Neurotrophin-3 gene-modified Schwann cells promote TrkC gene-modified mesenchymal stem cells to differentiate into neuron-like cells in poly(lactic-acid-co-glycolic acid) multiple-channel conduit

Cells Tissues Organs

Volumn 195, Issue 4, 2012, Pages 313-322

  Zhang, Yan Qing ^a   He, Liu Min ^b   Xing, Bin ^c   Zeng, Xiang ^a,b   Zeng, Chen Guang ^b   Zhang, Wei ^a   Quan, Da Ping ^b   Zeng, Yuan Shan ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bone marrow derived mesenchymal stem cells; Neuron like cells; Neurotrophin 3; Poly(lactic acid co glycolic acid); Schwann cells; TrkC

Indexed keywords

BETA TUBULIN; NESTIN; NEUROTROPHIN 3; NEUROTROPHIN 3 RECEPTOR; POLYGLACTIN; POSTSYNAPTIC DENSITY PROTEIN 95;

ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; DNA MODIFICATION; ELECTRON MICROSCOPY; GENETIC TRANSFECTION; MESENCHYMAL STEM CELL; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEURON LIKE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCANNING ELECTRON MICROSCOPY; SCHWANN CELL; SYNAPTOGENESIS; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; LACTIC ACID; MESENCHYMAL STEM CELLS; MICROSCOPY, ELECTRON, SCANNING; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; NEUROTROPHIN 3; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKC; SCHWANN CELLS; SYNAPSES; TISSUE SCAFFOLDS;

EID: 84859001365     PISSN: 14226405     EISSN: 14226421     Source Type: Journal    
DOI: 10.1159/000327724     Document Type: Article

References (41)

