Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster

Pharmacogenetics and Genomics

Volumn 22, Issue 4, 2012, Pages 285-289

  Kislukhin, Galina ^a   Murphy, Maura L ^a   Jafari, Mahtab ^a   Long, Anthony D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

carboplatin; chemotherapy toxicity; floxuridine; gemcitabine hydrochloride; genetic polymorphism; heritability; methotrexate; mitomycin C; topotecan hydrochloride

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; FLOXURIDINE; GEMCITABINE; METHOTREXATE; MITOMYCIN C; TOPOTECAN;

ANIMAL EXPERIMENT; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FEMALE; FEMALE FERTILITY; HERITABILITY; NONHUMAN; PRIORITY JOURNAL;

DROSOPHILA MELANOGASTER;

EID: 84859103457     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283514395     Document Type: Article

References (19)

1. Hardman JG, Limberd LE, Molinoff PB, Ruddon RW. Goodman and Gillman's the pharmacological basis of therapeutics. New York: McGraw-Hill; 1996.
2. Rothenberg M, Merepol N, Poplin E, Cutsem E, Wadler S. Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: summary findings of an independent panel. J Clin Oncol 2001; 18:3801-3807. (Pubitemid 32880058)
3. Lee W, Lockhart C, Kim R, Rothenberg M. Cancer pharmacogenomics: powerful tools in cancer chemotherapy and drug development. Oncologist 2005; 10:104-111. (Pubitemid 40261949)
4. Meirow D, Nugent D. The effects ofradiotherapy and chemotherapy on female reproduction. Hum Reprod Update 2001; 7:535-543. (Pubitemid 33069611)
5. Gajewski J, Ho W, Nimer S, Hirji K, Gekelman L, Jacobs A, et al. Efficacy ofintensive chemotherapy for acute myelogenous leukemia associated with a preleukemic syndrome. J Clin Oncol 1989; 7:1637-1645. (Pubitemid 19272833)
6. Watters J, McLeod H. Cancer pharmacogenomics: current and future applications. Biochim Biophys Acta 2003; 1603:99-111. (Pubitemid 36262943)
7. Wecker L,Watts S, Faingold C, Dunaway G, Crespo L. Brody's human pharmacology: molecular to clinical. 5th ed. Philadelphia: Mosby/Elsevier; 2010.
8. Cirulli E, Goldstein D. Uncovering the roles ofrare variants in common disease through whole-genome sequencing. Nat Rev Genet 2010; 11:415-425.
9. Falconer DS, Mackay TFC. Introduction to quantitative genetics. 4th ed. Harlow, Essex: Addison Wesley Longman; 1996.
10. Avanesian A, Semnani S, Jafari M. Can Drosophila melanogaster represent a model system for the detection of reproductive adverse drug reactions? Drug Discov Today 2009; 15:761-766.
11. Kerbel R, Kamen A. The anti-angiogenic basis ofmetronomic chemotherapy. Nature 2004; 4:423-436.
12. Macdonald S, Long A. Joint estimates ofquantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster. Genetics 2007; 176:1261-1281. (Pubitemid 46961120)
13. Bier E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet 2005; 6:9-23. (Pubitemid 39657894)
14. Lazzaro B, Sceurman B, Clark A. Genetic basis ofnatural variation in D. melanogaster antibacterial immunity. Science 2004; 303:1873-1876.
15. Becker WA. Manual of quantitative genetics. 5th ed. Pullman, WA, USA: Academic Enterprises; 1992. pp. 47-48.
16. Roff D, Mousseau T. Quantitative genetics and fitness: lessons from Drosophila. Heredity 1987; 58:103-118.
17. Affleck J, Neumann K, Wong L, Walker V. The effects ofmethotrexate on Drosophila development, female fecundity, and gene expression. Toxicol Sci 2006; 89:495-503. (Pubitemid 43126008)
18. Ashburner M, Ball C, Blake J, Botstein D, Butler H, Cherry M, et al. Gene Ontology: tool for the unification of biology. Nat Genet 2000; 25:25-29. (Pubitemid 30257031)
19. Pui C, Relling M, Evans W. Role ofpharmacogenomics and pharmacodynamics in the treatment of acute lymphoblastic leukemia. Best Prac Res Clin Haematol 2003; 15:741-756.