Targeted overexpression of Angptl6/angiopoietin-related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B

Journal of Dermatology

Volumn 39, Issue 4, 2012, Pages 366-374

  Okazaki, Hidenori ^a   Hirakawa, Satoshi ^b   Shudou, Masachika ^c   Nakaoka, Yoshiki ^a   Shirakata, Yuji ^a   Miyata, Keishi ^d   Oike, Yuichi ^d   Hashimoto, Koji ^a   Sayama, Koji ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c EHIME UNIVERSITY   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

Author keywords

collagen; photoaging; photosensitivity; transgenic mice; vascular endothelial growth factor

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 6; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DERMIS; ELECTRON MICROSCOPY; EPIDERMIS HYPERPLASIA; GENE OVEREXPRESSION; GENE TARGETING; LYMPH VESSEL; LYMPHATIC SYSTEM DISEASE; LYMPHATIC VESSEL ENLARGEMENT; MALE; MOUSE; NONHUMAN; SKIN DEFECT; ULTRAVIOLET B RADIATION;

ANGIOPOIETINS; ANIMALS; LYMPHANGIOGENESIS; MALE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; NEOVASCULARIZATION, PHYSIOLOGIC; PHOTOSENSITIVITY DISORDERS; SKIN; ULTRAVIOLET RAYS; UP-REGULATION; WOUND HEALING;

EID: 84858794356     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2011.01396.x     Document Type: Article

References (22)

1. Folkman J,. Tumor angiogenesis: therapeutic implications. N Eng J Med 1971; 285: 1182-1186.
2. Dvorak HF, Brown LF, Detmar M, Dvorak AM,. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146: 1029-1239.
3. Kligman LH,. Symposium on models for the study of human photoaging: American Society for Photobiology. Photochem Photobiol 1989; 50: 903-905.
4. Yano K, Oura H, Detmar M,. Targeted overexpression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photo-damage. J Invest Dermatol 2002; 118: 800-805. (Pubitemid 34526541)
5. Yano K, Kadoya K, Kajiya K, Hong YK, Detmar M,. Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1. Br J Dermatol 2005 (Jan); 152 (1): 115-121.
6. Kramer M, Sachsenmaier C, Herrlich P, Rahmsdorf HJ,. UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response. J Biol Chem 1993; 268: 6734-6741. (Pubitemid 23099381)
7. Strickland I, Rhodes LE, Flanagan BF, Friedmann PS,. TNF-alpha and IL-8 are upregulated in the epidermis of normal human skin after UVB exposure: correlation with neutrophil accumulation and E-selectin expression. J Invest Dermatol 1997; 108: 763-768. (Pubitemid 27192351)
8. Bielenberg DR, Bucana CD, Sanchez R, Donawho CK, Kripke ML, Fidler IJ,. Molecular regulation of UVB-induced cutaneous angiogenesis. J Invest Dermatol 1998; 111: 864-872. (Pubitemid 28509331)
9. Hirakawa S, Fujii S, Kajiya K, Yano K, Detmar M,. Vascular endothelial growth factor promotes sensitivity to ultraviolet B-induced cutaneous photodamage. Blood 2005; 105: 2392-2399. (Pubitemid 40387036)
10. Oike Y, Ito Y, Maekawa H, et al. Angiopoietin-related growth factor (AGF) promotes angiogenesis. Blood 2004; 103: 3760-3765. (Pubitemid 38596292)
11. Oike Y, Akao M, Yasunaga K, et al. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med 2005; 11: 400-408. (Pubitemid 40562330)
12. Hato T, Tabata M, Oike Y,. The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc Med 2008 (Jan); 18 (1): 6-14.
13. Oike Y, Yasunaga K, Ito Y, et al. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc Natl Acad Sci USA 2003; 100: 9494-9499. (Pubitemid 37033956)
14. Kajiya K, Hirakawa S, Detmar M,. Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol 2006; 169: 1496-1503. (Pubitemid 351194380)
15. Hirakawa S, Detmar M,. New insights into the biology and pathology of the cutaneous lymphatic system. J Dermatol Sci 2004 (Jun); 35 (1): 1-8. (Pubitemid 38759735)
16. Kajiya K, Sawane M, Huggenberger R, Detmar M,. Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis. J Invest Dermatol 2009; 129: 1292-1298.
17. Tabata M, Kadomatsu T, Fukuhara S, et al. Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab 2009; 10: 178-188.
18. Hirakawa S, Kodama S, Kunstfeld R, Kajiya K, Brown LF, Detmar M,. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 2005; 201: 1089-1099. (Pubitemid 40524677)
19. Hirakawa S, Detmar M, Kerjaschki D, et al. Nodal lymphangiogenesis and metastasis: role of tumor-induced lymphatic vessel activation in extramammary Paget's disease. Am J Pathol 2009; 175: 2235-2248.
20. Detmar M, Brown LF, Schön MP, et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 1998; 111: 1-6. (Pubitemid 28309201)
21. Urano T, Ito Y, Akao M, et al. Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model. Arterioscler Thromb Vasc Biol 2008; 28: 827-834. (Pubitemid 351544095)
22. Kajiya K, Detmar M,. An important role of lymphatic vessels in the control of UVB-induced edema formation and inflammation. J Invest Dermatol 2006; 126: 919-921.