Widespread distribution of HLA-DR-expressing cells in macroscopically undiseased intima of the human aorta: A possible role in surveillance and maintenance of vascular homeostasis

Immunobiology

Volumn 217, Issue 5, 2012, Pages 558-568

  Bobryshev, Yuri V ^a,b   Moisenovich, Michael M ^c   Pustovalova, Olga L ^c   Agapov, Igor I ^d   Orekhov, Alexander N ^a,e  

^a Institute of Chemical Problems of Ecology   (Russian Federation)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

^d SHUMAKOV NATIONAL MEDICAL RESEARCH CENTER OF TRANSPLANTOLOGY AND ARTIFICIAL ORGANS   (Russian Federation)

^e INSTITUTE OF GENERAL PATHOLOGY AND PATHOPHYSIOLOGY   (Russian Federation)

Author keywords

Aorta; Atherosclerosis; HLA DR; Intima

Indexed keywords

HLA DR ANTIGEN;

ADULT; ANTIGEN EXPRESSION; AORTA INTIMA; ARTICLE; BLOOD VESSEL REACTIVITY; CELL COMPOSITION; CELL COUNT; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL;

ADULT; ANTIGENS, CD1; AORTA; CELL COUNT; DENDRITIC CELLS; FEMALE; HLA-DR ANTIGENS; HOMEOSTASIS; HUMANS; MALE; MIDDLE AGED; TUNICA INTIMA;

EID: 84858793544     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2011.03.014     Document Type: Article

References (59)

