Optical imaging of tc-99m-based tracers: In vitro and in vivo results

Journal of Biomedical Optics

Volumn 16, Issue 11, 2011, Pages

  Spinelli, Antonello E ^a   Meo, Sergio L ^b   Calandrino, Riccardo ^a   Sbarbati, Andrea ^c   Federico, Boschi ^c  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b DEPARTMENT OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

Biology; Biomedical optics; Image formation; Radiation

Indexed keywords

ALPHA EMITTERS; BACKGROUND RATIO; BIOLUMINESCENCE IMAGING; EXPERIMENTAL DATA; GAMMA EMITTERS; HALF LIVES; IN-VITRO; IN-VIVO; IN-VIVO IMAGING; LUMINESCENCE DECAYS; LUMINESCENCE SIGNALS; NUDE MICE; OPTICAL IMAGE; OPTICAL IMAGING; OPTICAL PHOTONS; OPTICAL SIGNALS; SEQUENCE OF IMAGES; SMALL ANIMAL; VISIBLE LIGHT EMISSION; WATER SOLUTIONS;

BIOLOGY; GEOMETRICAL OPTICS; HEAT RADIATION; IMAGE PROCESSING; LUMINESCENCE; OPTICAL IMAGE STORAGE;

LIGHT;

ANIMALIA; MUS MUSCULUS;

DIAGNOSTIC AGENT; MEDRONATE TECHNETIUM TC 99M; RADIOPHARMACEUTICAL AGENT;

ANIMAL; ARTICLE; BLADDER; CHEMISTRY; METABOLISM; METHODOLOGY; MOUSE; NUDE MOUSE; OPTICS; SCINTISCANNING;

ANIMALS; MICE; MICE, NUDE; OPTICS AND PHOTONICS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M MEDRONATE; URINARY BLADDER;

EID: 84858740294     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3653963     Document Type: Article

References (14)

1. R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, "Optical imaging of Cerenkov light generation from positron-emitting radiotracers," Phys. Med. Biol. 54, N355-N365 (2009).
2. A. E. Spinelli, D. D'Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, "Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers," Phys. Med. Biol. 55, 483-495 (2010).
3. A. E. Spinelli, F. Boschi, D. D'Ambrosio, L. Calderan, M. Marengo, A. Fenzi, A. Sbarbati, A. Del Vecchio, and R. Calandrino, "Cerenkov radiation imaging of beta emitters: in vitro and in vivo results," Nucl. Instr.Meth. A 648, S310-S312 (2011).
4. F. Boschi, L. Calderan, D. D'Ambrosio, M. Marengo, A. Fenzi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, "In vivo (18)F-FDG tumour uptake measurements in small animals using Cerenkov radiation," Eur. J. Nucl. Med. 38, 120-127 (2011).
5. H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, "Molecular optical imaging with radioactive probes," PLoS One 5, e9470 (2010).
6. A. E. Spinelli, C. Kuo, B. W. Rice, R. Calandrino, P. Marzola, A. Sbarbati, and F. Boschi, "Multispectral Cerenkov luminescence tomography for small animal optical imaging," Opt. Express 19,12605-12618(2011).
7. J. V. Jelley, Cerenkov Radiation and Its Applications, Pergamon, London (1958).
8. A. Ruggiero, J. P. Holland, J. S. Lewis, and J. Grimm, "Cerenkov luminescence imaging of medical isotopes," J. Nucl. Med. 51, 1123-1130 (2010).
9. F. Boschi, S. Lo Meo, P. L. Rossi, R. Calandrino, A. Sbarbati, and A. E. Spinelli, "Optical imaging of alpha emitters: simulations, phantom and in vivo results" (submitted for publication).
10. F. Boschi, A. E. Spinelli, D. D'Ambrosio, L. Calderan, M. Marengo, and A. Sbarbati, "Combined optical and single photon emission imaging: preliminary results," Phys. Med. Biol. 54, L57-L62 (2009).
11. D. E. Alburger, P. Richards, and T. H. Ku, "Beta decay of Tc-99m," Phys. Rev. C 21, 705-711 (1980).
12. H. H. Ross, "Measurement of β-emitting nuclides using Cerenkov radiation," Anal. Chem. 41, 1260-1265 (1969).
13. D. N. Sitharamarao and J. F. Duncan, "Molecular excitation of water by γ -irradiation," J. Phys. Chem. 67, 2126-2132 (1963).
14. T. I. Uickenden and S. S. Que Hee, "The luminescence of water excited by ambient ionizing radiation," Radiât. Res. 46, 28-35 (1971).