A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS

Analytical and Bioanalytical Chemistry

Volumn 402, Issue 6, 2012, Pages 2033-2042

  Watanabe, Ken Ichi ^a   Ishikawa, Chihiro ^a   Kuwahara, Hiroshi ^b   Sato, Kimihiko ^a   Komuro, Setsuko ^a   Nakagawa, Tetsuya ^a   Nomura, Naruaki ^a   Watanabe, Shiro ^c   Yabuki, Masashi ^a  

^a R and D Manufacturing Group   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Biomarker; Column switching LC MS MS; Quantification; Rat brain; Total A , A x 38, A x 40, and A x 42

Indexed keywords

ACCURACY AND PRECISION; ACCURATE ANALYSIS; BIOLOGICAL SAMPLES; COLUMN SWITCHING; FLURBIPROFEN; HIGH REPRODUCIBILITY; LC/MS/MS; LINEAR CALIBRATION; MOLECULAR SPECIES; ORAL ADMINISTRATION; QUANTIFICATION; RAT BRAIN; RECOVERY TEST; RELATIVE ERRORS; RELATIVE STANDARD DEVIATIONS; STANDARD ADDITION;

BIOMARKERS; DIALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEINS;

RATS;

AMYLOID BETA PROTEIN; FLURBIPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BRAIN; DRUG EFFECT; EVALUATION; LIQUID CHROMATOGRAPHY; MALE; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; RAT; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; CHROMATOGRAPHY, LIQUID; FLURBIPROFEN; MALE; MOLECULAR SEQUENCE DATA; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84858698669     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5648-1     Document Type: Article

References (29)

