-
1
-
-
77952470629
-
Progress on antiangiogenic therapy for patients with malignant glioma
-
Ahluwalia MS, Gladson CL. Progress on antiangiogenic therapy for patients with malignant glioma. J. Oncol. 2010, 689018 (2010).
-
(2010)
J. Oncol
, pp. 2010
-
-
Ahluwalia, M.S.1
Gladson, C.L.2
-
2
-
-
0036984640
-
Role of angiogenesis in tumor growth and metastasis
-
Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29(6), 15-18 (2002).
-
(2002)
Semin. Oncol
, vol.29
, Issue.6
, pp. 15-18
-
-
Folkman, J.1
-
3
-
-
34447632643
-
Angiogenesis in brain tumours
-
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nat. Rev. Neurosci. 8(8), 610-622 (2007).
-
(2007)
Nat. Rev. Neurosci
, vol.8
, Issue.8
, pp. 610-622
-
-
Jain, R.K.1
Di Tomaso, E.2
Duda, D.G.3
Loeffler, J.S.4
Sorensen, A.G.5
Batchelor, T.T.6
-
4
-
-
77954720781
-
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
-
Batchelor TT, Duda DG, di Tomaso E et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J. Clin. Oncol. 28(17), 2817-2823 (2010).
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.17
, pp. 2817-2823
-
-
Batchelor, T.T.1
Duda, D.G.2
Di Tomaso, E.3
-
5
-
-
79952173475
-
The efficacy of cediranib as monotherapy and in combination with lomustine compared to lomustine alone in patients with recurrent glioblastoma: A Phase III randomized study
-
Batchelor T, Mulholland, P Neyns. The efficacy of cediranib as monotherapy and in combination with lomustine compared to lomustine alone in patients with recurrent glioblastoma: a Phase III randomized study. Neuro. Oncol. 12(Suppl. 4), iv69-iv78 (2010).
-
(2010)
Neuro. Oncol
, vol.12
-
-
Batchelor, T.1
Mulholland, P.N.2
-
6
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356(2), 125-134 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
8
-
-
33751160860
-
Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells
-
Jane EP, Premkumar DR, Pollack IF. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. N. Pharmacol. Exp. Ther. 319(3), 1070-1080 (2006).
-
(2006)
N. Pharmacol. Exp. Ther
, vol.319
, Issue.3
, pp. 1070-1080
-
-
Jane, E.P.1
Premkumar, D.R.2
Pollack, I.F.3
-
9
-
-
33749573178
-
Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: Induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways
-
Yu CR, Friday BB, Lai JP et al. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol. Cancer Ther. 5(9), 2378-2387 (2006).
-
(2006)
Mol. Cancer Ther
, vol.5
, Issue.9
, pp. 2378-2387
-
-
Yu, C.R.1
Friday, B.B.2
Lai, J.P.3
-
10
-
-
72049118293
-
Phase I/II study of sorafenib and temsirolimus for patients with recurrent glioblastoma (GBM) (NABTC 05-02)
-
Wen PY, Cloughesy T, Kuhn J et al. Phase I/II study of sorafenib and temsirolimus for patients with recurrent glioblastoma (GBM) (NABTC 05-02). ASCO Meeting Abstracts 27(15 Suppl.), 2006 (2009).
-
(2009)
ASCO Meeting Abstracts
, vol.27
, pp. 2006
-
-
Wen, P.Y.1
Cloughesy, T.2
Kuhn, J.3
-
11
-
-
72049118293
-
Phase I/II study of sorefenib and erlotinib for patients with recurrent glioblastoma (GBM) (NABTC 05-02)
-
Prados M, Gilbert M, Kuhn J et al. Phase I/II study of sorefenib and erlotinib for patients with recurrent glioblastoma (GBM) (NABTC 05-02). ASCO Meeting Abstracts 27(15S), 2005 (2009).
-
(2009)
ASCO Meeting Abstracts
, vol.27
, Issue.15S
, pp. 2005
-
-
Prados, M.1
Gilbert, M.2
Kuhn, J.3
-
12
-
-
85041032359
-
NABTT 0502: Phase 2 trial of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiform
-
Dallas, TX, USA, 15-17 November
-
Peereboom D, Ye X, Nabors B et al. NABTT 0502: Phase 2 trial of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme. Presented at: Society for Neuro-Oncology Meeting. Dallas, TX, USA, 15-17 November 2007.
-
(2007)
Presented At: Society for Neuro-Oncology Meeting
-
-
Peereboom, D.1
Ye, X.2
Nabors, B.3
-
13
-
-
77955363593
-
Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme
-
Hainsworth JD, Ervin T, Friedman E et al. Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme. Cancer 116(15), 3663-3669 (2010).
-
(2010)
Cancer
, vol.116
, Issue.15
, pp. 3663-3669
-
-
Hainsworth, J.D.1
Ervin, T.2
Friedman, E.3
-
14
-
-
79751535045
-
Effect of CYP3A-inducing antiepileptics on sorafenib exposure: Results of a Phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma
-
Reardon DA, Vredenburgh JJ, Desjardins A et al. Effect of CYP3A-inducing antiepileptics on sorafenib exposure: results of a Phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma. J. Neurooncol. 101(1), 57-66 (2011).
