The genetics of breast and ovarian cancer iii: A new model of family history with insurance applications

Scandinavian Actuarial Journal

Volumn 2006, Issue 6, 2006, Pages 338-367

  Hock Gui, Eng ^a   Lu, Baopeng ^a   Macdonald, Angus ^a   Waters, Howard ^a   Wekwete, Chessman ^a  

^a NONE   (United States)

Author keywords

BRCA1 gene; BRCA2 gene; Breast cancer; Critical illness insurance; Family history; Life insurance; Ovarian cancer

Indexed keywords

EID: 84858605753     PISSN: 03461238     EISSN: 16512030     Source Type: Journal    
DOI: 10.1080/03461230601026635     Document Type: Article

References (25)

1. Anglian Breast Cancer Study Group and Pharoah, P. (2000). Prevalence and penetrance of BRCA1 and BRCA2 in a population based series of breast cancer cases. British Journal of Cancer 83, 1301-1308.
2. Antoniou, A. C., Gayther, S. A., Stratton, J. F., Ponder, B. J. & Easton, D. F. (2000). Risk models for familial breast and ovarian cancer. Genetic Epidemiology 18, 173-190.
3. Antoniou, A. C., Pharoah, P. P. D., Mcmullan, G., Day, N. E., Stratton, M. R., Peto, J., Ponder, B. J. & Easton, D. F. (2002). A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. British Journal of Cancer 86, 76-83.
4. Antoniou, A. C., Pharoah, P. P. D., Narod, S., Risch, H. A., Eyfjord, J. E., Hopper, J. L., Loman, N., Olsson, H., Johannsson, O., Borg, A., Pasini, B., Radice, P., Manoukian, S., Eccles, D. M., Tang, N., Olah, E., Anton-Culver, H., Warner, E., Lubinski, J., Gronwald, J., Gorski, B., Tulinius, H., Thorlacius, S., Eerola, H., Nevanlinna, H., Syrjäkoski, K., Kallioniemi, O.-P., Thompson, D., Evans, C., Peto, J., Lalloo, F., Evans, D. G. & Easton, D. F. (2003). Average risks of breast and ovarian cancer associated with mutations in BRCA1 or BRCA2 detected in case series unselected for family history: A combined analysis of 22 studies. American Journal of Human Genetics 72, 1117-1130.
5. Claus, E. B., Risch, N. J. & Thompson, W. D. (1994). Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction. Cancer 73, 643-651.
6. Claus, E. B., Schildkraut, J. M., Thompson, W. D. & Risch, N. J. (1996). The genetic attributable risk of breast and ovarian cancer. Cancer 77, 2318-2324.
7. Coleman, M., Babb, P., Damiecki, P., Grosclaude, P. C., Honjo, S., Jones, J., Knerer, G., Pitard, A., Quinn, M. J., Sloggett, A. & De Stavola, B. L. (1999). Cancer survival trends for England and Wales, 1971-1995: Deprivation and NHS Region. Office of National Statistics, London.
8. Dinani, A., Grimshaw, D., Robjohns, N., Somerville, A. S. & Staffurth, J. (2000). A critical review: report of the critical illness healthcare study group. Presented to the Staple Inn Actuarial Society, London, on 14 March 2000.
9. Easton, D. F., Ford, D. & Bishop, D. T. (1995). Breast and ovarian cancer incidence in BRCA1-mutation carriers. American Journal of Human Genetics 56, 265-271.
10. Easton, D. F., Steele, L., Fields, P., Ormiston, W., Averill, D., Daly, P. A., McManus, R., Neuhausen, S. L., Ford, D., Wooster, R., Cannon-Albright, L. A., Stratton, M. R. & Goldgar, D. E. (1997). Cancer risks in two large breast cancer families linked to BRCA2 on chromosome 13q12-13. American Journal of Human Genetics 61, 120-128.
11. Ford, D., Easton, D. F., Bishop, D. T., Narod, S. A. & Goldgar, D. E. (1994). Risks of cancer in BRCA1 mutation carriers. The Lancet 343, 692-695.
12. Ford, D. & Easton, D. F. (1995). The genetics of breast and ovarian cancer. British Journal of Cancer 72, 805-812.
13. Ford, D., Easton, D. F., Stratton, M., Narod, S., Goldgar, D., Devilee, P., Bishop, D. T., Weber, B., Lenoir, G., Chang-Claude, J., Sobol, H., Teare, M. D., Struewing, J., Arason, A., Scherneck, S., Peto, J., Rebbeck, T. R., Tonin, P., Neuhausen, S., Barkardottir, R., Eyfjord, J., Lynch, H., Ponder, B. A., Gayther, S. A., Zelada-Hedman, M. and The Breast Cancer Linkage Consortium (1998). Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. American Journal of Human Genetics, 62, 676-89.
14. Futreal, P. A., Liu, Q., Shattuck-Eldens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L. M., Haugen-Strano, A., Swensen, J. & Miki, Y. (1994). BRCA1 mutations in primary breast and ovarian carcinomas. Science 266, 120-122.
15. Gutiérrez, M. C. & Macdonald, A. S. (2004). Huntington’s disease, critical illness insurance and life insurance. Scandinavian Actuarial Journal 2004, 279-313.
16. Houlston, R. S., Collins, A., Slack, J., Campbell, S., Collins, W. P., Whitehead, M. I. & Morton, N. E. (1991). Genetic epidemiology of ovarian cancer: segregation analysis. Annals of Human Genetics 55, 291-299.
17. Macdonald, A. S. (1999). Modelling the impact of genetics on insurance. North American Actuarial Journal 3 (1), 83-101.
18. Macdonald, A. S. (2003). Genetics and insurance: what we have learned so far? Scandinavian Actuarial Journal 2003, 324-348.
19. Macdonald, A. S., Waters, H. R. & Wekwete, C. T. (2003a). The genetics of breast and ovarian cancer I: A model of family history. Scandinavian Actuarial Journal 2003, 1-27.
20. Macdonald, A. S., Waters, H. R. & Wekwete, C. T. (2003b). The genetics of breast and ovarian cancer II: A model of critical illness insurance. Scandinavian Actuarial Journal 2003, 28-50.
21. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C., Hattier, T., Phelps, R., Haugenstrano, A., Katcher, H., Yakomo, K., Gholami, Z., Shaffer, D., Stone, S., Bayer, S., Wray, C., Bogden, R., Dayananth, P., Ward, J., Tonin, P., Narod, S., Bristow, P. K., Norris, F. H., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, J. C., Lewis, C., Neuhausen, S., Cannonalbright, L., Goldgar, D., Wiseman, R., Kamb, A. & Skolnick, M. H. (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 61-71.
22. Parmigiani, G., Berry, D. & Aguilar, O. (1998). Determining carrier probabilities for breast cancer susceptibility genes BRCA1 and BRCA2. American Journal of Human Genetics 62, 145-158.
23. Souhami, T. & Tobias, J. (1998). Cancer and its management. Blackwell Science. 3rd edition.
24. Subramanian, K., Lemaire, J., Hershey, J. C., Pauly, M. V., Armstrong, K. & Asch, D. A. (1999). Estimating adverse selection costs from genetic testing for breast and ovarian cancer: The case of life insurance. Journal of Risk and Insurance 66, 531-550.
25. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C. & Micklem, G. (1995). Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-792.