Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus

Molecular and Cellular Endocrinology

Volumn 355, Issue 1, 2012, Pages 180-187

  Männik, Jaana ^a   Vaas, Pille ^a,b   Rull, Kristiina ^a,b   Teesalu, Pille ^b   Laan, Maris ^a  

^a UNIVERSITY OF TARTU   (Estonia)

^b TARTU UNIVERSITY HOSPITAL   (Estonia)

Author keywords

Alternative mRNA transcripts; Fetal growth; Gestational diabetes mellitus; HGH CSH genes; Placental expression; Pre eclampsia

Indexed keywords

MESSENGER RNA;

ADULT; ARTICLE; CHORIONIC SOMATOMAMMOTROPIN 1 GENE; CHORIONIC SOMATOMAMMOTROPIN 2 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FETUS; FETUS GROWTH; FETUS OUTCOME; GENE; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GROWTH HORMONE 2 GENE; HUMAN; HUMAN TISSUE; INTRON RETENTION; LARGE FOR GESTATIONAL AGE; MOTHER FETUS RELATIONSHIP; NEWBORN; PLACENTA VILLUS; PLEIOTROPY; PREECLAMPSIA; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PRIORITY JOURNAL; RISK ASSESSMENT; TRANSCRIPTION REGULATION;

ADULT; ALTERNATIVE SPLICING; CASE-CONTROL STUDIES; DIABETES, GESTATIONAL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GROWTH HORMONE; HUMANS; INFANT, NEWBORN; INTRONS; PITUITARY GLAND; PLACENTA; PLACENTAL HORMONES; PLACENTAL LACTOGEN; PRE-ECLAMPSIA; PREGNANCY; PROTEIN ISOFORMS; RNA, MESSENGER;

EID: 84858746556     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.02.009     Document Type: Article

References (36)

