The Utility of Immunohistochemistry for the Identification of Hematopoietic and Lymphoid Cells in Normal Tissues and Interpretation of Proliferative and Inflammatory Lesions of Mice and Rats

Toxicologic Pathology

Volumn 40, Issue 2, 2012, Pages 345-374

  Rehg, Jerold E ^a   Bush, Dorothy ^a   Ward, Jerrold M ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Global VetPathology   (United States)

Author keywords

erythrocytes; immunohistochemistry; lymphocytes; macrophages; mice; myeloid; rats

Indexed keywords

CD163 ANTIGEN; CD3 ANTIGEN; CD34 ANTIBODY; CD40 ANTIGEN; CD45 ANTIGEN; CD45RB ANTIGEN; CD5 ANTIGEN; CD68 ANTIGEN; CD79 ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C3D RECEPTOR; GLYCOPHORIN A; GRANZYME B; HISTAMINE; IMMUNOGLOBULIN M; INTERFERON REGULATORY FACTOR 4; LECTIN; LEUKOSIALIN; LYSOZYME; PERFORIN; PROTEIN BCL 2; PROTEIN BCL 6; PROTEIN S 100; STEM CELL FACTOR RECEPTOR; SYNDECAN 1; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR RUNX1; UNINDEXED DRUG;

ANTIGEN EXPRESSION; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; DENDRITIC CELL; EOSINOPHIL; ERYTHROCYTE MEMBRANE; ERYTHROID CELL; GRANULOCYTE; HAPLOTYPE; HELPER CELL; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HISTIOCYTE; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KUPFFER CELL; LYMPHOCYTE; LYMPHOID CELL; MACROPHAGE; MAST CELL; MEGAKARYOCYTE; MONOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERITONEUM MACROPHAGE; PRE T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVIEW; T LYMPHOCYTE; TISSUE SECTION;

MURINAE; MUS; RATTUS;

EID: 84858769998     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623311430695     Document Type: Article

References (142)

1. Adams B. Dorfler P. Aguzzi A. Kozmik Z. Urbanek P. Maurer-Fogy I. Busslinger M. (1992). Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev 6, 1589–607.
2. Amanzada A. Malik I. A. Nischwitz M. Sultan S. Naz N. Ramadori G. (2011). Myeloperoxidase and elastase are only expressed by neutrophils in normal and in inflamed liver. Histochem Cell Biol 135, 305–15.
3. Arber D. A. Strickler J. G. Chen Y. Y. Weiss L. M. (1997). Splenic vascular tumors: a histologic, immunophenotypic, and virologic study. Am J Surg Pathol 21, 827–35.
4. Arber D. A. Tamayo R. Weiss L. M. (1998). Paraffin section detection of the c-kit gene product (CD117) in human tissues: Value in the diagnosis of mast cell disorders. Hum Pathol 29, 498–504.
5. Arber D. A. Weiss L. M. (1993). CD43: A review. Appl Immunochistochem 1, 88–96.
6. Arber D. A. Weiss L.M. (1997). CD 10: A review. Appl Immunohistochem 5, 125–40.
7. Ardavin C. Shortman K. (1992). Cell surface marker analysis of mouse thymic dendritic cells. Eur J Immunol 22, 859–62.
8. Arinobu Y. Iwasaki H. Gurish M. F. Mizuno S. Shigematsu H. Ozawa H. Tenen D. G. Austen K. F. Akashi K. (2005). Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102, 18105–10.
9. Barberis A. Widenhorn K. Vitelli L. Busslinger M. (1990). A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev 4, 849–59.
10. Bhandoola A. Sambandam A. (2006). From stem cell to T cell: One route or many? Nat Rev Immunol 6, 117–26.
11. Bhargava P. Kallakury B. V. Ross J. S. Azumi N. Bagg A. (2007). CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner. Am J Clin Pathol 128, 306–13.
12. Blasius A. L. Barchet W. Cella M. Colonna M. (2007). Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells. J Exp Med 204, 2561–8.