-
(2011)
J. Neurooncol
, vol.101
, Issue.1
, pp. 57-66
-
-
Reardon, D.A.1
Vredenburgh, J.J.2
Desjardins, A.3
-
15
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
-
Demetri GD, van Oosterom AT, Garrett CR et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368(9544), 1329-1338 (2006).
-
(2006)
Lancet
, vol.368
, Issue.9544
, pp. 1329-1338
-
-
Demetri, G.D.1
Van Oosterom, A.T.2
Garrett, C.R.3
-
16
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 356(2), 115-124 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
17
-
-
61449426233
-
Early development of sunitinib in hepatocellular carcinoma
-
Zhu AX, Raymond E. Early development of sunitinib in hepatocellular carcinoma. Expert Rev. Anticancer Ther. 9(1), 143-150 (2009).
-
(2009)
Expert Rev. Anticancer Ther.
, vol.9
, Issue.1
, pp. 143-150
-
-
Zhu, A.X.1
Raymond, E.2
-
18
-
-
79959795987
-
Phase II study of sunitinib malate in patients with recurrent high-grade glioma
-
Neyns B, Sadones J, Chaskis C et al. Phase II study of sunitinib malate in patients with recurrent high-grade glioma. J. Neurooncol. 103(3), 491-501 (2011).
-
(2011)
J. Neurooncol
, vol.103
, Issue.3
, pp. 491-501
-
-
Neyns, B.1
Sadones, J.2
Chaskis, C.3
-
19
-
-
82955232920
-
Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma
-
(Epub ahead of print)
-
Reardon DA, Vredenburgh JJ, Coan A et al. Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma. J. Neurooncol. DOI: 10.1007/s11060-011-0627-0 (2011) (Epub ahead of print).
-
(2011)
J. Neurooncol
-
-
Reardon, D.A.1
Vredenburgh, J.J.2
Coan, A.3
-
20
-
-
57349179851
-
Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy
-
Sloan B, Scheinfeld NS. Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy. Curr. Opin. Investig. Drugs 9(12), 1324-1335 (2008).
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, Issue.12
, pp. 1324-1335
-
-
Sloan, B.1
Scheinfeld, N.S.2
-
21
-
-
78149492402
-
Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02)
-
Iwamoto FM, Lamborn KR, Robins HI et al. Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). Neuro Oncol. 12(8), 855-861 (2010).
-
(2010)
Neuro Oncol
, vol.12
, Issue.8
, pp. 855-861
-
-
Iwamoto, F.M.1
Lamborn, K.R.2
Robins, H.I.3
-
22
-
-
34248631794
-
A Phase I dose-escalation study of the safety and pharmacokinetics of a XL184, a VEGFR and Met kinase inhibitor, administered orally to subjects with advanced malignancies
-
Kurzrock R, Camacho L, Hong D et al. A Phase I dose-escalation study of the safety and pharmacokinetics of a XL184, a VEGFR and Met kinase inhibitor, administered orally to subjects with advanced malignancies. EJC Suppl. 4(12), 405 (2006).
-
(2006)
EJC Suppl
, vol.4
, Issue.12
, pp. 405
-
-
Kurzrock, R.1
Camacho, L.2
Hong, D.3
-
23
-
-
77952538981
-
A phase 1 dose-escalation study of the safety and pharmacokinetics (PK) of XL184, a VEGFR and MET kinase inhibitor, administered orally to patients (pts) with advanced malignancies
-
Salgia R, Hong D, Sherman SI et al. A phase 1 dose-escalation study of the safety and pharmacokinetics (PK) of XL184, a VEGFR and MET kinase inhibitor, administered orally to patients (pts) with advanced malignancies. Mol. Cancer Ther. 6(12), 3385S-3385S (2007).
-
(2007)
Mol. Cancer Ther
, vol.6
, Issue.12
, pp. 3385S-3385S
-
-
Salgia, R.1
Hong, D.2
Sherman, S.I.3
-
24
-
-
19544389146
-
Salgia R. C-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention
-
Christensen JG, Burrows J, Salgia R. c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention. Cancer Lett. 225(1), 1-26 (2005).
-
(2005)
Cancer Lett
, vol.225
, Issue.1
, pp. 1-26
-
-
Christensen, J.G.1
Burrows, J.2
-
25
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216), 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, Issue.7216
, pp. 1061-1068
-
-
-
26
-
-
27644543354
-
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
-
Abounader R, Laterra J. Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol. 7(4), 436-451 (2005).
-
(2005)
Neuro Oncol
, vol.7
, Issue.4
, pp. 436-451
-
-
Abounader, R.1
Laterra, J.2
-
27
-
-
77956700164
-
Phase II study of XL184 (BMS 907351), an inhibitor of MET, VEGFR2, and RET, in patients (pts) with progressive glioblastoma (GB)
-
Wen PY, Prados M, Schiff D et al. Phase II study of XL184 (BMS 907351), an inhibitor of MET, VEGFR2, and RET, in patients (pts) with progressive glioblastoma (GB). ASCO Meeting Abstracts 28(15 Suppl.), 2006 (2010).
