Evidence for an increase in trisomy 21 (Down Syndrome) in Europe after the chernobyl reactor accident

Genetic Epidemiology

Volumn 36, Issue 1, 2012, Pages 48-55

  Sperling, Karl ^a   Neitzel, Heidemarie ^a   Scherb, Hagen ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Ionizing radiation; Maternal meiosis; Nondisjunction; Trend analysis

Indexed keywords

CESIUM 137; IODINE 131;

ARTICLE; BELARUS; CHERNOBYL ACCIDENT; CLOUD; CYTODIAGNOSIS; DOWN SYNDROME; GERMANY; HALF LIFE TIME; HUMAN; HUNGARY; LIVE BIRTH; MAJOR CLINICAL STUDY; MATERNAL AGE; NEWBORN; PREVALENCE; SWEDEN; TREND STUDY; UNITED KINGDOM;

BERLIN; CESIUM RADIOISOTOPES; CHERNOBYL NUCLEAR ACCIDENT; CHROMOSOME DISORDERS; DOSE-RESPONSE RELATIONSHIP, RADIATION; DOWN SYNDROME; EUROPE; FEMALE; HUMANS; INFANT, NEWBORN; IODINE RADIOISOTOPES; LIVE BIRTH; MATERNAL AGE; MOSAICISM; REPUBLIC OF BELARUS;

EID: 84859108636     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20662     Document Type: Article

References (25)

1. Anonymous. 1980. Health survey in high background radiation areas in China: High Background Radiation Research Group, China. Science 209:877-880.
2. Auvinen A, Vahteristo M, Arvela H, SuomelaM, Rahola T, Hakama M, Rytomaa T. 2001. Chernobyl fallout and outcome of pregnancy in Finland. Environ Health Perspect 109:179-185.
3. Bard D, Verger P, Hubert P. 1997. Chernobyl, 10 years after: health consequences. Epidemiol Rev 19:187-204.
4. BEIR V. Committee on the biological effects of ionizing radiation, National Research Council. 1990. Health effects of exposure to low levels of ionizing radiation (BEIR V). National Academy, Washington.
5. BfS, Bundesamt für Strahlenschutz. Jahresbericht 2005. Germany, Salzgitter 2006, p. 36.
6. Bishop JB, Dellarco VL, Hassold T, Ferguson LR, Wyrobek AJ, Friedman JM. 1996. Aneuploidy in germ cells: etiologies and risk factors. Environ Mol Mutagen 28:159-166.
7. Bond DJ, Chandley AC. 1983. Aneuploidy, Oxford Monographs on Medical Genetics, p. 11.
8. Bound JP, Francis BJ, Harvey PW. 1995. Down's syndrome: prevalence and ionising radiation in an area of north west England 1957-1991. J Epidemiol Community Health 49:164-170.
9. Burkart W, Grosche B, Schoetzau A. 1997. Down syndrome clusters in Germany after the Chernobyl accident. Radiat Res 147:321-328.
10. Champion MD, Hawley RS. 2002. Playing for half the deck: the molecular biology of meiosis. Nat Cell Biol 4:s50-s56.
11. Delange F, Heidemann P, Bourdoux P, Larsson A, Vigneri R, Klett M, Beckers C, Stubbe P. 1986. Regional variations of iodine nutrition and thyroid fuction during neonatal period in Europe. Biol Neonate 49:322-330.
12. Delhanty JD. 2005. Mechanisms of aneuploidy induction in human oogenesis and early embryogenesis. Cytogenet Genome Res 111:237-244.
13. Dobie KW, Hari KL, Maggert KA, Karpen GH. 1999. Centromere proteins and chromosome inheritance: a complex affair. Curr Opin Genet Dev 9:206-217.
14. Dolk H, Nichols R. 1999. Evaluation of the impact of Chernobyl on the prevalence of congenital anomalies in 16 regions of Europe. EUROCAT Working Group. Int J Epidemiol 28:941-948.
15. Drozdovitch V, Bouville A, Chobanova N, Filistovic V, Ilus T, KovacicM, Malatova I, MoserM, Nedveckaite T, Volkle H, Cardis E. 2007. Radiation exposure to the population of Europe following the Chernobyl accident. Radiat Prot Dosimetry 123:515-528.
16. Eichenlaub-Ritter U, Baart E, Yin H, Betzendahl I. 1996. Mechanisms of spontaneous and chemically-induced aneuploidy in mammalian oogenesis: basis of sex-specific differences in response to aneugens and the necessity for further tests. Mutat Res 372:279-294.
17. Ericson A, Källen B. 1994. Pregnancy outcome in Sweden after the Chernobyl accident. Environ Res 67:149-159.
18. Gembicki M, Stozharov AN, Arinchin AN, Moschik KV, Petrenko S, Khmara IM, Baverstock KF. 1997. Iodine deficiency in Belarusian children as a possible factor stimulating the irradiation of the thyroid gland during the Chernobyl catastrophe. Environ Health Perspect 105:1487-1490.
19. Harjulehto-Mervaala T, Salonen R, Aro T, Saxen L. 1992. The accident at Chernobyl and trisomy 21 in Finland. Mutat Res 275:81-86.
20. Hassold T, Hunt P. 2001. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2:280-291.
21. Hassold T, Abruzzo M, Adkins K, Grif fin D, Merrill M, Millie E, Saker D, Shen J, Zaragoza M. 1996. Human aneuploidy: incidence, origin, and etiology. Environ Mol Mutagen 28:167-175.
22. Hill AB. 1965. The environment and disease: association or causation. Proc R Soc Med 58:295-300.
23. Huether CA, Haroldson K, Ellis PM, Ramsay CN. 1996. Impact of prenatal diagnosis on revised livebirth prevalence estimates of Down syndrome in the Lothian region of Scotland, 1978-1992. Genet Epidemiol 13:367-375.
24. Huether CA, Ivanovich J, Goodwin BS, Krivchenia EL, Hertzberg VS, Edmonds LD, May DS, Priest JH. 1998. Maternal age specific risk rate estimates for Down syndrome among live births in whites and other races from Ohio and metropolitan Atlanta, 1970-1989. J Med Genet 35:482-490.
25. Irving C, Basu A, Richmond S, Burn J, Wren C. 2008. Twenty-year trends in prevalence and survival of Down syndrome. Eur J Hum Genet 16:1336-1340.