Acute altitude illnesses

BMJ (Online)

Volumn 343, Issue 7820, 2011, Pages

  Imray, Chris ^a   Booth, Adam ^b   Wright, Alex ^c   Bradwell, Arthur ^c  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b Jiggins Lane Medical Centre ^*  (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; ALDOSTERONE SYNTHASE; CARBONATE DEHYDRATASE; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE; GINKGO BILOBA EXTRACT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IBUPROFEN; NIFEDIPINE; NITRIC OXIDE SYNTHASE; PARACETAMOL; PLACEBO; SALMETEROL; SILDENAFIL; TADALAFIL;

ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; ANALGESIA; ARTERIAL OXYGEN SATURATION; ATAXIA; BRAIN EDEMA; CLINICAL FEATURE; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE COURSE; DISEASE SEVERITY; DIURESIS; DIZZINESS; DOSE RESPONSE; DROWSINESS; DRUG CONTRAINDICATION; DRUG HYPERSENSITIVITY; DRUG MECHANISM; ENVIRONMENTAL IMPACT; ENZYME INHIBITION; ENZYME POLYMORPHISM; EXERCISE TOLERANCE; FATIGUE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HEADACHE; HIGH ALTITUDE BRAIN EDEMA; HIGH ALTITUDE EDEMA; HIGH ALTITUDE HEADACHE; HIGH ALTITUDE LUNG EDEMA; HIGH RISK POPULATION; HUMAN; LOADING DRUG DOSE; LUNG EDEMA; MENTAL CAPACITY; MENTAL DEFICIENCY; MENTAL HEALTH; MONOTHERAPY; NAUSEA; OBESITY; OBSERVATIONAL STUDY; OXYGEN THERAPY; OXYGENATION; PARESTHESIA; PATHOGENESIS; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT; SIDE EFFECT; SLEEP DISORDER; STUPOR; TASTE DISORDER; TREATMENT OUTCOME; URINE VOLUME; VOMITING;

ACCLIMATIZATION; ACUTE DISEASE; ALTITUDE; ALTITUDE SICKNESS; BRAIN EDEMA; HEADACHE DISORDERS; HUMANS; MOUNTAINEERING; OXYGEN; PARTIAL PRESSURE; PULMONARY EDEMA;

EID: 84858689949     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.d4943     Document Type: Review

References (35)

