Human T cell derived, cell-bound complement iC3b is integrally involved in T cell activation

Immunology Letters

Volumn 143, Issue 1, 2012, Pages 131-136

  Török, Katalin ^a   Kremlitzka, Mariann ^a   Sándor, Noémi ^a,b   Tóth, Eszter Angéla ^a   Bajtay, Zsuzsa ^a,b   Erdei, Anna ^a,b  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Cell bound iC3b; Complement C3 production; Human T cell; T cell proliferation

Indexed keywords

CD3 ANTIBODY; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR4; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT IC3B; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHILD; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SCHOOL CHILD; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELL LINE; CELL PROLIFERATION; COMPLEMENT C3B; DENDRITIC CELLS; HUMANS; LYMPHOCYTE ACTIVATION; MICE; T-LYMPHOCYTES;

EID: 84858860862     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2012.02.003     Document Type: Article

References (23)

1. Erdei A., Fust G., Gergely J. The role of C3 in the immune response. Immunol Today 1991, 12:332-337.
2. Sacks S., Zhou W. The effect of locally synthesised complement on acute renal allograft rejection. J Mol Med (Berl) 2003, 81:404-410.
3. Sewell D.L., Nacewicz B., Liu F., Macvilay S., Erdei A., Lambris J.D., et al. Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist. J Neuroimmunol 2004, 155:55-63.
4. Lalli P.N., Strainic M.G., Yang M., Lin F., Medof M.E., Heeger P.S. Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood 2008, 112:1759-1766.
5. Heeger P.S., Kemper C. Novel roles of complement in T effector cell regulation. Immunobiology 2011.
6. van Kooten C., Fiore N., Trouw L.A., Csomor E., Xu W., Castellano G., et al. Complement production and regulation by dendritic cells: molecular switches between tolerance and immunity. Mol Immunol 2008, 45:4064-4072.
7. Veerhuis R., Nielsen H.M., Tenner A.J. Complement in the brain. Mol Immunol 2011, 48:1592-1603.
8. Strainic M.G., Liu J., Huang D., An F., Lalli P.N., Muqim N., et al. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 2008, 28:425-435.
9. Hashimoto M., Hirota K., Yoshitomi H., Maeda S., Teradaira S., Akizuki S., et al. Complement drives Th17 cell differentiation and triggers autoimmune arthritis. J Exp Med 2010, 207:1135-1143.
10. Laumonnier Y., Schmudde I., Kohl J. The role of complement in the diagnosis and management of allergic rhinitis and allergic asthma. Curr Allergy Asthma Rep 2011, 11:122-130.
11. Pantazis P., Kalyanaraman V.S., Bing D.H. Synthesis of the third component of complement (C3) by lectin-activated and HTLV-infected human T-cells. Mol Immunol 1990, 27:283-289.
12. Cardone J., Le Friec G., Vantourout P., Roberts A., Fuchs A., Jackson I., et al. Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol 2010, 11:862-871.
13. Triglia R.P., Linscott W.D. Titers of nine complement components, conglutinin and C3b-inactivator in adult and fetal bovine sera. Mol Immunol 1980, 17:741-748.
14. Werfel T., Kirchhoff K., Wittmann M., Begemann G., Kapp A., Heidenreich F., et al. Activated human T lymphocytes express a functional C3a receptor. J Immunol 2000, 165:6599-6605.
15. Pepys M.B. Role of complement in induction of antibody production in vivo. Effect of cobra factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responses. J Exp Med 1974, 140:126-145.
16. Tsokos G.C., Berger M., Balow J.E. Modulation of human B cell immunoglobulin secretion by the C3b component of complement. J Immunol 1984, 132:622-626.
17. Daha M.R., Bloem A.C., Ballieux R.E. Immunoglobulin production by human peripheral lymphocytes induced by anti-C3 receptor antibodies. J Immunol 1984, 132:1197-1201.
18. Melchers F., Erdei A., Schulz T., Dierich M.P. Growth control of activated, synchronized murine B cells by the C3d fragment of human complement. Nature 1985, 317:264-267.
19. Nemerow G.R., McNaughton M.E., Cooper N.R. Binding of monoclonal antibody to the Epstein Barr virus (EBV)/CR2 receptor induces activation and differentiation of human B lymphocytes. J Immunol 1985, 135:3068-3073.
20. Kerekes K., Prechl J., Bajtay Z., Jozsi M., Erdei A. A further link between innate and adaptive immunity: C3 deposition on antigen-presenting cells enhances the proliferation of antigen-specific T cells. Int Immunol 1998, 10:1923-1930.
21. Erdei A., Kohler V., Schafer H., Burger R. Macrophage-bound C3 fragments as adhesion molecules modulate presentation of exogenous antigens. Immunobiology 1992, 185:314-326.
22. Sandor N., Pap D., Prechl J., Erdei A., Bajtay Z. A novel, complement-mediated way to enhance the interplay between macrophages, dendritic cells and T lymphocytes. Mol Immunol 2009, 47:438-448.
23. Hamad O.A., Nilsson P.H., Wouters D., Lambris J.D., Ekdahl K.N., Nilsson B. Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1. J Immunol 2010, 184:2686-2692.