-
(2010)
ASCO Meeting Abstracts
, vol.28
, Issue.15
, pp. 2006
-
-
Wen, P.Y.1
Prados, M.2
Schiff, D.3
-
28
-
-
33845433396
-
Vandetanib, a novel multitargeted kinase inhibitor, in cancer therapy
-
Sathornsumetee S, Rich JN. Vandetanib, a novel multitargeted kinase inhibitor, in cancer therapy. Drugs Today 42(10), 657-670 (2006).
-
(2006)
Drugs Today
, vol.42
, Issue.10
, pp. 657-670
-
-
Sathornsumetee, S.1
Rich, J.N.2
-
29
-
-
28144450936
-
ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors
-
Rich JN, Sathornsumetee S, Keir ST et al. ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. Clin. Cancer Res. 11(22), 8145-8157 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, Issue.22
, pp. 8145-8157
-
-
Rich, J.N.1
Sathornsumetee, S.2
Keir, S.T.3
-
30
-
-
77950852399
-
ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain
-
Yiin JJ, Hu B, Schornack PA et al. ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain. Mol. Cancer Ther. 9(4), 929-941 (2010).
-
(2010)
Mol. Cancer Ther
, vol.9
, Issue.4
, pp. 929-941
-
-
Yiin, J.J.1
Hu, B.2
Schornack, P.A.3
-
31
-
-
23044500424
-
Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma
-
Damiano V, Melisi D, Bianco C et al. Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma. Clin. Cancer Res. 11(15), 5639-5644 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, Issue.15
, pp. 5639-5644
-
-
Damiano, V.1
Melisi, D.2
Bianco, C.3
-
32
-
-
77955922743
-
Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma
-
Drappatz J, Norden AD, Wong ET et al. Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma. Int. J. Radiat. Oncol. Biol. Phys. 78(1), 85-90 (2010).
-
(2010)
Int. J. Radiat. Oncol. Biol. Phys
, vol.78
, Issue.1
, pp. 85-90
-
-
Drappatz, J.1
Norden, A.D.2
Wong, E.T.3
-
33
-
-
33751108557
-
Metabolism and disposition of vatalanib (PTK787/ZK-222584) in cancer patients
-
Jost LM, Gschwind HP, Jalava T et al. Metabolism and disposition of vatalanib (PTK787/ZK-222584) in cancer patients. Drug Metab. Dispos. 34(11), 1817-1828 (2006).
-
(2006)
Drug Metab. Dispos
, vol.34
, Issue.11
, pp. 1817-1828
-
-
Jost, L.M.1
Gschwind, H.P.2
Jalava, T.3
-
34
-
-
68149172828
-
Vandetanib with FOLFIRI in patients with advanced colorectal adenocarcinoma: Results from an open-label, multicentre Phase I study. Cancer Chemother
-
Saunders MP, Wilson R, Peeters M et al. Vandetanib with FOLFIRI in patients with advanced colorectal adenocarcinoma: results from an open-label, multicentre Phase I study. Cancer Chemother. Pharmacol. 64(4), 665-672 (2009).
-
(2009)
Pharmacol
, vol.64
, Issue.4
, pp. 665-672
-
-
Saunders, M.P.1
Wilson, R.2
Peeters, M.3
-
35
-
-
33947182049
-
Vatalanib: The clinical development of a tyrosine kinase inhibitor of angiogenesis in solid tumours
-
Scott EN, Meinhardt G, Jacques C, Laurent D, Thomas AL. Vatalanib: the clinical development of a tyrosine kinase inhibitor of angiogenesis in solid tumours. Expert Opin. Invest. Drugs 16(3), 367-379 (2007).
-
(2007)
Expert Opin. Invest. Drugs
, vol.16
, Issue.3
, pp. 367-379
-
-
Scott, E.N.1
Meinhardt, G.2
Jacques, C.3
Laurent, D.4
Thomas, A.L.5
-
36
-
-
23044432756
-
Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK222584 administered twice daily in patients with advanced cancer
-
Thomas AL, Morgan B, Horsfield MA et al. Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK222584 administered twice daily in patients with advanced cancer. J. Clin. Oncol. 23(18), 4162-4171 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, Issue.18
, pp. 4162-4171
-
-
Thomas, A.L.1
Morgan, B.2
Horsfield, M.A.3
-
37
-
-
3543028023
-
PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization
-
Goldbrunner RH, Bendszus M, Wood J, Kiderlen M, Sasaki M, Tonn JC. PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization. Neurosurgery 55(2), 426-432; discussion 432 (2004).
-
Neurosurgery
, vol.55
, Issue.2
, pp. 426-432
-
-
Goldbrunner, R.H.1
Bendszus, M.2
Wood, J.3
Kiderlen, M.4
Sasaki, M.5
Tonn, J.C.6
-
38
-
-
16844382092
-
A Phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM)
-
Conrad C, Friedman H, Reardon D et al. A Phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM). ASCO Meeting Abstracts 22(14 Suppl.), 1512 (2004).
