Understanding otherness: The neural bases of action comprehension and pain empathy in a congenital amputee

Cerebral Cortex

Volumn 22, Issue 4, 2012, Pages 811-819

  Aziz Zadeh, Lisa ^a   Sheng, Tong ^a   Liew, Sook Lei ^a   Damasio, Hanna ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

action observation; body image; empathy; fMRI; mentalizing; mirror neuron system; pain matrix

Indexed keywords

ADULT; AGENESIS; ARTICLE; BODY IMAGE; CASE REPORT; CONGENITAL MALFORMATION; CONTROLLED STUDY; DISABLED PERSON; EMOTION; EMPATHY; FEMALE; FOOT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HAND MOVEMENT; HUMAN; INSULA; LIMB MALFORMATION; MOUTH; NUCLEAR MAGNETIC RESONANCE SCANNER; PAIN; PRIORITY JOURNAL; SENSORIMOTOR CORTEX; TASK PERFORMANCE; VIDEORECORDING;

EID: 84859097906     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhr139     Document Type: Article

References (53)

1. Amodio DM, Frith CD. 2006. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 7:268-277.
2. Avenanti A, Bolognini N, Maravita A, Aglioti SM. 2007. Somatic and motor components of action simulation. Curr Biol. 17:2129-2135.
3. Avenanti A, Bueti D, Galati G, Aglioti SM. 2005. Transcranial magnetic stimulation highlights the sensorimotor side of empathy for pain. Nat Neurosci. 8:955-960.
4. Avenanti A, Paluello IM, Bufalari I, Aglioti SM. 2006. Stimulus-driven modulation of motor-evoked potentials during observation of others' pain. Neuroimage. 32:316-324.
5. Avenanti A, Sirigu A, Aglioti SM. 2010. Racial bias reduces empathic sensorimotor resonance with other-race pain. Curr Biol. 20(11): 1018-1022.
6. Aziz-Zadeh L, Sheng T, Gheytanchi A. 2010. Common premotor regions for the perception and production of prosody and correlations with empathy and prosodic ability. PLoS One. 5:e8759.
7. Brass M, Schmitt RM, Spengler S, Gergely G. 2007. Investigating action understanding: inferential processes versus action simulation. Curr Biol. 17:2117-2121.
8. Brett M, Anton J, Valabregue R, Poline J. 2002. Region of interest analysis using an SPM toolbox [abstract]. Presented at the 8th International Conference on Functional Mapping of the Human Brain; 2002 Jun 2-6; Sendai (Japan). Available on CD-ROM in NeuroImage, Vol 16, No 2, abstract 497.
9. Buccino G, Lui F, Canessa N, Patteri I, Lagravinese G, Benuzzi F, Porro CA, Rizzolatti G. 2004. Neural circuits involved in the recognition of actions performed by nonconspecifics: an FMRI study. J Cogn Neurosci. 16:114-126.
10. Bufalari I, Aprile T, Avenanti A, Di Russo F, Aglioti SM. 2007. Empathy for pain and touch in the human somatosensory cortex. Cereb Cortex. 17:2553-2561.
11. Calvo-Merino B, Glaser DE, Grezes J, Passingham RE, Haggard P. 2005. Action observation and acquired motor skills: an FMRI study with expert dancers. Cereb Cortex. 15:1243-1249.
12. Costantini M, Galati G, Ferretti A, Caulo M, Tartaro A, Romani GL, Aglioti SM. 2005. Neural systems underlying observation of humanly impossible movements: an FMRI study. Cereb Cortex. 15(11): 1761-1767.
13. Cross ES, Hamilton AF, Grafton ST. 2006. Building a motor simulation de novo: observation of dance by dancers. Neuroimage. 31:1257-1267.
14. Danziger N, Faillenot I, Peyron R. 2009. Can we share a pain we never felt? Neural correlates of empathy in patients with congenital insensitivity to pain. Neuron. 61:203-212.
15. Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY, Iacoboni M. 2006. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci. 9:28-30.
16. de Lange FP, Spronk M, Willems RM, Toni I, Bekkering H. 2008. Complementary systems for understanding action intentions. Curr Biol. 18:454-457.
17. Ferrarri PF, Maiolini C, Addessi E, Fogassi L, Visalberghi E. 2005. The observation and hearing of eating actions activates motor programs related to eating in macaque monkeys. Behav Brain Res. 161(1):95-101.
18. Fletcher PC, Happe F, Frith U, Baker SC, Dolan RJ, Frackowiak RS, Frith CD. 1995. Other minds in the brain: a functional imaging study of "theory of mind" in story comprehension. Cognition. 57:109-128.
19. Gallese V, Goldman A. 1998. Mirror neurons and the simulation theory of mind-reading. Trends Cogn Sci. 2:493-501.
20. Gallese V, Keysers C, Rizzolatti G. 2004. A unifying view of the basis of social cognition. Trends Cogn Sci. 8:396-403.
21. Gazzola V, Aziz-Zadeh L, Keysers C. 2006. Empathy and the somatotopic auditory mirror system in humans. Curr Biol. 16:1824-1829.
22. Gazzola V, Rizzolatti G, Wicker B, Keysers C. 2007. The anthropomorphic brain: the mirror neuron system responds to human and robotic actions. Neuroimage. 35:1674-1684.
23. Gazzola V, van der Worp H, Mulder T, Wicker B, Rizzolatti G, Keysers C. 2007. Aplasics born without hands mirror the goal of hand actions with their feet. Curr Biol. 17:1235-1240.
