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Volumn 11, Issue 11, 2011, Pages 1641-1652

Role of fulvestrant in the management of postmenopausal breast cancer

Author keywords

Endocrine therapy; Fulvestrant; Selective estrogen receptor downregulator

Indexed keywords

ANASTROZOLE; EXEMESTANE; FULVESTRANT; GOSERELIN; LETROZOLE; PLACEBO; TAMOXIFEN; TOREMIFENE; ANTIESTROGEN; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; DRUG DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR;

EID: 84858719740     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/ERA.11.138     Document Type: Article
Times cited : (8)

References (61)
  • 1
    • 0025084510 scopus 로고
    • Inhibition of estrogen receptor-DNA binding by the ‘pure’ antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization
    • Fawell SE, White R, Hoare S et al. Inhibition of estrogen receptor-DNA binding by the ‘pure’ antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. Proc. Natl Acad. Sci. USA 87, 6883-6887 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 6883-6887
    • Fawell, S.E.1    White, R.2    Hoare, S.3
  • 3
    • 0027768899 scopus 로고
    • The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling
    • Dauvois S, White R, Parker MG. The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J. Cell Sci. 106(Pt 4), 1377-1388 (1993).
    • (1993) J. Cell Sci , vol.106 , pp. 1377-1388
    • Dauvois, S.1    White, R.2    Parker, M.G.3
  • 4
    • 0033305525 scopus 로고    scopus 로고
    • Comparative analyses of mechanistic differences among antioestrogens
    • Wijayaratne AL, Nagel SC, Paige LA et al. Comparative analyses of mechanistic differences among antioestrogens. Endocrinology. 140, 5828-5840 (1999).
    • (1999) Endocrinology , vol.140 , pp. 5828-5840
    • Wijayaratne, A.L.1    Nagel, S.C.2    Paige, L.A.3
  • 5
    • 1242338758 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators: Discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells
    • Frasor J, Stossi F, Danes JM et al. Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res. 64, 1522-1533 (2004).
    • (2004) Cancer Res , vol.64 , pp. 1522-1533
    • Frasor, J.1    Stossi, F.2    Danes, J.M.3
  • 6
    • 0041736202 scopus 로고    scopus 로고
    • Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells
    • Hutcheson IR, Knowlden JM, Madden T-A et al. Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells. Breast Cancer Res. Treat. 81, 81-93 (2003).
    • (2003) Breast Cancer Res. Treat , vol.81 , pp. 81-93
    • Hutcheson, I.R.1    Knowlden, J.M.2    Madden, T.-A.3
  • 7
    • 0027258030 scopus 로고
    • Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element
    • Ignar-Trowbridge DM, Teng CT, Ross KA et al. Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element. Mol. Endocrinol. 7, 992-998 (1993).
    • (1993) Mol. Endocrinol , vol.7 , pp. 992-998
    • Ignar-Trowbridge, D.M.1    Teng, C.T.2    Ross, K.A.3
  • 8
    • 0029916220 scopus 로고    scopus 로고
    • Short-term effects of pure anti-oestrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer
    • McClelland RA, Gee JM, Francis AB et al. Short-term effects of pure anti-oestrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancer. Eur. J. Cancer 32A, 413-416 (1996).
    • (1996) Eur. J. Cancer , vol.32A , pp. 413-416
    • McClelland, R.A.1    Gee, J.M.2    Francis, A.B.3
  • 9
    • 0018138071 scopus 로고
    • Estrogen control of progesterone receptor and estrogen receptor in human breast cancer
    • Horwitz KB, McGuire WL. Estrogen control of progesterone receptor and estrogen receptor in human breast cancer. J. Biol. Chem. 253, 2223-2238 (1978).
    • (1978) J. Biol. Chem , vol.253 , pp. 2223-2238
    • Horwitz, K.B.1    McGuire, W.L.2
  • 10
    • 0028905375 scopus 로고
    • Observations arising from the use of pure antioestrogens on oestrogen-responsive (MCF-7) and oestrogen growthindependent (K3) human breast cancer cells
    • Nicholson RI, Gee JM, Francis AB et al. Observations arising from the use of pure antioestrogens on oestrogen-responsive (MCF-7) and oestrogen growthindependent (K3) human breast cancer cells. Endocr. Relat. Cancer 2, 115-121 (1995).
