A simple and efficient synthesis of new substituted benzothienopyridazine spiro- derivatives of pyrazolone, pyrimidinone and diazepinone

Journal of Chemical and Pharmaceutical Research

Volumn 3, Issue 6, 2011, Pages 222-228

  Faty, Rasha A M ^a   Gaafar, Alaa M ^b   Youssef, Ayman M S ^c  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c FAYOUM UNIVERSITY   (Egypt)

Author keywords

Benzothienopyrida zinepyrazolone; Benzothienopyridazine; Benzothienopyridazinepyrimidinone and benzothienopyridazine diazepinone; Benzothiophene; Spiro

Indexed keywords

BENZOTHIENOPYRIDA-ZINEPYRAZOLONE; BENZOTHIENOPYRIDAZINE; BENZOTHIENOPYRIDAZINEPYRIMIDINONE AND BENZOTHIENOPYRIDAZINE-DIAZEPINONE; BENZOTHIOPHENE; SPIRO;

ACETONE; CARBOXYLATION; HYDRATES; THIOUREAS;

THIOPHENE;

ACETIC ACID DERIVATIVE; ACETYLACETONE; ALCOHOL; BENZOTHIENOPYRIDAZINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CHEMICAL COMPOUND; DIAZEPINONE DERIVATIVE; ETHOXIDE SODIUM; ETHYL 2 AMINO 4,5,6,7 TETRAHYDROBENZO[B]THIOPHENE 3 CARBOXYLATE; ETHYLCYANOACETATE; ETHYLENEDIAMINE; HYDRAZINE; MALONONITRILE; PYRAZOLONE DERIVATIVE; PYRIDAZINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; SPIRO DERIVATIVE; THIOUREA; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL PROCEDURES; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING;

EID: 84858672055     PISSN: None     EISSN: 09757384     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. CJF Bichard; EP Mitchell; MR Wormald; KA Waston; LN Johnson; SE Zographos; DD Koutra; NG Oikonomakos; GW Fleet, Tetrahedron Lett., 1995, 36, 2145.
2. N Siddiqui; P Ahuja; W Ahsan; SN Pandeya; MS Alam, J. Chem.Pharm.Res., 2009, 1 (1), 19-30.
3. F Risitano; G Grassi; F Foti; G Bruno; A Rotondo, Heterocycles, 2003, 60, 857.
4. V Nair; KV Radhakrishnan; KC Sheela; NP Rath, Tetrahedron, 1999, 55, 14199.
5. KC Liu; RK Howe, J. Org. Chem., 1983, 48, 4590.
6. T Ichiba; PJ Scheuer, J. Org. Chem., 1993, 58, 4149.
7. C Lacy; PJ Scheuer, J. Nat. Prod., 2000, 63, 119.
8. H Kumar; RP Chaudhary, J.Chem. Pharm. Res., 2010, 2 (3), 667-672.
9. RAM Faty; HAR Hussein; AMS Youssef, phosphorus, sulfur, and silicon, 2010,185,1484-1490.
10. AMS Youssef; RAM Faty; MM Youssef, J. of the Korean chemical Society, 2001, 45(5), 448-453.
11. RE Dolle; B Le Bourdonnec; AJ Goodman; GA Morales; JM Salvino; W Zhang, J. Comb. Chem., 2007, 9, 855.
12. JA Gonzalez-Vera; T Garcia-Lopez; R Herranz, J.Org. Chem., 2005,70, 3660.
13. C Ramalingan; S Balasubramanian; S Kabilan, Synth. Commun., 2004, 4, 1105-1116.
14. S Sharma; DN Prasad; RK Singh, J. Chem.Pharm.Res., 2011, 3(5):382-389.
15. LH Strenbach, J. Med. Chem., 1979, 22, 1.
16. ES Gewald; H Bottcher, Ber., 1966, 99, 94.