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Volumn 52, Issue 4, 2012, Pages 595-599

Modeling the relationship between drug lipophilicity and potential for an interaction with orlistat

Author keywords

drug interaction; lipophilicity; Orlistat

Indexed keywords

ALPHA TOCOPHEROL; AMIODARONE; AMITRIPTYLINE; ASTEMIZOLE; ATORVASTATIN; ATOVAQUONE; BETA CAROTENE; BEZAFIBRATE; CYCLOSPORIN; DESOGESTREL; DIGOXIN; ETHINYLESTRADIOL; FLUOXETINE; GLIBENCLAMIDE; ISOTRETINOIN; LOSARTAN; METFORMIN; NIFEDIPINE; NORTRIPTYLINE; PHENTERMINE; PHENYTOIN; PHYTOMENADIONE; PRAVASTATIN; RETINOL ACETATE; RETINOL PALMITATE; SIBUTRAMINE; SIMVASTATIN; TETRAHYDROLIPSTATIN; UNINDEXED DRUG; WARFARIN;

EID: 84859064590     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270011398363     Document Type: Article
Times cited : (4)

References (17)
  • 1
    • 0029085293 scopus 로고
    • The influence of reduced dietary fat absorption induced by orlistat on the pharmacokinetics of digoxin in healthy volunteers
    • Melia AT, Zhi J, Koss-Twardy SG, et al. The influence of reduced dietary fat absorption induced by orlistat on the pharmacokinetics of digoxin in healthy volunteers. J Clin Pharmacol. 1995;35:840-843.
    • (1995) J Clin Pharmacol , vol.35 , pp. 840-843
    • Melia, A.T.1    Zhi, J.2    Koss-Twardy, S.G.3
  • 2
    • 0029741559 scopus 로고    scopus 로고
    • The effect of orlistat on the pharmacokinetics of phenytoin in healthy volunteers
    • Melia AT, Mulligan TE, Zhi J. The effect of orlistat on the pharmacokinetics of phenytoin in healthy volunteers. J Clin Pharmacol. 1996;36:654-658. (Pubitemid 26260547)
    • (1996) Journal of Clinical Pharmacology , vol.36 , Issue.7 , pp. 654-658
    • Melia, A.T.1    Mulligan, T.E.2    Zhi, J.3
  • 4
    • 0029960012 scopus 로고    scopus 로고
    • Lack of effect of orlistat on the bioavailability of a single dose of nifedipine extended-release tablets (Procardia XL) in healthy volunteers
    • Melia AT, Mulligan TE, Zhi J. Lack of effect of orlistat on the bioavailability of a single dose of nifedipine extended-release tablets (Procardia XL) in healthy volunteers. J Clin Pharmacol. 1996;36:352-355. (Pubitemid 26125955)
    • (1996) Journal of Clinical Pharmacology , vol.36 , Issue.4 , pp. 352-355
    • Melia, A.T.1    Mulligan, T.E.2    Zhi, J.3
  • 5
    • 0036708028 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of the possible interaction between selected concomitant medications and orlistat at steady state in healthy subjects
    • Zhi J, Moore R, Kanitra L, Mulligan TE. Pharmacokinetic evaluation of the possible interaction between selected concomitant medications and orlistat at steady state in healthy subjects. J Clin Pharmacol. 2002;42:1011-1019. (Pubitemid 34920799)
    • (2002) Journal of Clinical Pharmacology , vol.42 , Issue.9 , pp. 1011-1019
    • Zhi, J.1    Moore, R.2    Kanitra, L.3    Mulligan, T.E.4
  • 6
    • 0037380717 scopus 로고    scopus 로고
    • Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs (amiodarone, fluoxetine, and simvastatin) in healthy volunteers
    • DOI 10.1177/0091270003252236
    • Zhi J, Moore R, Kanitra L, Mulligan TE. Effects of orlistat, alipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs (amiodarone, fluoxetine, and simvastatin) in healthy volunteers. J Clin Pharmacol. 2003;43:428-435. (Pubitemid 36368785)
    • (2003) Journal of Clinical Pharmacology , vol.43 , Issue.4 , pp. 428-435
    • Zhi, J.1    Moore, R.2    Kanitra, L.3    Mulligan, T.E.4
  • 7
    • 0033009311 scopus 로고    scopus 로고
    • Effect of orlistat, a novel anti-obesity agent, on the pharmacokinetics and pharmacodynamics of pravastatin in patients with mild hypercholesterolaemia
    • Oo C, Akbari B, Lee S, et al. Effect of orlistat, anovel antiobesity agent, on the pharmacokinetics and pharmacodynamics of pravastatin in patients with mild hypercholesterolaemia. Clin Drug Invest. 1999;17:217-223. (Pubitemid 29145735)
    • (1999) Clinical Drug Investigation , vol.17 , Issue.3 , pp. 217-223
    • Oo, C.Y.1    Akbari, B.2    Lee, S.3    Nichols, G.4    Hellmann, C.P.5
  • 8
    • 0029059581 scopus 로고
    • The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers
    • Zhi J, Melia AT, Koss-Twardy SG, et al. The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers. J Clin Pharmacol. 1995;35:521-525.