    • (1995) Endocr. Relat. Cancer , vol.2 , pp. 115-121
    • Nicholson, R.I.1    Gee, J.M.2    Francis, A.B.3
  • 11
    • 0029077113 scopus 로고
    • Responses to pure antiestrogens (ICI 164,384, ICI 182,780) in estrogensensitive and -resistant experimental and clinical breast cancer
    • Nicholson RI, Gee JM, Manning DL et al. Responses to pure antiestrogens (ICI 164,384, ICI 182,780) in estrogensensitive and -resistant experimental and clinical breast cancer. Ann. NY Acad. Sci. 761, 148-163 (1995).
    • (1995) Ann. NY Acad. Sci , vol.761 , pp. 148-163
    • Nicholson, R.I.1    Gee, J.M.2    Manning, D.L.3
  • 12
    • 0036174189 scopus 로고    scopus 로고
    • Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes
    • Dos Santos EG, Dieudonne MN, Pecquery R et al. Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes. Endocrinology. 143, 930-940 (2002).
    • (2002) Endocrinology , vol.143 , pp. 930-940
    • Dos Santos, E.G.1    Dieudonne, M.N.2    Pecquery, R.3
  • 13
    • 0023093455 scopus 로고
    • Steroidal pure antioestrogens
    • Wakeling A. E., Bowler J. Steroidal pure antioestrogens. J. Endocrinol. 112, R7-R10 (1987).
    • (1987) J. Endocrinol , vol.112 , pp. RR7-R10
    • Wakeling, A.E.1    Bowler, J.2
  • 14
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling AE, Dukes M, Bowler J. A potent specific pure antiestrogen with clinical potential. Cancer Res. 51, 3867-3873 (1991).
    • (1991) Cancer Res , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 15
    • 0027358687 scopus 로고
    • Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780
    • Hu XF, Veroni M, De Luise M et al. Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780. Int. J. Cancer 55, 873-876 (1993).
    • (1993) Int. J. Cancer , vol.55 , pp. 873-876
    • Hu, X.F.1    Veroni, M.2    De Luise, M.3
  • 16
    • 0028329961 scopus 로고
    • Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1
    • Lykkesfeldt AE, Madsen MW, Briand P. Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1. Cancer Res. 54, 1587-1595 (1994).
    • (1994) Cancer Res , vol.54 , pp. 1587-1595
    • Lykkesfeldt, A.E.1    Madsen, M.W.2    Briand, P.3
  • 17
    • 0029059562 scopus 로고
    • Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment
    • Lykkesfeldt AE, Larsen SS, Briand P. Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment. Int. J. Cancer 61, 529-534 (1995).
    • (1995) Int. J. Cancer , vol.61 , pp. 529-534
    • Lykkesfeldt, A.E.1    Larsen, S.S.2    Briand, P.3
  • 18
    • 15644377090 scopus 로고    scopus 로고
    • MCF7/LCC9: An antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen
    • Brünner N, Boysen B, Jirus S et al. MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen. Cancer Res. 57, 3486-3493 (1997).
    • (1997) Cancer Res , vol.57 , pp. 3486-3493
    • Brünner, N.1    Boysen, B.2    Jirus, S.3
  • 19
    • 0029075872 scopus 로고
    • Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer
    • Osborne CK, Coronado-Heinsohn EB, Hilsenbeck SG et al. Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J. Natl Cancer Inst. 87, 746-750 (1995).
    • (1995) J. Natl Cancer Inst , vol.87 , pp. 746-750
    • Osborne, C.K.1    Coronado-Heinsohn, E.B.2    Hilsenbeck, S.G.3
  • 20
    • 1842667818 scopus 로고    scopus 로고
    • Clarke DA et al Pharmacokinetics and metabolism of fulvestrant after oral, intravenous and intramuscular administration in healthy volunteers
    • Abstract 311
    • Harrison M, Laight A, Clarke DA et al Pharmacokinetics and metabolism of fulvestrant after oral, intravenous and intramuscular administration in healthy volunteers. Proc. ASCO 22, 45 (2003) (Abstract 311).