1. Allen, N.J., B.A. Barres (2005) Signaling between glia and neurons: focus on synaptic plasticity. Curr Opin Neurobiol 15: 542-548. (Pubitemid 41394398)
2. Bibel, M., Y.A. Barde (2000) Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 14: 2919-2937.
3. Blesch, A., P. Lu, M.H. Tuszynski (2002) Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull 57: 833-838. (Pubitemid 34522160)
4. Castellanos, D.A., P. Tsoulfas, B.R. Frydel, S. Gajavelli, J.C. Bes, J. Sagen (2002) TrkC overexpression enhances survival and migration of neural stem cell transplants in the rat spinal cord. Cell Transplant 11: 297-307. (Pubitemid 34665830)
5. Chao, M.V. (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4: 299-309. (Pubitemid 37271375)
6. Ding, Y., Q. Yan, J.W. Ruan, Y.Q. Zhang, W.J. Li, X. Zeng, S.F. Huang, Y.J. Zhang, S. Wang, H. Dong, Y.S. Zeng (2010) Bone marrow mesenchymal stem cells and electro-acupuncture downregulate the inhibitor molecules and promote the axonal regeneration in the transected spinal cord of rats. Cell Transplant, Epub ahead of print.
7. Dusart, I., M.E. Schwab (1994) Secondary cell death and the inflammatoryreaction after dorsal hemisection of the rat spinal cord. Eur J Neurosci 6: 712-724. (Pubitemid 24143919)
8. El-Husseini, A.E., E. Schnell, D.M. Chetkovich, R.A. Nicoll, D.S. Bredt (2000) PSD-95 involvement in maturation of excitatory synapses. Science 290: 1364-1368.
9. Giapetti, G., L. Ambrosio, G. Marletta, N. Baldini, A. Giunti (2006) Human bone marrowstromal cells: in vitro expansion and differentiation for bone engineering. Biomaterials 27: 6150-6160. (Pubitemid 44414980)
10. Gronthos, S., P.J. Simmons, S.E. Graves, P.G. Robey (2001) Integrinmediated interactions between human bone marrow stromal precursor cells and the extracellular matrix. Bone 28: 174-181. (Pubitemid 32140973)
11. Guo, J., H. Su, Y. Zeng, Y.X. Liang, W.M. Wong, R.G. Ellis-Behnke, K.F. So, W. Wu (2007) Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine 3: 311-321. (Pubitemid 350199643)
12. He, L.M., Y.Q. Zhang, C.G. Zeng, M. Ngiam, S. Liao, D.P. Quan, Y.S. Zeng, J. Lu, S. Ramakrishna (2009) Manufacture of PLGA multiple-channel conduits with precise hierarchical pore architectures and in vitro/vivo evaluation for spinal cord injury. Tissue Eng Part C Methods 15: 243-255.
13. Hulsebosch, C.E. (2002) Recent advances in pathophysiology and treatment of spinal cord injury. Adv Physiol Educ 26: 238-255
14. Je, H.S., F. Yang, J. Zhou, B. Lu (2006) Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms. J Cell Biol 175: 1029-1042. (Pubitemid 44969207)
15. Jori, F.P., M.A. Napolitano, M.A. Melone, M. Cipollaro, A. Cascino, L. Altucci, G. Peluso, A. Giordano, U. Galderisi (2005) Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells. J Cell Biochem 94: 645-655. (Pubitemid 41420266)
16. Klopotowska, D., L. Strzadala (2005) The role of TrkC receptor and neurotrophin-3 in the development and function of neural cells. Postepy Hig Med Dosw 59: 517-522.
17. Kreider, B.Q., A. Messing, H. Doan, S.U. Kim, R.P. Lisak, D.E. Pleasure (1981) Enrichment of Schwann cell cultures from neonatal rat sciatic nerve by differential adhesion. Brain Res 207: 433-444. (Pubitemid 11130097)
18. Lee, S.Y., J.H. Oh, J.C. Kim, Y.H. Kim, S.H. Kim, J.W. Choi (2003) In vivo conjunctival reconstruction using modified PLGA grafts for decreased scar formation and contraction. Biomaterials 24: 5049-5059. (Pubitemid 37237634)
19. Lu, B., P.T. Pang, N.H. Woo (2005) The yin and yang of neurotrophin action. Nat Rev Neurosci 6: 603-614. (Pubitemid 41059335)
20. Lucido, A.L., F. Suarez Sanchez, P. Thostrup, A.V. Kwiatkowski, S. Leal-Ortiz, G. Gopalakrishnan, D. Liazoghli, W. Belkaid, R.B. Lennox, P. Grutter, C.C. Garner, D.R. Colman (2009) Rapid assembly of functional presynaptic boutons triggered by adhesive contacts. J Neurosci 29: 12449-12466.
21. Moore, M.J., J.A. Friedman, E.B. Lewellyn, S.M. Mantila, A.J. Krych, S. Ameenuddin, A.M. Knight, L. Lu, B.L. Currier, R.J. Spinner, R.W. Marsh, A.J. Windebank, M.J. Yaszemski (2006) Multiple-channel scaffolds to promote spinal cord axon regeneration. Biomaterials 27: 419-429. (Pubitemid 41457245)