13. M.J., Borowitz, J.J.C., Chan, B lymphoblastic leukaemia/lymphoma, not otherwise specified, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Swerdlow, S., Campo, E., Harris, N., Jaffe, E., Piler, S., Stein, H., Thiele, J., Vardiman, J., International Agency for Research on Cancer, World Health Organization, Washington, DC, (2008), 168
14. Brown K. E. Brunt E. M. Heinecke J. W. (2001). Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver. Am J Pathol 159, 2081–8.
15. Carbone A. Manconi R. Poletti A. Colombatti A. Tirelli U. Volpe R. (1986). S-100 protein, fibronectin, and laminin immunostaining in lymphomas of follicular center cell origin. Cancer 58, 2169–76.
16. Ceredig R. Rolink T. (2002). A positive look at double-negative thymocytes. Nat Rev Immunol 2, 888–97.
17. Chen Z. Irani A. A. Bradford T. R. Craig S. S. Newlands G. Miller H. Huff T. Simmons W. H. Schwartz L. B. (1993). Localization of rat tryptase to a subset of the connective tissue type of mast cell. J Histochem Cytochem 41, 961–9.
18. Chilosi M. Pizzolo G. (1995). Review of terminal deoxynecleotidyl transferase. Appl Immunohistochem 3, 209–21.
19. Chilosi M. Pizzolo G. Caligaris-Cappio F. Ambrosetti A. Vinante F. Morittu L. Bonetti F. Fiore-Donati L. Janossy G. (1985). Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia. Cancer 56, 328–32.
20. Chu P. G. Chang K. L. Arber D. A. Weiss L. M. (1999). Practical applications of immunohistochemistry in hematolymphoid neoplasms. Ann Diagn Pathol 3, 104–33.
21. Chu P. G. Weiss L. (2009). Modern Immunohistochemistry. Cambridge University Press, Cambridge, UK.
22. Chuang S. S. Jung Y. C. Li C. Y. (2000). von Willebrand factor is the most reliable immunohistochemical marker for megakaryocytes of myelodysplastic syndrome and chronic myeloproliferative disorders. Am J Clin Pathol 113, 506–11.
23. Contos M. J. Kornstein M. J. Innes D. J. Ben-Ezra J. (1992). The utility of CD20 and CD43 in subclassification of low-grade B-cell lymhoma on paraffin sections. Mod Pathol 5, 631–3.
24. Corsetti M. T. Calabi F. (1997). Lineage- and stage-specific expression of runt box polypeptides in primitive and definitive hematopoiesis. Blood 89, 2359–68.
25. Costain D. J. Guha A. K. Liwski R. S. Lee T. D. (2001). Murine hypodense eosinophils induce tumour cell apoptosis by a granzyme B-dependent mechanism. Cancer Immunol Immunother 50, 293–9.
26. Dabbs D. J. (2010). Diagnostic Immunohistochemistry. Elsevier, New York, NY.
27. Davies M. Harris S. Rudland P. Barraclough R. (1995). Expression of the rat, S-100-related, calcium-binding protein gene, p9Ka, in transgenic mice demonstrates different patterns of expression between these two species. DNA Cell Biol 14, 825–32.
28. De Z. J. (1999). Myeloid cell-lineage and premylocytic-stage-specific-expression of the mouse myeloperoxidase gene is controlled at initiation as well as elongation levels of transcription. Cell Research 9, 107–34.
29. Debili N. Issaad C. Masse J. M. Guichard J. Katz A. Breton-Gorius J. Vainchenker W. (1992). Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation. Blood 80, 3022–35.
30. Dik W. A. Pike-Overzet K. Weerkamp F. de Ridder D. de Haas E. F. Baert M. R. van der Spek P. Koster E. E. Reinders M. J. van Dongen J. J. Langerak A. W. Staal F. J. (2005). New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med 201, 1715–23.