24. Hein G, Singer T. 2008. I feel how you feel but not always: the empathic brain and its modulation. Curr Opin Neurobiol. 18:153-158.
25. Iacoboni M, Koski LM, Brass M, Bekkering H, Woods RP, Dubeau MC, Mazziotta JC, Rizzolatti G. 2001. Reafferent copies of imitated actions in the right superior temporal cortex. Proc Natl Acad Sci USA. 98(24):13995-13999.
26. Iacoboni M, Molnar-Szakacs I, Gallese V, Buccino G, Mazziotta JC, Rizzolatti G. 2005. Grasping the intentions of others with one's own mirror neuron system. PLoS Biol. 3:e79.
27. Jabbi M, Bastiaansen J, Keysers C. 2008. A common anterior insula representation of disgust observation, experience and imagination shows divergent functional connectivity pathways. PLoSOne. 3:e2939.
28. Jackson PL, Brunet E, Meltzoff AN, Decety J. 2006. Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain. Neuropsychologia. 44:752-761.
29. Keysers C, Gazzola V. 2007. Integrating simulation and theory of mind: from self to social cognition. Trends Cogn Sci. 11:194-196.
30. Keysers C, Gazzola V. 2009. Expanding the mirror: vicarious activity for actions, emotions, and sensations. Curr Opin Neurobiol. 19:666-671.
31. Keysers C, Kaas JH, Gazzola V. 2010. Somatosensation in social perception. Nat Rev Neurosci. 11:417-428.
32. Keysers C, Wicker B, Gazzola V, Anton JL, Fogassi L, Gallese V. 2004. A touching sight: SII/PV activation during the observation and experience of touch. Neuron. 42:335-346.
33. Kilner JM, Frith CD. 2008. Action observation: inferring intentions without mirror neurons. Curr Biol. 18:R32-R33.
34. Lamm C, Batson CD, Decety J. 2007. The neural substrate of human empathy: effects of perspective-taking and cognitive appraisal. J Cogn Neurosci. 19:42-58.
35. Lamm C, Meltzoff AN, Decety J. 2010. How do we empathize with someone who is not like us? A functional magnetic resonance imaging study. J Cogn Neurosci. 22:362-376.
36. Liepelt R, Von Cramon DY, Brass M. 2008. How do we infer others' goals from non-stereotypic actions? The outcome of contextsensitive inferential processing in right inferior parietal and posterior temporal cortex. Neuroimage. 43:784-792.
37. Liew SL, Han S, Aziz-Zadeh L. 2011. Familiarity modulates mirror neuron and mentalizing regions during intention understanding. Human Brain Mapping. 32. doi: 10.1002/hbm.21164.
38. Oldfield RC. 1971. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia. 9(1):97-113.
39. Oztop E, Arbib MA. 2002. Schema design and implementation of the grasp-related mirror neuron system. Biol Cybern. 87:116-140.
40. Peyron R, Laurent B, Garcia-Larrea L. 2000. Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin. 30:263-288.
41. Preston SD, de Waal FB. 2002. Empathy: its ultimate and proximate bases. Behav Brain Sci. 25:1-20discussion: 20-71.
42. Rizzolatti G, Craighero L. 2004. The mirror-neuron system. Annu Rev Neurosci. 27:169-192.
43. Saxe R. 2005. Against simulation: the argument from error. Trends Cogn Sci. 9:174-179.
44. Schippers MB, Gazzola V, Goebel R, Keysers C. 2009. Playing charades in the fMRI: are mirror and/or mentalizing areas involved in gestural communication? PLoS One. 4:e6801.
45. Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD. 2004. Empathy for pain involves the affective but not sensory components of pain. Science. 303:1157-1162.
46. Singer T, Seymour B, O'Doherty JP, Stephan KE, Dolan RJ, Frith CD. 2006. Empathic neural responses are modulated by the perceived fairness of others. Nature. 439:466-469.
47. Spunt RP, Satpute AB, Lieberman MD. 2010. Identifying the what, why, and how of an observed action: an fMRI study of mentalizing and mechanizing during action observation. J Cogn Neurosci. 23:63-74.
48. Thesen S, Heid O, Mueller E, Schad LR. 2000. Prospective acquisition correction for head motion with image-based tracking for real-time fMRI. Magn Reson Med. 44:457-465.
49. Uddin LQ, Iacoboni M, Lange C, Keenan JP. 2007. The self and social cognition: the role of cortical midline structures and mirror neurons. Trends Cogn Sci. 11:153-157.
50. Valeriani M, Betti V, Le Pera D, De Armas L, Miliucci R, Restuccia D, Avenanti A, Aglioti SM. 2008. Seeing the pain of others while being in pain: a laser-evoked potentials study. Neuroimage. 40:1419-1428.
51. Van Overwalle F, Baetens K. 2009. Understanding others' actions and goals by mirror and mentalizing systems: a meta-analysis. Neuroimage. 48:564-584.
52. Xu X, Zuo X, Wang X, Han S. 2009. Do you feel my pain? Racial group membership modulates empathic neural responses. J Neurosci. 29(26):8525-8529.
53. Zaki J, Weber J, Bolger N, Ochsner K. 2009. The neural bases of empathic accuracy. Proc Natl Acad Sci USA. 106:11382-11387.