Observation of two modes of inhibition of human microsomal prostaglandin e synthase 1 by the cyclopentenone 15-deoxy-δ 12,14-prostaglandin J 2

Biochemistry

Volumn 51, Issue 11, 2012, Pages 2348-2356

  Prage, Edward B ^a   Morgenstern, Ralf ^b   Jakobsson, Per Johan ^b   Stec, Donald F ^a   Voehler, Markus W ^a   Armstrong, Richard N ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; COVALENT MODIFICATIONS; CYCLOPENTENONES; DEGRADATION PRODUCTS; GLUTATHIONES; H/D EXCHANGE; ISOPROSTANES; MICROSOMAL PROSTAGLANDIN; MPGES-1; NATIVE ENZYMES; NATURALLY OCCURRING; NONCOVALENT; NONCOVALENT BINDING; PROSTAGLANDINE; REGIOCHEMISTRY; SELECTIVE CONTROL; SPONTANEOUS REACTIONS; SYNTHASES;

AMIDES; BINDING ENERGY; DEGRADATION; MASS SPECTROMETRY; PEPTIDES; REACTION KINETICS; STEREOCHEMISTRY;

ENZYME INHIBITION;

CYCLOPENTENONE 15 DEOXY DELTA 12,14 PROSTAGLANDIN J2; GLUTATHIONE; GLUTATHIONE SULFONATE; ISOPROSTANE; PROSTAGLANDIN E SYNTHASE 1; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; DRUG BINDING; DRUG BINDING SITE; ENZYME INHIBITION; PRIORITY JOURNAL; STEREOCHEMISTRY;

ANTI-INFLAMMATORY AGENTS; BINDING SITES; GLUTATHIONE; HUMANS; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; MASS SPECTROMETRY; MICROSOMES; PROSTAGLANDIN D2;

EID: 84858674451     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2019332     Document Type: Article

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