Oversized vein grafts develop advanced atherosclerosis in hypercholesterolemic minipigs

BMC Cardiovascular Disorders

Volumn 12, Issue , 2012, Pages

  Thim, Troels ^a   Hagensen, Mette K ^a   Hørlyck, Arne ^a   Drouet, Ludovic ^b   Paaske, William P ^a   Bøtker, Hans E ^a   Falk, Erling ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Institut des Vaisseaux et du Sang   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; FLUNIXIN; HEPARIN;

ANGIOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTERY DIAMETER; ARTERY INTIMA PROLIFERATION; ARTERY THROMBOSIS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; AUTOPSY; CAROTID ARTERY; CONTROLLED STUDY; DISEASE COURSE; FOLLOW UP; GRAFT FAILURE; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; INTERNAL JUGULAR VEIN; JUGULAR VEIN; MALE; MICROSCOPY; MINIPIG; NONHUMAN; OUTCOME ASSESSMENT; PATHOGENESIS; PRIORITY JOURNAL; ULTRASOUND; VEIN GRAFT;

ANIMALS; ATHEROSCLEROSIS; CAROTID ARTERY, COMMON; DISEASE MODELS, ANIMAL; FOLLOW-UP STUDIES; GRAFT OCCLUSION, VASCULAR; HUMANS; HYPERCHOLESTEROLEMIA; JUGULAR VEINS; SWINE; SWINE, MINIATURE;

EID: 84859034434     PISSN: None     EISSN: 14712261     Source Type: Journal    
DOI: 10.1186/1471-2261-12-24     Document Type: Article

References (25)