    • (2003) Proc. ASCO , vol.22 , pp. 45
    • Harrison, M.1    Laight, A.2
  • 21
    • 3042847696 scopus 로고    scopus 로고
    • Pharmacokinetic profile of intramuscular fulvestrant in advanced breast cancer
    • Robertson JF, Erikstein B, Osborne KC et al. Pharmacokinetic profile of intramuscular fulvestrant in advanced breast cancer. Clin. Pharmacokinet. 43, 529-538 (2004).
    • (2004) Clin. Pharmacokinet , vol.43 , pp. 529-538
    • Robertson, J.F.1    Erikstein, B.2    Osborne, K.C.3
  • 22
    • 0242267021 scopus 로고    scopus 로고
    • Equivalent single-dose pharmacokinetics of two different dosing methods of prolongedrelease fulvestrant (‘Faslodex’) in postmenopausal women with advanced breast cancer
    • Robertson JF, Harrison MP. Equivalent single-dose pharmacokinetics of two different dosing methods of prolongedrelease fulvestrant (‘Faslodex’) in postmenopausal women with advanced breast cancer. Cancer Chemother. Pharmacol. 52(4), 346-348 (2003).
    • (2003) Cancer Chemother. Pharmacol , vol.52 , Issue.4 , pp. 346-348
    • Robertson, J.F.1    Harrison, M.P.2
  • 23
    • 0027433696 scopus 로고
    • Antiuterotrophic effects of the pure antioestrogen ICI 182,780 in adult female monkeys (Macaca nemestrina): Quantitative magnetic resonance imaging
    • Dukes M, Waterton JC, Wakeling AE. Antiuterotrophic effects of the pure antioestrogen ICI 182,780 in adult female monkeys (Macaca nemestrina): quantitative magnetic resonance imaging. J. Endocrinol. 138(2), 203-210 (1993).
    • (1993) J. Endocrinol , vol.138 , Issue.2 , pp. 203-210
    • Dukes, M.1    Waterton, J.C.2    Wakeling, A.E.3
  • 24
    • 0027971917 scopus 로고
    • The effects of fulvestrant, a pure anti-estrogen, on the hypothalamic- pituitary-gonadal axis and on endometrial proliferation in pre-menopausal women
    • Thomas EJ, Walton PL, Thomas NM, Dowsett M. The effects of fulvestrant, a pure anti-estrogen, on the hypothalamic- pituitary-gonadal axis and on endometrial proliferation in pre-menopausal women. Hum. Reprod. 9, 1991-1996 (1994).
    • (1994) Hum. Reprod , vol.9 , pp. 1991-1996
    • Thomas, E.J.1    Walton, P.L.2    Thomas, N.M.3    Dowsett, M.4
  • 25
    • 0037011660 scopus 로고    scopus 로고
    • Trial to assess the pharmacology of the new oestrogen receptor antagonist fulvestrant on the endometrium in healthy postmenopausal volunteers
    • Addo S, Yates RA, Laight A. A Phase I trial to assess the pharmacology of the new oestrogen receptor antagonist fulvestrant on the endometrium in healthy postmenopausal volunteers. Br. J. Cancer. 87, 1354-1359 (2002).
    • (2002) Br. J. Cancer , vol.87 , pp. 1354-1359
    • Addo, S.1    Yates, R.A.2    Laight, A.A.3    Phase, I.4
  • 26
    • 0037835462 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, dose-ranging trial comparing fulvestrant with goserelin in premenopausal patients with uterine fibroids awaiting hysterectomy
    • Donnez J, Hervais Vivancos B, Kudela M et al. A randomized, placebo-controlled, dose-ranging trial comparing fulvestrant with goserelin in premenopausal patients with uterine fibroids awaiting hysterectomy. Fertil. Steril. 79(6), 1380-1389 (2003).
