Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers

Clinical Infectious Diseases

Volumn 54, Issue 8, 2012, Pages 1162-1165

  Dupin, Nicolas ^a,b   Lecuyer, Hervé ^a,c,d   Carlotti, Agns ^b   Poyart, Claire ^a,b,e   Coureuil, Mathieu ^a,d   Chanal, Johan ^a   Schmitt, Alain ^e   Vacher Lavenu, Marie Cécile ^a,b   Taha, Muhamed Kheir ^f   Nassif, Xavier ^a,c,d   Morand, Philippe C ^a,b,e  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Hôpital Cochin ^*  (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d INSERM   (France)

^e CNRS   (France)

^f INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CEFTRIAXONE; GENTAMICIN;

ADULT; ARTICLE; CASE REPORT; CHRONIC DISEASE; DISLOCATION; EXTRAVASCULAR SPACE; FEVER; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; IN VIVO STUDY; KNEE ARTHRITIS; LYMPHANGITIS; MALE; MENINGOCOCCEMIA; NEISSERIA MENINGITIDIS; PAPULAR RASH; PLEURISY; PRIORITY JOURNAL; PUSTULE; REMISSION; SKIN BIOPSY; SKIN DEFECT; TACHYCARDIA; VASCULAR ENDOTHELIUM;

BACTEREMIA; CHRONIC DISEASE; ENDOTHELIUM; MENINGOCOCCAL INFECTIONS; SKIN DISEASES, BACTERIAL;

EID: 84859055553     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cis120     Document Type: Article

References (11)

1. Benoit FL. Chronic meningococcemia. Case report and review of the literature. Am J Med 1963; 35:103-12.
2. Pron B, Taha MK, Rambaud C, et al. Interaction of Neisseria meningitidis with the components of the blood-brain barrier correlates with an increased expression of PilC. J Infect Dis 1997; 176: 1285-92.
3. Guarner J, Greer PW, Whitney A, et al. Pathogenesis and diagnosis of human meningococcal disease using immunohistochemical and PCR assays. Am J Clin Pathol 2004; 122:754-64.
4. Join-Lambert O, Morand PC, Carbonnelle E, et al. Mechanisms of meningeal invasion by a bacterial extracellular pathogen, the example of Neisseria meningitidis. Prog Neurobiol 2010; 91:130-9.
5. Hoffmann I, Eugene E, Nassif X, Couraud PO, Bourdoulous S. Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis. J Cell Biol 2001; 155: 133-43.
6. Eugene E, Hoffmann I, Pujol C, Couraud PO, Bourdoulous S, Nassif X. Microvilli-like structures are associated with the internalization of virulent capsulated Neisseria meningitidis into vascular endothelial cells. J Cell Sci 2002; 115:1231-41.
7. Coureuil M, Mikaty G, Miller F, et al. Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium. Science 2009; 325:83-7.
8. Coureuil M, Lecuyer H, Scott MG, et al. Meningococcus hijacks a beta2-adrenoceptor/beta-arrestin pathway to cross brain microvasculature endothelium. Cell 2010; 143:1149-60.
9. Boisier P, Nicolas P, Djibo S, et al. Meningococcal meningitis: unprecedented incidence of serogroup X-related cases in 2006 in Niger. Clin Infect Dis 2007; 44:657-63.
10. Delrieu I, Yaro S, Tamekloe TA, et al. Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso. PLoS One 2011; 6:e19513.
11. Mairey E, Genovesio A, Donnadieu E, et al. Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrier. J Exp Med 2006; 203:1939-50.