Efficient Algorithms for Optimal Designs with Correlated Observations in Pharmacokinetics and Dose-Finding Studies

Biometrics

Volumn 68, Issue 1, 2012, Pages 138-145

  Holland Letz, Tim ^a   Dette, Holger ^b   Renard, Didier ^c  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Correlated observations; Dose finding studies; Heteroscedastic regression; Locally optimal design; Multiplicative algorithms; Population pharmacokinetics; Random effects

Indexed keywords

EFFICIENCY; OPTIMAL SYSTEMS; RANDOM PROCESSES;

CORRELATED OBSERVATIONS; DOSE FINDING; DOSE-FINDING STUDY; HETEROSCEDASTIC REGRESSIONS; LOCALLY OPTIMAL DESIGNS; MULTIPLICATIVE ALGORITHM; OPTIMAL DESIGN; POPULATION PHARMACOKINETICS; RANDOM EFFECTS; RANDOM EFFECTS MODEL;

PHARMACOKINETICS;

ALGORITHM; DESIGN; DRUG; EXPERIMENTAL DESIGN; EXPERIMENTAL STUDY; NUMERICAL MODEL; OBSERVATIONAL METHOD;

EID: 84858864307     PISSN: 0006341X     EISSN: 15410420     Source Type: Journal    
DOI: 10.1111/j.1541-0420.2011.01657.x     Document Type: Article

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