Supervised exercise training counterbalances the adverse effects of insulin therapy in overweight/obese subjects with type 2 diabetes

Diabetes Care

Volumn 35, Issue 1, 2012, Pages 39-41

  Balducci, Stefano ^a,b,c   Zanuso, Silvano ^d   Cardelli, Patrizia ^a,b   Salerno, Gerardo ^a,b   Fallucca, Sara ^a,b   Nicolucci, Antonio ^e   Pugliese, Giuseppe ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Metabolic Fitness Association   (Italy)

^d UNIVERSITY OF GREENWICH   (United Kingdom)

^e Consorzio Mario Negri Sud ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN A1C; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ORAL ANTIDIABETIC AGENT;

ADULT; AEROBIC EXERCISE; ARTICLE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE MARKER; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; INFLAMMATION; INSULIN TREATMENT; ISCHEMIC HEART DISEASE; ITALY; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATIENT COUNSELING; PHYSICAL ACTIVITY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; SEDENTARY LIFESTYLE; STRUCTURED EXERCISE COUNSELING; WAIST CIRCUMFERENCE;

AGED; BLOOD PRESSURE; BODY MASS INDEX; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; COUNSELING; DIABETES MELLITUS, TYPE 2; EXERCISE; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; RESISTANCE TRAINING; RISK FACTORS; WAIST CIRCUMFERENCE;

EID: 84859047387     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-1450     Document Type: Article

References (11)

1. Hansson GK, Robertson AK, Söderberg- Nauclér C.Inflammation and atherosclerosis. Annu Rev Pathol 2006;1:297-329
2. Hayden JM, Reaven PD. Cardiovascular disease indiabetes mellitus type 2: a potential role for novel cardiovascular risk factors. Curr Opin Lipidol 2000;11:519-528
3. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002;347: 1557-1565 (Pubitemid 35315836)
4. Ridker PM, Danielson E, Fonseca FA, et al.; JUPITER Trial Study Group. Reduction inC-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 2009; 373:1175-1182
5. Balducci S, Zanuso S, Nicolucci A, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010;20:608-617
6. Esposito K, Ciotola M, Maiorino MI, et al. Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial. Ann Intern Med 2008;149:531-539
7. Pradhan AD, Everett BM, Cook NR, Rifai N, Ridker PM. Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial. JAMA 2009;302:1186-1194
8. Aas AM, Seljeflot I, Torjesen PA, Diep LM, Thorsby PM, Birkeland KI. Blood glucose lowering bymeans of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes. Diabetologia 2006;49:872-880
9. Mavridis G, Souliou E, Diza E, et al. Inflammatory cytokines ininsulin-treated patients with type 2 diabetes. Nutr Metab Cardiovasc Dis 2008;18:471-476
10. Balducci S, Zanuso S, Massarini M, et al.; Italian Diabetes Exercise Study (IDES) Group. The Italian Diabetes and Exercise Study (IDES): design and methods for a prospective Italian multicentre trial of intensive lifestyle intervention in people with type 2 diabetes and the metabolic syndrome. Nutr Metab Cardiovasc Dis 2008;18:585-595
11. Balducci S, Zanuso S, Nicolucci A, et al.; Italian Diabetes Exercise Study (IDES) Investigators. Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). Arch Intern Med 2010;170: 1794-1803