Supercritical fluid chromatographic resolution of water soluble isomeric carboxyl/amine terminated peptides facilitated via mobile phase water and ion pair formation

Journal of Chromatography A

Volumn 1233, Issue , 2012, Pages 85-90

  Patel, M A ^a   Riley, F ^a   Ashraf Khorassani, M ^b   Taylor, L T ^b  

^a PFIZER INC   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Evaporative light scattering; Isomers; Mass spectrometry; Peptides; Supercritical fluid chromatography

Indexed keywords

AMINE SALTS; AMMONIUM ACETATE; ANALYTES; BARE SILICA; BONDED SILICA; CHIRAL SEPARATIONS; CHROMATOGRAPHIC RESOLUTIONS; EVAPORATIVE LIGHT SCATTERING; EVAPORATIVE LIGHT SCATTERING DETECTION; HIGH PURITY; ION PAIR FORMATION; ION PAIRING; ION PAIRS; MASS SPECTROMETRIC DETECTION; MOBILE PHASE; MOBILE-PHASE COMPOSITION; PACKED COLUMN; PEPTIDE PAIRS; RETENTION MECHANISM; STATIONARY PHASIS; SUPERCRITICAL FLUID CHROMATOGRAPHY; TRIFLUOROACETIC ACIDS; WATERSOLUBLE;

AMINO ACIDS; AMMONIUM COMPOUNDS; CHIRALITY; EFFLUENT TREATMENT; GAS CHROMATOGRAPHY; ISOMERS; LIGHT SCATTERING; MASS SPECTROMETRY; PEPTIDES; SILICA; SUPERCRITICAL FLUIDS;

SEPARATION;

2 ETHYLPYRIDINE; AMMONIUM ACETATE; PEPTIDE; PYRIDINE DERIVATIVE; SILICON DIOXIDE; SODIUM CHLORIDE; SULFONATE; SULFUR DERIVATIVE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; WATER;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ION PAIR CHROMATOGRAPHY; LIGHT SCATTERING; MASS SPECTROMETRY; PHASE SEPARATION; PRIORITY JOURNAL; SEPARATION TECHNIQUE; SOLUBILITY; SUPERCRITICAL FLUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, SUPERCRITICAL FLUID; ISOMERISM; PEPTIDES; SOLUBILITY; WATER;

EID: 84858623980     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.02.024     Document Type: Article

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