-
(2004)
ASCO Meeting Abstracts
, vol.22
, Issue.14
, pp. 1512
-
-
Conrad, C.1
Friedman, H.2
Reardon, D.3
-
39
-
-
16844371774
-
A Phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM)
-
Reardon D, Friedman H, Yung WKA et al. A Phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM). ASCO Meeting Abstracts 22(14 Suppl.), 1513 (2004).
-
(2004)
ASCO Meeting Abstracts
, vol.22
, Issue.14
, pp. 1513
-
-
Reardon, D.1
Friedman, H.2
Yung, W.3
-
40
-
-
79960554999
-
E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumour cell migration and invasion
-
Glen H, Mason S, Patel H, Macleod K, Brunton VG. E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumour cell migration and invasion. BMC Cancer 11(1), 309 (2011).
-
(2011)
BMC Cancer
, vol.11
, Issue.1
, pp. 309
-
-
Glen, H.1
Mason, S.2
Patel, H.3
Macleod, K.4
Brunton, V.G.5
-
41
-
-
0026772431
-
Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
-
Hermanson M, Funa K, Hartman M et al. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 52(11), 3213-3219 (1992).
-
(1992)
Cancer Res
, vol.52
, Issue.11
, pp. 3213-3219
-
-
Hermanson, M.1
Funa, K.2
Hartman, M.3
-
42
-
-
70849122697
-
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
-
Brennan C, Momota H, Hambardzumyan D et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One 4(11), e7752 (2009).
-
(2009)
Plos One
, vol.4
, Issue.11
-
-
Brennan, C.1
Momota, H.2
Hambardzumyan, D.3
-
43
-
-
0034665138
-
Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class
-
Kilic T, Alberta JA, Zdunek PR et al. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 60(18), 5143-5150 (2000).
-
(2000)
Cancer Res
, vol.60
, Issue.18
, pp. 5143-5150
-
-
Kilic, T.1
Alberta, J.A.2
Zdunek, P.R.3
-
44
-
-
33748376520
-
Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08
-
Wen PY, Yung WK, Lamborn KR et al. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin. Cancer Res. 12(16), 4899-4907 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.16
, pp. 4899-4907
-
-
Wen, P.Y.1
Yung, W.K.2
Lamborn, K.R.3
-
45
-
-
73249147637
-
Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08)
-
Wen PY, Yung WK, Lamborn KR et al. Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro Oncol. 11(6), 853-860 (2009).
-
(2009)
Neuro Oncol
, vol.11
, Issue.6
, pp. 853-860
-
-
Wen, P.Y.1
Yung, W.K.2
Lamborn, K.R.3
-
46
-
-
34247476830
-
Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas
-
Desjardins A, Quinn JA, Vredenburgh JJ et al. Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas. J. Neuro-Oncol. 83(1), 53-60 (2007).
-
(2007)
J. Neuro-Oncol
, vol.83
, Issue.1
, pp. 53-60
-
-
Desjardins, A.1
Quinn, J.A.2
Vredenburgh, J.J.3
-
47
-
-
33644830094
-
Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastorna multiforme
-
Reardon DA, Egorin MJ, Quinn JA et al. Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastorna multiforme. J. Clin. Oncol. 23(36), 9359-9368 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, Issue.36
, pp. 9359-9368
-
-
Reardon, D.A.1
Egorin, M.J.2
Quinn, J.A.3
-
48
-
-
71649102124
-
Multicentre Phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
-
Reardon DA, Dresemann G, Taillibert S et al. Multicentre Phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br. J. Cancer 101(12), 1995-2004 (2009).
-
(2009)
Br. J. Cancer
, vol.101
, Issue.12
, pp. 1995-2004
-
-
Reardon, D.A.1
Dresemann, G.2
Taillibert, S.3
-
49
-
-
75049085049
-
Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
-
Dresemann G, Weller M, Rosenthal MA et al. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J. Neurooncol. 96(3), 393-402 (2010).
-
(2010)
J. Neurooncol
, vol.96
, Issue.3
, pp. 393-402
-
-
Dresemann, G.1
Weller, M.2
Rosenthal, M.A.3
-
50
-
-
78651255671
-
Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells
-
Dong Y, Jia L, Wang X et al. Selective inhibition of PDGFR by imatinib elicits the sustained activation of ERK and downstream receptor signaling in malignant glioma cells. Int J. Oncol. 38(2), 555-569 (2011).
-
(2011)
Int J. Oncol
, vol.38
, Issue.2
, pp. 555-569
-
-
Dong, Y.1
Jia, L.2
Wang, X.3
-
51
-
-
21344470873
-
Lyn kinase activity is the predominant cellular Src kinase activity in glioblastoma tumor cells
-
Stettner MR, Wang W, Nabors LB et al. Lyn kinase activity is the predominant cellular Src kinase activity in glioblastoma tumor cells. Cancer Res. 65(13), 5535-5543 (2005).
