A phase II study of a paclitaxel-based chemoradiation regimen with selective surgical salvage for resectable locoregionally advanced esophageal cancer: Initial reporting of RTOG 0246

International Journal of Radiation Oncology Biology Physics

Volumn 82, Issue 5, 2012, Pages 1967-1972

  Swisher, Stephen G ^a   Winter, Kathryn A ^b   Komaki, Ritsuko U ^a   Ajani, Jaffer A ^a   Wu, Tsung T ^c   Hofstetter, Wayne L ^a   Konski, Andre A ^d   Willett, Christopher G ^e  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b RADIATION THERAPY ONCOLOGY GROUP   (United States)

^c MAYO CLINIC   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chemoradiation; Chemotherapy; Esophageal cancer; Radiation therapy; Salvage surgery

Indexed keywords

5-FLUOROURACIL (5-FU); CHEMORADIATION; CIS-PLATIN; CONCURRENT CHEMORADIATION; CONFIDENCE INTERVAL; ESOPHAGEAL CANCER; INDUCTION CHEMOTHERAPY; NONHEMATOLOGIC TOXICITY; PACLITAXEL; PHASE II; RADIATION THERAPY ONCOLOGY GROUPS; SALVAGE SURGERY; SURGICAL RESECTION; SURVIVAL RATE; SYSTEMIC DISEASE;

CHEMOTHERAPY; DISEASES; PLATINUM COMPOUNDS; RADIOTHERAPY; SURGERY;

CHEMORADIOTHERAPY;

CISPLATIN; FLUOROURACIL; PACLITAXEL; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADENOCARCINOMA; ADULT; ADVANCED CANCER; AGED; ALLERGY; ANASTOMOSIS LEAKAGE; ARTICLE; BLEEDING; BONE MARROW TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER EPIDEMIOLOGY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CARDIOVASCULAR DISEASE; CHEMORADIOTHERAPY; CLINICAL ARTICLE; CONTINUOUS INFUSION; ESOPHAGUS CANCER; ESOPHAGUS RESECTION; FEBRILE NEUTROPENIA; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HEARING DISORDER; HEART ARRHYTHMIA; HISTOLOGY; HUMAN; INDUCTION CHEMOTHERAPY; LIVER TOXICITY; LYMPHATIC SYSTEM DISEASE; MALE; METABOLIC DISORDER; MULTIPLE CYCLE TREATMENT; MULTIPLE ORGAN FAILURE; MUSCULOSKELETAL DISEASE; PAIN; PNEUMONIA; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; SKIN TOXICITY; SURVIVAL RATE; THROMBOSIS; TREATMENT DURATION; UROGENITAL TRACT DISEASE; VISUAL DISORDER;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CHEMORADIOTHERAPY; CISPLATIN; ESOPHAGEAL NEOPLASMS; FEMALE; FLUOROURACIL; HUMANS; INDUCTION CHEMOTHERAPY; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASM, RESIDUAL; PACLITAXEL; RADIOTHERAPY DOSAGE; SALVAGE THERAPY; SURVIVAL RATE;

EID: 84858666937     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.01.043     Document Type: Article

References (18)

