Does erythromycin have anti-inflammatory effects independent of its antimicrobial action?

Journal of Clinical Pharmacology

Volumn 52, Issue 4, 2012, Pages 613-614

  Oo, Charles ^a   Shah, Bharti ^a  

^a Asubio Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; BIOLOGICAL MARKER; DEXAMETHASONE; ERYTHROMYCIN; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; HOST CELL; INFLAMMATION; LETTER; LUNG DISEASE; PROSTHESIS FAILURE; SKIN DISEASE;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; ERYTHROMYCIN; HUMANS; JOINT PROSTHESIS; PROSTHESIS FAILURE; PROSTHESIS-RELATED INFECTIONS;

EID: 84859077339     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270011398245     Document Type: Letter

References (7)

1. Zhang P, Qin L. Potential use of erythromycin to prevent and treat prosthetic failure. J Clin Pharmacol. 2010;50:858-860.
2. Amsden GW. Anti-inflammatory effects of macrolides-an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? J Antimicrob Chemother. 2005;55:10-21. (Pubitemid 40192609)
3. Desaki M, Okazaki H, Sunazuka T, et al. Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation. Antimicrob Agents Chemother. 2004;48:1581-1585. (Pubitemid 38544362)
4. Sevilla-Sanchez D, Soy-Muner D, Soler-Porcar N. Usefulness of macrolides as anti-inflammatories in respiratory diseases. Arch Bronconeumol. 2010;46:244-254.
5. Cheung PS, Si EC, Hosseini K. Anti-inflammatory activity of azithromycin as measured by its NF-kappaB, inhibitory activity. Ocul Immunol Inflamm. 2010;18:32-37.
6. Bell SC, Senini SL, McCormack JG. Macrolides in cystic fibrosis. Chron Respir Dis. 2005;2:85-98.
7. Si-Tahar M, Touqui L, Chignard M. Innate immunity and inflammation-two facets of the same anti-infectious reaction. Clin Exp Immunol. 2009;156:194-198.