22. Olson, H.E., G.E. Rooney, L. Gross, J.J. Nesbitt, K.E. Galvin, A. Knight, B. Chen, M.J. Yaszemski, A.J. Windebank (2009) Neural stem cell-and Schwann cell-loaded biodegradable polymer scaffolds support axonal regeneration in the transected spinal cord. Tissue Eng Part A 15: 1797-1805.
23. Pittenger, M.F., A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, M.A. Moorman, D.W. Simonetti, S. Craig, D.R. Marshak (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147. (Pubitemid 29282067)
24. Prockop, D.J. (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276: 71-74. (Pubitemid 27161245)
25. Qian, L., W.M. Saltzman (2004) Improving the expansion and neuronal differentiation of mesenchymal stem cells through culture surface odification. Biomaterials 25: 1331-1337. (Pubitemid 37476209)
26. Quencer, R.M., R.P. Bunge (1996) The injured spinal cord: imaging, histopathological clinical correlates, and basic science approaches to enhancing neural function after spinal cord injury. Spine 21: 2064-2066. (Pubitemid 26330589)
27. Reddi, A.H. (2000) Morphogenesis and tissue engineering of bone and cartilage: inductive signals, stem cells, and biomimetic biomaterials. Tissue Eng 6: 351-359. (Pubitemid 30655945)
28. Richardson, S.M., J.M. Curran, R. Chen, A.V. Thomas, J.A. Hunt, A.J. Freemont, J.A. Hoyland (2006) The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-L-lactic acid (PLLA) scaffold. Biomaterials 27: 4069-4078.
29. Sanchez-Ramos, J., S. Song, F. Cardozo-Pelaez, C. Hazzi, T. Stedeford, A. Willing, T.B. Freeman, S. Saporta, W. Janssen, N. Patel, D.R. Cooper, P.R. Sanberg (2000) Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 164: 247-256. (Pubitemid 32008970)
30. Teng, Y.D., E.B. Lavik, X. Qu, K.I. Park, J. Ourednik, D. Zurakowski, R. Langer, E.Y. Snyder (2002) Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA 99: 3024-3029. (Pubitemid 34240579)
31. Tzeng, S.F. (2002) Neural progenitors isolated from newborn rat spinal cords differentiate into neurons and astroglia. J Biomed Sci 9: 10-16.
32. Ullian, E.M., B.T. Harris, A. Wu, J.R. Chan, B.A. Barres (2004) Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture. Mol Cell Neurosci 25: 241-251. (Pubitemid 38338637)
33. Wang, J.M., Y.S. Zeng, R.Y. Liu, W.L. Huang, Y. Xiong, Y.H. Wang, S.J. Chen, Y.D. Teng (2007) Recombinant adenovirus vector-mediated functional expression of neurotropin-3 receptor (TrkC) in neural stem cells. Exp Neurol 203: 123-127. (Pubitemid 44821170)
34. Wang, T.T., M. Tio, W. Lee, W. Beerheide, G. Udolph (2007) Neural differentiation of mesenchymal-like stem cells from cord blood is mediated by PKA. Biochem Biophys Res Commun 357: 1021-1027. (Pubitemid 46693673)
35. Woodbury, D., E.J. Schwarz, D.J. Prockop, I.B. Black (2000) Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61: 364-370. (Pubitemid 30620221)
36. Wright, K.T., W. El Masri, A. Osman, J. Chowdhury, W.E. Johnson (2010) Bone marrow for the treatment of spinal cord injury: mechanisms and clinical application. Stem Cells, Epub ahead of print.
37. Zhang, W., Y.S. Zeng, X.B. Zhang, J.M. Wang, W. Zhang, S.J. Chen (2006) Combination of adenoviral vector-mediated neurotrophin-3 gene transfer and retinoic acid promotes adult bone marrow cells to differentiate into neuronal phenotypes. Neurosci Lett 408: 98-103. (Pubitemid 44498947)
38. Zhang, W., Q. Yan, Y.S. Zeng, X.B. Zhang, Y. Xiong, J.M. Wang, S.J. Chen, Y. Li, I.C. Bruce, W.T. Wu (2010) Implantation of adult bone marrow-derived mesenchymal stem cells transfected with the neurotrophin-3 gene and pretreated with retinoic acid in completely transected spinal cord. Brain Res 1358: 256-271.
39. Zhang, Y.Q., X. Zeng, L.M. He, Y. Ding, Y. Li, Y.S. Zeng (2010) NT-3 gene modified Schwann cells promote TrkC gene modified mesenchymal stem cells to differentiate into neuron-like cells in vitro. Anat Scie Inter 85: 61-67.
40. Zurita, M., J. Vaquero, S. Oya, M. Miguel (2005) Schwann cells induce neuronal differentiation of bone marrow stromal cells. Neuroreport 16: 505-508. (Pubitemid 40477557)
41. Zurita, M., J. Vaquero, S. Oya, C. Bonilla, C. Aguayo (2007) Neurotrophic Schwann-cell factors induce neural differentiation of bone marrow stromal cells. Neuroreport 18: 1713-1717. (Pubitemid 47549140)