Atrial natriuretic peptide-Fc, ANP-Fc, fusion proteins: Semisynthesis, in vitro activity and pharmacokinetics in rats

Bioconjugate Chemistry

Volumn 23, Issue 3, 2012, Pages 518-526

  Mezo, Adam R ^a   McDonnell, Kevin A ^b   Low, Susan C ^b   Song, Jeff ^b   Reidy, Tom J ^a   Lu, Qi ^a   Amari, John V ^a   Hoehn, Todd ^a   Peters, Robert T ^a   Dumont, Jennifer ^a   Bitonti, Alan J ^a  

^a BIOGEN   (United States)

^b BIND Biosciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; DISEASES; PHARMACOKINETICS; RATS;

ATRIAL NATRIURETIC PEPTIDES; CARDIOVASCULAR DISEASE; FC FUSION PROTEINS; HALF LIVES; IN-VITRO; IN-VIVO; MONOMERICS; N TERMINUS; SEMISYNTHESIS; VITRO ACTIVITY;

PEPTIDES;

ATRIAL NATRIURETIC FACTOR; ATRIAL NATRIURETIC FACTOR IMMUNOGLOBULIN FC FRAGMENT CONJUGATE; CYCLIC GMP; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; MESNA; THIOESTER; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG HALF LIFE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT;

RATTUS;

EID: 84858718379     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200592c     Document Type: Article

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