31. Drew E. Merkens H. Chelliah S. Doyonnas R. McNagny K. M. (2002). CD34 is a specific marker of mature murine mast cells. Exp Hematol 30, 1211–8.
32. Elagib K. E. Racke F. K. Mogass M. Khetawat R. Delehanty L. L. Goldfarb A. N. (2003). RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Blood 101, 4333–41.
33. Enerback L. (1981). The gut mucosal mast cell. Monogr Allergy 17, 222–32.
34. Escribano L. Ocqueteau M. Almeida J. Orfao A. San Miguel J. F. (1998). Expression of the c-kit (CD117) molecule in normal and malignant hematopoiesis. Leuk Lymphoma 30, 459–66.
35. Falini B. Fizzotti M. Pucciarini A. Bigerna B. Marafioti T. Gambacorta M. Pacini R. Alunni C. Natali-Tanci L. Ugolini B. Sebastiani C. Cattoretti G. Pileri S. Dalla-Favera R. Stein H. (2000). A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 95, 2084–92.
36. Falini B. Flenghi L. Pileri S. Gambacorta M. Bigerna B. Durkop H. Eitelbach F. Thiele J. Pacini R. Cavaliere A. Masssimo M. Cardarelli N. Sabattini E. Poggi S. Stein H. (1993). PG-M1: A new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule. Am J Pathol 142, 1359–72.
37. Flotte T. J. Springer T. A. Thorbecke G. J. (1983). Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets. Am J Pathol 111, 112–24.
38. Franco V. Florena A. M. Lannitto E. (2003). Splenic marginal zone lymphoma. Blood 101, 2464–72.
39. Fredrickson T. N. Langdon W. Y. Hoffman P. M. Hartley J. W. Morse H. C., III (1984). Histologic and cell surface antigen studies of hematopoietic tumors induced by Cas-Br-M murine leukemia virus. J Natl Cancer Inst 72, 447–54.
40. Galili U. Galili N. Or R. Polliack A. (1981). Analysis of the peanut agglutinin-binding site as a differentiation marker of normal and malignant human lymphoid cells. Clin Exp Immunol 43, 311–8.
41. Gewirtz A. M. (1995). Megakaryocytopoiesis: the state of the art. Thromb Haemost 74, 204–9.
42. Godfrey D. I. Kennedy J. Suda T. Zlotnik A. (1993). A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol 150, 4244–52.
43. Godfrey D. I. Zlotnik A. Suda T. (1992). Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. J Immunol 149, 2281–5.
44. Gordon S. Lawson L. Rabinowitz S. Crocker P. R. Morris L. Perry V. H. (1992). Antigen markers of macrophage differentiation in murine tissues. Curr Top Microbiol Immunol 181, 1–37.
45. S.S.P., Gordon, S.-H., Lee, L., Morris, S., Rabinowitz, Trophic and defense functions of murine macrophages, Mechaninisms of Host Resistance to Infectious Agents, Tumors, and Allografts, Steinman, R. M., North, R. J., Rockefeller University Press, New York, NY, (1986)
46. Gordon S. Martinez F. O. (2010). Alternative activation of macrophages: Mechanism and functions. Immunity 32, 593–604.
47. Gouon-Evans V. Lin E. Y. Pollard J. W. (2002). Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development. Breast Cancer Res 4, 155–64.
48. Gualco G. Weiss L. M. Bacchi C. E. (2010). MUM1/IRF4: A review. Appl Immunohistochem Mol Morphol 18, 301–10.
49. Hallgren J. Gurish M. F. (2007). Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cell. Immunol Rev 217, 8–18.
50. Hao X. Fredrickson T. N. Chattopadhyay S. K. Han W. Qi C. F. Wang Z. Ward J. M. Hartley J. W. Morse H. C., III (2010). The histopathologic and molecular basis for the diagnosis of histiocytic sarcoma and histiocyte-associated lymphoma of mice. Vet Pathol 47, 434–45.
