Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Garrido Sánchez, Lourdes ^a   García Fuentes, Eduardo ^b,c   Fernández García, Diego ^c,d   Escoté, Xavier ^a   Alcaide, Juan ^b,d   Perez Martinez, Pablo ^c,e   Vendrell, Joan ^a   Tinahones, Francisco J ^c,d  

^a HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^b Hospital University Carlos Haya de Málaga   (Spain)

^c Instituto de Salud Carlos III   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^e HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; GLUCOSE; INSULIN; TRIACYLGLYCEROL; ARABIDOPSIS PROTEIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; MARNERAL SYNTHASE, ARABIDOPSIS; MUTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SEMINAL PLASMA PROTEIN; ZN ALPHA 2 GLYCOPROTEIN; ZN-ALPHA-2-GLYCOPROTEIN;

ADIPOSE TISSUE; ADULT; ARTICLE; ATGL GENE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE LOCATION; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; IRS 1 GENE; IRS 2 GENE; LIPID METABOLISM; LIPOLYSIS; MALE; MARKER GENE; MORBID OBESITY; NUCLEOTIDE SEQUENCE; PPARGAMMA GENE; PROTEIN BLOOD LEVEL; QUANTITATIVE STUDY; TISSUE DISTRIBUTION; TRIACYLGLYCEROL BLOOD LEVEL; ZAG GENE; BIOSYNTHESIS; CLINICAL TRIAL; GENE EXPRESSION REGULATION; INTRAABDOMINAL FAT; METABOLISM; MIDDLE AGED; PATHOLOGY; SUBCUTANEOUS FAT;

ADULT; ARABIDOPSIS PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; INTRAMOLECULAR TRANSFERASES; LIPOLYSIS; MALE; MIDDLE AGED; OBESITY, MORBID; PPAR GAMMA; SEMINAL PLASMA PROTEINS; SUBCUTANEOUS FAT;

EID: 84858593956     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033264     Document Type: Article

References (34)

