Relation between NT-proBNP levels, iron overload, and early stage of myocardial dysfunction in β-thalassemia major patients

Echocardiography

Volumn 29, Issue 3, 2012, Pages 318-325

  Balkan, Can ^a   Tuluce, Selcen Yakar ^a   Basol, Gunes ^a   Tuluce, Kamil ^a   Ay, Yílmaz ^a   Karapinar, Deniz Yilmaz ^a   Gurgun, Cemil ^a   Bayindir, Oya ^a   Kavakli, Kaan ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

thalassemia; iron; myocardial dysfunction; NT proBNP

Indexed keywords

FERRITIN; NATRIURETIC FACTOR;

ADULT; ARTICLE; BLOOD TRANSFUSION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIASTOLE; DISEASE SEVERITY; FEMALE; HUMAN; IRON OVERLOAD; LABORATORY TEST; MALE; MYOCARDIAL DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THALASSEMIA MAJOR; TISSUE DOPPLER IMAGING;

BETA-THALASSEMIA; BIOLOGICAL MARKERS; COMORBIDITY; ECHOCARDIOGRAPHY; FEMALE; HUMANS; IRON OVERLOAD; MALE; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; PREVALENCE; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; RISK FACTORS; SENSITIVITY AND SPECIFICITY; TURKEY; VENTRICULAR DYSFUNCTION, LEFT; YOUNG ADULT;

EID: 84858792276     PISSN: 07422822     EISSN: 15408175     Source Type: Journal    
DOI: 10.1111/j.1540-8175.2011.01584.x     Document Type: Article

References (36)