51. Hao X. Shin M. S. Zhou J. X. Lee C. H. Qi C. F. Naghashfar Z. Hartley J. W. Fredrickson T. N. Ward J. M. Morse H. C. III (2006). Histologic and molecular characterizations of megakaryocytic leukemia in mice. Leuk Res 30, 397–406.
52. Hard G. C. Snowden R. T. (1991). Hyaline droplet accumulation in rodent kidney proximal tubules: An association with histiocytic sarcoma. Toxicol Pathol 19, 88–97.
53. Hardy R. R. Kincade P. W. Dorshkind K. (2007). The protean nature of cells in the B lymphocyte lineage. Immunity 26, 703–14.
54. Hashimoto M. Yamashita Y. Mon N. (2002). Immunohistochemical detection of CD79a expression in precursor T-cell lymphoblastic lymphoma/leukaemias. J Pathol 197, 341–7.
55. Hayakawa Y. Huntington N. D. Nutt S. L. Smyth M. J. (2006). Functional subsets of mouse natural killer cells. Immunol Rev 214, 47–55.
56. Hirsch S. Gordon S. (1983). Polymorphic expression of a neutrophil differentiation antigen revealed by monoclonal antibody 7/4. Immunogenetics 18, 229–39.
57. Hisa T. Spence S. E. Rachel R. A. Fujita M. Nakamura T. Ward J. M. Devor-Henneman D. E. Saiki Y. Kutsuna H. Tessarollo L. Jenkins N. A. Copeland N. G. (2004). Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. Embo J 23, 450–9.
58. Hung S. I. Chang A. C. Kato I. Chang N. C. (2002). Transient expression of Ym1, a heparin-binding lectin, during developmental hematopoiesis and inflammation. J Leukoc Biol 72, 72–82.
59. Jaffe E. S. (1996). Classification of natural killer (NK) cell and NK-like T-cell malignancies. Blood 87, 1207–10.
60. Kaiserling E. Xiao J. C. Ruck P. Horny H. P. (1993). Aberrant expression of macrophage-associated antigens (CD68 and Ki-M1P) by Schwann cells in reactive and neoplastic neural tissue. Light- and electron-microscopic findings. Mod Pathol 6, 463–8.
61. Kalled S. L. Siva N. Stein H. Reinherz E. L. (1995). The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is similar in non-lymphoid organs but differs within the hematopoietic system: Absence on murine T and B lymphoid progenitors. Eur J Immunol 25, 677–87.
62. Kaufman G. d’Ovidio R. Kaldawy A. Assy B. Ullmann Y. Etzioni A. Paus R. Gilhar A. (2010). An unexpected twist in alopecia areata pathogenesis: Are NK cells protective and CD49b+ T cells pathogenic? Exp Dermatol 19, e347–9.
63. Kina T. Ikuta K. Takayama E. Wada K. Majumdar A. S. Weissman I. L. Katsura Y. (2000). The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol 109, 280–7.
64. King B. E. Chen C. Locker J. Kant J. Okuyama K. Falini B. Swerdlow S. H. (2000). Immunophenotypic and genotypic markers of follicular center cell neoplasia in diffuse large B-cell lymphomas. Mod Pathol 13, 1219–31.
65. Klockars M. Osserman E. F. (1974). Localization of lysozyme in normal rat tissues by an immunoperoxidase method. J Histochem Cytochem 22, 139–46.
66. Kohler C. (2007). Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis. Cell Tissue Res 330, 291–302.
67. Kunder S. Calzada-Wack J. Holzlwimmer G. Muller J. Kloss C. Howat W. Schmidt J. Hofler H. Warren M. Quintanilla-Martinez L. (2007). A comprehensive antibody panel for immunohistochemical analysis of formalin-fixed, paraffin-embedded hematopoietic neoplasms of mice: Analysis of mouse specific and human antibodies cross-reactive with murine tissue. Toxicol Pathol 35, 366–75.
68. Lagasse E. Weissman I. L. (1996). Flow cytometric identification of murine neutrophils and monocytes. J Immunol Methods 197, 139–50.
