Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT 2C agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2560-2564

  Conway, Richard J ^a   Valant, Celine ^a   Christopoulos, Arthur ^a   Robertson, Alan D ^b,c   Capuano, Ben ^a   Crosby, Ian T ^a,d  

^a MONASH UNIVERSITY   (Australia)

^b Zenyth Therapeutics Limited Australia   (Australia)

^c Pharmaxis Ltd   (Australia)

^d LA TROBE UNIVERSITY   (Australia)

Author keywords

5 HT 2C agonists; Anti obesity; SAR; Synthesis

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 4 (2 CHLOROPHENYL) 1,2,3,6 TETRAHYDROPYRIDINE; 4 (3 CHLOROPHENYL) 1,2,3,6 TETRAHYDROPYRIDINE; 4 (3 TRIFLUOROMETHYLPHENYL) 1,2,3,6 TETRAHYDROPYRI DINE; 4 (3 TRIFLUOROMETHYLPHENYL)PIPERIDINE; 4 ARYL 1,2,3,6 TETRAHYDROPYRIDINE; 4 ARYLPIPERIDINE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 2C AGONIST; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG SYNTHESIS; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; APPETITE DEPRESSANTS; CALCIUM; ERGOLINES; HUMANS; KINETICS; PIPERIDINES; PROTEIN BINDING; PYRIDINES; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN 5-HT2 RECEPTOR AGONISTS; SEROTONIN ANTAGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858706017     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.122     Document Type: Article

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