Synergistic interaction between baclofen administration into the median raphe nucleus and inconsequential visual stimuli on investigatory behavior of rats

Psychopharmacology

Volumn 220, Issue 1, 2012, Pages 15-25

  Vollrath Smith, Fiori R ^a   Shin, Rick ^a   Ikemoto, Satoshi ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Baclofen; Dopamine; GABA B receptors; Incentive motivation; Median and dorsal raphe nuclei; Sensation seeking; Serotonin; Visual stimuli

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 5,5 DIMETHYL 2 MORPHOLINEACETIC ACID; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BACLOFEN; DOPAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; DORSAL RAPHE NUCLEUS; DRIVE; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; HYPERACTIVITY; LOCOMOTION; MALE; MEDIAN RAPHE NUCLEUS; MOTIVATION; NONHUMAN; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REWARD; STIMULUS RESPONSE; VISUAL DISCRIMINATION; VISUAL STIMULATION;

ANIMALS; BACLOFEN; BEHAVIOR, ANIMAL; BENZAZEPINES; DOPAMINE; EXPLORATORY BEHAVIOR; GABA-B RECEPTOR AGONISTS; MALE; MORPHOLINES; MOTIVATION; MOTOR ACTIVITY; PHOTIC STIMULATION; RAPHE NUCLEI; RATS; RATS, WISTAR; REWARD; SELF ADMINISTRATION;

EID: 84858440361     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2450-x     Document Type: Article

References (39)