69. Lau S. Chu P. G. Weiss L. M. (2004). A specific marker of macrophages in paraffin-embedded tissue samples. Am J Clin Pathol 122, 794–801.
70. Leenen P. J. de Bruijn M. F. Voerman J. S. Campbell P. A. van Ewijk W. (1994). Markers of mouse macrophage development detected by monoclonal antibodies. J Immunol Methods 174, 5–19.
71. Lesley J. Schulte R. Trotter J. Hyman R. (1988). Qualitative and quantitative heterogeneity in Pgp-1 expression among murine thymocytes. Cell Immunol 112, 40–54.
72. Li W. V. Kapadia S. B. Sonmez-Alpan E. Swerdlow S. H. (1996). Immunohistochemical characterization of mast cell disease in paraffin sections using tryptase, CD68, myeloperoxidase, lysozyme, and CD20 antibodies. Mod Pathol 9, 982–8.
73. Lopez A. F. Strath M. Sanderson C. J. (1984). Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies. Br J Haematol 57, 489–94.
74. Lorsbach R. B. Moore J. Ang S. O. Sun W. Lenny N. Downing J. R. (2004). Role of RUNX1 in adult hematopoiesis: Analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Blood 103, 2522–9.
75. Malorny U. Michels E. Sorg C. (1986). A monoclonal antibody against an antigen present on mouse macrophages and absent from monocytes. Cell Tissue Res 243, 421–8.
76. Matsui Y. Natori S. Obinata M. (1985). Induction of glycophorin gene expression in cultured murine erythroleukemia cells. Differentiation 29, 268–74.
77. Mazzucchelli R. Durum S. K. (2007). Interleukin-7 receptor expression: Intelligent design. Nat Rev Immunol 7, 144–54.
78. McCafferty D. M. Miampamba M. Sihota E. Sharkey K. A. Kubes P. (1999). Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut 45, 864–73.
79. McComb R. D. Jones T. R. Pizzo S. V. Bigner D. D. (1982). Specificity and sensitivity of immunohistochemical detection of factor VIII/von Willebrand factor antigen in formalin-fixed paraffin-embedded tissue. J Histochem Cytochem 30, 371–7.
80. McGarry M. P. Stewart C. C. (1991). Murine eosinophil granulocytes bind the murine macrophage-monocyte specific monoclonal antibody F4/80. J Leukoc Biol 50, 471–8.
81. Mikaelian I. Nanney L. B. Parman K. S. Kusewitt D. F. Ward J. M. Naf D. Krupke D. M. Eppig J. T. Bult C. J. Seymour R. Ichiki T. Sundberg J. P. (2004). Antibodies that label paraffin-embedded mouse tissues: A collaborative endeavor. Toxicol Pathol 32, 181–91.
82. Milner J. D. Orekov T. Ward J. M. Cheng L. Torres-Velez F. Junttila I. Sun G. Buller M. Morris S. C. Finkelman F. D. Paul W. E. (2010). Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation. Blood 116, 2476–83.
83. Morse H. C. III Anver M. R. Fredrickson T. N. Haines D. C. Harris A. W. Harris N. L. Jaffe E. S. Kogan S. C. MacLennan I. C. Pattengale P. K. Ward J. M. (2002). Bethesda proposals for classification of lymphoid neoplasms in mice. Blood 100, 246–58.
84. Morton J. Coles B. Wright K. Gallimore A. Morrow J. D. Terry E. S. Anning P. B. Morgan B. P. Dioszeghy V. Kuhn H. Chaitidis P. Hobbs A. J. Jones S. A. O’Donnell V. B. (2008). Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice. Blood 111, 5187–94.
85. Muler J. H. Valdez R. Hayes C. Kaminski M. S. (2002). Acute megakaryocytic leukemia presenting as hypercalcemia with skeletal lytic lesions. Eur J Haematol 68, 392–6.
86. Nagendra S. Schlueter A. J. (2004). Absence of cross-reactivity between murine Ly-6C and Ly-6G. Cytometry A 58, 195–200.
