메뉴 건너뛰기




Volumn 12, Issue 1, 2012, Pages 27-30

Statins to treat Alzheimer’s disease: An incomplete story

Author keywords

Alzheimer s disease; atorvastatin; cholesterol; clinical trials; cognitive decline; simvastatin; statins

Indexed keywords


EID: 84858951810     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.11.171     Document Type: Article
Times cited : (10)

References (25)
  • 1
    • 9844226208 scopus 로고    scopus 로고
    • Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer’s disease?
    • Sparks DL. Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer’s disease? Ann. NY Acad. Sci. 826, 128 –146 (1997).
    • (1997) Ann. NY Acad. Sci. , vol.826 , pp. 128-146
    • Sparks, D.L.1
  • 2
    • 18144419392 scopus 로고    scopus 로고
    • ApoE genotype, cholesterol level, lipid-lowering treatment and dementia. The Three-City Study
    • Dufouil C, Richard F, Fievet N et al. ApoE genotype, cholesterol level, lipid-lowering treatment and dementia. The Three-City Study. Neurology 64, 1531 –1538 (2005).
    • (2005) Neurology , vol.64 , pp. 1531-1538
    • Dufouil, C.1    Richard, F.2    Fievet, N.3
  • 3
    • 0000721195 scopus 로고    scopus 로고
    • Elevated systolic blood pressure and high cholesterol levels at midlife are risk factors for late-life dementia
    • Kivipelto M, Helkala EL, Hallikainen M et al. Elevated systolic blood pressure and high cholesterol levels at midlife are risk factors for late-life dementia. Neurobiol. Aging 21 (1 Suppl.), S174 (2000).
    • (2000) Neurobiol. Aging , vol.21 , pp. S174
    • Kivipelto, M.1    Helkala, E.L.2    Hallikainen, M.3
  • 4
    • 0037992873 scopus 로고    scopus 로고
    • Plasma total cholesterol level as a risk factor for Alzheimer disease
    • Tan ZS, Seshadri S, Beiser A et al. Plasma total cholesterol level as a risk factor for Alzheimer disease. Arch. Intern. Med. 163, 1053 –1057 (2003).
    • (2003) Arch. Intern. Med. , vol.163 , pp. 1053-1057
    • Tan, Z.S.1    Seshadri, S.2    Beiser, A.3
  • 5
    • 12844269330 scopus 로고    scopus 로고
    • Is there a characteristic lipid profile in Alzheimer’s disease?
    • Sabbagh MN, Zahiri HR, Ceimo J et al. Is there a characteristic lipid profile in Alzheimer’s disease? J. Alzheimers Dis. 6 (6), 585 –589 (2004).
    • (2004) J. Alzheimers Dis. , vol.6 , Issue.6 , pp. 585-589
    • Sabbagh, M.N.1    Zahiri, H.R.2    Ceimo, J.3
  • 6
    • 0036126850 scopus 로고    scopus 로고
    • Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    • Rockwood K, Kirkland S, Hogan DB et al. Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. Arch. Neurol. 59, 223 –227 (2002).
    • (2002) Arch. Neurol. , vol.59 , pp. 223-227
    • Rockwood, K.1    Kirkland, S.2    Hogan, D.B.3
  • 7
    • 67649252917 scopus 로고    scopus 로고
    • Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study
    • Cramer C, Haan MN, Galea S, Langa KM, Kalbfleisch JD. Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study. Neurology 71, 344 –350 (2008).
    • (2008) Neurology , vol.71 , pp. 344-350
    • Cramer, C.1    Haan, M.N.2    Galea, S.3    Langa, K.M.4    Kalbfleisch, J.D.5
  • 8
    • 0038350752 scopus 로고    scopus 로고
    • The role of lipid-lowering drugs in cognitive function: a meta-analysis of observational studies
    • Etminan M, Gill S, Samii A. The role of lipid-lowering drugs in cognitive function: a meta-analysis of observational studies. Pharmacotherapy 6, 726 –730 (2003).
    • (2003) Pharmacotherapy , vol.6 , pp. 726-730
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 9
    • 0942278990 scopus 로고    scopus 로고
    • Association between statin use and Alzheimer’s disease
    • Zamrini E, McGwin G, Roseman JM. Association between statin use and Alzheimer’s disease. Neuroepidemiology 23 (1–2), 94 –98 (2004).
    • (2004) Neuroepidemiology , vol.23 , Issue.1-2 , pp. 94-98
    • Zamrini, E.1    McGwin, G.2    Roseman, J.M.3
  • 10
    • 8644239495 scopus 로고    scopus 로고
    • Statin therapy and risk of dementia in the elderly: a community based prospective cohort study
    • Li G, Higdon R, Kukull W et al. Statin therapy and risk of dementia in the elderly: a community based prospective cohort study. Neurology 63 (9), 1624 –1628 (2004).
    • (2004) Neurology , vol.63 , Issue.9 , pp. 1624-1628
    • Li, G.1    Higdon, R.2    Kukull, W.3
  • 11
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomized controlled trial
    • Shepherd J. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomized controlled trial. Lancet 360, 1623 –1630 (2002).
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1
  • 12
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trial
    • Group HPSC. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trial. Lancet 360, 7 –22 (2002).
    • (2002) Lancet , vol.360 , pp. 7-22
  • 13
    • 35048870502 scopus 로고    scopus 로고
    • Role of HMG-CoA reductase inhibitors in neurological disorders: progress to date
    • Reiss AB, Wirkowski E. Role of HMG-CoA reductase inhibitors in neurological disorders: progress to date. Drugs 67 (15), 2111 –2120 (2007).
    • (2007) Drugs , vol.67 , Issue.15 , pp. 2111-2120
