Phase II study evaluating the addition of cetuximab to the concurrent delivery of weekly carboplatin, paclitaxel, and daily radiotherapy for patients with locally advanced squamous cell carcinomas of the head and neck

International Journal of Radiation Oncology Biology Physics

Volumn 82, Issue 5, 2012, Pages 1845-1850

  Suntharalingam, Mohan ^a   Kwok, Young ^a   Goloubeva, Olga ^a   Parekh, Arti ^a   Taylor, Rodney ^a   Wolf, Jeffrey ^a   Zimrin, Ann ^a   Strome, Scott ^a   Ord, Robert ^a   Cullen, Kevin J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Chemoradiation; Concurrent cetuximab; Concurrent chemotherapy; Locally advanced head and neck cancer

Indexed keywords

CARBOPLATIN; CETUXIMAB; CHEMORADIATION; COMPLETE RESPONSE; CONCURRENT CHEMOTHERAPY; CONTROL RATES; DISEASE FREE SURVIVAL; EPIDERMAL GROWTH FACTOR RECEPTORS; HEAD AND NECK; HEAD-AND-NECK CANCER; LEUCOPENIA; LOCAL CONTROL; LOCAL RECURRENCE; MUCOSITIS; NEUTROPENIA; OROPHARYNGEAL; OVERALL SURVIVAL; PACLITAXEL; PHASE II; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TREATMENT BREAK;

CHEMOTHERAPY; RADIOTHERAPY;

DESIGN;

CARBOPLATIN; CETUXIMAB; DEXAMETHASONE; DIPHENHYDRAMINE; PACLITAXEL;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL ARTICLE; CONTINUOUS INFUSION; DEHYDRATION; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DYSPHAGIA; FEMALE; FEVER; FOLLOW UP; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; HYPOMAGNESEMIA; INTENSITY MODULATED RADIATION THERAPY; LEUKOPENIA; LOADING DRUG DOSE; MALE; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; OVERALL SURVIVAL; PATIENT COMPLIANCE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DERMATITIS; RADIATION DOSE; SQUAMOUS CELL CARCINOMA; THROMBOCYTOPENIA; TREATMENT RESPONSE; WART VIRUS; XEROSTOMIA;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AREA UNDER CURVE; CARBOPLATIN; CARCINOMA, SQUAMOUS CELL; CHEMORADIOTHERAPY; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HEAD AND NECK NEOPLASMS; HUMANS; HYPOPHARYNGEAL NEOPLASMS; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; OROPHARYNGEAL NEOPLASMS; PACLITAXEL; PAPILLOMAVIRIDAE; PROSPECTIVE STUDIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REMISSION INDUCTION;

EID: 84858699322     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.02.062     Document Type: Article

References (17)

1. Pignon JP, Bourhis J, Domenge C, et al. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data. MACH-NC collaborative group. metaanalysis of chemotherapy on head and neck cancer. Lancet 2000;355:949-955. (Pubitemid 30148259)
2. Pignon JP, le Maitre A, Maillard E, et al. Meta-Analysis of Chemotherapy in Head and Neck Cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiother Oncol 2009;92:4-14.
3. Calais G, Alfonsi M, Bardet E, et al. Randomized trial of radiation therapy vs. concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 1999;91:2081-2086. (Pubitemid 30019568)
4. Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349:2091-2098. (Pubitemid 37464533)
5. Suntharalingam M, Haas ML, Conley BA, et al. The use of carboplatin and paclitaxel with daily radiotherapy in patients with locally advanced squamous cell carcinomas of the head and neck. Int J Radiat Oncol Biol Phys 2000;47:49-56. (Pubitemid 30179676)
6. Milas L, Mason K, Hunter N, et al. In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res 2000;6:701-708. (Pubitemid 30111496)
7. Baselga J. The EGFR as a target for anticancer therapy-focus on cetuximab. Eur J Cancer 2001;37(Suppl 4):S16-S22. (Pubitemid 32938125)
8. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-Year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010;11:21-28.
9. Denis F, Garaud P, Bardet E, et al. Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol 2004;22:69-76. (Pubitemid 41095116)
10. Fu KK, Pajak TF, Trotti A, et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000;48:7-16. (Pubitemid 30488207)
11. Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24-35.
12. Milas L, Fan Z, Andratschke NH, et al. Epidermal growth factor receptor and tumor response to radiation: In vivo preclinical studies. Int J Radiat Oncol Biol Phys 2004;58:966-971. (Pubitemid 38221157)
13. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354:567-578. (Pubitemid 43209104)
14. Pfister DG, Su YB, Kraus DH, et al. Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: A pilot phase II study of a new combined-modality paradigm. J Clin Oncol 2006;24:1072-1078. (Pubitemid 46638804)
15. Birnbaum A, Dipetrillo T, Rathore R, et al. Cetuximab, paclitaxel, carboplatin, and radiation for head and neck cancer: A toxicity analysis. Am J Clin Oncol 2010;33:144-147.
16. D'Souza G, Kreimer AR, Viscidi R, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007;356:1944-1956. (Pubitemid 46740304)
17. Fakhry C,Westra WH, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008;100:261-269. (Pubitemid 351480538)