87. Nagra R. M. Becher B. Tourtellotte W. W. Antel J. P. Gold D. Paladino T. Smith R. A. Nelson J. R. Reynolds W. F. (1997). Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis. J Neuroimmunol 78, 97–107.
88. Nair M. G. Cochrane D. W. Allen J. E. (2003). Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. Immunol Lett 85, 173–80.
89. Neuhauser T. S. Derringer G. A. Thompson L. D. Fanburg-Smith J. C. Miettinen M. Saaristo A. Abbondanzo S. L. (2000). Splenic angiosarcoma: A clinicopathologic and immunophenotypic study of 28 cases. Mod Pathol 13, 978–87.
90. O’Connell F. P. Pinkus J. L. Pinkus G. S. (2004). CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Am J Clin Pathol 121, 254–63.
91. Osmond D. G. Rolink A. Melchers F. (1998). Murine B lymphopoiesis: Towards a unified model. Immunol Today 19, 65–8.
92. Pardo J. Wallich R. Ebnet K. Iden S. Zentgraf H. Martin P. Ekiciler A. Prins A. Mullbacher A. Huber M. Simon M. M. (2007). Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin. Cell Death Differ 14, 1768–79.
93. Pedrocchi M. Hauer C. R. Schafer B. W. Erne P. Heizmann C. W. (1993). Analysis of CA(2+)-binding S100 proteins in human heart by HPLC-electrospray mass spectrometry. Biochem Biophys Res Commun 197, 529–35.
94. Perry V. H. Crocker P. R. Gordon S. (1992). The blood-brain barrier regulates the expression of a macrophage sialic acid-binding receptor on microglia. J Cell Sci 101, 201–7.
95. Perry V. H. Lawson L. J. Reid D. M. (1994). Biology of the mononuclear phagocyte system of the central nervous system and HIV infection. J Leukoc Biol 56, 399–406.
96. Pileri S. A. Grogan T. M. Harris N. L. Banks P. Campo E. Chan J. K. Favera R. D. Delsol G. De Wolf-Peeters C. Falini B. Gascoyne R. D. Gaulard P. Gatter K. C. Isaacson P. G. Jaffe E. S. Kluin P. Knowles D. M. Mason D. Y. Mori S. Muller-Hermelink H. K. Piris M. A. Ralfkiaer E. Stein H. Su I. J. Warnke R. A. Weiss L. M. (2002). Tumours of histiocytes and accessory dendritic cells: An immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 41, 1–29.
97. Pilozzi E. Pulford K. Jones M. Muller-Hermelink H. K. Falini B. Ralfkiaer E. Pileri S. Pezzella F. De Wolf-Peeters C. Arber D. Stein H. Mason D. Gatter K. (1998). Co-expression of CD79a (JCB117) and CD3 by lymphoblastic lymphoma. J Pathol 186, 140–3.
98. Pinkus G. S. Pinkus J. L. (1991). Myeloperoxidase: A specific marker for myeloid cells in paraffin sections. Mod Pathol 4, 733–41.
99. Pusztaszeri M. P. Seelentag W. Bosman F. T. (2006). Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem 54, 385–95.
100. Rabinowitz S. S. Gordon S. (1991). Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J Exp Med 174, 827–36.
101. Raffegerst S. H. Hoelzlwimmer G. Kunder S. Mysliwietz J. Quintanilla-Martinez L. Schendel D. J. (2009). Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice. PLoS One 4, e8539.
102. Ramos-Vara J. A. (2005). Technical aspects of immunohistochemistry. Vet Pathol 42, 405–26.
103. Ree H. J. Hsu S. M. (1983). Lectin histochemistry of malignant tumors. I. Peanut agglutinin (PNA) receptors in follicular lymphoma and follicular hyperplasia: An immunohistochemical study. Cancer 51, 1631–8.
104. Rehg J. E. Sundberg J. P. (2008). Utility of antiPax5 in the diagnosis of lymphoproliferative disorders and neoplasia in mice. Comp Med 58, 246–52.