1. H Hampel Y Shen DM Walsh P Aisen LM Shaw H Zetterberg JQ Trojanowski K Blennow 2010 Biological markers of amyloid β-related mechanisms in Alzheimer's disease Exp Neurol 223 334 346 10.1016/j.expneurol.2009.09.024 1:CAS:528:DC%2BC3cXlsFShs7c%3D
2. A Gabelle S Roche C Gény K Bennys P Labauge Y Tholance I Quadrio L Tiers B Gor C Chaulet A Vighetto B Croisile P Krolak-Salmon J Touchon A Perret-Liaudet S Lehmann 2010 Correlations between soluble α/β forms of amyloid precursor protein and Aβ38, 40, and 42 in human cerebrospinal fluid Brain Res 1357 175 183 10.1016/j.brainres.2010.08.022 1:CAS:528: DC%2BC3cXht1Wht7%2FO
3. M Bibl P Lewczuk H Esselmann B Mollenhauer HW Klafki V Welge S Wolf C Trenkwalder M Otto J Kornhuber J Wiltfang 2008 CSF amyloid-β 1-38 and 1-42 in FTD and AD: biomarker performance critically depends on the detergent accessible fraction Proteomics Clin Appl 2 1548 1556 10.1002/prca.200800006 1:CAS:528:DC%2BD1cXht1ymtL7E
4. M Bibl B Mollenhauer P Lewczuk H Esselmann S Wolf M Otto J Kornhuber E Rüther J Wiltfang 2011 Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias Dement Geriatr Cogn Disord 31 37 44 10.1159/000322370 1:CAS:528:DC%2BC3MXhtlSmt7c%3D
5. TA Lanz JB Schachter 2006 Demonstration of a common artifact in immunosorbent assays of brain extracts: development of a solid-phase extraction protocol to enable measurement of amyloid-beta from wild-type rodent brain J Neurosci Methods 157 71 81 10.1016/j.jneumeth.2006.03.023 1:CAS:528: DC%2BD28Xoslyrs7s%3D (Pubitemid 44308360)
6. JD Best MT Jay F Otu J Ma A Nadin S Ellis HD Lewis C Pattison M Reilly T Harrison MS Shearman TL Williamson JR Atack 2005 Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5- difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6, 7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide] J Pharmacol Exp Ther 313 902 908 10.1124/jpet.104.081174 1:CAS:528:DC%2BD2MXktFemt74%3D (Pubitemid 40604194)
7. A Jablonowska M Bakun A Kupniewska-Kozak M Dadlez 2004 Alzheimer's disease Abeta peptide fragment 10-30 forms a spectrum of metastable oligomers with marked preference for N to N and C to C monomer termini proximity J Mol Biol 344 1037 1049 10.1016/j.jmb.2004.09.083 1:CAS:528:DC%2BD2cXpslWmsbc%3D (Pubitemid 39491248)
8. YM Kuo TA Kokjohn W Kalback D Luehrs DR Galasko N Chevallier EH Koo MR Emmerling AE Roher 2000 Amyloid-beta peptides interact with plasma proteins and erythrocytes: implications for their quantitation in plasma Biochem Biophys Res Commun 268 750 756 10.1006/bbrc.2000.2222 1:CAS:528:DC%2BD3cXhtFGisLg%3D (Pubitemid 30150863)
9. JR Slemmon CL Painter S Nadanaciva F Catana A Cook R Motter P Seubert 2007 Distribution of Abeta peptide in whole blood J Chromatogr B Anal Technol Biomed Life Sci 846 24 31 10.1016/j.jchromb.2006.08.003 1:CAS:528: DC%2BD2sXhtVKgsLY%3D (Pubitemid 46149484)
10. Y Du R Dodel H Hampel K Buerger S Lin B Eastwood K Bales F Gao HJ Moeller W Oertel M Farlow S Paul 2001 Reduced levels of amyloid beta-peptide antibody in Alzheimer disease Neurology 57 801 805 1:CAS:528:DC%2BD3MXntFGksbc%3D (Pubitemid 32845498)
11. S Mruthinti JJ Buccafusco WD Hill JL Waller TW Jackson EY Zamrini RF Schade 2004 Autoimmunity in Alzheimer's disease: increased levels of circulating IgGs binding Abeta and RAGE peptides Neurobiol Aging 25 1023 1032 10.1016/j.neurobiolaging.2003.11.001 1:CAS:528:DC%2BD2cXltVGjtbY%3D (Pubitemid 38798064)
12. TA Lanz MJ Karmilowicz KM Wood N Pozdnyakov P Du MA Piotrowski TM Brown CE Nolan KE Richter JE Finley Q Fei CF Ebbinghaus YL Chen DK Spracklin B Tate KF Geoghegan LF Lau DD Auperin JB Schachter 2006 Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor LY-450139 J Pharmacol Exp Ther 319 924 933 10.1124/jpet.106.110700 1:CAS:528:DC%2BD28XhtFOkurnN
13. T Oe BL Ackermann K Inoue MJ Berna CO Garner V Gelfanova RA Dean ER Siemers DM Holtzman MR Farlow IA Blair 2006 Quantitative analysis of Amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry Rapid Commun Mass Spectrom 20 23 35 10.1002/rcm.2787 (Pubitemid 44935325)