1. Cooper JS, Guo MD, Herskovic A, et al. Chemoradiotherapy of locally advanced esophageal cancer: Long-term follow-up of a prospective randomized trial (RTOG 85-01). JAMA 1999;281:1623-1626.
2. Minsky BD, Neuberg D, Kelsen DP, et al. Neoadjuvant Chemotherapy Plus Concurrent Chemotherapy and High-Dose Radiation for Squamous Cell Carcinoma of the Esophagus: A Preliminary Analysis of the Phase II Intergroup Trial 0122. J Clin Oncol 1996;14:149-155. (Pubitemid 26020007)
3. Minsky BD, Pajak TF, Ginsberg RJ, et al. INT 0123 (Radiation Therapy Oncology Group 94-05) Phase III Trial of Combined-Modality Therapy for Esophageal Cancer: High-Dose Versus Standard-Dose Radiation Therapy. J Clin Oncol 2001;20:1167-1174. (Pubitemid 34177421)
4. Herskovic A, Martz K, Al-Sarraf M, et al. Combined Chemotherapy and Radiotherapy Compared with Radiotherapy Alone in Patients with Cancer of the Esophagus. N Engl J Med 1992;326:1593-1598.
5. Kaplan EL, Meier P. Non-parameteric estimation from in complete observations. J Am Stat Assoc 1958;53:457-481.
6. Ajani JA, Komaki R, Putnam JB, et al. A Three-Step Strategy of Induction Chemotherapy Then Chemoradiation Followed by Surgery in Patients with Potentially Resectable Carcinoma of the Esophagus or Gastroesophageal Junction. Cancer 2001;92:279-286. (Pubitemid 32664433)
7. Ajani JA, Winter K, Komaki R, et al. Phase II Randomized Trial of Two Nonoperative Regimens of Induction Chemotherapy Followed by Chemoradiation in Patients with Localized Carcinoma of the Esophagus: RTOG 0113. J Clin Oncol 2008;26:1-6.
8. Bedenne L, Michel P, Bouche O, et al. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol 2007;23:1160-1168. (Pubitemid 46640561)
9. Stahl M, Stuschke M, Lehmann N, et al. Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol 2005;23:2310-2317. (Pubitemid 46218723)
10. Swisher SG,Wynn P, Putnam JB, et al. Salvage esophagectomy for recurrent tumors after definitive chemotherapy and radiotherapy. J Thorac Cardiovasc Surg 2001;123:175-183.
11. Yang Q, Cleary KR, Yao JC, et al. Significance of post-chemoradiation biopsy in predicting residual esophageal carcinoma in the surgical specimen. Dis Esophagus 2004;17:38-43. (Pubitemid 38807874)
12. Beseth BD, Bedford R, Isacoff WH, et al. Endopscopic ultrasound does not accurate assess pathologic stage of esophageal cancer after neoadjuvant chemoradiotherapy. Am Surg 2000;66:827-831. (Pubitemid 30666925)
13. Jones DR, Parker LA, Detterbeck FC, et al. Inadequacy of computed tomography in assessing patients with esophageal carcinoma after induction chemoradiotherapy. Cancer 1999;85:1026-1032. (Pubitemid 29115579)
14. Swisher SG, Maish M, Erasmus JJ, et al. Utility of PET, CT, and EUS to identify pathologic responders in esophageal cancer. Ann Thorac Surg 2004;78:1152-1160. (Pubitemid 39303827)
15. Erasmus JJ, Munden RF, Truong MT, et al. Preoperative chemo-radiation-induced ulceration in patients with esophageal cancer: a confounding factor in tumor response assessment in integrated computed tomographic-positron emission tomographic imaging. J Thorac Oncol 2006;1:478-486. (Pubitemid 47181426)
16. Urba SG, Orringer MB, Turrisi A, et al. Randomized Trial of Preoperative Chemoradiation Versus Surgery Alone in Patients With Locoregional Esophageal Carcinoma. J Clin Oncol 2001;19:305-313. (Pubitemid 32112841)
17. Kelsen DP, Ginsberg R, Pajak TF, et al. Chemotherapy Followed by Surgery Compared with Surgery Alone for Localized Esophageal Cancer. N Engl J Med 1998;339:1979-1984. (Pubitemid 29024130)
18. Kelsen DP, Winter KA, Gunderson LL, et al. Long-Term Results of RTOG Trial 8911 (USA Intergroup 113): A Random Assignment Trial Comparison of Chemotherapy Followed by Surgery Compared with Surgery Alone for Esophageal Cancer. J Clin Oncol 2007;25:3719-3725. (Pubitemid 47372613)