Mirtazapine and mefloquine therapy for progressive multifocal leukoencephalopathy in a patient infected with human immunodeficiency virus

American Journal of Health-System Pharmacy

Volumn 69, Issue 6, 2012, Pages 496-498

  Moenster, Ryan P ^a,b   Jett, R Andrew ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b ST LOUIS COLLEGE OF PHARMACY   (United States)

^c SLVAMC   (United States)

Author keywords

Antidepressants; Antimalarial agents; HIV infections; Leukoencephalopathy; Mefloquine hydrochloride; Mirtazapine; Toxicity

Indexed keywords

COTRIMOXAZOLE; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ETRAVIRINE; MEFLOQUINE; MIRTAZAPINE; PREDNISONE;

ADULT; ARTICLE; ATAXIA; BRAIN ATROPHY; CASE REPORT; CEREBELLUM ATROPHY; COGNITIVE DEFECT; DROWSINESS; DRUG EFFICACY; DRUG TOLERABILITY; DYSARTHRIA; FATALITY; GAIT DISORDER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; JC VIRUS; LUMBAR PUNCTURE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PNEUMONIA; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; RESPIRATORY FAILURE; WHITE MATTER;

EID: 84858977207     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp110392     Document Type: Article

References (12)

1. Tan CS, Koralnik IJ. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010;9:425-37.
2. Brew BJ, Davies NW, Cinque P et al. Progressive multifocal leukoencephalopathy and other forms of JC virus disease. Nat Rev Neurol. 2010; 6:667-79.
3. Verma S, Cikurel K, Koralnik IJ et al. Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera. J Infect Dis. 2007; 196:709-11. (Pubitemid 47293853)
4. Cettomai D, McArthur JC. Mirtazapine use in human immunodeficiency virus-infected patients with progressive multifocal leukoencephalopathy. Arch Neurol. 2009; 66:255-8.
5. Elphick GF, Querbes W, Jordan JA et al. The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science. 2004; 306:1380-3. (Pubitemid 39532516)
6. Altshuler EL, Kast RE. The atypical anti-psychotic agents ziprasidone, risperidone and olanzapine as treatment for and prophylaxis against progressive multifocal leukoencephalopathy. Med Hypotheses. 2005; 65:585-6. (Pubitemid 40956959)
7. Brickelmaier M, Lugovskoy A, Kartikeyan R et al. Identification and characterization of mefloquine efficacy against JC virus in vitro. Antimicrob Agents Chemother. 2009; 53:1840-9.
8. Kishida S, Tanaka K. Mefloquine treatment in a patient suffering from progressive multifocal leukoencephalopathy after umbilical cord blood transplant. Intern Med. 2010; 49:2509-13.
9. Schroder A, Lee DH, Hellwig K et al. Successful management of natalizumab-associated progressive multifocal leukoencephalopathy and immune reconstitution syndrome in a patient with multiple sclerosis. Arch Neurol. 2010; 67:1391-4.
10. ClinicalTrials.gov. Study to explore the effect of mefloquine in subjects with progressive multifocal leukoencephalopathy (PML). http://clinicaltrials. gov/ct2/show/NCT00746941?term=pml+and+mefloqu ine&rank=1 (accessed 2011 May 13).
11. De Luca A, Ammassari A, Pezzotti P et al. Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive multifocal leukoencephalopathy: a multicohort analysis. AIDS. 2008; 22:1759-67.
12. Hall CD, Dafni U, Simpson D et al. Failure of cytarabine in progressive multifocal leukoencephalopathy associated with human immunodeficiency virus infection. N Engl J Med. 1998; 338:1345-51. (Pubitemid 28216663)