105. Reinherz E. L. Schlossman S. F. (1980). The differentiation and function of human T lymphocytes. Cell 19, 821–7.
106. Rensen S. S. Slaats Y. Nijhuis J. Jans A. Bieghs V. Driessen A. Malle E. Greve J. W. Buurman W. A. (2009). Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis. Am J Pathol 175, 1473–82.
107. Richter N. Petersson A. S. Wennmalm A. Schimke I. (1999). Detection of an approximately 100 kD protein with strong immunoreactivity to antibodies specific for inducible nitric oxide synthase (iNOS) but without NOS activity in neutrophils of patients suffering from sepsis: Results of a preliminary study. Inflamm Res 48, 651–6.
108. M., Romeo, M.M.L.F., Chauffaille, D.D.M., Bahia, M.M.R., Silva, Hyperfibrotic myelodysplaisa: case report with response to steroid therapy, Relato De Caso Case Report, (2002), 38, 149-151
109. Rosas M. Thomas B. Stacey M. Gordon S. Taylor P. R. (2010). The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B. J Leukoc Biol 88, 169–80.
110. Rose M. L. Malchiodi F. (1981). Binding of peanut lectin to thymic cortex and germinal centres of lymphoid tissue. Immunology 42, 583–91.
111. Sadahira Y. Kanzaki A. Wada H. Yawata Y. (1999). Immunohistochemical identification of erythroid precursors in paraffin embedded bone marrow sections: Spectrin is a superior marker to glycophorin. J Clin Pathol 52, 919–21.
112. Sanderson R. D. Lalor P. Bernfield M. (1989). B lymphocytes express and lose syndecan at specific stages of differentiation. Cell Regul 1, 27–35.
113. Schick P. K. Konkle B. A. He X. Thornton R. D. (1993). P-selectin mRNA is expressed at a later phase of megakaryocyte maturation than mRNAs for von Willebrand factor and glycoprotein Ib-alpha. J Lab Clin Med 121, 714–21.
114. Schwarting R. Gerdes J. Durkop H. Falini B. Pileri S. Stein H. (1989). BER-H2: A new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood 74, 1678–89.
115. Seagal J. Leider N. Wildbaum G. Karin N. Melamed D. (2003). Increased plasma cell frequency and accumulation of abnormal syndecan-1plus T-cells in Igmu-deficient/lpr mice. Int Immunol 15, 1045–52.
116. Seftalioglu A. Karakus S. (2003). Syndecan-1/CD138 expression in normal myeloid, acute lymphoblastic and myeloblastic leukemia cells. Acta Histochem 105, 213–21.
117. Soga H. Nakamura M. Yagi H. Kayaba S. Ishii T. Gotoh T. Itoh T. (1997). Heterogeneity of mouse thymic macrophages: I. Immunohistochemical analysis. Arch Histol Cytol 60, 53–63.
118. Speece A. J. (1964). Histochemical distribution of lysozyme activity in organs of normal mice and radiation chimeras. J Histochem Cytochem 12, 384–91.
119. Swerdlow S. Campo E. Harris N. Jaffe E. Pileri S. Stein H. Thiele J. Vardiman J. (2008). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. International Agency for Research on Cancer, World Health Organization, Washington, DC.
120. Sykora K. W. Tomeczkowski J. Reiter A. (1997). C-kit receptors in childhood malignant lymphoblastic cells. Leuk Lymphoma 25, 201–16.
121. Tacchini-Cottier F. Zweifel C. Belkaid Y. Mukankundiye C. Vasei M. Launois P. Milon G. Louis J. A. (2000). An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major. J Immunol 165, 2628–36.
122. Takahashi K. Isobe T. Ohtsuki Y. Sonobe H. Takeda I. Akagi T. (1984). Immunohistochemical localization and distribution of S-100 proteins in the human lymphoreticular system. Am J Pathol 116, 497–503.
123. Taylor P. R. Martinez-Pomares L. Stacey M. Lin H. H. Brown G. D. Gordon S. (2005). Macrophage receptors and immune recognition. Annu Rev Immunol 23, 901–44.
