Bivalent carbohydrate binding is required for biological activity of Clitocybe nebularis lectin (CNL), the N,N′-diacetyllactosediamine (GalNAcβ1-4GlcNAc,LacdiNAc)-specific lectin from basidiomycete C. nebularis

Journal of Biological Chemistry

Volumn 287, Issue 13, 2012, Pages 10602-10612

  Pohleven, Jure ^a   Renko, Miha ^a   Magister, Špela ^a   Smith, David F ^b   Künzler, Markus ^c   Štrukelj, Borut ^a,d   Turk, Dušan ^a   Kos, Janko ^a,d   Sabotič, Jerica ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ETH ZURICH   (Switzerland)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS; CARBOHYDRATE BINDING; GLYCAN MICROARRAYS; HUMAN BLOODS; MULTIVALENCY; MUTANT STRAIN; RICIN B; T CELLS;

BINDING ENERGY; ESCHERICHIA COLI; FUNGI; ORGANIC COMPOUNDS; SUGARS;

BIOACTIVITY;

GLYCAN; HOMODIMER; LACTOSE; LECTIN; MONOMER; MUTANT PROTEIN; N,N' DIACETYLLACETOSEDIAMINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BASIDIOMYCETES; BINDING KINETICS; BINDING SITE; BIOCHEMISTRY; CAENORHABDITIS ELEGANS; CLITOCYBE NEBULARIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY TEST; ESCHERICHIA COLI; FUNGAL VIRULENCE; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MYCOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MICROARRAY; STRUCTURE ANALYSIS;

ABO BLOOD-GROUP SYSTEM; AGARICALES; AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CRYSTALLOGRAPHY, X-RAY; ERYTHROCYTES; ESCHERICHIA COLI; HUMANS; JURKAT CELLS; LACTOSE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; RICIN;

CAENORHABDITIS ELEGANS; ESCHERICHIA COLI; LEPISTA NEBULARIS; LOTUS;

EID: 84858963344     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.317263     Document Type: Article

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