Single embryo transfer with comprehensive chromosome screening Results in improved ongoing pregnancy rates and decreased miscarriage rates

Human Reproduction

Volumn 27, Issue 4, 2012, Pages 1217-1222

  Forman, E J ^a,b   Tao, X ^a   Ferry, K M ^a   Taylor, D ^a,b,c   Treff, N R ^a,b,c   Scott, R T ^a,b  

^a REPRODUCTIVE MEDICINE ASSOCIATES OF NEW JERSEY   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

comprehensive chromosome screening; IVF; multiple gestation; pregnancy rate; single embryo transfer

Indexed keywords

ADULT; ANEUPLOIDY; ARTICLE; BIRTH WEIGHT; BLASTOCYST; CHROMOSOME ANALYSIS; COMPREHENSIVE CHROMOSOME SCREENING; CONTROLLED STUDY; DELIVERY; ECTODERM; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; GENETIC SCREENING; GESTATIONAL AGE; GROUPS BY AGE; HUMAN; HUMAN TISSUE; INFERTILITY; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MONOZYGOTIC TWINS; OBSTETRIC OPERATION; PREGNANCY RATE; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; SPONTANEOUS ABORTION; TREATMENT OUTCOME; TROPHECTODERM BIOPSY;

EID: 84858411892     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des020     Document Type: Article

References (29)