    • (2003) Fertil. Steril , vol.79 , Issue.6 , pp. 1380-1389
    • Donnez, J.1    Hervais Vivancos, B.2    Kudela, M.3
  • 27
    • 10744232401 scopus 로고    scopus 로고
    • Fulvestrant in postmenopausal women with advanced breast cancer
    • Bross PF, Baird A, Chen G et al. Fulvestrant in postmenopausal women with advanced breast cancer. Clin. Cancer Res. 9, 430 (2003).
    • (2003) Clin. Cancer Res , vol.9 , pp. 430
    • Bross, P.F.1    Baird, A.2    Chen, G.3
  • 28
    • 0028084758 scopus 로고
    • Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer
    • DeFriend DJ, Howell A, Nicholson RI et al. Investigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancer. Cancer Res. 54, 408-414 (1994).
    • (1994) Cancer Res , vol.54 , pp. 408-414
    • Defriend, D.J.1    Howell, A.2    Nicholson, R.I.3
  • 29
    • 0035884408 scopus 로고    scopus 로고
    • Comparison of the short-term biological effects of 7α-[9-(4,4,5,5,5- pentafluoropentylsulfinyl)-nonyl] estra-1,3,5,(10)-triene-3,17β-diol (FVT) versus tamoxifen in postmenopausal women with primary breast cancer
    • Robertson JF, Nicholson RI, Bundred NJ et al. Comparison of the short-term biological effects of 7α-[9-(4,4,5,5,5- pentafluoropentylsulfinyl)-nonyl] estra-1,3,5,(10)-triene-3,17β-diol (FVT) versus tamoxifen in postmenopausal women with primary breast cancer. Cancer Res. 18, 6739-6746 (2001).
    • (2001) Cancer Res , vol.18 , pp. 6739-6746
    • Robertson, J.F.1    Nicholson, R.I.2    Bundred, N.J.3
  • 30
    • 33751102860 scopus 로고    scopus 로고
    • Oestrogen receptor expression in human breast cancer during long-term fulvestrant treatment
    • Abstract 536
    • Robertson JFR, Gutteridge E, Cheung KL et al. Oestrogen receptor expression in human breast cancer during long-term fulvestrant treatment. Proc. Am. Soc. Clin. Oncol. 11 (2004) (Abstract 536).
    • (2004) Proc. Am. Soc. Clin. Oncol , pp. 11
    • Robertson, J.1    Gutteridge, E.2    Cheung, K.L.3
  • 31
    • 0028861402 scopus 로고
    • Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer
    • Howell A, DeFriend DJ, Robertson JF et al. Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer. Lancet 345(8941), 29-30 (1995).
    • (1995) Lancet , vol.345 , Issue.8941 , pp. 29-30
    • Howell, A.1    Defriend, D.J.2    Robertson, J.F.3
  • 32
    • 0030730273 scopus 로고    scopus 로고
    • Duration of remission to ICI 182780 compared to megestrol acetate in tamoxifen resistant breast cancer
    • Robertson JR, Howell A, DeFriend DJ et al. Duration of remission to ICI 182780 compared to megestrol acetate in tamoxifen resistant breast cancer. Breast 6(4), 186-189 (1997).
    • (1997) Breast , vol.6 , Issue.4 , pp. 186-189
    • Robertson, J.R.1    Howell, A.2    Defriend, D.J.3
  • 33
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • Howell A, Robertson JF, Quaresma Albano J et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J. Clin. Oncol. 20, 3396-3403 (2002).
    • (2002) J. Clin. Oncol , vol.20 , pp. 3396-3403
    • Howell, A.1    Robertson, J.F.2    Quaresma Albano, J.3
  • 34
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results of a North American trial
    • Osborne CK, Pippen J, Jones SE et al. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J. Clin. Oncol. 20, 3386-3395 (2002).
    • (2002) J. Clin. Oncol , vol.20 , pp. 3386-3395
    • Osborne, C.K.1    Pippen, J.2    Jones, S.E.3
  • 35
    • 0038683988 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: A prospective combined analysis of two multicenter trials
    • Robertson JF, Osborne CK, Howell A et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials. Cancer 98, 229-238 (2003).
    • (2003) Cancer , vol.98 , pp. 229-238
    • Robertson, J.F.1    Osborne, C.K.2    Howell, A.3
  • 36
    • 22244449598 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: A prospectively planned combined survival analysis of two multicenter trials
    • Howell A, Pippen J, Elledge RM et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trials. Cancer 104(2), 236-239 (2005).