124. Thomas J. Haseman J. K. Goodman J. I. Ward J. M. Loughran T. P. Jr Spencer P. J. (2007). A review of large granular lymphocytic leukemia in Fischer 344 rats as an initial step toward evaluating the implication of the endpoint to human cancer risk assessment. Toxicol Sci 99, 3–19.
125. Tiacci E. Pileri S. Orleth A. Pacini R. Tabarrini A. Frenguelli F. Liso A. Diverio D. Lo-Coco F. Falini B. (2004). PAX5 expression in acute leukemias: Higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia. Cancer Res 64, 7399–404.
126. Torchia E. C. Boyd K. Rehg J. E. Qu C. Baker S. J. (2007). EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol 27, 7918–34.
127. Torlakovic E. Slipicevic A. Robinson C. DeCoteau J. F. Alfsen G. C. Vyberg M. Chibbar R. Florenes V. A. (2006). Pax-5 expression in nonhematopoietic tissues. Am J Clin Pathol 126, 798–804.
128. Tung J. W. Mrazek M. D. Yang Y. Herzenberg L. A. (2006). Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse. Proc Natl Acad Sci U S A 103, 6293–8.
129. Vosshenrich C. A. Lesjean-Pottier S. Hasan M. Richard-Le Goff O. Corcuff E. Mandelboim O. Di Santo J. P. (2007). CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells. J Exp Med 204, 2569–78.
130. Ward J. M. Erexson C. R. Faucette L. J. Foley J. F. Dijkstra C. Cattoretti G. (2006). Immunohistochemical markers for the rodent immune system. Toxicol Pathol 34, 616–30.
131. Ward J. M. Rehm S. (1990). Applications of immunohistochemistry in rodent tumor pathology. Exp Pathol 40, 301–12.
132. Ward J. M. Sheldon W. (1993). Expression of mononuclear phagocyte antigens in histiocytic sarcoma of mice. Vet Pathol 30, 560–5.
133. Ward J. M. Yoon M. Anver M. R. Haines D. C. Kudo G. Gonzalez F. J. Kimura S. (2001). Hyalinosis and Ym1/Ym2 gene expression in the stomach and respiratory tract of 129S4/SvJae and wild-type and CYP1A2-null B6,129 mice. Am J Pathol 158, 323–32.
134. Weerkamp F. Pike-Overzet K. Staal F. J. (2006). T-sing progenitors to commit. Trends Immunol 27, 125–31.
135. Weiss L. M. Arber D. Chang K. L. (1993). CD45: A review. Appl Immunohistochem 1, 166–81.
136. Weiss L. M. Arber D. Chang K. (1994). CD68: A review. Appl Immunohistochem 2, 2–8.
137. Weiss L. M. Arber D. A. Chang K. L. (1997). Clonality in lymphocyte predominance Hodgkin’s disease. Cancer Surv 30, 125–41.
138. Welle M. (1997). Development, significance, and heterogeneity of mast cells with particular regard to the mast cell-specific proteases chymase and tryptase. J Leukoc Biol 61, 233–45.
139. Wick M. (2006). Immunohistology of melanocytic neoplasms. In Diagnostic Immunohistochemistry (Dabbs D., ed.), Chapter 6, pp. 162–79. Churchill Livingstone Elsevier, Philadelphia, PA.
140. Willcox T. M. Speer R. W. Schlinkert R. T. Sarr M. G. (2000). Hemangioma of the spleen: Presentation, diagnosis, and management. J Gastrointest Surg 4, 611–3.
141. Woloschalk G. E. Krco C. J. (1987). Regulation of kappa/lambda immunoglobulin light chain expression in normal murine lymphocytes. Mol Immunol 24, 751–7.
142. Zon L. I. Gurish M. F. Stevens R. L. Mather C. Reynolds D. S. Austen K. F. Orkin S. H. (1991). GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem 266, 22948–53.