Hormonal therapies and meningioma: Is there a link?

Cancer Epidemiology

Volumn 36, Issue 2, 2012, Pages 198-205

  Cea Soriano, Lucía ^a   Blenk, Tilo ^b   Wallander, Mari Ann ^b,c   Rodríguez, Luis A García ^a  

^a Department of Pharmacoepidemiology   (Spain)

^b BAYER PHARMA AG   (Germany)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Cancer; Cyproterone; Exogenous hormones; Hormonal replacement therapy; Meningioma; Nested case control; Oral contraceptives

Indexed keywords

ANDROGEN; ANTIANDROGEN; CYPROTERONE ACETATE; ESTROGEN; FLUOXYMESTERONE; GONADORELIN AGONIST; MESTEROLONE; ORAL CONTRACEPTIVE AGENT; PROGESTERONE;

ADOLESCENT; ADULT; ARTICLE; BREAST CANCER; CANCER DIAGNOSIS; CANCER INCIDENCE; CANCER RISK; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG MEGADOSE; FEMALE; GENITAL TRACT CANCER; HEALTH CARE SYSTEM; HORMONE SUBSTITUTION; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MENINGIOMA; ORAL CONTRACEPTION; PATIENT REFERRAL; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PROSTATE CANCER; SOCIAL STATUS; TREATMENT DURATION; UNITED KINGDOM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANDROGEN ANTAGONISTS; CASE-CONTROL STUDIES; COHORT STUDIES; CONTRACEPTIVES, ORAL, HORMONAL; CYPROTERONE ACETATE; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; MALE; MENINGEAL NEOPLASMS; MENINGIOMA; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; YOUNG ADULT;

EID: 84858797232     PISSN: 18777821     EISSN: 1877783X     Source Type: Journal    
DOI: 10.1016/j.canep.2011.08.003     Document Type: Article

References (61)