1. Bettio D, Venci A, Levi Setti PE. Chromosomal abnormalities in miscarriages after different assisted reproduction procedures. Placenta 2008;29(Suppl. B):126-128.
2. Bromer JG, Ata B, Seli M, Lockwood CJ, Seli E. Preterm deliveries that result from multiple pregnancies associated with assisted reproductive technologies in the USA: a cost analysis. Curr Opin Obstet Gynecol 2011;23:168-173.
3. Centers for Disease Control and Prevention. National Summary Report: Assisted Reproductive Technology (ART) Report, Atlanta: U.S. Department of Health and Human Services, 2009.
4. Davis LB, Lathi RB, Westphal LM, Milki AA. Elective single blastocyst transfer in women older than 35. Fertil Steril 2008;89:230-231.
5. Fritz MA. Perspectives on the efficacy and indications for preimplantation genetic screening: where are we now? Hum Reprod 2008;23:2617-2621.
6. Gardner DK, Schoolcraft WB. In vitro culture of human blastocysts. In: Jansen R, Mortimer D (eds). Towards Reproductive Certainty: Infertility and Genetics Beyond. Carnforth: Parthenon Press, 1999.
7. Jansen RP, Bowman MC, de Boer KA, Leigh DA, Lieberman DB, McArthur SJ. What next for preimplantation genetic screening (PGS)? Experience with blastocyst biopsy and testing for aneuploidy. Hum Reprod 2008;23:1476-1478.
8. Jungheim ES, Ryan GL, Levens ED, Cunningham AF, Macones GA, Carson KR, Beltsos AN, Odem RR. Embryo transfer practices in the United States: a survey of clinics registered with the Society for Assisted Reproductive Technology. Fertil Steril 2010;94:1432-1436.
9. Nasseri A, Mukherjee T, Grifo JA, Noyes N, Krey L, Copperman AB. Elevated day 3 serum follicle stimulating hormone and/or estradiol may predict fetal aneuploidy. Fertil Steril 1999;71:715-718.
10. Pandian Z, Bhattacharya S, Ozturk O, Serour G, Templeton A. Number of embryos for transfer following in-vitro fertilisation or intra-cytoplasmic sperm injection. Cochrane Database Syst Rev (Online) 2009;2:CD003416.
11. Papanikolaou EG, Camus M, Kolibianakis EM, Van Landuyt L, Van Steirteghem A, Devroey P. In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. N Engl J Med 2006;354:1139-1146.
12. Practice Committee of the Society for Assisted Reproductive Technology and Practice Committee of the American Society for Reproductive Medicine. Preimplantation genetic testing: a Practice Committee opinion. Fertil Steril 2007;88:1497-1504.
13. Practice Committee of the Society for Assisted Reproductive Technology and Practice Committee of the American Society for Reproductive Medicine. Guidelines on number of embryos transferred. Fertil Steril 2009;92:1518-1519.
14. Reddy UM, Wapner RJ, Rebar RW, Tasca RJ. Infertility, assisted reproductive technology, and adverse pregnancy outcomes: executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol 2007;109:967-977.
15. Ryan GL, Sparks AE, Sipe CS, Syrop CH, Dokras A, Van Voorhis BJ. A mandatory single blastocyst transfer policy with educational campaign in a United States IVF program reduces multiple gestation rates without sacrificing pregnancy rates. Fertil Steril 2007;88:354-360.
16. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. NatProtocols 2008;3:1101-1108.
17. Schoolcraft WB, Fragouli E, Stevens J, Munne S, Katz-Jaffe M, Wells D. Clinical application of comprehensive chromosomal screening at the blastocyst stage. Fertil Steril 2010;94:1700-1706.
18. Schoolcraft WB, Treff NR, Stevens JM, Ferry K, Katz-Jaffe M, Scott RT Jr. Live birth outcome with trophectoderm biopsy, blastocyst vitrification, and single-nucleotide polymorphism microarray-based comprehensive chromosome screening in infertile patients. Fertil Steril 2011; 96:638-640.
19. Scott RT Jr, Treff NR. Assessing the reproductive competence of individual embryos: a proposal for the validation of new '-omics' technologies. Fertil Steril 2010;94:791-794.
20. Scott RT Jr, Miller KA, Olivares R, Su J, Fratterelli J, Treff NR. Microarray based 24 chromosome preimplantation genetic diagnosis (mPGD) is highly predictive of the reproductive potential of human embryos:a prospective blinded non-selection trial. Fertil Steril 2008;90:22.
21. Scott KL, Taylor D, Ferry KM, Treff NR, Scott RT Jr. Characterizing the relationship between morphologic embryonic development and ploidy status as assessed by 24 chromosome microarray PGD. Fertil Steril 2010a;94:S122-S123.
22. Scott RT Jr, Tao X, Taylor D, Ferry K, Treff N. A prospective randomized controlled trial demonstrating significantly increased clinical pregnancy rates following 24 chromosome aneuploidy screening: biopsy and analysis on day 5 with fresh transfer. Fertil Steril 2010b;94:S2.
23. Staessen C, VerpoestW, Donoso P, Haentjens P, Van der Elst J, Liebaers I, Devroey P. Preimplantation genetic screening does not improve delivery rate in women under the age of 36 following single-embryo transfer. Hum Reprod 2008;23:2818-2825.
24. Thurin A, Hausken J, Hillensjo T, Jablonowska B, Pinborg A, Strandell A, Bergh C. Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization. N Engl J Med 2004;351: 2392-2402.
25. Treff N, Su J, Tao X, Miller K, Scott RT Jr. First IVF babies born after rapid 24 chromosome embryo aneuploidy screening and fresh embryo transfer. Fertil Steril 2009a;92:S49.
26. Treff NR, Su J, Tao X, Miller KA, Levy B, Scott RT Jr. A novel single-cell DNA fingerprinting method successfully distinguishes sibling human embryos. Fertil Steril 2009b;94:477-484.
27. Treff NR, Su J, Tao X, Levy B, Scott RT Jr. Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays. Fertil Steril 2010; 94:2017-2021.
28. Treff NR, Tao X, Ferry KM, Su J, Taylor D, Scott RT. Development and validation of an accurate quantitative real-time PCR based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Fertil Steril 2012 (in press).
29. Verberg MF, Eijkemans MJ, Heijnen EM, Broekmans FJ, de Klerk C, Fauser BC, Macklon NS. Why do couples drop-out from IVF treatment? A prospective cohort study. Hum Reprod 2008; 23:2050-2055.