1. Barbour L.A., Shao J., Qiao L., Pulawa L.K., Jensen D.R., Bartke A., Garrity M., Draznin B., Friedman J.E. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am. J. Obstet. Gynecol. 2002, 186:512-517.
2. Barsh G.S., Seeburg P.H., Gelinas R.E. The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids Res. 1983, 11:3939-3958.
3. Boguszewski C.L., Svensson P.A., Jansson T., Clark R., Carlsson L.M., Carlsson B. Cloning of two novel growth hormone transcripts expressed in human placenta. J. Clin. Endocrinol. Metab. 1998, 83:2878-2885.
4. Caceres J.F., Kornblihtt A.R. Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet. 2002, 18:186-193.
5. Chellakooty M., Skibsted L., Skouby S.O., Andersson A.M., Petersen J.H., Main K.M., Skakkebaek N.E., Juul A. Longitudinal study of serum placental GH in 455 normal pregnancies: correlation to gestational age, fetal gender, and weight. J. Clin. Endocrinol. Metab. 2002, 87:2729-2734.
6. Chellakooty M., Vangsgaard K., Larsen T., Scheike T., Falck-Larsen J., Legarth J., Andersson A.M., Main K.M., Skakkebaek N.E., Juul A. A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth. J. Clin. Endocrinol. Metab. 2004, 89:384-391.
7. Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H. The human growth hormone locus: nucleotide sequence, biology, and evolution. Genomics 1989, 4:479-497.
8. Cooke N.E., Ray J., Emery J.G., Liebhaber S.A. Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins. J. Biol. Chem. 1988, 263:8996-9001.
9. Cooke N.E., Ray J., Watson M.A., Estes P.A., Kuo B.A., Liebhaber S.A. Human growth hormone gene and the highly homologous growth hormone variant gene display different splicing patterns. J. Clin. Invest. 1988, 82:270-275.
10. Cooper T.A., Wan L., Dreyfuss G. RNA and disease. Cell 2009, 136:777-793.
11. Freemark M. Regulation of maternal metabolism by pituitary and placental hormones: roles in fetal development and metabolic programming. Horm. Res. 2006, 65(Suppl 3):41-49.
12. Fuglsang J., Lauszus F., Flyvbjerg A., Ovesen P. Human placental growth hormone, insulin-like growth factor I and -II, and insulin requirements during pregnancy in type 1 diabetes. J. Clin. Endocrinol. Metab. 2003, 88:4355-4361.
13. George D.L., Phillips J.A., Francke U., Seeburg P.H. The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter. Hum. Genet. 1981, 57:138-141.
14. Grill S., Rusterholz C., Zanetti-Dallenbach R., Tercanli S., Holzgreve W., Hahn S., Lapaire O. Potential markers of preeclampsia - a review. Reprod. Biol. Endocrinol. 2009, 7:70.
15. Handwerger S. The growth hormone gene cluster: physiological actions and regulation during pregnancy. Growth, Genetics and Hormones 2009, 25:1-8.
16. Handwerger S., Freemark M. The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development. J. Pediatr. Endocrinol. Metab. 2000, 13:343-356.
17. Ho Y., Liebhaber S.A., Cooke N.E. Activation of the human GH gene cluster: roles for targeted chromatin modification. Trends Endocrinol. Metab. 2004, 15:40-45.
18. Hu L., Lytras A., Bock M.E., Yuen C.K., Dodd J.G., Cattini P.A. Detection of placental growth hormone variant and chorionic somatomammotropin-L RNA expression in normal and diabetic pregnancy by reverse transcriptase-polymerase chain reaction. Mol. Cell. Endocrinol. 1999, 157:131-142.
19. Huppertz B. Placental pathology in pregnancy complications. Thromb Res. 2011, 127(Suppl 3):S96-99.
20. James J.L., Whitley G.S., Cartwright J.E. Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces. J. Pathol. 2010, 221:363-378.
21. Karro H., Rahu M., Gornoi K., Baburin A. Sünnikaalu jaotumine raseduse kestuse järgi Eestis aastail 1992-1994. Eesti Arst 1997, 4:299-303.
22. Kimura A.P., Sizova D., Handwerger S., Cooke N.E., Liebhaber S.A. Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation. Mol. Cell. Biol. 2007, 27:6555-6568.
23. Luco R.F., Pan Q., Tominaga K., Blencowe B.J., Pereira-Smith O.M., Misteli T. Regulation of alternative splicing by histone modifications. Science 2010, 327:996-1000.
24. MacLeod J.N., Lee A.K., Liebhaber S.A., Cooke N.E. Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster. J. Biol. Chem. 1992, 267:14219-14226.
25. McIntyre H.D., Serek R., Crane D.I., Veveris-Lowe T., Parry A., Johnson S., Leung K.C., Ho K.K., Bougoussa M., Hennen G., Igout A., Chan F.Y., Cowley D., Cotterill A., Barnard R. Placental growth hormone (GH), GH-binding protein, and insulin-like growth factor axis in normal, growth-retarded, and diabetic pregnancies: correlations with fetal growth. J. Clin. Endocrinol. Metab. 2000, 85:1143-1150.
26. Männik J., Vaas P., Rull K., Teesalu P., Rebane T., Laan M. Differential expression profile of growth hormone/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns. J. Clin. Endocrinol. Metab. 2010, 95:2433-2442.
27. Mirlesse V., Frankenne F., Alsat E., Poncelet M., Hennen G., Evain-Brion D. Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation. Pediatr. Res. 1993, 34:439-442.
28. Misra-Press A., Cooke N.E., Liebhaber S.A. Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene. J. Biol. Chem. 1994, 269:23220-23229.
29. Mittal P., Espinoza J., Hassan S., Kusanovic J.P., Edwin S.S., Nien J.K., Gotsch F., Than N.G., Erez O., Mazaki-Tovi S., Romero R. Placental growth hormone is increased in the maternal and fetal serum of patients with preeclampsia. J. Matern. Fetal. Neonatal. Med. 2007, 20:651-659.
30. Newbern D., Freemark M. Placental hormones and the control of maternal metabolism and fetal growth. Curr Opin Endocrinol Diabetes Obes. 2011, 18:409-416.
31. Newhouse S.M., Davidge S.T., Winkler-Lowen B., Demianczuk N., Guilbert L.J. In vitro differentiation of villous trophoblasts from pregnancies complicated by intrauterine growth restriction with and without pre-eclampsia. Placenta 2007, 28:999-1003.
32. Redman C.W.G., Sargent I.L. Immunology of preeclampsia. Am. J. Reprod. Immunol. 2010, 63:534-543.
33. Schiessl B., Strasburger C.J., Bidlingmaier M., Gutt B., Kirk S.E., Oberhoffer R., Friese K. Role of placental growth hormone in the alteration of maternal arterial resistance in pregnancy. J. Reprod. Med. 2007, 52:313-316.
34. Sedman L., Padhukasahasram B., Kelgo P., Laan M. Complex signatures of locus-specific selective pressures and gene conversion on Human Growth Hormone/Chorionic Somatomammotropin genes. Hum. Mutat. 2008, 29:1181-1193.
35. Spellacy W.N., Buhi W.C. Glucagon, insulin and glucose levels in maternal and imbilical cord plasma with studies of placental transfer. Obstet. Gynecol. 1976, 47:291-294.
36. Untergasser G., Hermann M., Rumpold H., Pfister G., Berger P. An unusual member of the human growth hormone/placental lactogen (GH/PL) family, the testicular alternative splicing variant hPL-A2: recombinant expression revealed a membrane-associated growth factor molecule. Mol. Cell. Endocrinol. 2000, 167:117-125.