1. Fosburg MT, Nathan DG,: Treatment of Cooley's anemia. Blood 1990; 76: 435-444.
2. Kremastinos DT, Tiniakos G, Theodorakis GN, et al,: Myocarditis in beta-thalassemia major. A cause of heart failure. Circulation 1995; 91: 66-71.
3. Kremastinos DT, Flevari P, Spyropoulou M, et al,: Association of heart failure in homozygous beta-thalassemia with the major histocompatibility complex. Circulation 1999; 100: 2074-2078.
4. Economou-Petersen E, Aessopos A, Kladi A, et al,: Apolipoprotein E epsilon-4 allele as a genetic risk factor for left ventricular failure in homozygous beta-thalassemia. Blood 1998; 92: 3455-3459.
5. Brili SV, Tzonou AI, Castelanos SS, et al,: The effect of iron overload in the hearts of patients with beta-thalassemia. Clin Cardiol 1997; 20: 541-546.
6. Engle MA, Erlandson M, Smith CH,: Late cardiac complications of chronic, severe, refractory anemia with hemochromatosis. Circulation 1964; 30: 698-705.
7. Olivieri NF,: The beta-thalassemias. N Engl J Med 1999; 341: 99-109.
8. Kremastinos DT, Tsiapras DP, Tsetsos GA, et al,: Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Circulation 1993; 88: 1127-1135.
9. Hahalis G, Alexopoulos D, Kremastinos D, et al,: Heart failure in beta-thalassemia syndromes: A decade of progress. Am J Med 2005; 118: 957-967.
10. Porter JB, Davis BA,: Monitoring chelation therapy to achieve optimal outcome in the treatment of thalassaemia. Best Pract Res Clin Haematol 2002; 15: 329-368.
11. Nagueh SF, Middleton KJ, Kopelen HA, et al,: Doppler tissue imaging: A noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997; 30: 1527-1533.
12. Ommen SR, Nishimura RA, Appleton CP, et al,: Clinical utility of Doppler echocardiography and Tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler- catheterization study. Circulation 2000; 102: 1788-1794.
13. Sagnella GA,: Measurement and importance of plasma brain natriuretic peptide and related peptides. Ann Clin Biochem 2001; 38: 83-93.
14. Daniels LB, Maisel AS,: Natriuretic peptides. J Am Coll Cardiol 2007; 50: 2357-2368.
15. Kremastinos DT, Tsiapras DP, Kostopoulou AG, et al,: NT-proBNP levels and diastolic dysfunction in β-thalassemia major patients. Eur J Heart Fail 2007; 9: 531-536.
16. Kremastinos DT, Hamodraka E, Parissis J, et al,: Predictive value of B-type natriuretic peptides in detecting latent left ventricular diastolic dysfunction in β-thalassemia major. Am Heart J 2010; 159: 68-74.
17. Tsutamoto T, Wada A, Maeda K, et al,: Plasma brain natriuretic peptide level as a biochemical marker of morbidity and mortality in patients with asymptomatic or minimally symptomatic left ventricular dysfunction: Comparison with plasma angiotensin II and endothelin-1. Eur Heart J 1999; 20: 1799-1807.
18. Lang RM, Bierig M, Devereux RB, et al,: Recommendations for chamber quantification: A report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18: 1440-1463.
19. Devereux RB, Reichek N,: Echocardiographic determination of left ventricular mass. Anatomic validation of the method. Circulation 1977; 55: 613-618.
20. Spirito P, Lupi G, Melevendi C, et al,: Restrictive diastolic abnormalities identified by Doppler echocardiography in patients with thalassemia major. Circulation 1990; 82: 88-94.
21. Kremastinos DT, Tsetsos GA, Tsiapras DP, et al,: Heart failure in beta-thalassemia: A 5-year follow-up study. Am J Med 2001; 111: 349-354.
22. Mavrogeni SI, Gotis ED, Markussis V, et al,: T2 relaxation time study of iron overload in b-thalassemia. MAGMA 1998; 6: 7-12.
23. Anderson LJ, Holden S, Davis B, et al,: Cardiovascular T2-star (T2) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001; 22: 2171-2179.
24. Wang TJ, Larson MG, Levy D, et al,: Plasma natriuretic peptide levels and the risk of cardiovascular events and death. N Engl J Med 2004; 350: 655-663.
25. Tschope C, Kasner M, Westermann D, et al,: The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: Correlation with echocardiographic and invasive measurements. Eur Heart J 2005; 26: 2277-2284.
26. Chrysohou C, Greenberg M, Pitsavos C, et al,: Diastolic function in young patients with beta-thalassemia major: An echocardiographic study. Echocardiography 2006; 23: 38-44.
27. Akpinar O, Acartürk E, Kanadasi M, et al,: Tissue Doppler imaging and NT-proBNP levels show the early impairment of ventricular function in patients with β-thalassaemia major. Acta Cardiol 2007; 62: 225-231.
28. Kremastinos DT, Rentoukas E, Mavrogeni S, et al,: Left ventricular filling pattern in β-thalassaemia major Doppler echocardiographic study. Eur Heart J 1993; 14: 351-357.
29. Bilge AK, Altinkaya E, Ozben B, et al,: Early detection of left ventricular dysfunction with strain imaging in thalassemia patients. Clin Cardiol 2010; 33: 29-34.
30. Sanderson JE, Wang M, Yu CM,: Tissue Doppler imaging for predicting outcome in patients with cardiovascular disease. Curr Opin Cardiol 2007; 19: 458-463.
31. Aessopos A, Farmakis D, Polonifi A, et al,: Plasma B-type natriuretic peptide concentration in beta-thalassaemia patients. Eur J Heart Fail 2007; 9: 537-541.
32. Nagueh SF, Appleton CP, Gillebert TC, et al,: Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr 2009; 10: 165-193.
33. Marcí M, Pitrolo L, Lo Pinto C, et al,: Detection of early cardiac dysfunction doppler in patients with beta thalassemia by tissue echocardiography. Echocardiography 2011; 28: 175-180.
34. Kim H, Jun DW, Cho YK, et al,: The correlation of left atrial volume index to the level of N-terminal Pro-BNP in heart failure with a preserved ejection fraction. Echocardiography 2008; 25: 961-967.
35. Olivieri NF, Nathan DG, MacMillan JH, et al,: Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med 1994; 331: 574-578.
36. Nikolidakis S, Flessa C, Nikolaou N, et al,: Brain natriuretic peptide as marker of myocardial iron load in β-thalassemia. Int J Cardiol 2007; 118: 408-409.