Effective prevention of Pseudomonas aeruginosa cross-infection at a cystic fibrosis centre - Results of a 10-year prospective study

International Journal of Medical Microbiology

Volumn 302, Issue 2, 2012, Pages 69-77

  Wiehlmann, Lutz ^a   Cramer, Nina ^a   Ulrich, Jutta ^a   Hedtfeld, Silke ^a   Weißbrodt, Hartmut ^a   Tümmler, Burkhard ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cohort segregation; Cystic fibrosis; Infection control; Pseudomonas aeruginosa; Respiratory tract infections

Indexed keywords

TAP WATER;

ADULT; ARTICLE; BACTERIUM CULTURE; BACTERIUM DETECTION; BACTERIUM ISOLATE; CLINICAL EFFECTIVENESS; CROSS INFECTION; CYSTIC FIBROSIS; FILTRATION; HOSPITAL INFECTION; HUMAN; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; NONHUMAN; PROSPECTIVE STUDY; PSEUDOMONAS INFECTION;

CROSS INFECTION; CYSTIC FIBROSIS; GENOTYPE; HUMANS; HYGIENE; INFECTION CONTROL; PROSPECTIVE STUDIES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 84858799004     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2011.11.001     Document Type: Article

References (43)

1. Aaron S.D., Vandemheen K.L., Ramotar K., Giesbrecht-Lewis T., Tullis E., Freitag A., Paterson N., Jackson M., Lougheed M.D., Dowson C., Kumar V., Ferris W., Chan F., Doucette S., Fergusson D. Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis. JAMA 2010, 304:2145-2153.
2. Al-Aloul M., Crawley J., Winstanley C., Hart C.A., Ledson M.J., Walshaw M.J. Increased morbidity associated with chronic infection by an epidemic Pseudomonas aeruginosa strain in CF patients. Thorax 2004, 59:334-336.
3. Armstrong D.S., Nixon G.M., Carzino R., Bigham A., Carlin J.B., Robins-Browne R.M., Grimwood K. Detection of a widespread clone of Pseudomonas aeruginosa in a pediatric cystic fibrosis clinic. Am. J. Respir. Crit. Care Med. 2002, 66:983-987.
4. Armstrong D., Bell S., Robinson M., Bye P., Rose B., Harbour C., Lee C., Service H., Nissen M., Syrmis M., Wainwright C. Evidence for spread of a clonal strain of Pseudomonas aeruginosa among cystic fibrosis clinics. J. Clin. Microbiol. 2003, 41:2266-2267.
5. Bohn Y.S., Brandes G., Rakhimova E., Horatzek S., Salunkhe P., Munder A., van Barneveld A., Jordan D., Bredenbruch F., Häussler S., Riedel K., Eberl L., Jensen P.Ø., Bjarnsholt T., Moser C., Hoiby N., Tümmler B., Wiehlmann L. Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection. Mol. Microbiol. 2009, 71:730-747.
6. Bosshammer J., Fiedler B., Gudowius P., von der Hardt H., Römling U., Tümmler B. Comparative hygienic surveillance of contamination with pseudomonads in a cystic fibrosis ward over a 4-year period. J. Hosp. Infect. 1995, 31:261-274.
7. Conway S.P., Lee T.W. Prevention of chronic Pseudomonas aeruginosa infection in people with cystic fibrosis. Expert Rev. Respir. Med. 2009, 3:349-361.
8. Corey M., Farewell V. Determinants of mortality from cystic fibrosis in Canada, 1970-1989. Am. J. Epidemiol. 1996, 143:1007-1017.
9. Cramer N., Wiehlmann L., Tümmler B. Clonal epidemiology of Pseudomonas aeruginosa in cystic fibrosis. Int. J. Med. Microbiol. 2010, 300:526-533.
10. Cramer N., Klockgether J., Wrasman K., Schmidt M., Davenport C.F., Tümmler B. Microevolution of the major common Pseudomonas aeruginosa clones C and PA14 in cystic fibrosis lungs. Environ. Microbiol. 2011, 13:1690-1704.
11. Cystic Fibrosis Trust Control of Infection Group Pseudomonas aeruginosa in People with Cystic Fibrosis: Suggestions for Prevention and Infection Control 2001, Cystic Fibrosis Trust, London.
12. Döring G., Ulrich M., Müller W., Bitzer J., Schmidt-Koenig L., Münst L., Grupp H., Wolz C., Stern M., Botzenhart K. Generation of Pseudomonas aeruginosa aerosols during handwashing from contaminated sink drains, transmission to hands of hospital personnel, and its prevention by use of a new heating device. Zentralbl. Hyg. Umweltmed. 1991, 191:494-505.
13. Döring G. Prevention of Pseudomonas aeruginosa infection in cystic fibrosis patients. Int. J. Med. Microbiol. 2010, 300:573-577.
14. Griffiths A.L., Jamsen K., Carlin J.B., Grimwood K., Carzino R., Robinson P.J., Massie J., Armstrong D.S. Effects of segregation on an epidemic Pseudomonas aeruginosa strain in a cystic fibrosis clinic. Am. J. Respir. Crit. Care Med. 2005, 171:1020-1025.
15. Hancock R.E., Carey A.M. Outer membrane of Pseudomonas aeruginosa: heat-2-mercaptoethanol-modifiable proteins. J. Bacteriol. 1979, 140:902-910.
16. Hogardt M., Heesemann J. Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung. Int. J. Med. Microbiol. 2010, 300:557-562.
17. Jelsbak L., Johansen H.K., Frost A.L., Thøgersen R., Thomsen L.E., Ciofu O., Yang L., Haagensen J.A., Høiby N., Molin S. Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients. Infect. Immun. 2007, 75:2214-2224.