14. RJ Bateman ER Siemers KG Mawuenyega G Wen KR Browning WC Sigurdson KE Yarasheski SW Friedrich RB Demattos PC May SM Paul DM Holtzman 2009 A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system Ann Neurol 66 48 54 10.1002/ana.21623 1:CAS:528: DC%2BD1MXhtFWju7fM
15. ME Lame EE Chambers M Blatnik 2011 Quantitation of amyloid beta peptides Aβ(1-38), Aβ(1-40), and Aβ(1-42) in human cerebrospinal fluid by ultra-performance liquid chromatography-tandem mass spectrometry Anal Biochem 419 133 139 10.1016/j.ab.2011.08.010 1:CAS:528:DC%2BC3MXhtlejtLnK
16. J Kamiie S Ohtsuki R Iwase K Ohmine Y Katsukura K Yanai Y Sekine Y Uchida S Ito T Terasaki 2008 Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria Pharm Res 25 1469 1483 10.1007/s11095-008-9532-4 1:CAS:528:DC%2BD1cXltFCjsLs%3D
17. H Kawakami S Ohtsuki J Kamiie T Suzuki T Abe T Terasaki 2011 Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection J Pharm Sci 100 341 352 10.1002/jps.22255 1:CAS:528:DC%2BC3cXhsFegtr7P
18. WB Stine Jr KN Dahlgren GA Krafft MJ LaDu 2003 In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis J Biol Chem 278 11612 11622 10.1074/jbc.M210207200 1:CAS:528:DC%2BD3sXit1Kgtbs%3D (Pubitemid 36792723)
19. M Jemal A Schuster DB Whigan 2003 Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine: method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of a stable isotope analog internal standard Rapid Commun Mass Spectrom 17 1723 1734 10.1002/rcm.1112 1:CAS:528:DC%2BD3sXlvFSit70%3D (Pubitemid 36916982)
20. W Li LH Cohen 2003 Quantitation of endogenous analytes in biofluid without a true blank matrix Anal Chem 75 5854 5859 10.1021/ac034505u 1:CAS:528:DC%2BD3sXnsFens7w%3D (Pubitemid 37356467)
21. N Sergeant S Bombois A Ghestem H Drobecq V Kostanjevecki C Missiaen A Wattez JP David E Vanmechelen C Sergheraert A Delacourte 2003 Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach J Neurochem 85 1581 1591 10.1046/j.1471-4159.2003. 01818.x 1:CAS:528:DC%2BD3sXkslOktbs%3D (Pubitemid 36702570)
22. K Watanabe T Segawa K Nakamura M Kodaka T Konakahara H Okuno 2001 Identification of the molecular interaction site of amyloid beta peptide by using a fluorescence assay J Pept Res 58 342 346 10.1034/j.1399-3011.2001.00920. x 1:CAS:528:DC%2BD3MXnvFSgtr8%3D (Pubitemid 32989227)
23. LO Tjernberg A Tjernberg N Bark Y Shi BP Ruzsicska Z Bu J Thyberg DJ Callaway 2002 Assembling amyloid fibrils from designed structures containing a significant amyloid β-peptide Biochem J 366 343 351 1:CAS:528: DC%2BD3sXptFOhtbw%3D (Pubitemid 34971835)
24. Heinig K, Wirz T, Yuan M, Tingler M, Mylott W (2011) An improved LC-MS/MS method for the determination of taspoglutide in plasma and urine using orthogonal HILIC-RP column switching, ultra-performance LC separation and 'wrong-way-round' electrospray ionization. Biomed Chromatogr. doi: 10.1002/bmc.1593
25. Y Kita T Takahashi N Uozumi T Shimizu 2005 A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry Anal Biochem 342 134 143 10.1016/j.ab.2005.03.048 1:CAS:528:DC%2BD2MXlt1Gktr0%3D (Pubitemid 40805637)
26. G Mitulovic C Stingl I Steinmacher O Hudecz JR Hutchins JM Peters K Mechtler 2009 Preventing carryover of peptides and proteins in nano LC-MS separations Anal Chem 81 5955 5960 10.1021/ac900696m 1:CAS:528: DC%2BD1MXnsVOmsb4%3D
27. S Leuchtenberger D Beher S Weggen 2006 Selective modulation of Abeta42 production in Alzheimer's disease: non-steroidal anti-inflammatory drugs and beyond Curr Pharm Des 12 4337 4355 10.2174/138161206778793029 1:CAS:528:DC%2BD28Xht1GntrbO (Pubitemid 44718293)
28. JL Eriksen SA Sagi TE Smith S Weggen P Das DC McLendon VV Ozols KW Jessing KH Zavitz EH Koo TE Golde 2003 NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo J Clin Invest 112 440 449 1:CAS:528:DC%2BD3sXmtFemtrY%3D (Pubitemid 38063773)
29. MZ Kounnas AM Danks S Cheng C Tyree E Ackerman X Zhang K Ahn P Nguyen D Comer L Mao C Yu D Pleynet PJ Digregorio G Velicelebi KA Stauderman WT Comer WC Mobley YM Li SS Sisodia RE Tanzi SL Wagner 2010 Modulation of g-secretase reduces β-amyloid deposition in a transgenic mouse model of Alzheimer's disease Neuron 67 769 780 10.1016/j.neuron.2010.08.018 1:CAS:528: DC%2BC3cXhtFamtb%2FI