-
(2005)
Cancer Res
, vol.65
, Issue.13
, pp. 5535-5543
-
-
Stettner, M.R.1
Wang, W.2
Nabors, L.B.3
-
52
-
-
60149089005
-
Beadbased profiling of tyrosine kinase phosphorylation identifies Src as a potential target for glioblastoma therapy
-
Du J, Bernasconi P, Clauser KR et al. Beadbased profiling of tyrosine kinase phosphorylation identifies Src as a potential target for glioblastoma therapy. Nat. Biotechnol. 27(1), 77-83 (2009).
-
(2009)
Nat. Biotechnol
, vol.27
, Issue.1
, pp. 77-83
-
-
Du, J.1
Bernasconi, P.2
Clauser, K.R.3
-
53
-
-
77957937844
-
Targeting Src in glioblastoma tumors and brain metastases: Rationale and preclinical studies
-
Ahluwalia MS, Groot J, Liu WM, Gladson CL. Targeting Src in glioblastoma tumors and brain metastases: rationale and preclinical studies. Cancer Lett. 298(2), 139-149 (2010).
-
(2010)
Cancer Lett
, vol.298
, Issue.2
, pp. 139-149
-
-
Ahluwalia, M.S.1
Groot, J.2
Liu, W.M.3
Gladson, C.L.4
-
54
-
-
80052749324
-
Retrospective study of dasatinib for recurrent glioblastoma after bevacizumab failure
-
Lu-Emerson C, Norden AD, Drappatz J et al. Retrospective study of dasatinib for recurrent glioblastoma after bevacizumab failure. J. Neurooncol. 104(1), 287-291 (2010).
-
(2010)
J. Neurooncol
, vol.104
, Issue.1
, pp. 287-291
-
-
Lu-Emerson, C.1
Norden, A.D.2
Drappatz, J.3
-
55
-
-
33845806858
-
Vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinibresistant Bcr-Abl+ neoplastic cells
-
Puttini M, Coluccia AM, Boschelli F et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinibresistant Bcr-Abl+ neoplastic cells. Cancer Res. 66(23), 11314-11322 (2006).
-
(2006)
Cancer Res
, vol.66
, Issue.23
, pp. 11314-11322
-
-
Puttini, M.1
Coluccia, A.M.2
Boschelli, F.3
-
56
-
-
28444479480
-
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
-
Kimura S, Naito H, Segawa H et al. NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia. Blood, 106(12), 3948-3954 (2005).
-
(2005)
Blood
, vol.106
, Issue.12
, pp. 3948-3954
-
-
Kimura, S.1
Naito, H.2
Segawa, H.3
-
57
-
-
79952743082
-
Bafetinib, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia
-
Santos FP, Kantarjian H, Cortes J, Quintas-Cardama A. Bafetinib, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia. Curr. Opin. Investig. Drugs 11(12), 1450-1465 (2011).
-
(2011)
Curr. Opin. Investig. Drugs
, vol.11
, Issue.12
, pp. 1450-1465
-
-
Santos, F.P.1
Kantarjian, H.2
Cortes, J.3
Quintas-Cardama, A.4
-
58
-
-
3042823868
-
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
-
Chakravarti A, Zhai G, Suzuki Y et al. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J. Clin. Oncol. 22(10), 1926-1933 (2004).
-
(2004)
J. Clin. Oncol
, vol.22
, Issue.10
, pp. 1926-1933
-
-
Chakravarti, A.1
Zhai, G.2
Suzuki, Y.3
-
59
-
-
21044431575
-
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest
-
Chang SM, Wen P, Cloughesy T et al. Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme. Invest. New Drugs 23(4), 357-361 (2005).
-
(2005)
New Drugs
, vol.23
, Issue.4
, pp. 357-361
-
-
Chang, S.M.1
Wen, P.2
Cloughesy, T.3
-
60
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
-
Galanis E, Buckner JC, Maurer MJ et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J. Clin. Oncol. 23(23), 5294-5304 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, Issue.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
-
61
-
-
79953052206
-
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide
-
Prasad G, Sottero T, Yang X et al. Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide. Neuro Oncol. 13(4), 384-392 (2011).
-
(2011)
Neuro Oncol
, vol.13
, Issue.4
, pp. 384-392
-
-
Prasad, G.1
Sottero, T.2
Yang, X.3
-
62
-
-
51449096001
-
A Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of a novel PI3K inhibitor, XL765, administered orally to patients with advanced solid tumors
-
Papadopoulos KP, Tabernero J, Patnaik A et al. A Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of a novel PI3K inhibitor, XL765, administered orally to patients with advanced solid tumors. J. Clin. Oncol. (Meeting Abstracts) 26, 3510 (2008).
-
(2008)
J. Clin. Oncol. (Meeting Abstracts)
, vol.26
, pp. 3510
-
-
Papadopoulos, K.P.1
Tabernero, J.2
Patnaik, A.3
-
63
-
-
78651385352
-
Dual PI3K/mTOR inhibitor, PI-103, cooperates with stem cell-delivered TRAIL in experimental glioma models
-
Bagci-Onder T, Wakimoto H, Anderegg M, Cameron C, Shah K. A dual PI3K/mTOR inhibitor, PI-103, cooperates with stem cell-delivered TRAIL in experimental glioma models. Cancer Res. 71(1), 154-163 (2011).
