Rapid screening of 18 nonsteroidal anti-inflammatory drugs (NSAIDs) using novel NAGINATA™ gas chromatography-mass spectrometry software

Forensic Toxicology

Volumn 30, Issue 1, 2012, Pages 11-18

  Nagamatsu, Kumi ^a,b   Kudo, Keiko ^a   Usumoto, Yosuke ^a   Tsuji, Akiko ^a   Nishi, Hiroyuki ^b   Ikeda, Noriaki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b YASUDA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Calibration locking database; GC MS; Mixed mode anion exchange column; NAGINATA; NSAIDs; Trimethylsilylation

Indexed keywords

DIAZEPAM; DICHLOROMETHANE; DICLOFENAC; ETODOLAC; FLUFENAMIC ACID; IBUPROFEN; INDOMETACIN; KETOPROFEN; LOXOPROFEN; MEFENAMIC ACID; N METHYL N (TRIMETHYLSILYL)TRIFLUOROACETAMIDE; NABUMETONE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OXAPROZIN; PARACETAMOL; PHENYLBUTAZONE; PRANOPROFEN; SALICYLAMIDE; SALICYLIC ACID; TIAPROFENIC ACID; TOLFENAMIC ACID; TRIFLUOROACETAMIDE DERIVATIVE; TRIMETHYLSILYL DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BLOOD ANALYSIS; CALIBRATION; CONTROLLED STUDY; DATA ANALYSIS; DATA ANALYSIS SOFTWARE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG RETENTION; DRUG SCREENING; DRUG STRUCTURE; HUMAN; MASS FRAGMENTOGRAPHY; MIXED MODE ANION EXCHANGE COLUMN EXTRACTION; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUALITATIVE RESEARCH; QUANTITATIVE STUDY; STANDARD;

EID: 84858699704     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-011-0121-6     Document Type: Article

References (16)

1. Maurer HH, Tauvel FX, Kreaemer T (2001) Screening procedure for detection of non-steroidal anti-inflammatory drugs and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry after extractive methylation. J Anal Toxicol 25:237-244 (Pubitemid 32466507)
2. Maurer HH (1999) Systematic toxicological analysis procedures for acidic drugs and/or metabolites relevant to clinical and forensic toxicology and/or doping control. J Chromatogr B 733:3-25
3. Farre M, Petrovic M, Barcelo D (2007) Recently developed GCMS and LC-MS methods for determining NSAIDs in water samples. Anal Bioanal Chem 387:1203-1214 (Pubitemid 46220405)
4. Ishida T, Kudo K, Naka S, Toubou K, Noguchi T, Ikeda N (2007) Rapid diagnosis of drug intoxication using novel NAGINATATM gas chromatography-mass spectrometry software. Rapid Commun Mass Spectrom 21:3129-3138 (Pubitemid 47401451)
5. Kudo K, Ishida T, Hikiji W, Hayashida M, Uekusa K, Usumoto Y, Tsuji A, Ikeda N (2009) Construction of calibration-locking databases for rapid and reliable drug screening by gas chromatography-mass spectrometry. Forensic Toxicol 27:21-31
6. Kudo K, Ishida T, Hikiji W, Usumoto Y, Umehara T, Nagamatsu K, Tsuji A, Ikeda N (2010) Pattern of poisoning in Japan: selection of drugs and poisons for systematic toxicological analysis. Forensic Toxicol 28:25-32
7. el Haj BM, al Ainri AM, Hassan MH, Bin Khadem RK, Marzouq MS (1999) The GC-MS analysis of some commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) in pharmaceutical dosage forms and in urine. Forensic Sci Int 105:141-153 (Pubitemid 29502179)
8. Adamowicz P, Kala M (2010) Simultaneous screening for and determination of 128 date-rape drugs in urine by gas chromatography-electron ionization-mass spectrometry. Forensic Sci Int 198:39-45
9. Thomas S, Sutton A, Garg U (2010) Quantitation of indomethacin in serum and plasma using gas chromatography-mass spectrometry (GC-MS). Methods Mol Biol 603:297-305
10. Gunnar T, Ariniemi K, Lillsunde P (2005) Determination of 14 benzodiazepines and hydroxyl metabolites, zaleplon and zolpidem as tert-butyldimethylsilyl derivatives compared with other common silylating reagents in whole blood by gas chromatography-mass spectrometry. J Chromatogr B 818:175-189 (Pubitemid 40331822)
11. Simonsen KW, Steentoft A, Buck M, Hansen L, Linnet K (2010) Screening and quantitative determination of twelve acidic and neutral pharmaceuticals in whole blood by liquid-liquid extraction and liquid chromatography-tandem mass spectrometry. J Anal Toxicol 34:367-373
12. http://www.waters.com/waters/nav.htm?cid=513209&locale=en- US. Accessed 15 Sept 2011
13. Laven M, Alsberg T, Yu Y, Adolfsson-Erici M, Sun H (2009) Serial mixed-mode cation- and anion-exchange solid-phase extraction for separation of basic, neutral and acidic pharmaceuticals in wastewater and analysis by high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. J Chromatogr A 1216:49-62
14. Suzuki Y, Nojima H, Kaneko T (2010) Determination of trazodone and its metabolites in human urine. In: Abstract of the 29th annual meeting of Japanese Association of Forensic Toxicology, p. 72-73 (Japanese with English summary)
15. Winek CL, Wahba WW, Winek CL Jr, Balzer TW (2001) Drug and chemical blood-level data 2001. Forensic Sci Int 122:107-123 (Pubitemid 32979233)
16. Schulz M, Schmoldt A (2003) Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmaize 58:447-474 (Pubitemid 36869876)