1. Helseth A., Mork S.J., Johansen A., Tretli S. Neoplasms of the central nervous system in Norway. IV. A population-based epidemiological study of meningiomas. APMIS 1989, 97(7):646-654.
2. Staneczek W., Janisch W. Epidemiologic data on meningiomas in East Germany 1961-1986: incidence, localization, age and sex distribution. Clin Neuropathol 1992, 11(3):135-141.
3. Longstreth W.T., Dennis L.K., McGuire V.M., Drangsholt M.T., Koepsell T.D. Epidemiology of intracranial meningioma. Cancer 1993, 72(3):639-648.
4. DeAngelis L.M. Brain tumors. N Engl J Med 2001, 344(2):114-123.
5. Sughrue M.E., Rutkowski M.J., Aranda D., Barani I.J., McDermott M.W., Parsa A.T. Treatment decision making based on the published natural history and growth rate of small meningiomas. J Neurosurg 2010, 113(5):1036-1042.
6. Radhakrishnan K., Mokri B., Parisi J.E., O'Fallon W.M., Sunku J., Kurland L.T. The trends in incidence of primary brain tumors in the population of Rochester, Minnesota. Ann Neurol 1995, 37(1):67-73.
7. Morris Z., Whiteley W.N., Longstreth W.T., Weber F., Lee Y.C., Tsushima Y., et al. Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2009, 339:b3016.
8. Krampla W., Newrkla S., Pfisterer W., Jungwirth S., Fischer P., Leitha T., et al. Frequency and risk factors for meningioma in clinically healthy 75-year-old patients: results of the Transdanube Ageing Study (VITA). Cancer 2004, 100(6):1208-1212.
9. Liu Y., Li F., Zhu S., Liu M., Wu C. Clinical features and treatment of meningiomas in children: report of 12 cases and literature review. Pediatr Neurosurg 2008, 44(2):112-117.
10. Acebes X., Arruga J., Acebes J.J., Majos C., Munoz S., Valero I.A. Intracranial meningiomatosis causing foster kennedy syndrome by unilateral optic nerve compression and blockage of the superior sagittal sinus. J Neuroophthalmol 2009, 29(2):140-142.
11. Bhatoe H.S., Singh P., Dutta V. Intraventricular meningiomas: a clinicopathological study and review. Neurosurg Focus 2006, 20(3):E9.
12. Alexiou G.A., Gogou P., Markoula S., Kyritsis A.P. Management of meningiomas. Clin Neurol Neurosurg 2010, 112(3):177-182.
13. Sadetzki S., Flint-Richter P., Ben-Tal T., Nass D. Radiation-induced meningioma: a descriptive study of 253 cases. J Neurosurg 2002, 97(5):1078-1082.
14. Katsuyama J., Papenhausen P.R., Herz F., Gazivoda P., Hirano A., Koss L.G. Chromosome abnormalities in meningiomas. Cancer Genet Cytogenet 1986, 22(1):63-68.
15. Hardell L., Carlberg M. Mobile phones, cordless phones and the risk for brain tumours. Int J Oncol 2009, 35(1):5-17.
16. Hardell L., Carlberg M., Hansson Mild K. Pooled analysis of case-control studies on malignant brain tumours and the use of mobile and cordless phones including living and deceased subjects. Int J Oncol 2011, 38(5):1465-1474.
17. The INTERPHONE Study Group Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study. Int J Epidemiol 2010, 39(3):675-694.
18. Preston-Martin S., Pogoda J.M., Schlehofer B., Blettner M., Howe G.R., Ryan P., et al. An international case-control study of adult glioma and meningioma: the role of head trauma. Int J Epidemiol 1998, 27(4):579-586.
19. Inskip P.D., Mellemkjaer L., Gridley G., Olsen J.H. Incidence of intracranial tumors following hospitalization for head injuries (Denmark). Cancer Causes Control 1998, 9(1):109-116.
20. Phillips L.E., Koepsell T.D., van Belle G., Kukull W.A., Gehrels J.A., Longstreth W.T. History of head trauma and risk of intracranial meningioma: population-based case-control study. Neurology 2002, 58(12):1849-1852.
21. Hemminki K., Tretli S., Sundquist J., Johannesen T.B., Granstrom C. Familial risks in nervous-system tumours: a histology-specific analysis from Sweden and Norway. Lancet Oncol 2009, 10(5):481-488.
22. Smith M.J., Higgs J.E., Bowers N.L., Halliday D., Paterson J., Gillespie J., et al. Cranial meningiomas in 411 neurofibromatosis type 2 (NF2) patients with proven gene mutations: clear positional effect of mutations, but absence of female severity effect on age at onset. J Med Genet 2011, 48(4):261-265.
23. Klaeboe L., Lonn S., Scheie D., Auvinen A., Christensen H.C., Feychting M., et al. Incidence of intracranial meningiomas in Denmark, Finland, Norway and Sweden, 1968-1997. Int J Cancer 2005, 117(6):996-1001.
24. Olson J.J. Laboratory evidence for the hormonal dependency of meningiomas. Hum Reprod 1994, 9(Suppl. 1):195-201.
25. Poisson M., Pertuiset B.F., Hauw J.J., Philippon J., Buge A., Moguilewsky M., et al. Steroid hormone receptors in human meningiomas, gliomas and brain metastases. J Neurooncol 1983, 1(3):179-189.
26. Magdelenat H., Pertuiset B.F., Poisson M., Martin P.M., Philippon J., Pertuiset B., et al. Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases. Acta Neurochir (Wien) 1982, 64(3-4):199-213.
27. Custer B.S., Koepsell T.D., Mueller B.A. The association between breast carcinoma and meningioma in women. Cancer 2002, 94(6):1626-1635.
28. Claus E.B., Black P.M., Bondy M.L., Calvocoressi L., Schildkraut J.M., Wiemels J.L., et al. Exogenous hormone use and meningioma risk: what do we tell our patients?. Cancer 2007, 110(3):471-476.
29. Benson V.S., Pirie K., Green J., Bull D., Casabonne D., Reeves G.K., et al. Hormone replacement therapy and incidence of central nervous system tumours in the Million Women Study. Int J Cancer 2010, 127(7):1692-1698.
