Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells

Histopathology

Volumn 60, Issue 5, 2012, Pages 826-837

  Mitsuhashi, Yuko ^a   Horiuchi, Akiko ^a   Miyamoto, Tsutomu ^a   Kashima, Hiroyasu ^a   Suzuki, Akihisa ^a   Shiozawa, Tanri ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

secretase inhibitor; Endometrial carcinoma; Immunohistochemistry; Invasion; Notch

Indexed keywords

JAGGED1; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR;

ARTICLE; CANCER INVASION; CANCER PROGNOSIS; CARCINOMA CELL; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CALCIUM-BINDING PROTEINS; CARCINOMA, ENDOMETRIOID; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DIPEPTIDES; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; NEOPLASM INVASIVENESS; PROGNOSIS; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; TUMOR MARKERS, BIOLOGICAL;

EID: 84858999856     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.04158.x     Document Type: Article

References (43)

1. Ronnett B, Zaino R, Ellenson L, Kurman R. Endometrial carcinoma. In Kurman R ed. Blaustein's pathology of the female genital tract, 5th edn. New York: Springer-Verlag, 2002; 501-559.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J. Clin. 2009; 59; 225-249.
3. Ueda SM, Kapp DS, Cheung MK et al. Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths. Am. J. Obstet. Gynecol. 2008; 198; 218e1-218e6.
4. Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat. Rev. Cancer 2003; 3; 756-767.
5. Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer. Curr. Opin. Genet. Dev. 2007; 17; 52-59.
6. Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006; 107; 2223-2233.
7. Shih I, Wang TL. Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res. 2007; 67; 1879-1882.
8. Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell. Physiol. 2003; 194; 237-255.
9. Lee SY, Kumano K, Nakazaki K et al. Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. Cancer Sci. 2009; 100; 920-926.
10. Miyamoto Y, Maitra A, Ghosh B et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003; 3; 565-576.
11. Santagata S, Demichelis F, Riva A et al. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res. 2004; 64; 6854-6857.
12. Cuevas IC, Slocum AL, Jun P et al. Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res. 2005; 65; 5070-5075.
13. Shiozawa T, Li S, Nakayama K et al. Relationship between the expression of cyclins/cyclin-dependent kinases and sex-steroid receptors/Ki67 in normal human endometrial glands and stroma during the menstrual cycle. Mol. Hum. Reprod. 1996; 2; 745-752.
14. Kashima H, Shiozawa T, Miyamoto T et al. Autocrine stimulation of IGF1 in estrogen-induced growth of endometrial carcinoma cells: involvement of the mitogen-activated protein kinase pathway followed by up-regulation of cyclin D1 and cyclin E. Endocr. Relat. Cancer 2009; 16; 113-122.
15. Suzuki A, Horiuchi A, Ashida T et al. Cyclin A2 confers cisplatin resistance to endometrial carcinoma cells via up-regulation of an Akt-binding protein, periplakin. J. Cell Mol. Med. 2010; 14; 2305-2317.
16. Albini A, Iwamoto Y, Kleinman HK et al. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 1987; 47; 3239-3245.
17. Dong P, Xu Z, Jia N et al. Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway. Mol. Cancer 2009; 16; 103.
18. Ito T, Williams JD, Fraser D et al. Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells. Am. J. Pathol. 2004; 164; 1979-1988.
19. Cobellis L, Caprio F, Trabucco E et al. The pattern of expression of Notch protein members in normal and pathological endometrium. J. Anat. 2008; 213; 464-472.
20. Mazella J, Liang S, Tseng L. Expression of Delta-like protein 4 in the human endometrium. Endocrinology 2008; 149; 15-19.
21. Reedijk M, Odorcic S, Zhang H et al. Activation of Notch signaling in human colon adenocarcinoma. Int. J. Oncol. 2008; 33; 1223-1229.
22. Wang Z, Li Y, Banerjee S et al. Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. J. Cell. Biochem. 2010; 109; 726-736.
23. Bin Hafeez B, Adhami VM, Asim M et al. Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin. Cancer Res. 2009; 15; 452-459.
24. Tohda S, Nara N. Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells. Leuk. Lymphoma 2001; 42; 467-472.
25. Wang Z, Azmi AS, Ahmad A et al. TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res. 2009; 69; 2757-2765.
26. Reedijk M, Odorcic S, Chang L et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 2005; 65; 8530-8537.
27. Yeh TS, Wu CW, Hsu KW et al. The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. Cancer Res. 2009; 69; 5039-5048.
28. Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH. Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res. 2006; 66; 2778-2784.
29. Fan X, Khaki L, Zhu TS et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010; 28; 5-16.
30. Rizzo P, Miao H, D'Souza G et al. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res. 2008; 68; 5226-5235.
31. Li JL, Harris AL. Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front. Biosci. 2009; 14; 3094-3110.
32. Fakhry H, Miyamoto T, Kashima H et al. Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells. Hum. Pathol. 2010; 41; 848-858.
33. Ridgway J, Zhang G, Wu Y et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006; 444; 1083-1087.
34. Fre S, Pallavi SK, Huyghe M et al. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc. Natl Acad. Sci. USA 2009; 106; 6309-6314.
35. Meurette O, Stylianou S, Rock R, Collu GM, Gilmore AP, Brennan K. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer Res. 2009; 69; 5015-5022.
36. Zeng Q, Li S, Chepeha DB et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 2005; 8; 13-23.
37. Wu Y, Cain-Hom C, Choy L et al. Therapeutic antibody targeting of individual Notch receptors. Nature 2010; 464; 1052-1057.
38. Singh SK, Hawkins C, Clarke ID et al. Identification of human brain tumour initiating cells. Nature 2004; 432; 396-401.
39. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 2003; 100; 3983-3988.
40. Bapat SA, Mali AM, Koppikar CB, Kurrey NK. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res. 2005; 65; 3025-3029.
41. Kato K, Yoshimoto M, Kato K et al. Characterization of side-population cells in human normal endometrium. Hum. Reprod. 2007; 22; 1214-1223.
42. Rutella S, Bonanno G, Procoli A et al. Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors. Clin. Cancer Res. 2009; 15; 4299-4311.
43. Hubbard SA, Friel AM, Kumar B et al. Evidence for cancer stem cells in endometrial carcinoma. Cancer Res. 2009; 69; 8241-8248.