1. Pollard A., Murdoch D. The high altitude medicine handbook. 3rd ed. Radcliffe Publishing, 2003.
2. Grocott M.P., Martin D.S., Levett D.Z., McMorrow R., Windsor J., Montgomery H.E. Arterial blood gases and oxygen content in climbers on Mount Everest. N Engl J Med 2009;360:140-149
3. Wilson M.H., Newman S., Imray C.H. The cerebral effects of ascent to high altitude. Lancet Neurology 2009;8:175-191
4. Peacock A.J. Oxygen at high altitude. BMJ 1998;317:1063-1066
5. Imray C., Wright A., Subudhi A., Roach R. Acute mountain sickness; pathophysiology, prevention, and treatment. Prog Cardiovasc Dis 2010;52:467-484
6. Wilson M.H., Mark Edsell M., Davagnanam I., Hirani S.P., Martin D., Levett D.Z.H., et al. Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia - an ultrasound and MRI study. J Cereb Blood Flow Metab 2011, published online 8 June.
7. Maggirorini M. Prevention and treatment of high-altitude pulmonary edema. Prog Cardiovasc Dis 2010;52:500-506
8. MacInnis M.J., Wang P., Koehle M.S., Rupert J.L. The genetics of altitude tolerance: The evidence for inherited susceptibility to acute mountain sickness. J Occup Env Med 2011;53:159-168
9. Karinen H.M., Peltonen J.E., Kahonen M., Tikhanen H.O. Prediction of acute mountain sickness by monitoring arterial oxygen saturation during ascent. High Alt Med Biol 2010;11:325-332
10. Moraga F.A., Pederos C.P., Rodriguez C.E. Acute mountain sickness in children and their parents after rapid ascent to 3500 m (Putre, Chile). Wilderness Environ Med 2008;19:287-292
11. Ri-Li G., Chase P.J., Witkowski S., Wyrick B.L., Stone J.A., Levine B.D., Babb T.G. Obesity: Associations with acute mountain sickness. Ann Intern Med 2003;139:253-257
12. Burtscher M., Szubski C., Faulhaber M. Prediction of the susceptibility to AMS in simulated altitude. Sleep Breathing 2008;12:103-108
13. Singh I., Khanna P.K., Srivastava M.C., Lal M., Roy S.B., Subramanyam C.S. Acute mountain sickness. N Engl J Med 1969;280:175-218.
14. Hackett P.H., Rennie I.D., Levine H.D. The incidence, importance, and prophylaxis of acute mountain sickness. Lancet 1976;2:1149-1154
15. Subudhi A., Panerai R., Roach R.: Effects of hypobaric hypoxia on cerebral autoregulation. Stroke 2010;41:641-646
16. Roach R.C., Bärtsch P., Oelz O., Hachett P., Lake Louise AMS Scoring Consensus Committee. The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Houston CS, Coates G, eds. Hypoxia and molecular medicine. Queen City Press, 1993; 272-274
17. Southard A., Niermeyer S., Yaron M. Language used in the Lake Louise scoring system under estimates symptoms of acute mountain sickness in 4- to 11-old children. High Alt Med Biol 2007;8:124-130 (Pubitemid 47001199)
18. Wagner D.R., Tatsugawa K., Parker D., Young T.A. Reliability and utility of a visual analog scale for the assessment of acute mountain sickenss. High Alt Med Biol 2007;8:27-31. (Pubitemid 46587445)
19. Medex. Travel at high altitude. www.medex.org.uk/v26%20booklet.pdf.
20. Hackett P., Roach R.C.: High-altitude illness. N Engl J Med 2001;345:107-114 (Pubitemid 32634570)
21. Forster P.J. Effect of different ascent profiles on performance at 4200 m elevation. Aviat Space Environ Med 1985;56:758-764 (Pubitemid 15047741)
22. Wu T.Y., Ding S.Q., Liu J.L., Yu M.T., Jia J.H., Duan J.Q., et al. Reduced incidence and severity of acute mountain sickness in Qinghai-Tibet railroad construction workers after repeated 7-month exposures despite 5-month low altitude periods. High Alt Med Biol 2009;10:221-232
23. Beidleman B.A., Muza S.R., Fulco C.S., Cymerman A., Ditzler D., Stulz D., et al. Intermittent altitude exposures reduce acute mountain sickness at 4300 m. Clin Sci (Lond) 2004;106:321-328 (Pubitemid 38365840)
24. Fulco C.S., Muza S.R., Beidleman B., Jones J., Staab J., Rock P.B., Cymerman A. Exercise performance of sea-level residents at 4300 m after 6 days at 2200 m. Aviat Space Environ Med 2009;80:955-961
25. Beidleman B.A., Fulco C.S., Muza S.R., Rock P.B., Staab J.E., Forte V.A., et al. Effect of six days of staging on physiologic adjustments and acute mountain sickness during ascent to 4300 meters. High Alt Med Biol 2009;10:253-260
26. Schommer K., Weisegart N., Menold E., Haas U., Lahr K., Buhl H., et al. Training in normobaric hypoxia and its effects on acute mountain sickness after rapid ascent to 4559m. High Alt Med Biol 2010;11:19-25.
27. Ried L.D., Carter K.A., Ellsworth A.: Acetazolamide or dexamethasone for prevention of acute mountain sickness: A meta-analysis. J Wilderness Med 1994;5:34-48. (Pubitemid 24156615)
28. Dumont L., Mardirosoff C., Tramer M. Efficacy and harm of pharmacological prevention of acute mountain sickness: Quantitative systematic review. BMJ 2000;321:267-272 (Pubitemid 30487464)
29. Johnson T.S., Rock P.B., Fulco C.S., Trad L.A., Spark R.F., Maher J.T.Prevention of acute mountain sickness by dexamethasone. N Engl J Med 1984;310:683-686 (Pubitemid 14164643)
30. Leadbetter G., Keyes L.E., Maakestad K.M., Olson S., Tissot van Patot M.C., Hackett P.H. Ginkgo biloba does - and does not - prevent acute mountain sickness. Wilderness Environ Med 2009;20:66-71.
31. Bernhard W.N., Schalick L.M., Delaney P.A., Bernhard T.M., Barnas G.M. Acetazolamide plus low-dose dexamethasone is better than acetazolamide alone to ameliorate symptoms of acute mountain sickness. Aviat Space Environ Med 1998;69:883-886
32. H-R Keller, M. Maggiorini, P. Bartsch, O. Oelz. Simulated descent v dexamethasone in treatment of acute mountain sickness: A randomised trial. BMJ 1995;13:1232-1235
33. West J.B.: The Qinghai-Tibet railway. High Alt Med Biol 2008;9:1-2.
34. West J.B. Improving oxygenation at high altitude: Acclimatisation and O2 enrichment. High Alt Med Biol 2003;4:389-398 (Pubitemid 37259243)
35. Ross R.T. The random nature of cerebral mountain sickness. Lancet 1985;1:990-991 (Pubitemid 15124002)