Anxiolytic effects of repeated treatment with an essential oil from Lippia alba and (R)-(-)-carvone in the elevated T-maze

Brazilian Journal of Medical and Biological Research

Volumn 45, Issue 3, 2012, Pages 238-243

  Hatano, V Y ^a   Torricelli, A S ^a   Giassi, A C C ^b   Coslope, L A ^c   Viana, M B ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF OTTAWA   (Canada)

^c NONE   (Brazil)

Author keywords

Anxiety; Carvone; Elevated T maze; Essential oil; Lippia alba

Indexed keywords

CARVONE; DIAZEPAM; ESSENTIAL OIL; LIPPIA ALBA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; DRUG EFFECT; GENERALIZED ANXIETY DISORDER; MALE; MAZE TEST; MENTAL DISEASE; MOUSE; NONHUMAN; PANIC; RAT; REPEATED DRUG DOSE; TRANQUILIZING ACTIVITY;

LIPPIA ALBA; RATTUS NORVEGICUS; VERBENACEAE;

EID: 84858379247     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2012007500021     Document Type: Article

References (20)

1. Hennebelle T, Sahpaz S, Joseph H, Bailleul F. Ethnopharmacology of Lippia alba. J Ethnopharmacol 2008; 116: 211-222.
2. Pino Alea JA, Ortega Luis AG, Rosado Pérez A, Rodríguez Jorge M, Baluja R. Composición y propriedades antibacterianas del aceite esencial de Lippia alba. Rev Cubana Farm 1998; 30: 0-10.
3. Holetz FB, Pessini GL, Sanches NR, Cortez DA, Nakamura CV, Filho BP. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 2002; 97: 1027-1031.
4. Abad MJ, Bermejo P, Villar A, Sanchez Palomino S, Carrasco L. Antiviral activity of medicinal plant extracts. Phytother Res 1997; 11: 198-202.
5. Matos FJA, Machado MIL, Craveiro AA, Alencar JW. Essential oil composition of two chemotypes of Lippia alba grown in Northeast Brazil. J Essent Oil Res 1996; 8: 695-698.
6. Vale TG, Matos FJ, de Lima TC, Viana GS. Behavioral effects of essential oils from Lippia alba (Mill.) N.E. Brown chemotypes. J Ethnopharmacol 1999; 67: 127-133.
7. do Vale TG, Furtado EC, Santos JG Jr, Viana GS. Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) N.E. Brown. Phytomedicine 2002; 9: 709-714.
8. Handley SL, McBlane JW. 5HT drugs in animal models of anxiety. Psychopharmacology 1993; 112: 13-20.
9. Rodgers RJ, Dalvi A. Anxiety, defence and the elevated plusmaze. Neurosci Biobehav Rev 1997; 21: 801-810.
10. Graeff FG, Zangrossi H Jr. Animal models of anxiety. In: D'Haenen D, Den Boer JA, Willner P (Editors), Biological psychiatry. London: John Wiley & Sons; 2002. p 1-15.
11. Viana MB, Tomaz C, Graeff FG. The elevated T-maze: a new animal model of anxiety and memory. Pharmacol Biochem Behav 1994; 49: 549-554.
12. Graeff FG, Netto CF, Zangrossi H Jr. The elevated T-maze as an experimental model of anxiety. Neurosci Biobehav Rev 1998; 23: 237-246.
13. Teixeira RC, Zangrossi H, Graeff FG. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol Biochem Behav 2000; 65: 571-576.
14. Poltronieri SC, Zangrossi H Jr, de Barros V. Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. Behav Brain Res 2003; 147: 185-192.
15. Nutt D. Anxiety and its therapy: Today and tomorrow. In: Briley M, File S (Editors), New concepts in anxiety. London: MacMillan Press; 1991. p 1-12.
16. de Sousa DP, de Farias Nobrega FF, de Almeida RN. Influence of the chirality of (R)-(-)-and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 2007; 19: 264-268.
17. Sena LM, Bueno C, Pobbe RL, Andrade TG, Zangrossi H Jr, Viana MB. The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats. Behav Brain Res 2003; 142: 125-133.
18. Mora S, Díaz-Veliz G, Millan R, Lungenstrass H, Quiros S, Coto-Morales T, et al. Anxiolytic and antidepressant-like effects of the hydroalcoholic extract from Aloysia polystachya in rats. Pharmacol Biochem Behav 2005; 82: 373-378.
19. Buchbauer G, Jäger W, Gruber A, Dietrich H. R-(+)-and S-(-)-carvone: Influence of chirality on locomotion activity in mice. Flavour Frag J 2005; 20: 686-689.
20. Granger RE, Campbell EL, Johnston GA. (+)-And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol 2005; 69: 1101-1111.