1. Andreeva E.R., Pugach I.M., Orekhov A.N. Collagen-synthesizing cells in initial and advanced atherosclerotic lesions of human aorta. Atherosclerosis 1997, 130:133-142.
2. Andreeva E.R., Pugach I.M., Gordon D., Orekhov A.N. Continuous subendothelial network formed by pericyte-like cells in human vascular bed. Tissue Cell 1998, 30:127-135.
3. Babaev V.R., Bobryshev Y.V., Stenina O.V., Tararak E.M., Gabbiani G. Heterogeneity of smooth muscle cells in atheromatous plaque of human aorta. Am. J. Pathol. 1990, 136:1031-1042.
4. Babaev V.R., Bobryshev Y.V., Sukhova G.K., Kasantseva I.A. Monocyte/macrophage accumulation and smooth muscle cell phenotypes in early atherosclerotic lesions of human aorta. Atherosclerosis 1993, 100:237-248.
5. Bentzon J.F., Falk E. Atherosclerotic lesions in mouse and man: is it the same disease?. Curr. Opin. Lipidol. 2010, 21:434-440.
6. Bobryshev Y.V. Intracellular localization of oxidized low-density lipoproteins in atherosclerotic plaque cells revealed by electron microscopy combined with laser capture microdissection. J. Histochem. Cytochem. 2005, 53:793-797.
7. Bobryshev Y.V. Monocyte recruitment and foam cell formation in atherosclerosis. Micron 2006, 37:208-222.
8. Bobryshev Y.V. Dendritic cells and their role in atherogenesis. Lab. Invest. 2010, 90:970-984.
9. Bobryshev Y.V., Lord R.S. Ultrastructural recognition of cells with dendritic cell morphology in human aortic intima. Contacting interactions of vascular dendritic cells in athero-resistant and athero-prone areas of the normal aorta. Arch. Histol. Cytol. 1995, 58:307-322.
10. Bobryshev Y.V., Lord R.S. Langhans cells of human arterial intima: uniform by stellate appearance but different by nature. Tissue Cell 1996, 28:177-194.
11. Bobryshev Y.V., Lord R.S. Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions. Cardiovasc. Res. 1998, 37:799-810.
12. Bobryshev Y.V., Lord R.S. CD1 expression and the nature of CD1-expressing cells in human atherosclerotic plaques. Am. J. Pathol. 2000, 156:1477-1478.
13. Bobryshev Y.V., Lord R.S. Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis. J. Vasc. Surg. 2002, 35:368-375.
14. Bobryshev Y.V., Lord R.S., Rainer S., Jamal O.S., Munro V.F. Vascular dendritic cells and atherosclerosis. Pathol. Res. Pract. 1996, 192:462-467.
15. Bobryshev Y.V., Lord R.S., Watanabe T. Structural peculiarities of vascular dendritic cell tubulovesicular system in human atherosclerotic aorta. J. Submicrosc. Cytol. Pathol. 1997, 29:553-561.
16. Bobryshev Y.V., Babaev V.R., Lord R.S., Watanabe T. Ultrastructural identification of cells with dendritic cell appearance in atherosclerotic aorta of apolipoprotein E deficient mice. J. Submicrosc. Cytol. Pathol. 1999, 31:527-531.
17. Bobryshev Y.V., Taksir T., Lord R.S., Freeman M.W. Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice. Histol. Histopathol. 2001, 16:801-808.
18. Bochaton-Piallat M.L., Gabbiani G. Modulation of smooth muscle cell proliferation and migration: role of smooth muscle cell heterogeneity. Handb. Exp. Pharmacol. 2005, pp. 645-663.
19. Daugherty A., Lu H., Howatt D.A., Rateri D.L. Modes of defining atherosclerosis in mouse models: relative merits and evolving standards. Methods Mol. Biol. 2009, 573:1-15.
20. Geissmann F., Manz M.G., Jung S., Sieweke M.H., Merad M., Ley K. Development of monocytes, macrophages, and dendritic cells. Science 2010, 327:656-661.
21. Goldstein J.L., Brown M.S. The low-density lipoprotein pathway and its relation to atherosclerosis. Annu. Rev. Biochem. 1977, 46:897-930.
22. Gordon S. Macrophage heterogeneity and tissue lipids. J. Clin. Invest. 2007, 117:89-93.
23. Guyton J.R., Lindsay K.L., Dao D.T. Comparison of aortic intima and inner media in young adult versus aging rats. Am. J. Pathol. 1983, 111:234-246.
24. Handunnetthi L., Ramagopalan S.V., Ebers G.C., Knight J.C. Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes Immun. 2010, 11:99-112.
25. Hansson G.K. Atherosclerosis - an immune disease: the Anitschkov lecture 2007. Atherosclerosis 2009, 202:2-10.
26. Hansson G.K., Jonasson L. The discovery of cellular immunity in the atherosclerotic plaque. Arterioscler. Thromb. Vasc. Biol. 2009, 29:1714-1717.
27. Hansson G.K., Jonasson L., Holm J., Claesson-Welsh L. Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain. Clin. Exp. Immunol. 1986, 64:261-268.
28. Hao H., Gabbiani G., Bochaton-Piallat M.L. Arterial smooth muscle cell heterogeneity: implications for atherosclerosis and restenosis development. Arterioscler. Thromb. Vasc. Biol. 2003, 23:1510-1520.
29. Jonasson L., Holm J., Skalli O., Gabbiani G., Hansson G.K. Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J. Clin. Invest. 1985, 76:125-131.
30. Katsuda S., Boyd H.C., Fligner C., Ross R., Gown A.M. Human atherosclerosis. III. Immunocytochemical analysis of the cell composition of lesions of young adults. Am. J. Pathol. 1992, 140:907-914.