30. Michaud D.S., Gallo V., Schlehofer B., Tjonneland A., Olsen A., Overvad K., et al. Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study. Cancer Epidemiol Biomarkers Prev 2010, 19(10):2562-2569.
31. Korhonen K., Raitanen J., Isola J., Haapasalo H., Salminen T., Auvinen A. Exogenous sex hormone use and risk of meningioma: a population-based case-control study in Finland. Cancer Causes Control 2010, 21(12):2149-2156.
32. Wigertz A., Lonn S., Hall P., Auvinen A., Christensen H.C., Johansen C., et al. Reproductive factors and risk of meningioma and glioma. Cancer Epidemiol Biomarkers Prev 2008, 17(10):2663-2670.
33. Durmaz R., Deliorman S., Isiksoy S., Uyar R., Tel E. Luteinizing hormone releasing hormone increases proliferation of meningioma cells in vitro. Arch Physiol Biochem 1999, 107(4):286-291.
34. Froelich S., Dali-Youcef N., Boyer P., Kehrli P., Maitrot D., Auwerx J., et al. Does cyproterone acetate promote multiple meningiomas?. Endocr Abstr 2008, 16158.
35. Goncalves A.M., Page P., Domigo V., Meder J.F., Oppenheim C. Abrupt regression of a meningioma after discontinuation of cyproterone treatment. AJNR Am J Neuroradiol 2010, [Epub ahead of print].
36. Lewis J.D., Schinnar R., Bilker W.B., Wang X., Strom B.L. Validation studies of the health improvement network (THIN) database for pharmacoepidemiology research. Pharmacoepidemiol Drug Saf 2007, 16(4):393-401.
37. Bourke A., Dattani H., Robinson M. Feasibility study and methodology to create a quality-evaluated database of primary care data. Inform Prim Care 2004, 12(3):171-177.
38. Stuart-Buttle C.D., Read J.D., Sanderson H.F., Sutton Y.M. A language of health in action: Read Codes, classifications and groupings. Proc AMIA Annu Fall Symp 1996, 7:5-9.
39. O'Neil M., Payne C., Read J. Read Codes version 3: a user led terminology. Methods Inf Med 1995, 34(1-2):187-192.
40. MULTILEX for Primary Care; 2010. Available from: [accessed 04.11.10]. http://www.firstdatabank.co.uk/8/multilex-drug-data-file.
41. Custer B., Longstreth W.T., Phillips L.E., Koepsell T.D., Van Belle G. Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study. BMC Cancer 2006, 6152.
42. Hatch E.E., Linet M.S., Zhang J., Fine H.A., Shapiro W.R., Selker R.G., et al. Reproductive and hormonal factors and risk of brain tumors in adult females. Int J Cancer 2005, 114(5):797-805.
43. Jhawar B.S., Fuchs C.S., Colditz G.A., Stampfer M.J. Sex steroid hormone exposures and risk for meningioma. J Neurosurg 2003, 99(5):848-853.
44. Wigertz A., Lonn S., Mathiesen T., Ahlbom A., Hall P., Feychting M. Risk of brain tumors associated with exposure to exogenous female sex hormones. Am J Epidemiol 2006, 164(7):629-636.
45. Benson V.S., Pirie K., Green J., Casabonne D., Beral V. Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort. Br J Cancer 2008, 99(1):185-190.
46. Blitshteyn S., Crook J.E., Jaeckle K.A. Is there an association between meningioma and hormone replacement therapy?. J Clin Oncol 2008, 26(2):279-282.
47. Lee E., Grutsch J., Persky V., Glick R., Mendes J., Davis F. Association of meningioma with reproductive factors. Int J Cancer 2006, 119(5):1152-1157.
48. Chen J., Chen G. Expression of androgen receptor in meningiomas. J Tongji Med Univ 2001, 21(2):140-142.
49. Leães C.G., Meurer R.T., Coutinho L.B., Ferreira N.P., Pereira-Lima J.F., daCosta Oliveira M. Immunohistochemical expression of aromatase and estrogen, androgen and progesterone receptors in normal and neoplastic human meningeal cells. Neuropathology 2010, 30(1):44-49.
50. Heidenreich A., Aus G., Bolla M., Joniau S., Matveev V.B., Schmid H.P., et al. EAU guidelines on prostate cancer. Eur Urol 2008, 53(1):68-80.
51. Lee K.L., Terris M.K. Luteinizing hormone-releasing hormone agonists and meningioma: a treatment dilemma. Urology 2003, 62(2):351.
52. Guidelines on prostate cancer: European Association of Urology; 2009. Available from: [accessed 31.03.10]. http://www.uroweb.org/fileadmin/tx_eauguidelines/2009/Full/Prostate_Cancer.pdf.
53. Neumann F., Kalmus J. Cyproterone acetate in the treatment of sexual disorders: pharmacological base and clinical experience. Exp Clin Endocrinol 1991, 98(2):71-80.
54. Wiegratz I., Kuhl H. Managing cutaneous manifestations of hyperandrogenic disorders: the role of oral contraceptives. Treat Endocrinol 2002, 1(6):372-386.
55. Gooren L.J., Giltay E.J., Bunck M.C. Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience. J Clin Endocrinol Metab 2008, 93(1):19-25.
56. Neumann F. The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research. Exp Clin Endocrinol 1994, 102(1):1-32.
57. Gazzeri R., Galarza M., Gazzeri G. Growth of a meningioma in a transsexual patient after estrogen-progestin therapy. N Engl J Med 2007, 357(23):2411-2412.
58. Helseth A., Mork S.J., Glattre E. Neoplasms of the central nervous system in Norway. V. Meningioma and cancer of other sites. An analysis of the occurrence of multiple primary neoplasms in meningioma patients in Norway from 1955 through 1986. APMIS 1989, 97(8):738-744.
59. Malmer B., Tavelin B., Henriksson R., Gronberg H. Primary brain tumours as second primary: a novel association between meningioma and colorectal cancer. Int J Cancer 2000, 85(1):78-81.
60. Rao G., Giordano S.H., Liu J., McCutcheon I.E. The association of breast cancer and meningioma in men and women. Neurosurgery 2009, 65(3):483-489. discussion 489.
61. Jacobs D.H., Holmes F.F., McFarlane M.J. Meningiomas are not significantly associated with breast cancer. Arch Neurol 1992, 49(7):753-756.