1. Motwani JG, Topol EJ. Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention. Circulation 1998, 97:916-931.
2. Qiao JH, Walts AE, Fishbein MC. The severity of atherosclerosis at sites of plaque rupture with occlusive thrombosis in saphenous vein coronary artery bypass grafts. Am Heart J 1991, 122:955-958. 10.1016/0002-8703(91)90457-S, 1927881.
3. Thim T, Hagensen MK, Bentzon JF, Falk E. From vulnerable plaque to atherothrombosis. J Intern Med 2008, 263:506-516. 10.1111/j.1365-2796.2008.01947.x, 18410594.
4. Falk E, Thuesen L. Pathology of coronary microembolisation and no reflow. Heart 2003, 89:983-985. 10.1136/heart.89.9.983, 1767861, 12923001.
5. Hasler-Rapacz J, Ellegren H, Fridolfsson AK, Kirkpatrick B, Kirk S, Andersson L, Rapacz J. Identification of a mutation in the low density lipoprotein receptor gene associated with recessive familial hypercholesterolemia in swine. Am J Med Genet 1998, 76:379-386. 10.1002/(SICI)1096-8628(19980413)76:5<379::AID-AJMG3>3.0.CO;2-I, 9556295.
6. Thim T. Human-like atherosclerosis in minipigs: a new model for detection and treatment of vulnerable plaques. Dan Med Bull 2010, 57:B4161.
7. Thim T, Hagensen MK, Drouet L, Bal dit SC, Bonneau M, Granada JF, Nielsen LB, Paaske WP, Botker HE, Falk E. Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies. EuroIntervention 2010, 6:261-268. 10.4244/EIJV6I2A42, 20562079.
8. Thim T, Hagensen MK, Wallace-Bradley D, Granada JF, Kaluza GL, Drouet L, Paaske WP, Botker HE, Falk E. Unreliable assessment of necrotic core by virtual histology intravascular ultrasound in porcine coronary artery disease. Circ Cardiovasc Imaging 2010, 3:384-391. 10.1161/CIRCIMAGING.109.919357, 20460496.
9. Falk E, Fallon JT, Mailhac A, Fernandez-Ortiz A, Meyer BJ, Weng D, Shah PK, Badimon JJ, Fuster V. Muramidase: A useful monocyte/macrophage immunocytochemical marker in swine, of special interest in experimental cardiovascular disease. Cardiovasc Pathol 1994, 3:183-189.
10. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000, 20:1262-1275. 10.1161/01.ATV.20.5.1262, 10807742.
11. Nicolaides AN, Shifrin EG, Bradbury A, Dhanjil S, Griffin M, Belcaro G, Williams M. Angiographic and duplex grading of internal carotid stenosis: can we overcome the confusion?. J Endovasc Surg 1996, 3:158-165. 10.1583/1074-6218(1996)003<0158:AADGIC>2.0.CO;2, 8798134.
12. Owens CD. Adaptive changes in autogenous vein grafts for arterial reconstruction: Clinical implications. J Vasc Surg 2010, 51:736-746. 10.1016/j.jvs.2009.07.102, 2834835, 19837532.
13. Campeau L, Enjalbert M, Lesperance J, Bourassa MG, Kwiterovich P, Sniderman A, Wacholder S. The relation of risk factors to the development of atherosclerosis in saphenous-vein bypass grafts and the progression of disease in the native circulation. A study 10 years after aortocoronary bypass surgery. N Engl J Med 1984, 311:1329-1332. 10.1056/NEJM198411223112101, 6333635.
14. Lie JT, Lawrie GM, Morris GC. Aortocoronary bypass saphenous vein graft atherosclerosis. Anatomic study of 99 vein grafts from normal and hyperlipoproteinemic patients up to 75 months postoperatively. Am J Cardiol 1977, 40:906-914. 10.1016/0002-9149(77)90041-8, 303864.
15. Campeau L, Hunninghake DB, Knatterud GL, White CW, Domanski M, Forman SA, Forrester JS, Geller NL, Gobel FL, Herd JA, et al. Aggressive cholesterol lowering delays saphenous vein graft atherosclerosis in women, the elderly, and patients with associated risk factors. NHLBI post coronary artery bypass graft clinical trial. Post CABG Trial Investigators. Circulation 1999, 99:3241-3247.
16. Cashin-Hemphill L, Mack WJ, Pogoda JM, Sanmarco ME, Azen SP, Blankenhorn DH. Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up. JAMA 1990, 19(264):3013-3017.
17. Zou Y, Dietrich H, Hu Y, Metzler B, Wick G, Xu Q. Mouse model of venous bypass graft arteriosclerosis. Am J Pathol 1998, 153:1301-1310. 10.1016/S0002-9440(10)65675-1, 1853044, 9777962.
18. Zwolak RM, Kirkman TR, Clowes AW. Atherosclerosis in rabbit vein grafts. Arteriosclerosis 1989, 9:374-379. 10.1161/01.ATV.9.3.374, 2719597.
19. Angelini GD, Bryan AJ, Williams HM, Soyombo AA, Williams A, Tovey J, Newby AC. Time-course of medial and intimal thickening in pig venous arterial grafts: relationship to endothelial injury and cholesterol accumulation. J Thorac Cardiovasc Surg 1992, 103:1093-1103.
20. Angelini GD, Lloyd C, Bush R, Johnson J, Newby AC. An external, oversized, porous polyester stent reduces vein graft neointima formation, cholesterol concentration, and vascular cell adhesion molecule 1 expression in cholesterol-fed pigs. J Thorac Cardiovasc Surg 2002, 124:950-956. 10.1067/mtc.2002.127004, 12407378.
21. Schachner T, Laufer G, Bonatti J. In vivo (animal) models of vein graft disease. Eur J Cardiothorac Surg 2006, 30:451-463. 10.1016/j.ejcts.2006.06.015, 16870461.
22. Roth JA, Cukingnan RA, Brown BG, Gocka E, Carey JS. Factors influencing patency of saphenous vein grafts. Ann Thorac Surg 1979, 28:176-183. 10.1016/S0003-4975(10)63777-0, 314277.
23. Solymoss BC, Nadeau P, Millette D, Campeau L. Late thrombosis of saphenous vein coronary bypass grafts related to risk factors. Circulation 1988, 78:I140-I143.
24. Onohara T, Okadome K, Yamamura S, Komori K, Ishii T, Odashiro T, Sugimachi K. Impaired endothelial prostacyclin production of the canine vein graft in a poor distal runoff limb. Surgery 1993, 113:700-708.
25. Morinaga K, Okadome K, Kuroki M, Miyazaki T, Muto Y, Inokuchi K. Effect of wall shear stress on intimal thickening of arterially transplanted autogenous veins in dogs. J Vasc Surg 1985, 2:430-433.