IMRT for locally advanced anal cancer: Clinical experience of the Montpellier Cancer Center

Radiation Oncology

Volumn 7, Issue 1, 2012, Pages

  Vieillot, Sabine ^a   Fenoglietto, Pascal ^a   Lemanski, Claire ^a   Moscardo, Carmen L ^a   Gourgou, Sophie ^a   Dubois, Jean Bernard ^a   Aillères, Norbert ^a   Azria, David ^a  

^a CENTRE VAL D AURELLE   (France)

Author keywords

Acute toxicity; Anal canal cancer; IMRT; Late toxicity

Indexed keywords

CISPLATIN; FLUOROURACIL; MITOMYCIN; ANTINEOPLASTIC AGENT;

ADULT; ADVANCED CANCER; ANEMIA; ANUS CANCER; ARTICLE; ASTHENIA; BONE DISEASE; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RELAPSE; CANCER STAGING; CLINICAL ARTICLE; COLORECTAL CANCER; COLOSTOMY; CONTROLLED STUDY; DERMATITIS; DISTANT METASTASIS; DOSIMETRY; FEMALE; FIBROSIS; GASTROINTESTINAL TOXICITY; GENITAL SYSTEM DISEASE; HEMATOLOGIC DISEASE; HUMAN; INGUINAL LYMPH NODE; INTENSITY MODULATED RADIATION THERAPY; LIVER DYSFUNCTION; LUNG EMBOLISM; MALE; NEUTROPENIA; OVERALL SURVIVAL; SKIN DISEASE; SURVIVAL RATE; THROMBOCYTOPENIA; UROGENITAL TRACT DISEASE; VAGINA DISEASE; AGED; ANUS TUMOR; COMPUTER ASSISTED RADIOTHERAPY; KAPLAN MEIER METHOD; METHODOLOGY; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; RADIATION DOSE; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM STAGING; RADIATION DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, INTENSITY-MODULATED;

EID: 84858731290     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-7-45     Document Type: Article

References (25)