1. Abellán MT, Jolas T, Aghajanian GK, Artigas F (2000) Dual control of dorsal raphe serotonergic neurons by GABA(B) receptors. Electrophysiological and microdialysis studies. Synapse 36:21-34 (Pubitemid 30134122)
2. Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning or incentive salience? Brian Res Rev 28:309-369 (Pubitemid 29012677)
3. Chaudhri N, Caggiula AR, Donny EC, Palmatier MI, Liu X, Sved AF (2006) Complex interactions between nicotine and nonpharmaco-logical stimuli reveal multiple roles for nicotine in reinforcement. Psychopharmacology 184:353-366 (Pubitemid 43255852)
4. Daw ND, Kakade S, Dayan P (2002) Opponent interactions between serotonin and dopamine. Neural Netw 15:603-616 (Pubitemid 34951146)
5. Deakin JFW (1983) Roles of serotonergic systems in escape, avoidance and other behaviour. In: Cooper SJ (ed) Theory in psychopharmacology. Academic, London, pp 149-193
6. Donny EC, Chaudhri N, Caggiula AR, Evans-Martin FF, Booth S, Gharib MA, Clements LA, Sved AF (2003) Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement. Psychopharmacology 169:68-76 (Pubitemid 37088616)
7. Evans KR, Vaccarino FJ (1990) Amphetamine- and morphine-induced feeding: evidence for involvement of reward mechanisms. Neurosci Biobehav Rev 14:9-22 (Pubitemid 20115609)
8. Fletcher PJ (1995) Effects of d-fenfluramine and metergoline on responding for conditioned reward and the response potentiating effect of nucleus accumbens d-amphetamine. Psychopharmacology 118:155-163
9. Fletcher P (1996) Injection of 5-HT into the nucleus accumbens reduces the effects of d-amphetamine on responding for conditioned reward. Psychopharmacology 126:62-69 (Pubitemid 26238500)
10. Fletcher PJ, Korth KM (1999) RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors. Behav Pharmacol 10:183-193 (Pubitemid 29150038)
11. Fletcher PJ, Korth KM, Chambers JW (1999) Selective destruction of brain serotonin neurons by 5,7-dihydroxytryptamine increases responding for a conditioned reward. Psychopharmacology 147:291-299 (Pubitemid 30010550)
12. Fray PJ, Sahakian BJ, Robbins TW, Koob GF, Iversen SD (1980) An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine. Psychopharmacology 69:253-259 (Pubitemid 10045691)
13. Ikemoto S (2007) Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev 56:27-78 (Pubitemid 350110353)
14. Ikemoto S (2010) Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory. Neurosci Biobehav Rev 35:129-150
15. Ikemoto S, Panksepp J (1999) The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking. Brain Res Rev 31:6-41 (Pubitemid 30009611)
16. Ikemoto S, Sharpe LG (2001) A head-attachable device for injecting nanoliter volumes of drug solutions into brain sites of freely moving rats. J Neurosci Methods 110:135-140 (Pubitemid 32846547)
17. Kapur S, Remington G (1996) Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psych 153:466-476 (Pubitemid 26113309)
18. Kelley AE, Delfs JM (1991) Dopamine and conditioned reinforcement. I. Differential effects of amphetamine microinjections into striatal subregions. Psychopharmacology 103:187-196
19. Kelley AE, Winnock M, Stinus L (1986) Amphetamine, apomorphine and investigatory behavior in the rat: analysis of the structure and pattern of responses. Psychopharmacology 88:66-74 (Pubitemid 16147783)
20. Kelley AE, Gauthier AM, Lang CG (1989) Amphetamine microinjections into distinct striatal subregions cause dissociable effects on motor and ingestive behavior. Behav Brain Res 35:27-39
21. Kish GB (1966) Studies of sensory reinforcement. In: Honing WK (ed) Operant behavior: areas of research and application. Appleton-Century-Crofts, New York pp, 109-159
22. Le AD, Funk D, Harding S, Juzytsch W, Li Z, Fletcher PJ (2008) Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward. Psychopharmacology 195:605-615 (Pubitemid 50002455)
23. Liu ZH, Ikemoto S (2007) The midbrain raphe nuclei mediate primary reinforcement via GABA(A) receptors. Eur J Neurosci 25:735-743
24. McDonald JH (2009) Handbook of biological statistics, 2nd edn. Sparky House, Baltimore
25. Mineur Y, Abizaid A, Rao Y, Salas R, DiLeone R, Gndisch D, Diano S, De Biasi M, Horvath T, Gao X-B, Picciotto M (2011) Nicotine decreases food intake through activation of POMC neurons. Science 332:1330-1332
26. Palmatier M, Evans-Martin F, Hoffman A, Caggiula A, Chaudhri N, Donny E, Liu X, Booth S, Gharib M, Craven L, Sved A (2006) Dissociating the primary reinforcing and reinforcement-enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcers. Psycho-pharmacology 184:391-400 (Pubitemid 43255855)
27. Panksepp J (1998) Affective neuroscience: the foundations of human and animal emotions. Oxford University Press, New York
28. Paxinos G, Watson C (2005) The rat brain in stereotaxic coordinates, 5th edn. Elsevier, Burlington
29. Sanger DJ (1987) The actions of SCH 23390, a D1 receptor antagonist, on operant and avoidance behavior in rats. Pharmacol Biochem Behav 26:509-513 (Pubitemid 17047722)
30. Shim I, Javaid J, Wirtshafter D (1997) Dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus. Behav Brain Res 89:191-198 (Pubitemid 28062710)
31. Shin R, Ikemoto S (2010) The GABA(B) receptor agonist baclofen administered into the median and dorsal raphe nuclei is rewarding as shown by intracranial self-administration and conditioned place preference in rats. Psychopharmacology 208:545-554
32. Shin R, Cao J, Webb SM, Ikemoto S (2010) Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats. PLoS One 5: e8741
33. Stewart J (1960) Reinforcing effects of light as a function of intensity and reinforcement schedule. J Comp Physiol Psychol 53:187-193
34. Takahashi A, Shimamoto A, Boyson CO, DeBold JF, Miczek KA (2010) GABAB receptor modulation of serotonin neurons in the dorsal raphe nucleus and escalation of aggression in mice. J Neurosci 30:11771-11780
35. Taylor JR, Robbins TW (1984) Enhanced behavioral control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens. Psychopharmacology 84:405-412 (Pubitemid 15205970)
36. Taylor JR, Robbins TW (1986) 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine. Psychopharmacology 90:390-397 (Pubitemid 16022477)
37. Varga V, Sik A, Freund TF, Kocsis B (2002) GABA(B) receptors in the median raphe nucleus: distribution and role in the serotonergic control of hippocampal activity. Neuroscience 109:119-132 (Pubitemid 34088151)
38. Wirtshafter D, Sheppard AC (2001) Localization of GABAB receptors in midbrain monoamine containing neurons in the rat. Brain Res Bull 56:1-5 (Pubitemid 32962931)
39. Wirtshafter D, Stratford TR, Pitzer MR (1993) Studies on the behavioral activation produced by stimulation of GABAB receptors in the median raphe nucleus. Behav Brain Res 59:83-93