Silent cerebrovascular events and Alzheimer's disease: An overlooked opportunity for prevention?

American Journal of Psychiatry

Volumn 169, Issue 3, 2012, Pages 251-254

  Murali Doraiswamy, P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NOOTROPIC AGENT;

ALZHEIMER DISEASE; BRAIN BLOOD FLOW; BRAIN EMBOLISM; DEMENTIA; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE COURSE; DOPPLER ECHOGRAPHY; EDITORIAL; HUMAN; MICROEMBOLISM; NEUROPROTECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION;

EID: 84858993758     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2011.11121830     Document Type: Editorial

References (13)

1. Maurer K, Volk S, Gerbaldo H: Auguste D and Alzheimer's disease. Lancet 1997; 349:1546-1549 (Pubitemid 27216376)
2. de la Torre JC: Is Alzheimer's disease a neurodegenerative or a vascular disorder? data, dogma, and dialectics. Lancet Neurol 2004; 3:184-190
3. Sperling RA, Johnson KA: Dementia: new criteria but no new treatments. Lancet Neurol 2012; 11:4-5
4. de la Torre JC, Kalaria RN, Nakajima K, Nagata K (eds): Alzheimer's Disease: Vascular Etiology and Pathology. New York, New York Academy of Sciences, 2002
5. Han F, Ali Raie A, Shioda N, Qin ZH, Fukunaga K: Accumulation of beta-amyloid in the brain microvessels accompanies increased hyperphosphorylated tau proteins following microsphere embolisms in aged rats. Neuroscience 2008; 2:414-427
6. Roher AE, Tyas SL, Daugs ID, Kokjohn TA, Emmerling MR, Garami Z, Belohlavek M, Sabbagh MN, Sue LI, Beach TG: Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia. Alzheimers Dement 2011; 7:436-444
7. Snowdon J, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR: Brain infarction and the clinical expression of Alzheimer's disease: the Nun Study. JAMA 1997; 277:813-817 (Pubitemid 27111317)
8. Nicolakakis N, Hamel E: Neurovascular function in Alzheimer's disease patients and experimental models. J Cereb Blood Flow Metab 2011; 31:1354-1370
9. Skoog I: The interaction between vascular disorders and Alzheimer's disease, in Alzheimer's Disease and Related Disorders: Etiology, Pathogenesis and Therapeutics. New York, John Wiley & Sons, 1999, pp 523-530
10. Reitz C, Tang MX, Schupf N, Manly JJ, Mayeux R, Luchsinger JA: A summary risk score for the prediction of Alzheimer disease in elderly persons. Arch Neurol 2010; 67:835-841
11. Kivipelto M, Ngandu T, Laaitikainen T, Winblad B, Soininen H, Tuomilehto J: Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol 2006; 5:735-741 (Pubitemid 44205512)
12. Purandare N, Burns A, Morris J, Perry EP, Wren J, McCollum C: Association of cerebral emboli with accelerated cognitive deterioration in Alzheimer's disease and vascular dementia. Am J Psychiatry 2012; 169:300-308
13. Ghanem A, Müller A, Nähle CP, Kocurek J, Werner N, Hammerstingl C, Schild HH, Schwab JO, Mellert F, Fimmers R, Nickenig G, Thomas D: Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imaging. J Am Coll Cardiol 2010; 55:1427-1432