1. Libby P, Ridker PM, Maseri A, (2002) Inflammation and atherosclerosis. Circulation 105: 1135-43 Review.
2. Trayhurn P, Beattie JH, (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 60: 329-39 Review.
3. Guerre-Millo M, (2002) Adipose tissue hormones. J Endocrinol Invest 25: 855-61.
4. Hu E, Liang P, Spiegelman BM, (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271: 10697-10703.
5. Tada T, Ohkubo I, Niwa M, Sasaki M, Tateyama H, et al. (1991) Immunohistochemical localization of Zn-α2-glycoprotein in normal human tissues. J Histochem Cytochem 39: 1221-1226.
6. Bao Y, Bing C, Hunter L, Jenkins JR, Wabitsch M, et al. (2005) Zinc-α2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes. FEBS Lett 579: 41-47.
7. Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, et al. (2010) The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity. Clin Endocrinol (Oxf) 72: 334-41.
8. Bing C, Bao Y, Jenkins J, Sanders P, Manieri M, et al. (2004) Zinc-α2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci USA 101: 2500-2505.
9. Tzanavari T, Bing C, Trayhurn P, (2007) Postnatal expression of zinc-alpha2-glycoprotein in rat white and brown adipose tissue. Mol Cell Endocrinol 279: 26-33.
10. Hirai K, Hussey HJ, Barber MD, Price SA, Tisdale MJ, (1998) Biological evaluation of a lipid mobilizing factor isolated from the urine of cancer patients. Cancer Res 58: 2359-2365.
11. Todorov PT, McDevitt TM, Meyer DJ, Ueyama H, Ohkubo I, et al. (1998) Purification and characterization of a tumor lipid-mobilizing factor. Cancer Res 58: 2353-8.
12. Marrades MP, Martínez JA, Moreno-Aliaga MJ, (2008) ZAG, a lipid mobilizing adipokine, is downregulated in human obesity. J Physiol Biochem 64: 61-66.
13. Rolli V, Radosavljevic M, Astier V, Macquin C, Castan-Laurell I, et al. (2007) Lipolysis is altered in MHC class 1 zinc-alpha-2-glycoprotein deficient mice. FEBS Lett 581: 394-400.
14. Gong FY, Zhang SJ, Deng JY, Zhu HJ, Pan H, et al. (2009) Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue. Int J Obes (Lond) 33: 1023-30.
15. Russell ST, Zimmerman TP, Domin BA, Tisdale MJ, (2004) Induction of lipolysis in vitro and loss of body fat in vivo by zinc-α2-glycoprotein. Biochim Biophys Acta 1636: 59-68.
16. Russell ST, Tisdale MJ, (2005) The role of glucocorticoids in the induction of zinc-alpha2-glycoprotein expression in adipose tissue in cancer cachexia. Br J Cancer 92: 876-81.
17. Russell ST, Hirai K, Tisdale MJ, (2002) Role of β3-adrenergic receptors in the action of a tumour lipid mobilizing factor. Br J Cancer 86: 424-428.
18. Tinahones FJ, Garrido-Sanchez L, Miranda M, García-Almeida JM, Macias-Gonzalez M, et al. (2010) Obesity and insulin resistance-related changes in the expression of lipogenic and lipolytic genes in morbidly obese subjects. Obes Surg 20: 1559-67.
19. Selva DM, Lecube A, Hernández C, Baena JA, Fort JM, et al. (2009) Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance. J Clin Endocrinol Metab 94: 4499-507.
20. Ballantyne GH, Gumbs A, Modlin IM, (2005) Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin. Obes Surg 15: 692-9 Review.
21. Gohda T, Makita Y, Shike T, Tanimoto M, Funabiki K, et al. (2003) Identification of epistatic interaction involved in obesity using the KK/Ta mouse as a type 2 diabetes model: is Zn-α2 glycoprotein-1 a candidate gene for obesity?. Diabetes 52: 2175-2181.
22. Stejskal D, Karpisek M, Reutova H, Stejskal P, Kotolova H, et al. (2008) Determination of serum zinc-alpha-2-glycoprotein in patients with metabolic syndrome by a new ELISA. Clin Biochem 41: 313-316.
23. Ceperuelo-Mallafré V, Naf S, Escoté X, Caubet E, Gomez JM, et al. (2009) Circulating and Adipose Tissue Gene Expression of Zinc-α2-Glycoprotein in Obesity: Its Relationship with Adipokine and Lipolytic Gene Markers in Subcutaneous and Visceral Fat. J Clin Endocrinol Metab 94: 5062-9.
24. Dahlman I, Kaaman M, Olsson T, Tan GD, Bickerton AS, et al. (2005) A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects. J Clin Endocrinol Metab 90: 5834-40.
25. White MF, Kahn CR, (1994) The insulin signaling system. J Biol Chem 269: 1-4.
26. Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, Lauro R, (2001) Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J 15: 2099-2111.
27. Smith U, (2002) Impaired ('diabetic') insulin signaling and action occur in fat cells long before glucose intolerance-is insulin resistance initiated in the adipose tissue?. Int J Obes Relat Metab Disord 26: 897-904.
28. Barbarroja N, López-Pedrera R, Mayas MD, García-Fuentes E, Garrido-Sánchez L, et al. (2010) The obese healthy paradox: is inflammation the answer?. Biochem J 430: 141-9.
29. Garcia-Fuentes E, Murri M, Garrido-Sanchez L, Garcia-Serrano S, García-Almeida JM, et al. (2010) PPARγ expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons. Obesity (Silver Spring) 18: 952-8.
30. Large V, Arner P, (1998) Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes, and hyperlipidaemia. Diabetes Metab 24: 409-18.
31. Bing C, Russell ST, Beckett EE, Collins P, Taylor S, et al. (2002) Expression of uncoupling proteins-1,-2 and-3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor. Br J Cancer 86: 612-8.
32. Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, et al. (2006) Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312: 734-7.
33. Bing C, Trayhurn P, (2008) Regulation of adipose tissue metabolism in cancer cachexia. Curr Opin Clin Nutr Metab Care 11: 201-7 Review.
34. Garrido-Sánchez Lourdes, Vendrell Joan, Fernández-García Diego, Ceperuelo-Mallafré Victoria, Chacón MatildeR, et al. (2012) De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. PLoS One (In press).