메뉴 건너뛰기




Volumn 129, Issue 4, 2012, Pages

Liporetro-D-peptides - A novel class of highly selective thrombin inhibitors

Author keywords

Anticoagulant; Inhibitor; Liporetro D peptide; Selectivity; Serine protease; Thrombin

Indexed keywords

BLOOD CLOTTING FACTOR 10; DEXTRO ARGININE; DEXTRO PHENYLALANINE; LAURIC ACID; LIPOPEPTIDE; LIPORETRO D PEPTIDE; MYRISTIC ACID; PLASMIN; THROMBIN; THROMBIN INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

EID: 84858341719     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.10.009     Document Type: Article
Times cited : (4)

References (26)
  • 1
    • 33845480738 scopus 로고    scopus 로고
    • Direct thrombin inhibitors - A survey of recent developments
    • A. Schwienhorst Direct thrombin inhibitors - a survey of recent developments Cell Mol Life Sci 63 2006 2773 2791
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2773-2791
    • Schwienhorst, A.1
  • 3
    • 27144505651 scopus 로고    scopus 로고
    • Molecular recognition mechanisms of thrombin
    • J.A. Huntington Molecular recognition mechanisms of thrombin J Thromb Haemost 3 2005 1861 1872
    • (2005) J Thromb Haemost , vol.3 , pp. 1861-1872
    • Huntington, J.A.1
  • 4
    • 0022817559 scopus 로고
    • Inhibition of the proteolytic activity of thrombin by methyl esters of arginine-containing oligopeptides
    • S.A. Poiarkova, V.K. Kibirev, and S.B. Serebrianyi Inhibition of the proteolytic activity of thrombin by methyl esters of arginine-containing oligopeptides Ukr Biokhim Zh 58 1986 3 8
    • (1986) Ukr Biokhim Zh , vol.58 , pp. 3-8
    • Poiarkova, S.A.1    Kibirev, V.K.2    Serebrianyi, S.B.3
  • 6
    • 85056049329 scopus 로고    scopus 로고
    • Influence of aromatic and aliphatic moieties on thrombin inhibitors potency
    • A. Poyarkov, X. Rocabayera, S. Poyarkova, and V. Kukhar Influence of aromatic and aliphatic moieties on thrombin inhibitors potency Open Biochem J 2 2008 143 149
    • (2008) Open Biochem J , vol.2 , pp. 143-149
    • Poyarkov, A.1    Rocabayera, X.2    Poyarkova, S.3    Kukhar, V.4
  • 7
    • 0017725427 scopus 로고
    • Human thrombins. Production, evaluation, and properties of alpha-thrombin
    • J.W. Fenton II, M.J. Fasco, and A.B. Stackrow Human thrombins. Production, evaluation, and properties of alpha-thrombin J Biol Chem 252 1977 3587 3598
    • (1977) J Biol Chem , vol.252 , pp. 3587-3598
    • Fenton, I.I.J.W.1    Fasco, M.J.2    Stackrow, A.B.3
  • 9
    • 0027050807 scopus 로고
    • The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships
    • W. Bode, D. Turk, and A. Karshikov The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships Protein Sci 1 1992 426 471
    • (1992) Protein Sci , vol.1 , pp. 426-471
    • Bode, W.1    Turk, D.2    Karshikov, A.3
  • 13
    • 0025328906 scopus 로고
    • Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H
    • S. Bajusz, E. Szell, D. Bagdy, E. Barabas, G. Horvath, and M. Dioszegi Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H J Med Chem 33 1990 1729 1735
    • (1990) J Med Chem , vol.33 , pp. 1729-1735
    • Bajusz, S.1    Szell, E.2    Bagdy, D.3    Barabas, E.4    Horvath, G.5    Dioszegi, M.6
  • 14
    • 0029093733 scopus 로고
    • Amide and [alpha]-keto carbonyl inhibitors of thrombin based on arginine and lysine: Synthesis, stability and biological characterization
    • S.F. Brady, J.T. Sisko, K.J. Stauffer, C.D. Colton, H. Qiu, and S.D. Lewis Amide and [alpha]-keto carbonyl inhibitors of thrombin based on arginine and lysine: Synthesis, stability and biological characterization Bioorg Med Chem 3 1995 1063 1078
    • (1995) Bioorg Med Chem , vol.3 , pp. 1063-1078
    • Brady, S.F.1    Sisko, J.T.2    Stauffer, K.J.3    Colton, C.D.4    Qiu, H.5    Lewis, S.D.6
  • 15
    • 0035251672 scopus 로고    scopus 로고
    • The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: Intestinal absorption properties, biochemical and pharmacodynamic effects
    • D. Gustafsson, J. Nystrom, S. Carlsson, U. Bredberg, U. Eriksson, and E. Gyzander The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects Thromb Res 101 2001 171 181
    • (2001) Thromb Res , vol.101 , pp. 171-181