    • (2005) Cancer , vol.104 , Issue.2 , pp. 236-239
    • Howell, A.1    Pippen, J.2    Elledge, R.M.3
  • 37
    • 2442648038 scopus 로고    scopus 로고
    • Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: A multinational, double-blind, randomized trial
    • Howell A, Robertson JF, Abram P et al. Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial. J. Clin. Oncol. 22, 1605-1613 (2004).
    • (2004) J. Clin. Oncol , vol.22 , pp. 1605-1613
    • Howell, A.1    Robertson, J.F.2    Abram, P.3
  • 38
    • 33644984327 scopus 로고    scopus 로고
    • Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032
    • Ingle J, Suman VJ, Rowland KM et al. Fulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032. J. Clin. Oncol. 24, 1052-1056 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 1052-1056
    • Ingle, J.1    Suman, V.J.2    Rowland, K.M.3
  • 39
    • 33846543806 scopus 로고    scopus 로고
    • Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: Final results of Phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00)
    • Perey L, Paridaens R, Hawle H et al. Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of Phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00). Ann. Oncol. 18(1), 64-69 (2007).
    • (2007) Ann. Oncol , vol.18 , Issue.1 , pp. 64-69
    • Perey, L.1    Paridaens, R.2    Hawle, H.3
  • 40
    • 0026446844 scopus 로고
    • Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women
    • Evans TR, Di Salle E, Ornati G et al. Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women. Cancer Res. 52, 5933-5939 (1992).
    • (1992) Cancer Res , vol.52 , pp. 5933-5939
    • Evans, T.R.1    Di Salle, E.2    Ornati, G.3
  • 41
    • 17144472154 scopus 로고    scopus 로고
    • Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: A Phase II trial
    • Lønning PE, Bajetta E, Murray R et al. Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: a Phase II trial. J. Clin. Oncol. 18, 2234-2244 (2000).
    • (2000) J. Clin. Oncol , vol.18 , pp. 2234-2244
    • Lønning, P.E.1    Bajetta, E.2    Murray, R.3
  • 42
    • 43249130208 scopus 로고    scopus 로고
    • Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: Results from EFECT
    • Chia S, Gradishar W, Mauriac L et al. Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: Results from EFECT. J. Clin. Oncol. 26, 1664-1670 (2008).
    • (2008) J. Clin. Oncol , vol.26 , pp. 1664-1670
    • Chia, S.1    Gradishar, W.2    Mauriac, L.3
  • 43
    • 69049097227 scopus 로고    scopus 로고
    • Activity of fulvestrant versus exemestane in advanced breast cancer patients with or without visceral metastases: Data from the EFECT trial.
    • Mauriac L, Romieu G, Bines J. Activity of fulvestrant versus exemestane in advanced breast cancer patients with or without visceral metastases: data from the EFECT trial. Breast Cancer Res. Treat. 117(1), 69-75 (2009).
    • (2009) Breast Cancer Res. Treat , vol.117 , Issue.1 , pp. 69-75
    • Mauriac, L.1    Romieu, G.2    Bines, J.3
  • 44
    • 77949273210 scopus 로고    scopus 로고
    • First Results from FACT - an open-label, randomized Phase III study investigating loading dose of fulvestrant combined with anastrozole versus anastrozole at first relapse in hormone receptor positive breast cancer.
    • San Antonio, TX, USA, 9-13 December, (Abstract 23)
    • Bergh J, Jonsson PE, Lidbrink E et al. First Results from FACT - an open-label, randomized Phase III study investigating loading dose of fulvestrant combined with anastrozole versus anastrozole at first relapse in hormone receptor positive breast cancer. Presented at: 32nd Annual San Antonio Breast Cancer Symposium. San Antonio, TX, USA, 9-13 December 2009 (Abstract 23).
