A Translational View of Biomarkers in Preterm Labor

American Journal of Reproductive Immunology

Volumn 67, Issue 4, 2012, Pages 268-272

  Hanna, Nazeeh ^a   Kiefer, Daniel ^b  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b LEHIGH VALLEY HOSPITAL   (United States)

Author keywords

Biomarkers; Cytokines; Inflammation; Intrauterine compartments; Non invasive sampling; Preterm labor

Indexed keywords

BIOLOGICAL MARKER; EOTAXIN; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PLATELET DERIVED GROWTH FACTOR; RANTES; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

AMNION FLUID; DISEASE COURSE; ECHOGRAPHY; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; MATERNAL BLOOD; NON INVASIVE PROCEDURE; PREDICTIVE VALUE; PREMATURE LABOR; PRIORITY JOURNAL; REVIEW; SALIVA; SENSITIVITY AND SPECIFICITY; TRANSLATIONAL RESEARCH; URINE; UTERINE CERVIX; UTERINE CERVIX MUCUS; UTERUS CONTRACTION; VAGINA SECRETION;

BIOLOGICAL MARKERS; EARLY DIAGNOSIS; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; OBSTETRIC LABOR, PREMATURE; PREGNANCY; PREGNANCY COMPLICATIONS; PREMATURE BIRTH;

EID: 84858707681     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2012.01112.x     Document Type: Review

References (19)

1. March of Dimes website. Help Reduce Cost: The Economics Costs. Accessed January 9, 2012. Available from:
2. Iams JD, Goldenberg RL, Meis PJ, Mercer BM, Moawad A, Das A, Thom E, McNellis D, Copper RL, Johnson F, Roberts JM: The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. N Eng J Med 1996; 334:567-572.
3. Berghella V, Odibo AO, To MS, Rust OA, Althuisius SM: Cerclage for short cervix on ultrasonography: meta-analysis of trials using individual patient-level data. Obstet Gynecol 2005; 106:181-189.
4. Rust OA, Atlas RO, Reed J, van Gaalen J, Balducci J: Revisiting the short cervix detected by transvaginal ultrasound in the second trimester: why cerclage therapy may not help. Am J Obstet Gynecol 2001; 185:1098-1105.
5. Owen J, Hankins G, Iams JD, Berghella V, Sheffield JS, Perez-Delboy A, Egerman RS, Wing DA, Tomlinson M, Silver R, Ramin SM, Guzman ER, Gordon M, How HY, Knudtson EJ, Szychowski JM, Cliver S, Hauth JC: Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length. Am J Obstet Gynecol 2009; 201:375.e371-378.
6. Peltier MR: Immunology of term and preterm labor. Reprod Biol Endocrinol 2003; 1:122.
7. Lockwood CJ, Kuczynski E: Markers of risk for preterm delivery. J Perinat Med 1999; 27:5-20.
8. Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T, Mazor M: The preterm parturition syndrome. BJOG 2006; 113(Suppl 3):17-42.
9. Iams JD, Johnson FF, Sonek J, Sachs L, Gebauer C, Samuels P: Cervical competence as a continuum: a study of ultrasonographic cervical length and obstetric performance. Am J Obstet Gynecol 1995; 172:1097-1103. discussion 1104-1096.
10. Rust OA, Atlas RO, Jones KJ, Benham BN, Balducci J: A randomized trial of cerclage versus no cerclage among patients with ultrasonographically detected second-trimester preterm dilatation of the internal os. Am J Obstet Gynecol 2000; 183:830-835.
11. Keeler SM, Kiefer DG, Rust OA, Vintzileos A, Atlas RO, Bornstein E, Hanna N: Comprehensive amniotic fluid cytokine profile evaluation in women with a short cervix: which cytokine(s) correlates best with outcome? Am J Obstet Gynecol 2009; 201:276.e271-276.
12. Kiefer DG, Keeler SM, Rust O, Chow SS, Craig ME, Peltier MR, Vintzileos AM, Rawlinson WD, Hanna N: Amniotic fluid inflammatory score is associated with pregnancy outcome in patients with mid trimester short cervix. Am J Obstet Gynecol 2012; 206:68. e61-66.
13. Chow SS, Craig ME, Jones CA, Hall B, Catteau J, Lloyd AR, Rawlinson WD: Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection. Cytokine 2008; 44:78-84.
14. Kiefer D, Keeler M, Muscat J, Demishev M, Hanna N: Can non-invasive sampling determine the inflammatory status of the intra-uterine environment? Presented at the Society for Maternal-Fetal Medicine, San Francisco, CA Am J Obstet Gynecol 2011; 204:90.
15. Hanna N, Bonifacio L, Weinberger B, Reddy P, Murphy S, Romero R, Sharma S: Evidence for interleukin-10-mediated inhibition of cyclo- oxygenase-2 expression and prostaglandin production in preterm human placenta. Am J Reprod Immunol 2006; 55:19-27.
16. Severi FM, Bocchi C, Voltolini C, Borges LE, Florio P, Petraglia F: Thickness of fetal membranes: a possible ultrasound marker for preterm delivery. Ultrasound Obstet Gynecol 2008; 32:205-209.
17. Kiefer DG, Keeler SM, Rust OA, Wayock CP, Vintzileos AM, Hanna N: Is midtrimester short cervix a sign of intraamniotic inflammation? Am J Obstet Gynecol 2009; 200:374-e371.
18. Romero R, Yoon BH, Mazor M, Gomez R, Diamond MP, Kenney JS, Ramirez M, Fidel PL, Sorokin Y, Cotton D, Sehgal P: The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and gram stain in patients with preterm labor and intact membranes. Am J Obstet Gynecol 1993; 169:805-816.
19. Esplin MS, Peltier MR, Hamblin S, Smith S, Fausett MB, Dildy GA, Branch DW, Silver RM, Adashi EY: Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor. Placenta 2005; 26:661-671.