    • Gustafsson, D.1    Nystrom, J.2    Carlsson, S.3    Bredberg, U.4    Eriksson, U.5    Gyzander, E.6
  • 16
    • 0342981699 scopus 로고    scopus 로고
    • An efficient preparation of the potent and selective pseudopeptide thrombin inhibitor, inogatran
    • P. Préville, J.X. He, M. Tarazi, M.A. Siddiqui, W.L. Cody, and A.M. Doherty An efficient preparation of the potent and selective pseudopeptide thrombin inhibitor, inogatran Bioorg Med Chem Lett 7 1997 1563 1566
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 1563-1566
    • Préville, P.1    He, J.X.2    Tarazi, M.3    Siddiqui, M.A.4    Cody, W.L.5    Doherty, A.M.6
  • 17
    • 0041424038 scopus 로고    scopus 로고
    • New proline mimetics: Synthesis of thrombin inhibitors incorporating cyclopentane- and cyclopentenedicarboxylic acid templates in the P2 position. Binding conformation investigated by X-ray crystallography
    • D. Noteberg, J. Branalt, I. Kvarnstrom, M. Linschoten, D. Musil, and J.E. Nystrom New proline mimetics: synthesis of thrombin inhibitors incorporating cyclopentane- and cyclopentenedicarboxylic acid templates in the P2 position. Binding conformation investigated by X-ray crystallography J Med Chem 43 2000 1705 1713
    • (2000) J Med Chem , vol.43 , pp. 1705-1713
    • Noteberg, D.1    Branalt, J.2    Kvarnstrom, I.3    Linschoten, M.4    Musil, D.5    Nystrom, J.E.6
  • 18
    • 0029099769 scopus 로고
    • Thrombin active site inhibitors
    • J. Das, and S. David Kimball Thrombin active site inhibitors Bioorg Med Chem 3 1995 999 1007
    • (1995) Bioorg Med Chem , vol.3 , pp. 999-1007
    • Das, J.1    David Kimball, S.2
  • 19
    • 0031024174 scopus 로고    scopus 로고
    • Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor
    • T.A. Lyle, Z. Chen, S.D. Appleby, R.M. Freidinger, S.J. Gardell, and S.D. Lewis Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor Bioorg Med Chem Lett 7 1997 67 72
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 67-72
    • Lyle, T.A.1    Chen, Z.2    Appleby, S.D.3    Freidinger, R.M.4    Gardell, S.J.5    Lewis, S.D.6
  • 20
    • 0024431034 scopus 로고
    • The refined 1.9 A crystal structure of human alpha-thrombin: Interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment
    • W. Bode, I. Mayr, U. Baumann, R. Huber, S.R. Stone, and J. Hofsteenge The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment EMBO J 8 1989 3467 3475
    • (1989) EMBO J , vol.8 , pp. 3467-3475
    • Bode, W.1    Mayr, I.2    Baumann, U.3    Huber, R.4    Stone, S.R.5    Hofsteenge, J.6
  • 21
    • 0027409404 scopus 로고
    • A player of many parts: The spotlight falls on thrombin's structure
    • M.T. Stubbs, and W. Bode A player of many parts: the spotlight falls on thrombin's structure Thromb Res 69 1993 1 58
    • (1993) Thromb Res , vol.69 , pp. 1-58
    • Stubbs, M.T.1    Bode, W.2
  • 22
    • 27944434785 scopus 로고    scopus 로고
    • Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles
    • R.C. Isaacs, M.G. Solinsky, K.J. Cutrona, C.L. Newton, A.M. Naylor-Olsen, and J.A. Krueger Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles Bioorg Med Chem Lett 16 2006 338 342
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 338-342
    • Isaacs, R.C.1    Solinsky, M.G.2    Cutrona, K.J.3    Newton, C.L.4    Naylor-Olsen, A.M.5    Krueger, J.A.6
  • 23
    • 56949084877 scopus 로고    scopus 로고
    • Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
    • F. Kratz Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles J Control Release 132 2008 171 183
    • (2008) J Control Release , vol.132 , pp. 171-183
    • Kratz, F.1
  • 25
    • 33144488817 scopus 로고    scopus 로고
    • Insulin detemir: From concept to clinical experience
    • P. Home, and P. Kurtzhals Insulin detemir: from concept to clinical experience Expert Opin Pharmacother 7 2006 325 343
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 325-343
    • Home, P.1    Kurtzhals, P.2
  • 26
    • 0036119489 scopus 로고    scopus 로고
    • Drug conjugates with albumin and transferrin
    • F. Kratz Drug conjugates with albumin and transferrin Expert Opin Ther Pat 12 2002 433 439
    • (2002) Expert Opin Ther Pat , vol.12 , pp. 433-439
    • Kratz, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.