Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N 1-methylnicotinamide in human blood vessels

Hypertension

Volumn 59, Issue 4, 2012, Pages 825-832

  Domagala, Teresa B ^a   Szeffler, Agata ^b   Dobrucki, Lawrence W ^c,d   Dropinski, Jerzy ^a   Polanski, Stanisław ^a   Leszczynska Wiloch, Magdalena ^b   Kotula Horowitz, Katarzyna ^a   Wojciechowski, Jacek ^b   Wojnowski, Leszek ^e   Szczeklik, Andrzej ^a   Kalinowski, Leszek ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

endothelial cells; endothelial nitric oxide synthase; flow mediated dilation; N 1 methylnicotinamide; nitric oxide; oxidized low density lipoprotein; superoxide

Indexed keywords

ACETYLCHOLINE; ARGININE; CALCIMYCIN; CALCIUM IONOPHORE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LOW DENSITY LIPOPROTEIN; N METHYLNICOTINAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PLACEBO;

ADULT; ARTICLE; ATHEROSCLEROSIS; BIOAVAILABILITY; BLOOD PRESSURE; BRACHIAL ARTERY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME RELEASE; ENZYME SYNTHESIS; HEART RATE; HUMAN; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; IN VIVO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; VASODILATATION;

ACETYLCHOLINE; ADULT; BRACHIAL ARTERY; CALCIMYCIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; HUMANS; HYPERCHOLESTEROLEMIA; NIACINAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; OXYGEN; VASODILATION;

EID: 84858702649     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.183210     Document Type: Article

References (16)

1. +homeostasis in man. Cell Mol Life Sci. 2004;61: 19-34.
2. Gebicki J, Sysa-Jedrzejowska A, Adamus J, Wozniacka A, Rybak M, Zielonka J. 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin. Pol J Pharmacol. 2003;55:109-112. (Pubitemid 36411126)
3. +), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. Br J Pharmacol. 2007;152: 230-239. (Pubitemid 47517607)
4. +) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats. Pharmacol Rep. 2008; 60:127-138. (Pubitemid 351586551)
5. Bryniarski K, Biedron R, Jakubowski A, Chlopicki S, Marcinkiewicz J. Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin. Eur J Pharmacol. 2008;578:332-338. (Pubitemid 350309577)
6. Mogielnicki A, Kramkowski K, Pietrzak L, Buczko W. N-Methylnicotinamide inhibits arterial thrombosis in hypertensive rats. J Physiol Pharmacol. 2007;58:515-527. (Pubitemid 47523094)
7. Kawashima S. The two faces of endothelial nitric oxide synthase in the pathophysiology of atherosclerosis. Endothelium. 2004;11:99-107. (Pubitemid 39207183)
8. Landmesser U, Hornig B, Drexler H. Endothelial function: a critical determinant in atherosclerosis?. Circulation. 2004;109:II27-II33. (Pubitemid 38724153)
9. Braam B, Verhaar MC. Understanding eNOS for pharmacological modulation of endothelial function: a translational view. Curr Pharm Des. 2007;13:1727-1740. (Pubitemid 46979711)
10. Dobrucki LW, Marsh BJ, Kalinowski L. Elucidating structure-function relationships from molecule-to-cell-to-tissue: from research modalities to clinical realities. J Physiol Pharmacol. 2009;60(suppl 4)83-93.
11. Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation. 2006;113:1708-1714.
12. Kalinowski L, Dobrucki IT, Malinski T. Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases. Circulation. 2004;109:2511-2517. (Pubitemid 38720549)
13. Kalinowski L, Matys T, Chabielska E, Buczko W, Malinski T. Angiotensin II AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide release. Hypertension. 2002;40:521-527.
14. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111-1115.
15. Musfeld C, Biollaz J, Belaz N, Kesselring UW, Decosterd LA. Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow. J Pharm Biomed Anal. 2001;24:391-404. (Pubitemid 32121965)
16. Hsyu PH, Gisclon LG, Hui AC, Giacomini KM. Interactions of organic anions with the organic cation transporter in renal BBMV. Am J Physiol. 1988;254:F56-F61.