    • (2009) 32Nd Annual San Antonio Breast Cancer Symposium
    • Bergh, J.1    Jonsson, P.E.2    Lidbrink, E.3
  • 45
    • 76749091057 scopus 로고    scopus 로고
    • Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: Results From the FIRST Study
    • Robertson JF, Llombart-Cussac K, Rolski K et al. Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: Results From the FIRST Study. J. Clin. Oncol. 27(27), 4530-4535 (2009).
    • (2009) J. Clin. Oncol , vol.27 , Issue.27 , pp. 4530-4535
    • Robertson, J.F.1    Llombart-Cussac, K.2    Rolski, K.3
  • 46
    • 55549137832 scopus 로고    scopus 로고
    • Fulvestrant 500 mg vs 250 mg: First results from NEWEST, a randomized, Phase II neoadjuvant trial in postmenopausal women with locally advanced, estrogen receptor-positive breast cancer
    • Abstract 589
    • Kuter I, Hegg R, Singer CF et al. Fulvestrant 500 mg vs 250 mg: First results from NEWEST, a randomized, Phase II neoadjuvant trial in postmenopausal women with locally advanced, estrogen receptor-positive breast cancer. Breast Cancer Res. Treat. 106 (2007) (Abstract 589).
    • (2007) Breast Cancer Res. Treat , pp. 106
    • Kuter, I.1    Hegg, R.2    Singer, C.F.3
  • 47
    • 78049523306 scopus 로고    scopus 로고
    • Results of the CONFIRM Phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer
    • Di Leo A, Jerusalem G, Petruzelka L et al. Results of the CONFIRM Phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer. J. Clin. Oncol. 28, 4594-4600 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 4594-4600
    • Di Leo, A.1    Jerusalem, G.2    Petruzelka, L.3
  • 48
    • 78649467540 scopus 로고    scopus 로고
    • Three dose regimens of fulvestrant in postmenopausal Japanese women with advanced breast cancer: Results from a double-blind, Phase II comparative study (FINDER1)
    • Ohno S, Rai Y, Iwata H et al. Three dose regimens of fulvestrant in postmenopausal Japanese women with advanced breast cancer: results from a double-blind, Phase II comparative study (FINDER1). Ann. Oncol. 21(12), 2342-2347 (2010).
    • (2010) Ann. Oncol , vol.21 , Issue.12 , pp. 2342-2347
    • Ohno, S.1    Rai, Y.2    Iwata, H.3
  • 49
    • 77956164319 scopus 로고    scopus 로고
    • A Phase II study (FINDER 2) comparing three dosing regimens of fulvestrant in postmenopausal women with estrogen receptor-positive advanced breast cancer
    • Pritchard K, Rolski J, Pápai Z et al. A Phase II study (FINDER 2) comparing three dosing regimens of fulvestrant in postmenopausal women with estrogen receptor-positive advanced breast cancer. Breast Cancer Res. Treat. 123(2), 453-461 (2010).
    • (2010) Breast Cancer Res. Treat , vol.123 , Issue.2 , pp. 453-461
    • Pritchard, K.1    Rolski, J.2    Pápai, Z.3
  • 50
    • 38749129651 scopus 로고    scopus 로고
    • Effects of fulvestrant 750 mg in premenopausal women with oestrogenreceptor- positive primary breast cancer
    • Young OE, Renshaw L, Macaskill EJ et al. Effects of fulvestrant 750 mg in premenopausal women with oestrogenreceptor- positive primary breast cancer. Eur. J. Cancer 44, 391-399 (2008).
    • (2008) Eur. J. Cancer , vol.44 , pp. 391-399
    • Young, O.E.1    Renshaw, L.2    Macaskill, E.J.3
  • 51
    • 0028853923 scopus 로고
    • Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells
    • Masamura S, Santner SJ, Heitjan DF et al. Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. J. Clin. Endocrinol. Metab. 80(10), 2918-2925 (1995).
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , Issue.10 , pp. 2918-2925
    • Masamura, S.1    Santner, S.J.2    Heitjan, D.F.3
  • 52
    • 0035714726 scopus 로고    scopus 로고
    • Adaptive hypersensitivity to estradiol: Potential mechanism for secondary hormonal responses in breast cancer patients
    • Santen R, Jeng MH, Wang JP et al. Adaptive hypersensitivity to estradiol: potential mechanism for secondary hormonal responses in breast cancer patients. J. Steroid Biochem. Mol. Biol. 79(1-5), 115-125 (2001).