-
(2011)
Cancer Res
, vol.71
, Issue.1
, pp. 154-163
-
-
Bagci-Onder, T.1
Wakimoto, H.2
Eregg, M.3
Cameron, C.4
Shah, K.A.5
-
64
-
-
34247218483
-
Gefitinib in patients with progressive high-grade gliomas: A multicentre Phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
-
Franceschi E, Cavallo G, Lonardi S et al. Gefitinib in patients with progressive high-grade gliomas: a multicentre Phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). Br. J. Cancer 96(7), 1047-1051 (2007).
-
(2007)
Br. J. Cancer
, vol.96
, Issue.7
, pp. 1047-1051
-
-
Franceschi, E.1
Cavallo, G.2
Lonardi, S.3
-
65
-
-
1842500007
-
Phase II trial of gefitinib in recurrent glioblastoma
-
Rich JN, Reardon DA, Peery T et al. Phase II trial of gefitinib in recurrent glioblastoma. J. Clin. Oncol. 22(1), 133-142 (2004).
-
(2004)
J. Clin. Oncol
, vol.22
, Issue.1
, pp. 133-142
-
-
Rich, J.N.1
Reardon, D.A.2
Peery, T.3
-
66
-
-
75749110539
-
A Phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas
-
Raizer JJ, Abrey LE, Lassman AB et al. A Phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas. Neuro Oncol. 12(1), 87-94 (2010).
-
(2010)
Neuro Oncol
, vol.12
, Issue.1
, pp. 87-94
-
-
Raizer, J.J.1
Abrey, L.E.2
Lassman, A.B.3
-
67
-
-
75749122223
-
A Phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy
-
Raizer JJ, Abrey LE, Lassman AB et al. A Phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Neuro Oncol. 12(1), 95-103 (2010).
-
(2010)
Neuro Oncol
, vol.12
, Issue.1
, pp. 95-103
-
-
Raizer, J.J.1
Abrey, L.E.2
Lassman, A.B.3
-
68
-
-
85041060080
-
Response rate to single agent therapy with the EGFR tyrosine kinase inhibitor erlotinib in recurrent blioblastoma multiforme: Results of a Phase II study. Proceedings of: Ninth Meeting of the Society for Neuro-Oncology. Toronto
-
(Abstract TA-359)
-
Vogelbaum MA, Peereboom D, Stevens G, Barnett GH, Brewer C. Response rate to single agent therapy with the EGFR tyrosine kinase inhibitor erlotinib in recurrent blioblastoma multiforme: results of a Phase II study. Proceedings of: Ninth Meeting of the Society for Neuro-Oncology. Toronto, Canada, 18-21 November 2004 (Abstract TA-359).
-
(2004)
Canada
, pp. 18-21
-
-
Vogelbaum, M.A.1
Peereboom, D.2
Stevens, G.3
Barnett, G.H.4
Brewer, C.5
-
69
-
-
78650102866
-
Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma
-
Sathornsumetee S, Desjardins A, Vredenburgh JJ et al. Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neuro Oncol. 12(12), 1300-1310 (2010).
-
(2010)
Neuro Oncol
, vol.12
, Issue.12
, pp. 1300-1310
-
-
Sathornsumetee, S.1
Desjardins, A.2
Vredenburgh, J.J.3
-
70
-
-
57149118473
-
Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
-
Brown PD, Krishnan S, Sarkaria JN et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J. Clin. Oncol. 26(34), 5603-5609 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, Issue.34
, pp. 5603-5609
-
-
Brown, P.D.1
Krishnan, S.2
Sarkaria, J.N.3
-
71
-
-
77953617053
-
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme
-
Peereboom DM, Shepard DR, Ahluwalia MS et al. Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme. J. Neurooncol. 98(1), 93-99 (2009).
-
(2009)
J. Neurooncol
, vol.98
, Issue.1
, pp. 93-99
-
-
Peereboom, D.M.1
Shepard, D.R.2
Ahluwalia, M.S.3
-
72
-
-
59149086517
-
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
-
Prados MD, Chang SM, Butowski N et al. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J. Clin. Oncol. 27(4), 579-584 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.4
, pp. 579-584
-
-
Prados, M.D.1
Chang, S.M.2
Butowski, N.3
-
73
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
Mellinghoff IK, Wang MY, Vivanco I et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 353(19), 2012-2024 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, Issue.19
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
Wang, M.Y.2
Vivanco, I.3
-
74
-
-
35348822482
-
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
-
Stommel JM, Kimmelman AC, Ying H et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318(5848), 287-290 (2007).
-
(2007)
Science
, vol.318
, Issue.5848
, pp. 287-290
-
-
Stommel, J.M.1
Kimmelman, A.C.2
Ying, H.3
-
75
-
-
36849020698
-
Phase I study of erlotinib and CCI-779 (Temsirolimus) for patients with recurrent malignant gliomas (MG) (NABTC 04-02)
-
Robins HI, Wen PY, Chang SM et al. Phase I study of erlotinib and CCI-779 (temsirolimus) for patients with recurrent malignant gliomas (MG) (NABTC 04-02). ASCO Meeting Abstracts 25(18 Suppl.), 2057 (2007).