31. Kolpakov V., Polishchuk R., Bannykh S., Rekhter M., Solovjev P., Romanov Y., Tararak E., Antonov A., Mironov A. Atherosclerosis-prone branch regions in human aorta: microarchitecture and cell composition of intima. Atherosclerosis 1996, 122:173-189.
32. Kruth H.S. Macrophage foam cells and atherosclerosis. Front. Biosci. 2001, 6:D429-D455.
33. Dendritic Cells: Biology and Clinical Applications 2001, Academic Press, San Diego, CA. second ed. M.T. Lotze, A.W. Thomson (Eds.).
34. McNeill E., Channon K.M., Greaves D.R. Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications. Clin. Sci. (Lond.) 2010, 118:641-655.
35. Millonig G., Niederegger H., Rabl W., Hochleitner B.W., Hoefer D., Romani N., Wick G. Network of vascular-associated dendritic cells in intima of healthy young individuals. Arterioscler. Thromb. Vasc. Biol. 2001, 21:503-508.
36. Millonig G., Niederegger H., Wick G. Analysis of the cellular composition of the arterial intima with modified en face techniques. Lab. Invest. 2001, 81:639-641.
37. Millonig G., Schwentner C., Mueller P., Mayerl C., Wick G. The vascular-associated lymphoid tissue: a new site of local immunity. Curr. Opin. Lipidol. 2001, 12:547-553.
38. Nielsen M., Lund O., Buus S., Lundegaard C. MHC class II epitope predictive algorithms. Immunology 2010, 130:319-328.
39. Orekhov A.N., Andreeva E.R., Andrianova I.V., Bobryshev Y.V. Peculiarities of cell composition and cell proliferation in different type atherosclerotic lesions in carotid and coronary arteries. Atherosclerosis 2010, 212:436-443.
40. Ozmen J., Bobryshev Y.V., Lord R.S., Ashwell K.W. Identification of dendritic cells in aortic atherosclerotic lesions in rats with diet-induced hypercholesterolaemia. Histol. Histopathol. 2002, 17:223-237.
41. Porcelli S.A. The CD1 family: a third lineage of antigen-presenting molecules. Adv. Immunol. 1995, 59:1-98.
42. Rekhter M.D., Andreeva E.R., Mironov A.A., Orekhov A.N. Three-dimensional cytoarchitecture of normal and atherosclerotic intima of human aorta. Am. J. Pathol. 1991, 138:569-580.
43. Rekhter M.D., Andreeva E.R., Andrianova I.V., Mironov A.A., Orekhov A.N. Stellate cells of aortic intima: I. Human and rabbit. Tissue Cell 1992, 24:689-696.
44. Rekhter M.D., Zhang K., Narayanan A.S., Phan S., Schork M.A., Gordon D. Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions. Am. J. Pathol. 1993, 143:1634-1648.
45. Ross R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 1999, 340:115-126.
46. Schwartz S.M., deBlois D., O'Brien E.R.M. The intima: soil for atherosclerosis and restenosis. Circ. Res. 1995, 77:445-465.
47. Singh V., Tiwari R.L., Dikshit M., Barthwal M.K. Models to study atherosclerosis: a mechanistic insight. Curr. Vasc. Pharmacol. 2009, 7:75-109.
48. Stary H.C., Blankenhorn D.H., Chandler A.B., Glagov S., Insull W., Richardson M., Rosenfeld M.E., Schaffer S.A., Schwartz C.J., Wagner W.D., Wissler R.W. A definition of the intima of human arteries and of its atherosclerosis-prone regions. Circulation 1992, 85:391-405.
49. Stemme S., Fager G., Hansson G.K. MHC class II antigen expression in human vascular smooth muscle cells is induced by interferon-gamma and modulated by tumour necrosis factor and lymphotoxin. Immunology 1990, 69:243-249.
50. Tertov V.V., Orekhov A.N. Metabolism of native and naturally occurring multiple modified low density lipoprotein in smooth muscle cells of human aortic intima. Exp. Mol. Pathol. 1997, 64:127-145.
51. Tertov V.V., Sobenin I.A., Gabbasov Z.A., Popov E.G., Jaakkola O., Solakivi T., Nikkari T., Smirnov V.N., Orekhov A.N. Multiple-modified desialylated low density lipoproteins that cause intracellular lipid accumulation. Isolation, fractionation and characterization. Lab. Invest. 1992, 67:665-675.
52. Trowbridge I.S., Thomas M.L. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu. Rev. Immunol. 1994, 12:85-116.
53. Vanderlaan P.A., Reardon C.A. The unusual suspects: an overview of the minor leukocyte populations in atherosclerosis. J. Lipid. Res. 2005, 46:829-838.
54. Waltner-Romen M., Falkensammer G., Rabl W., Wick G. A previously unrecognized site of local accumulation of mononuclear cells. The vascular-associated lymphoid tissue. J. Histochem. Cytochem. 1998, 46:1347-1350.
55. Wick G., Romen M., Amberger A., Metzler B., Mayr M., Falkensammer G., Xu Q. Atherosclerosis, autoimmunity, and vascular-associated lymphoid tissue. FASEB J. 1997, 11:1199-1207.
56. Wick G., Knoflach M., Xu Q. Autoimmune and inflammatory mechanisms in atherosclerosis. Annu. Rev. Immunol. 2004, 22:361-403.
57. Wright I. The microscopical appearances of human peripheral arteries during growth and aging. J. Clin. Pathol. 1963, 16:499-522.
58. Xu Q.B., Oberhuber G., Gruschwitz M., Wick G. Immunology of atherosclerosis: cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens. Clin. Immunol. Immunopathol. 1990, 56:344-359.
59. Yilmaz A., Lochno M., Traeg F., Cicha I., Reiss C., Stumpf C., Raaz D., Anger T., Amann K., Probst T., Ludwig J., Daniel W.G., Garlichs C.D. Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques. Atherosclerosis 2004, 176:101-110.