18. Jones A.M., Govan J.R., Doherty C.J., Dodd M.E., Isalska B.J., Stanbridge T.N., Webb A.K. Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic. Lancet 2001, 358:557-558.
19. Jones A.M., Webb A.K., Govan J.R., Hart C.A., Walshaw M.J. Pseudomonas aeruginosa cross-infection in cystic fibrosis. Lancet 2002, 359:527-528.
20. Jones A.M., Govan J.R., Doherty C.J., Dodd M.E., Isalska B.J., Stanbridge T.N., Webb A.K. Identification of airborne dissemination of epidemic multiresistant strains of Pseudomonas aeruginosa at a CF centre during a cross infection outbreak. Thorax 2003, 58:525-527.
21. Jones A.M., Dodd M.E., Govan J.R., Doherty C.J., Smith C.M., Isalska B.J., Webb A.K. Prospective surveillance for Pseudomonas aeruginosa cross-infection at a cystic fibrosis center. Am. J. Respir. Crit. Care Med. 2005, 171:257-260.
22. Klockgether J., Würdemann D., Reva O., Wiehlmann L., Tümmler B. Diversity of the abundant pKLC102/PAGI-2 family of genomic islands in Pseudomonas aeruginosa. J. Bacteriol. 2007, 189:2443-2459.
23. Köhler T., Buckling A., van Delden C. Cooperation and virulence of clinical Pseudomonas aeruginosa populations. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:6339-6344.
24. Lee T.W.R., Brownlee K.G., Conway S.P., Denton M., Littlewood J.M. Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. J. Cyst. Fibros. 2003, 2:29-34.
25. Mahenthiralingam E., Campbell M.E., Foster J., Lam J.S., Speert D.P. Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients with cystic fibrosis. J. Clin. Microbiol. 1996, 34:1129-1135.
26. Maiden M.C. Multilocus sequence typing of bacteria. Annu. Rev. Microbiol. 2006, 60:561-588.
27. Mathee K., Narasimhan G., Valdes C., Qiu X., Matewish J.M., Koehrsen M., Rokas A., Yandava C.N., Engels R., Zeng E., Olavarietta R., Doud M., Smith R.S., Montgomery P., White J.R., Godfrey P.A., Kodira C., Birren B., Galagan J.E., Lory S. Dynamics of Pseudomonas aeruginosa genome evolution. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:3100-3105.
28. Oliver A. Mutators in cystic fibrosis chronic lung infection: prevalence, mechanisms, and consequences for antimicrobial therapy. Int. J. Med. Microbiol. 2010, 300:563-572.
29. Rakhimova E., Wiehlmann L., Brauer A.L., Sethi S., Murphy T.F., Tümmler B. Pseudomonas aeruginosa population biology in COPD. J. Infect. Dis. 2009, 200:1928-1935.
30. Ratjen F., Döring G., Nikolaizik W.H. Effect of inhaled tobramycin on early Pseudomonas aeruginosa colonisation in patients with cystic fibrosis. Lancet 2001, 358:983-984.
31. Ratjen F., Döring G. Cystic fibrosis. Lancet 2003, 361:681-689.
32. Ratjen F., Walter H., Haug M., Meisner C., Grasemann H., Döring G. Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients. Pediatr. Pulmonol. 2007, 42:249-255.
33. Römling U., Fiedler B., Bosshammer J., Grothues D., Greipel J., von der Hardt H., Tümmler B. Epidemiology of chronic Pseudomonas aeruginosa infections in cystic fibrosis. J. Infect. Dis. 1994, 170:1616-1621.
34. Sadikot R.T., Blackwell T.S., Christman J.W., Prince A.S. Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am. J. Respir. Crit. Care Med. 2005, 171:1209-1223.
35. Saiman L., Siegel J. Cystic Fibrosis Foundation Consensus Conference on Infection Control Participants. Infection control recommendations for patients with cystic fibrosis: Microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission. Am. J. Infect. Control 2003, 31(3 Suppl.):S1-S62.
36. Saiman L., Siegel J. Infection control in cystic fibrosis. Clin. Microbiol. Rev. 2004, 17:57-71.
37. Saiman L., Garber E. Infection control in cystic fibrosis: barriers to implementation and ideas for improvement. Curr. Opin. Pulm. Med. 2009, 10.1097/MCP.0b013e328330d974.
38. Scott F.W., Pitt T.L. Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and Wales. J. Med. Microbiol. 2004, 53:609-615.
39. Tümmler B., Koopmann U., Grothues D., Weissbrodt H., Steinkamp G., von der Hardt H. Nosocomial acquisition of Pseudomonas aeruginosa by cystic fibrosis patients. J. Clin. Microbiol. 1991, 29:1265-1267.
40. Tümmler B. Clonal variations in Pseudomonas aeruginosa. Pseudomonas 2006, vol. 4:35-68. Springer, Heidelberg.
41. Wainwright C.E., Vidmar S., Armstrong D.S., Byrnes C.A., Carlin J.B., Cheney J., Cooper P.J., Grimwood K., Moodie M., Robertson C.F., Tiddens H.A., ACFBAL Study Investigators Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis: a randomized trial. JAMA 2011, 306:163-171.
42. Wiehlmann L., Wagner G., Cramer N., Siebert B., Gudowius P., Morales G., Köhler T., van Delden C., Weinel C., Slickers P., Tümmler B. Population structure of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:8101-8106.
43. Yang L., Jelsbak L., Molin S. Microbial ecology and adaptation in cystic fibrosis airways. Environ. Microbiol. 2011, 13:1682-1689.