 72
    • 38149055920 scopus 로고    scopus 로고
    • Pharmacokinetics of avanafil, a new PDE5 inhibitor being developed for erectile dysfunction
    • Peterson C, Swearingen D. Pharmacokinetics of avanafil, a new PDE5 inhibitor being developed for erectile dysfunction. J Sex Med. 2006;3(Suppl 3):253-254.
    • (2006) J Sex Med , vol.3 , Issue.SUPPL. 3 , pp. 253-254
    • Peterson, C.1    Swearingen, D.2
  • 73
    • 38149078344 scopus 로고    scopus 로고
    • Rigiscan evaluation of TA-1790, a novel PDE5 inhibitor for the treatment of men with erectile dysfunction
    • Lewis RW, Hellstrom W, Gittelman M. Rigiscan evaluation of TA-1790, a novel PDE5 inhibitor for the treatment of men with erectile dysfunction. J Urol. 2006;171(4 Suppl):316.
    • (2006) J Urol , vol.171 , Issue.4 SUPPL. , pp. 316
    • Lewis, R.W.1    Hellstrom, W.2    Gittelman, M.3
  • 74
    • 77954626094 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of avanafil, a phosphodiesterase type 5 inhibitor: A single-and multiple-dose, double-blind, randomized, placebo-controlled, dose-escalation study in healthy Korean male volunteers
    • Jung J, Choi S, Cho SH, et al. Tolerability and pharmacokinetics of avanafil, a phosphodiesterase type 5 inhibitor: a single-and multiple-dose, double-blind, randomized, placebo-controlled, dose-escalation study in healthy Korean male volunteers. Clin Ther. 2010;32(6):1178-1187.
    • (2010) Clin Ther , vol.32 , Issue.6 , pp. 1178-1187
    • Jung, J.1    Choi, S.2    Cho, S.H.3
  • 75
    • 84859112868 scopus 로고    scopus 로고
    • Results Announced For TA-1790 Phase II Head-to-head Study With Viagra
    • VIVUS, Inc, press releases March 4, Available from
    • Results announced for TA-1790 Phase II head-to-head study with Viagra. VIVUS, Inc, press releases March 4, 2004. Available from: http://www.prnewswire.com/news-releases/vivus-announces-resultsfor-ta-1790-in-phase-2-head-to-head-study-with-viagrar-58872542. html.
    • (2004)
  • 76
    • 77958471963 scopus 로고    scopus 로고
    • Haemodynamic effects of co-administration of avanafil and glyceryl trinitrate
    • Nehra A, Swearingen D, Dietrich J, Peterson C. Haemodynamic effects of co-administration of avanafil and glyceryl trinitrate. Eur Urol. 2006;5(2):138.
    • (2006) Eur Urol , vol.5 , Issue.2 , pp. 138
    • Nehra, A.1    Swearingen, D.2    Dietrich, J.3    Peterson, C.4
  • 77
    • 33845370693 scopus 로고    scopus 로고
    • Safety and Efficacy of Avanafil, a New PDE5 Inhibitor For Treating Erectile Dysfunction
    • Kaufman J, Dietrich J. Safety and efficacy of avanafil, a new PDE5 inhibitor for treating erectile dysfunction. 2006;5(2):138.
    • (2006) , vol.5 , Issue.2 , pp. 138
    • Kaufman, J.1    Dietrich, J.2
  • 78
    • 84859123599 scopus 로고    scopus 로고
    • Investigating avanafil in the treatment of erectile dysfunction: Results of a Phase III, multicenter, randomized, double-blind, placebo controlled clinical trial
    • San Francisco, CA
    • Goldstein I. BC, DiDonato K, et al. Investigating avanafil in the treatment of erectile dysfunction: results of a Phase III, multicenter, randomized, double-blind, placebo controlled clinical trial. AUA Late-Breaking Science Forum 2010, San Francisco, CA; 2010.
    • (2010) AUA Late-Breaking Science Forum
    • Goldstein I., B.C.1    Didonato, K.2
  • 79
    • 84859112869 scopus 로고    scopus 로고
    • VIVUS Announces Positive Results From Avanafil Phase 3 Study In Diabetics Presented At the 47th EASD Annual Meeting
    • 13 September, Available from
    • VIVUS Announces Positive Results From Avanafil Phase 3 Study in Diabetics Presented at the 47th EASD Annual Meeting. 13 September 2011. Available from: http://ir.vivus.com/releasedetail.cfm?ReleaseID=604819.
    • (2011)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.