    • Reiss, A.B.1    Wirkowski, E.2
  • 14
    • 34548291482 scopus 로고    scopus 로고
    • Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    • Li G, Larson EB, Sonnen JA et al. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 69, 878 –885 (2007).
    • (2007) Neurology , vol.69 , pp. 878-885
    • Li, G.1    Larson, E.B.2    Sonnen, J.A.3
  • 15
    • 43249094747 scopus 로고    scopus 로고
    • Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
    • Arvanitakis Z, Schneider JA, Wilson RS et al. Statins, incident Alzheimer disease, change in cognitive function, and neuropathology. Neurology 70 (19 Pt 2), 1795 –1802 (2008).
    • (2008) Neurology , vol.70 , Issue.19 , pp. 1795-1802
    • Arvanitakis, Z.1    Schneider, J.A.2    Wilson, R.S.3
  • 16
    • 20844440894 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of mild-to-moderate alzheimer’s disease: preliminary results
    • Sparks DL, Sabbagh MN, Connor DJ et al. Atorvastatin for the treatment of mild-to-moderate alzheimer’s disease: preliminary results. Arch. Neurol. 62, 753 –757 (2005).
    • (2005) Arch. Neurol. , vol.62 , pp. 753-757
    • Sparks, D.L.1    Sabbagh, M.N.2    Connor, D.J.3
  • 17
    • 80053336026 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
    • Sano M, Bell KL, Galasko D et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease. Neurology 77 (6), 556 –563 (2011).
    • (2011) Neurology , vol.77 , Issue.6 , pp. 556-563
    • Sano, M.1    Bell, K.L.2    Galasko, D.3
  • 18
    • 77949908687 scopus 로고    scopus 로고
    • Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
    • Feldman HH, Doody RS, Kivipelto M et al. Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe. Neurology 74 (12), 956 –964 (2010).
    • (2010) Neurology , vol.74 , Issue.12 , pp. 956-964
    • Feldman, H.H.1    Doody, R.S.2    Kivipelto, M.3
  • 19
    • 33745739157 scopus 로고    scopus 로고
    • Circulating cholesterol levels, apolipoprotein E genotype, and dementia severity influence the benefit of atorvastatin treatment in AD: results from the Alzheimer’s disease Cholesterol Lowering Treatment Trial
    • Sparks DL, Connor DJ, Sabbagh MN, Petersen RB, Lopez J, Browne P. Circulating cholesterol levels, apolipoprotein E genotype, and dementia severity influence the benefit of atorvastatin treatment in AD: results from the Alzheimer’s disease Cholesterol Lowering Treatment Trial. Acta Neurol. Scand. 185, S3 –S7 (2006).
    • (2006) Acta Neurol. Scand. , vol.185 , pp. S3-S7
    • Sparks, D.L.1    Connor, D.J.2    Sabbagh, M.N.3    Petersen, R.B.4    Lopez, J.5    Browne, P.6
  • 20
    • 0041382978 scopus 로고    scopus 로고
    • Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice
    • Park IH, Hwang EM, Hong HS et al. Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol. Aging 24 (5), 637 –643 (2003).
    • (2003) Neurobiol. Aging , vol.24 , Issue.5 , pp. 637-643
    • Park, I.H.1    Hwang, E.M.2    Hong, H.S.3
  • 21
    • 77956947971 scopus 로고    scopus 로고
    • KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy
    • Li Y, Iakoubova O, Shiffman D, Devlin JJ, Forrester JS, Superko HR KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy. Am. J. Cardiol. 106, 994 –998 (2010).
    • (2010) Am. J. Cardiol. , vol.106 , pp. 994-998
    • Li, Y.1    Iakoubova, O.2    Shiffman, D.3    Devlin, J.J.4    Forrester, J.S.5    Superko, H.R.6
  • 22
    • 77955467684 scopus 로고    scopus 로고
    • KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study
    • Iakoubova OA, Robertson M, Tong CH et al. KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study. Eur. J. Cardiovasc. Prev. Rehabil. 17, 455 –461 (2010).
    • (2010) Eur. J. Cardiovasc. Prev. Rehabil. , vol.17 , pp. 455-461
    • Iakoubova, O.A.1    Robertson, M.2    Tong, C.H.3
  • 23
    • 37549058754 scopus 로고    scopus 로고
    • Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study
    • Shiffman D, O’Meara ES, Bare LA et al. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. Arterioscler. Thromb. Vasc. Biol. 28, 173 –179 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 173-179
    • Shiffman, D.1    O’Meara, E.S.2    Bare, L.A.3
  • 24
    • 49149095635 scopus 로고    scopus 로고
    • Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
    • Medina MW, Gao F, Ruan W, Rotter JI, Krauss RM. Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation 118 (4), 355 –362 (2008).
    • (2008) Circulation , vol.118 , Issue.4 , pp. 355-362
    • Medina, M.W.1    Gao, F.2    Ruan, W.3    Rotter, J.I.4    Krauss, R.M.5
  • 25
    • 80052030839 scopus 로고    scopus 로고
    • Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer’s disease suggests a role for rs3846662 and HMGCR splicing in disease risk
    • Simmons CR, Zou F, Younkin SG, Estus S. Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer’s disease suggests a role for rs3846662 and HMGCR splicing in disease risk. Mol. Neurodegener. 6, 62 (2011).
    • (2011) Mol. Neurodegener. , vol.6 , pp. 62
    • Simmons, C.R.1    Zou, F.2    Younkin, S.G.3    Estus, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.