-
(2007)
ASCO Meeting Abstracts
, vol.25
, Issue.18
, pp. 2057
-
-
Robins, H.I.1
Wen, P.Y.2
Chang, S.M.3
-
76
-
-
21444450373
-
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
-
Haas-Kogan DA, Prados MD, Tihan T et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J. Natl Cancer Inst. 97(12), 880-887 (2005).
-
(2005)
J. Natl Cancer Inst
, vol.97
, Issue.12
, pp. 880-887
-
-
Haas-Kogan, D.A.1
Prados, M.D.2
Tihan, T.3
-
77
-
-
71349088046
-
A Phase I/II trial of GW572016 (Lapatinib) in recurrent glioblastoma multiforme: Clinical outcomes, pharmacokinetics and molecular correlation
-
Thiessen B, Stewart C, Tsao M et al. A Phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoma multiforme: clinical outcomes, pharmacokinetics and molecular correlation. Cancer Chemother. Pharmacol. 65(2), 353-361 (2010).
-
(2010)
Cancer Chemother. Pharmacol
, vol.65
, Issue.2
, pp. 353-361
-
-
Thiessen, B.1
Stewart, C.2
Tsao, M.3
-
78
-
-
79960856289
-
Drug-induced effects on erlotinib metabolism
-
Mir O, Blanchet B, Goldwasser F. Drug-induced effects on erlotinib metabolism. N. Engl. J. Med. 365(4), 379-380 (2011).
-
(2011)
N. Engl. J. Med
, vol.365
, Issue.4
, pp. 379-380
-
-
Mir, O.1
Blanchet, B.2
Goldwasser, F.3
-
79
-
-
34250182404
-
Chemotherapy delivery issues in central nervous system malignancy: A reality check
-
Muldoon LL, Soussain C, Jahnke K et al. Chemotherapy delivery issues in central nervous system malignancy: a reality check. J. Clin. Oncol. 25(16), 2295-2305 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.16
, pp. 2295-2305
-
-
Muldoon, L.L.1
Soussain, C.2
Jahnke, K.3
-
80
-
-
78650785470
-
The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain
-
Agarwal S, Sane R, Ohlfest JR, Elmquist WF. The role of the breast cancer resistance protein (ABCG2) in the distribution of sorafenib to the brain. J. Pharmacol. Exp. Ther. 336(1), 223-233 (2011).
-
(2011)
J. Pharmacol. Exp. Ther
, vol.336
, Issue.1
, pp. 223-233
-
-
Agarwal, S.1
Sane, R.2
Ohlfest, J.R.3
Elmquist, W.F.4
-
81
-
-
77953783419
-
Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux
-
Agarwal S, Sane R, Gallardo JL, Ohlfest JR, Elmquist WF. Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux. J. Pharmacol. Exp. Ther. 334(1), 147-155 (2010).
-
(2010)
J. Pharmacol. Exp. Ther
, vol.334
, Issue.1
, pp. 147-155
-
-
Agarwal, S.1
Sane, R.2
Gallardo, J.L.3
Ohlfest, J.R.4
Elmquist, W.F.5
-
82
-
-
80255137111
-
Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration
-
(Epub ahead of print)
-
Tang SC, Lagas JS, Lankheet NA et al. Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. Int. J. Cancer DOI: 10.1002/ijc.26000 (2011) (Epub ahead of print).
-
(2011)
Int. J. Cancer
-
-
Tang, S.C.1
Lagas, J.S.2
Lankheet, N.A.3
-
83
-
-
65249151331
-
Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment
-
Lagas JS, van Waterschoot RA, van Tilburg VA et al. Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment. Clin. Cancer Res. 15(7), 2344-2351 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, Issue.7
, pp. 2344-2351
-
-
Lagas, J.S.1
Van Waterschoot, R.A.2
Van Tilburg, V.A.3
-
84
-
-
85041018594
-
-
ClinicalTrials.gov
-
ClinicalTrials.gov http://clinicaltrials.gov
-
-
-
-
85
-
-
85041044070
-
-
ClinicalTrials.gov. Hospital; MG. A Phase I Study of Vandetanib and Sirolimus in Patients With Recurrent Glioblastoma. National Library of Medicine. NLM Identifier: NCT00821080, Bethesda, MD, USA
-
ClinicalTrials.gov. Hospital; MG. A Phase I Study of Vandetanib and Sirolimus in Patients With Recurrent Glioblastoma. National Library of Medicine. NLM Identifier: NCT00821080, Bethesda, MD, USA (2000) http://clinicaltrials.gov/ct2/show/NCT00821080
-
(2000)
-
-
-
86
-
-
85041031576
-
-
ClinicalTrials.gov. An Open-Label, Three-Cohort, Phase 2 Study of E7080 in Subjects With Recurrent Malignant Glioma. National Library of Medicine, Bethesda, MD, USA, NLM Identifier: NCT01137604
-
ClinicalTrials.gov. An Open-Label, Three-Cohort, Phase 2 Study of E7080 in Subjects With Recurrent Malignant Glioma. National Library of Medicine, Bethesda, MD, USA, NLM Identifier: NCT01137604 (2000) http://clinicaltrials.gov/show/NCT01137604