    • (2001) J. Steroid Biochem. Mol. Biol , vol.79 , Issue.1-5 , pp. 115-125
    • Santen, R.1    Jeng, M.H.2    Wang, J.P.3
  • 53
    • 0036702132 scopus 로고    scopus 로고
    • Molecular changes associated with acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation
    • Chan CM, Martin LA, Johnston SR et al. Molecular changes associated with acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation. J. Steroid Biochem. Mol. Biol. 81(4-5), 333-341 (2002).
    • (2002) J. Steroid Biochem. Mol. Biol , vol.81 , Issue.4-5 , pp. 333-341
    • Chan, C.M.1    Martin, L.A.2    Johnston, S.R.3
  • 54
    • 0031791623 scopus 로고    scopus 로고
    • Estrogen receptor expression and function in longterm estrogen-deprived human breast cancer cells
    • Jeng MH, Shupnik MA, Bender TP et al. Estrogen receptor expression and function in longterm estrogen-deprived human breast cancer cells. Endocrinology 139 (10), 4164-4174 (1998).
    • (1998) Endocrinology , vol.139 , Issue.10 , pp. 4164-4174
    • Jeng, M.H.1    Shupnik, M.A.2    Bender, T.P.3
  • 55
    • 20444448539 scopus 로고    scopus 로고
    • Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model
    • Jelovac D, Macedo L, Goloubeva OG et al. Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model. Cancer Res. 65, 5439-5444 (2005).
    • (2005) Cancer Res , vol.65 , pp. 5439-5444
    • Jelovac, D.1    Macedo, L.2    Goloubeva, O.G.3
  • 56
    • 44849089392 scopus 로고    scopus 로고
    • Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model
    • Macedo LF, Sabnis GJ, Goloubeva OG et al. Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model. Cancer Res. 68, 3516-3522 (2008).
    • (2008) Cancer Res , vol.68 , pp. 3516-3522
    • Macedo, L.F.1    Sabnis, G.J.2    Goloubeva, O.G.3
  • 57
    • 1642386264 scopus 로고    scopus 로고
    • Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model
    • Long BJ, Jelovac D, Handratta V et al. Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model. J. Natl Cancer Inst. 96, 456-465 (2004).
    • (2004) J. Natl Cancer Inst , vol.96 , pp. 456-465
    • Long, B.J.1    Jelovac, D.2    Handratta, V.3
  • 58
    • 0035992421 scopus 로고    scopus 로고
    • The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: Long-term studies using the intratumoral aromatase postmenopausal breast cancer model
    • Long BJ, Jelovac D, Thiantanawat A, Brodie AM. The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model. Clin. Cancer Res. 8, 2378-2388 (2002).
    • (2002) Clin. Cancer Res , vol.8 , pp. 2378-2388
    • Long, B.J.1    Jelovac, D.2    Thiantanawat, A.3    Brodie, A.M.4
  • 59
    • 77953980796 scopus 로고    scopus 로고
    • Activity of fulvestrant in HER2- overexpressing advanced breast cancer
    • Robertson JF, Steger GG, Neven P et al. Activity of fulvestrant in HER2- overexpressing advanced breast cancer. Ann. Oncol. 21, 1246-1253 (2010).
    • (2010) Ann. Oncol , vol.21 , pp. 1246-1253
    • Robertson, J.F.1    Steger, G.G.2    Neven, P.3
  • 61
    • 0028031372 scopus 로고
    • Pharmacology of novel steroidal inhibitors of cytochrome P450(17) α (17 α-hydroxylase/C17-20 lyase)
    • Barrie SE, Potter GA, Goddard PM et al. Pharmacology of novel steroidal inhibitors of cytochrome P450(17) α (17 α-hydroxylase/C17-20 lyase). J. Steroid Biochem. Mol. Biol. 50, 267-273 (1994).
    • (1994) J. Steroid Biochem. Mol. Biol , vol.50 , pp. 267-273
    • Barrie, S.E.1    Potter, G.A.2    Goddard, P.M.3


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