Emergency room management of acute bronchiolitis: A randomized trial of nebulized epinephrine

Turkish Journal of Pediatrics

Volumn 53, Issue 6, 2011, Pages 651-660

  Şimşek Kiper, Pelin Özlem ^a   Kiper, Nural ^a   Hasçelik, Gülşen ^a   Dolgun, Anil ^a   Yalçin, Ebru ^a   Doǧru Ersöz, Deniz ^a   Özçelik, Uǧur ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Acute bronchiolitis; Epinephrine; Respiratory syncytial virus; Salbutamol; Wheezing

Indexed keywords

ADRENALIN; SALBUTAMOL; BRONCHODILATING AGENT; OXYGEN;

ARTICLE; BREATHING RATE; BRONCHIOLITIS; CHILD; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG CHOICE; DRUG EFFICACY; DRUG SAFETY; EMERGENCY TREATMENT; FEMALE; HEART RATE; HOSPITALIZATION; HUMAN; HYPERTENSION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NEBULIZATION; OUTCOME ASSESSMENT; OXYGEN SATURATION; PALLOR; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE; TREMOR; VIRUS IDENTIFICATION; ACUTE DISEASE; AEROSOL; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; EMERGENCY HEALTH SERVICE; INFANT; INHALATIONAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PRESCHOOL CHILD; VIRAL BRONCHIOLITIS;

ACUTE DISEASE; ADMINISTRATION, INHALATION; AEROSOLS; ALBUTEROL; BRONCHIOLITIS, VIRAL; BRONCHODILATOR AGENTS; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; EMERGENCY SERVICE, HOSPITAL; EPINEPHRINE; FEMALE; HOSPITALIZATION; HUMANS; INFANT; MALE; OXYGEN; RESPIRATORY RATE;

EID: 84858720341     PISSN: 00414301     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Hubble D, Osborn GR. Acute bronchiolitis in children. Br Med J 1941; 1: 107-110.
2. American Academy of Pediatrics, Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics 2006; 118: 1774-1793.
3. Seiden AJ, Scarfone RJ. Bronchiolitis: an evidence-based approach to management. Clin Pediatr Emerg Med 2009; 10: 75-81.
4. Glezen WP, Taber LH, Frank AL, et al. Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 1986; 140: 543-546.
5. Hall CB, Weinberg GA, Iwane MK, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360: 588-598.
6. Henrickson KJ, Hoover S, Kehl KS, Hua W. National disease burden of respiratory viruses detected in children by polymerase chain reaction. Pediatr Infect Dis J 2004; 23: 11-18.
7. Wolf DG, Greenberg D, Kalkstein D, et al. Comparison of human metapneumovirus, respiratory syncytial virus, and influenza A lower respiratory tract infections in hospitalized young children. Pediatr Infect Dis J 2006; 25: 320-324.
8. Steiner RW. Treating acute bronchiolitis associated with RSV. Am Fam Physician 2004; 69: 325-330.
9. Fjaerli H-O, Farstad T, Rod G, et al. Acute bronchiolitis in infancy as a risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway. BMC Pediatrics 2005; 5: 31.
10. Thompson W, Shay D, Weintraub E, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289: 179-186.
11. Hall CB. Respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001; 344: 1917-1928.
12. Willson DF, Horn SD, Hendly JO, Smout R, Gassaway J. Effect of practice variation on resource utilization in infants hospitalized for viral lower respiratory illness. Pediatrics 2001; 108: 851-855.
13. Zorc JZ, Hall CB. Bronchiolitis: recent evidence on diagnosis and management. Pediatrics 2010; 125: 342-349.
14. Behrendt CE, Decker MD, Burch DJ, Watson PH. International variation in the management of infants hospitalized with respiratory syncytial virus. Eur J Pediatr 1998; 157: 215-220.
15. Henderson FW, Clyde WA, Collier AM, et al. The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. J Pediatr 1979; 95: 183.
16. Whol ME, Chernick V. State of the art: bronchiolitis. Am Rev Respir Dis 1978; 118: 759-781.
17. Menon K, Sutcliffe T, Klassen TP. A randomized trial comparing the efficacy of epinephrine with salbutamol in the treatment of acute bronchiolitis. J Pediatr 1995; 126: 1004-1007.
18. Wright M, Mullett CJ, Piedimonte G. Pharmacological management of acute bronchiolitis. Ther Clin Risk Manag 2008; 4: 895-903.
19. Lowell DI, Lister G, Von Koss H, McCarthy P. Wheezing in infants: the response to epinephrine. Pediatrics 1987; 79: 939-945.
20. Ray MS, Singh V. Comparison of nebulized adrenaline versus salbutamol in wheeze associated respiratory tract infection in infants. Indian Pediatr 2002; 39: 12-22.
21. Gadomski AM, Brower M. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev 2010; (12): CD001266.
22. Wainwright C, Altamirano L, Cheney M, et al. A multicenter, randomized, double-blind, controlled trial of nebulized epinephrine in infants with acute bronchiolitis. N Engl J Med 2003; 349: 27-35.
23. Rusconi F, Castagneto M, Gagliardi L, et al. Reference values for respiratory rate in the first 3 years of life. Pediatrics 1994; 94: 350-355.
24. Dobson JV, Stephens-Groff SM, McMahon SR, Stemmler MM, Brallier SL, Bay C. The use of albuterol in hospitalized infants with bronchiolitis. Pediatrics 1998; 101: 361-368.
25. Kellner JD, Ohlsson A, Gadomski AM, Wang EE. Efficacy of bronchodilator therapy in bronchiolitis: a meta-analysis. Arch Pediatr Adolesc Med 1996; 150: 1166-1172.
26. Newcomb RW. Use of adrenergic bronchodilators by pediatric allergists and pulmonologists. Am J Dis Child 1989; 143: 481-485.
27. Flores G, Horwitz RI. Efficacy of beta2 agonists in bronchiolitis: a reappraisal and meta-analysis. Pediatrics 1997; 100: 233-239.
28. Hartling L, Wiebe N, Math M, Russel K, Patel H, Klassen TP. A meta-analysis of randomized controlled trials evaluating the efficacy of epinephrine for the treatment of acute viral bronchiolitis. Arch Pediatr Adolesc Med 2003; 157: 957-964.
29. Mull CC, Scarfone RJ, Ferri LR, et al. A randomized trial of nebulized epinephrine vs albuterol in the emergency department treatment of bronchiolitis. Arch Pediatr Adolesc Med 2004; 158: 113-118.
30. Bertrand P, Araníbar H, Castro E, Sánchez I. Efficacy of nebulized epinephrine versus salbutamol in hospitalized infants with bronchiolitis. Pediatr Pulmonol 2001; 31: 284-288.
31. Klassen TP. Recent advances in the treatment of bronchiolitis and laryngitis. Pediatr Clin North Am 1997; 94: 249-261.
32. Zhang L, Sanguebsche LS. The safety of nebulization with 3 to 5 ml of adrenaline (1:1000) in children: an evidence based review. J Pediatr (Rio J) 2005; 81: 193-197.
33. Butte MJ, Nguyen BX, Hutchison TJ, et al. Pediatric myocardial infarction after racemic epinephrine administration. Pediatrics 1999; 104: 9.
34. Ho L, Collis G, Landau LL, LeSouef PN. Effects of salbutamol on oxygen saturation in bronchiolitis. Arch Dis Child 1991; 60: 1061-1064.