    • (1995) J Clin Pharmacol , vol.35 , pp. 521-525
    • Zhi, J.1    Melia, A.T.2    Koss-Twardy, S.G.3
  • 10
    • 0029989469 scopus 로고    scopus 로고
    • The effect of orlistat, an inhibitor of dietary fat absorption, on the pharmacokinetics of â-carotene in healthy volunteers
    • Zhi J, Melia AT, Koss-Twardy SG, Arora S, Patel IH. The effect of orlistat, an inhibitor of dietary fat absorption, on the pharmacokinetics of â-carotene in healthy volunteers. J Clin Pharmacol. 1996;36:152-159. (Pubitemid 26082401)
    • (1996) Journal of Clinical Pharmacology , vol.36 , Issue.2 , pp. 152-159
    • Zhi, J.1    Melia, A.T.2    Koss-Twardy, S.G.3    Arora, S.4    Patel, I.H.5
  • 11
    • 0029784311 scopus 로고    scopus 로고
    • The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers
    • Melia AT, Koss-Twardy SG, Zhi J. The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers. J Clin Pharmacol. 1996;36:647-653. (Pubitemid 26260546)
    • (1996) Journal of Clinical Pharmacology , vol.36 , Issue.7 , pp. 647-653
    • Melia, A.T.1    Koss-Twardy, S.G.2    Zhi, J.3
  • 12
    • 0030997330 scopus 로고    scopus 로고
    • Olestra: Assessing its potential to interact with drugs in the gastrointestinal tract
    • DOI 10.1016/S0009-9236(97)90094-1
    • Goldman P. Olestra: assessing its potential to interact with drugs in the gastrointestinal tract. Clin Pharmacol Ther. 1997;61: 613-618. (Pubitemid 27279922)
    • (1997) Clinical Pharmacology and Therapeutics , vol.61 , Issue.6 , pp. 613-618
    • Goldman, P.1
  • 13
    • 0028103894 scopus 로고
    • Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers
    • Zhi J, Melia AT, Guerciolini R, Chung J, Kinberg J, Hauptman JB, Patel IH. Retrospective population-based analysis of the doseresponse (fecal fat excretion) relationship of orlistat in normal and obese volunteers. Clin Pharmacol Ther. 1994;56:82-85. (Pubitemid 24251568)
    • (1994) Clinical Pharmacology and Therapeutics , vol.56 , Issue.1 , pp. 82-85
    • Zhi, J.1    Melia, A.T.2    Guerciolini, R.3    Chung, J.4    Kinberg, J.5    Hauptman, J.B.6    Patel, I.H.7
  • 14
    • 0036157184 scopus 로고    scopus 로고
    • The effect of orlistat on plasma levels of psychotropic drugs in patients with long-term psychopharmacotherapy
    • DOI 10.1097/00004714-200202000-00011
    • Hilger E, Quiner S, Ginzel I, Walter H, Saria L, Barnas C. The effect of orlistat on plasma levels of psychotropic drugs in patients with long-term psychopharmacotherapy. J Clin Psychopharmacol. 2002;22:68-70. (Pubitemid 34101295)
    • (2002) Journal of Clinical Psychopharmacology , vol.22 , Issue.1 , pp. 68-70
    • Hilger, E.1    Quiner, S.2    Ginzel, I.3    Walter, H.4    Saria, L.5    Barnas, C.6
  • 15
    • 40549137751 scopus 로고    scopus 로고
    • A comparison of theoretical methods of calculation of partition coefficients for selected drugs
    • Pyka A, Babuska M, Zachariasz M. A comparison of theoretical methods of calculation of partition coefficients for selected drugs. Acta Pol Pharm. 2006;63:159-167. (Pubitemid 351359750)
    • (2006) Acta Poloniae Pharmaceutica - Drug Research , vol.63 , Issue.3 , pp. 159-167
    • Pyka, A.1    Babuska, M.2    Zachariasz, M.3
  • 16
    • 0033057651 scopus 로고    scopus 로고
    • Differentiation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors by their relative lipophilicity
    • Joshi HN, Fakes MG, Serajuddin ATM. Differentiation of 3:hydroxy-3-methylglutaryl-coenzyme Areductase inhibitors by their relative lipophilicity. Pharm Pharmacol Commun. 1999;5:269-271. (Pubitemid 29245825)
    • (1999) Pharmacy and Pharmacology Communications , vol.5 , Issue.4 , pp. 269-271
    • Joshi, H.N.1    Fakes, M.G.2    Serajuddin, A.T.M.3
  • 17
    • 0033973249 scopus 로고    scopus 로고
    • Lack of pharmacokinetic drug-drug interaction between orlistat and cerivastatin
    • Mück W, Adelmann H-G, Ruf T, et al. Lack of pharmacokinetic drug-drug interaction between orlistat and cerivastatin. Clin Drug Invest. 2000;19:71-73. (Pubitemid 30071991)
    • (2000) Clinical Drug Investigation , vol.19 , Issue.1 , pp. 71-73
    • Muck, W.1    Adelmann, H.-G.2    Ruf, T.3    Unger, S.4    Voith, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.