1. Myerson RJ, Karnell LH, Menck HR. The National Cancer Data Base report on carcinoma of the anus. Cancer 1997, 80:805-815. 10.1002/(SICI)1097-0142(19970815)80:4<805::AID-CNCR20>3.0.CO;2-W, 9264365.
2. Nigro ND. An evaluation of combined therapy for squamous cell cancer of the anal canal. Dis Colon Rectum 1984, 27:763-766. 10.1007/BF02553933, 6499614.
3. Papillon J, Mayer M, Montbarbon JF, Gerard JP, Chassard JL, Bailly C. A new approach to the management of epidermoid carcinoma of the anal canal. Cancer 1983, 51:1830-1837. 10.1002/1097-0142(19830515)51:10<1830::AID-CNCR2820511013>3.0.CO;2-Z, 6831349.
4. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet 1996, 348:1049-1054. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research.
5. Bartelink H, Roelofsen F, Eschwege F, Rougier P, Bosset JF, Gonzalez DG, Peiffert D, van Glabbeke M, Pierart M. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 1997, 15:2040-2049.
6. Allal AS, Mermillod B, Roth AD, Marti MC, Kurtz JM. The impact of treatment factors on local control in T2-T3 anal carcinomas treated by radiotherapy with or without chemotherapy. Cancer 1997, 79:2329-2335. 10.1002/(SICI)1097-0142(19970615)79:12<2329::AID-CNCR6>3.0.CO;2-G, 9191520.
7. Weber DC, Kurtz JM, Allal AS. The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy. Int J Radiat Oncol Biol Phys 2001, 50:675-680. 10.1016/S0360-3016(01)01510-3, 11395235.
8. Chen YJ, Liu A, Tsai PT, Vora NL, Pezner RD, Schultheiss TE, Wong JY. Organ sparing by conformal avoidance intensity-modulated radiation therapy for anal cancer: dosimetric evaluation of coverage of pelvis and inguinal/femoral nodes. Int J Radiat Oncol Biol Phys 2005, 63:274-281. 10.1016/j.ijrobp.2005.05.052, 16111597.
9. Lin A, Ben-Josef E. Intensity-modulated radiation therapy for the treatment of anal cancer. Clin Colorectal Cancer 2007, 6:716-719. 10.3816/CCC.2007.n.041, 18039425.
10. Menkarios C, Azria D, Laliberte B, Moscardo CL, Gourgou S, Lemanski C, Dubois JB, Ailleres N, Fenoglietto P. Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans. Radiat Oncol 2007, 2:41. 10.1186/1748-717X-2-41, 2204019, 18005443.
11. Milano MT, Jani AB, Farrey KJ, Rash C, Heimann R, Chmura SJ. Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 2005, 63:354-361. 10.1016/j.ijrobp.2005.02.030, 16168830.
12. Pepek JM, Willett CG, Wu QJ, Yoo S, Clough RW, Czito BG. Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis. Int J Radiat Oncol Biol Phys 2010, 78:1413-1419. 10.1016/j.ijrobp.2009.09.046, 20231064.
13. Salama JK, Mell LK, Schomas DA, Miller RC, Devisetty K, Jani AB, Mundt AJ, Roeske JC, Liauw SL, Chmura SJ. Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience. J Clin Oncol 2007, 25:4581-4586. 10.1200/JCO.2007.12.0170, 17925552.
14. Brixey CJ, Roeske JC, Lujan AE, Yamada SD, Rotmensch J, Mundt AJ. Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys 2002, 54:1388-1396. 10.1016/S0360-3016(02)03801-4, 12459361.
15. Lujan AE, Mundt AJ, Yamada SD, Rotmensch J, Roeske JC. Intensity-modulated radiotherapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiotherapy. Int J Radiat Oncol Biol Phys 2003, 57:516-521. 10.1016/S0360-3016(03)00521-2, 12957265.
16. Mell LK, Kochanski JD, Roeske JC, Haslam JJ, Mehta N, Yamada SD, Hurteau JA, Collins YC, Lengyel E, Mundt AJ. Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy. Int J Radiat Oncol Biol Phys 2006, 66:1356-1365. 10.1016/j.ijrobp.2006.03.018, 16757127.
17. Mell LK, Schomas DA, Salama JK, Devisetty K, Aydogan B, Miller RC, Jani AB, Kindler HL, Mundt AJ, Roeske JC, Chmura SJ. Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2008, 70:1431-1437. 10.1016/j.ijrobp.2007.08.074, 17996390.
18. Greene FL, Blach CM, Fleming ID. Cancer staging manual. 2002, New York: Springer, AJCC, 6.
19. International Commission on Radiation Units and Measurements Report no. 50. Prescribing, recording, and reporting photon beam therapy 1993, Washington: DC: ICRU, International Commission on Radiation Units and Measurements.
20. Taylor A, Rockall AG, Reznek RH, Powell ME. Mapping pelvic lymph nodes: guidelines for delineation in intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2005, 63:1604-1612. 10.1016/j.ijrobp.2005.05.062, 16198509.
21. Devisetty K, Mell LK, Salama JK, Schomas DA, Miller RC, Jani AB, Roeske JC, Aydogan B, Chmura SJ. A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy. Radiother Oncol 2009, 93:298-301. 10.1016/j.radonc.2009.07.006, 19717198.
22. Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB, Thomas CR, Mayer RJ, Haddock MG, Rich TA, Willett C. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA 2008, 299:1914-1921. 10.1001/jama.299.16.1914, 18430910.
23. Mell LK, Tiryaki H, Ahn KH, Mundt AJ, Roeske JC, Aydogan B. Dosimetric comparison of bone marrow-sparing intensity-modulated radiotherapy versus conventional techniques for treatment of cervical cancer. Int J Radiat Oncol Biol Phys 2008, 71:1504-1510. 10.1016/j.ijrobp.2008.04.046, 18640499.
24. Mauch P, Constine L, Greenberger J, Knospe W, Sullivan J, Liesveld JL, Deeg HJ. Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys 1995, 31:1319-1339. 10.1016/0360-3016(94)00430-S, 7713791.
25. Vieillot S, Azria D, Lemanski C, Moscardo CL, Gourgou S, Dubois JB, Ailleres N, Fenoglietto P. Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensity-modulated radiation therapy (IMRT) in anal canal cancer. Radiat Oncol 2010, 5:92. 10.1186/1748-717X-5-92, 2965153, 20942958.