-
(2000)
-
-
-
87
-
-
85041032229
-
-
ClinicalTrials.gov. NIH; Warren Grant Magnuson Clinical Center. Tandutinib plus bevacizumab to treat recurrent brain tumors. National Library of Medicine, Bethesda, MD, USA, NLM Identifier: NCT00667394
-
ClinicalTrials.gov. NIH; Warren Grant Magnuson Clinical Center. Tandutinib plus bevacizumab to treat recurrent brain tumors. National Library of Medicine, Bethesda, MD, USA, NLM Identifier: NCT00667394 (2000) www.cancer.gov/clinicaltrials/NCT00667394
-
(2000)
-
-
-
88
-
-
85041051160
-
-
ClinicalTrials.gov. Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancer. National Library of Medicine, Bethesda, MD, USA, NLM Identifier NCT00959946
-
ClinicalTrials.gov. Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancer. National Library of Medicine, Bethesda, MD, USA, NLM Identifier NCT00959946 (2000) http://clinicaltrials.gov/ct2/show/NCT00959946
-
(2000)
-
-
-
89
-
-
85041020444
-
-
ClinicalTrials.gov. Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancer. National Library of Medicine, Bethesda, MD, USA, NLM Identifier NCT00959946
-
ClinicalTrials.gov. Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancer. National Library of Medicine, Bethesda, MD, USA, NLM Identifier NCT00959946 (2000) http://clinicaltrials.gov/ct2/show/NCT00959946
-
(2000)
-
-
-
90
-
-
85041026353
-
-
ClinicalTrials.gov. National Cancer Institute; City of Hope Medical Center. BAFETINIB-P1-GBM-01: A Pilot Study Using Intracerebral Microdialysis to Determine the Neuropharmacokinetics of Bafetinib in Patients With Recurrent Brain Tumors. National Library of Medicine, Bethesda, MD, USA, NLM Identifier NCT01234740
-
ClinicalTrials.gov. National Cancer Institute; City of Hope Medical Center. BAFETINIB-P1-GBM-01: A Pilot Study Using Intracerebral Microdialysis to Determine the Neuropharmacokinetics of Bafetinib in Patients With Recurrent Brain Tumors. National Library of Medicine, Bethesda, MD, USA, NLM Identifier NCT01234740 (2000) http://clinicaltrials.gov/ct2/show/NCT01234740
-
(2000)
-
-
-
91
-
-
85041047757
-
-
ClinicalTrials.gov. University of California SD. A Phase II Study of PDGFR Kinase Inhibitor in Biomarker-Enriched Recurrent Malignant Gliomas. National Library of Medicine, Bethesda, MD, USA, NLM Identifier NCT01140568
-
ClinicalTrials.gov. University of California SD. A Phase II Study of PDGFR Kinase Inhibitor in Biomarker-Enriched Recurrent Malignant Gliomas. National Library of Medicine, Bethesda, MD, USA, NLM Identifier NCT01140568 (2000) http://clinicaltrials.gov/show/NCT01140568
-
(2000)
-
-
-
92
-
-
85041088281
-
-
ClinicalTrials.gov. Exploratory Study of XL765 (SAR245409) or XL147 (SAR245408) in Subjects With Recurrent Glioblastoma Who Are Candidates for Surgical Resection. Bethesda, MD, USA; National Library of Medicine, USA
-
ClinicalTrials.gov. Exploratory Study of XL765 (SAR245409) or XL147 (SAR245408) in Subjects With Recurrent Glioblastoma Who Are Candidates for Surgical Resection. Bethesda, MD, USA; National Library of Medicine, USA (2000) http://clinicaltrials.gov/ct2/show/NCT01240460?term=xl765&rank=1
-
(2000)
-
-
-
93
-
-
85041049402
-
-
ClinicalTrials.gov. Phase II Study of BKM120 for Subjects With Recurrent Glioblastoma. Bethesda, MD, USA; National Library of Medicine, USA
-
ClinicalTrials.gov. Phase II Study of BKM120 for Subjects With Recurrent Glioblastoma. Bethesda, MD, USA; National Library of Medicine, USA (2000) http://clinicaltrials.gov/ct2/show/NCT01339052?term=bkm120&rank=6
-
(2000)
-
-
-
94
-
-
85041059339
-
-
ClinicalTrials.gov. Combination of BKM120 and Bevacizumab in Refractory Solid Tumors and Relapsed/Refractory Glioblastoma Multiforme. Bethesda, MD, USA; National Library of Medicine, USA
-
ClinicalTrials.gov. Combination of BKM120 and Bevacizumab in Refractory Solid Tumors and Relapsed/Refractory Glioblastoma Multiforme. Bethesda, MD, USA; National Library of Medicine, USA (2000) http://clinicaltrials.gov/ct2/show/NCT01349660?term=bkm120&rank=5
-
(2000)
-
-
|