Increased number of Purkinje cell dendritic swellings in essential tremor

European Journal of Neurology

Volumn 19, Issue 4, 2012, Pages 625-630

  Yu, M ^a   Ma, K ^a   Faust, P L ^b   Honig, L S ^a,c   Cortes E ^b   Vonsattel, J P G ^b,c   Louis, E D ^a,c,d  

^a Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c NONE   (United States)

^d NONE   (United States)

Author keywords

Brain; Dendritic swellings; Essential tremor; Neurodegenerative; Pathology; Purkinje cell

Indexed keywords

PRIMIDONE; PROPRANOLOL;

ARTICLE; AUTOPSY; BRAIN WEIGHT; CELL COUNT; CELL SWELLING; CEREBELLUM; CONTROLLED STUDY; DENDRITIC CELL; DISEASE DURATION; ESSENTIAL TREMOR; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NERVE DEGENERATION; NERVE PLEXUS; NEUROIMAGING; PARKINSON DISEASE; PRIORITY JOURNAL; PURKINJE CELL; STAGING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BRAIN EDEMA; CELL COUNT; CEREBELLAR CORTEX; CHILD; CHILD, PRESCHOOL; DENDRITES; ESSENTIAL TREMOR; FEMALE; HUMANS; MALE; MIDDLE AGED; PURKINJE CELLS; STAINING AND LABELING; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 84858340332     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2011.03598.x     Document Type: Article

References (23)

1. Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord 2010; 25: 534-541.
2. Lombardi WJ, Woolston DJ, Roberts JW, Gross RE. Cognitive deficits in patients with essential tremor. Neurology 2001; 57: 785-790.
3. Benito-Leon J, Louis ED, Bermejo-Pareja F, et al. Population-based case-control study of cognitive function in essential tremor. Neurology 2006; 66: 69-74.
4. Jenkins IH, Bain PG, Colebatch JG, et al. A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections. Ann Neurol 1993; 34: 82-90.
5. Koster B, Deuschl G, Lauk M, Timmer J, Guschlbauer B, Luking CH. Essential tremor and cerebellar dysfunction: abnormal ballistic movements. J Neurol Neurosurg Psychiatry 2002; 73: 400-405.
6. Benito-Leon J, Alvarez-Linera J, Hernandez-Tamames JA, Alonso-Navarro H, Jimenez-Jimenez FJ, Louis ED. Brain structural changes in essential tremor: Voxel-based morphometry at 3-tesla. J Neurol Sci 2009; 287: 138-142.
7. Helmchen C, Hagenow A, Miesner J, et al. Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction. Brain 2003; 126: 1319-1332.
8. Axelrad JE, Louis ED, Honig LS, et al. Reduced Purkinje cell number in essential tremor: a postmortem study. Arch Neurol 2008; 70: 1452-1455.
9. Louis ED, Faust PL, Vonsattel JP, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 2007; 130: 3297-3307.
10. Erickson-Davis CR, Faust PL, Vonsattel JP, et al. "Hairy baskets" associated with degenerative Purkinje cell changes in essential tremor. J Neuropathol Exp Neurol 2010; 69: 262-271.
11. Kuo SH, Erickson-Davis CR, Gillman A, Faust PL, Vonsattel JP, Louis ED. Increased number of heterotopic Purkinje cells in essential tremor. J Neurol Neurosurg Psychiatry 2010; 82: 1038-1040.
12. Harasymiw JW, Bean P. Identification of heavy drinkers by using the early detection of alcohol consumption score. Alcohol Clin Exp Res 2001; 25: 228-235.
13. Louis ED, Zheng W, Applegate L, Shi L, Factor-Litvak P. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology 2005; 65: 391-396.
14. Braak H, Braak E. Diagnostic criteria for neuropathologic assessment of Alzheimer's disease. Neurobiol Aging 1997; 18: S85-S88.
15. Braak H, Alafuzoff I, Arzberger T, Kretzchmar H, Del Tredici K. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 2006; 112: 389-404.
16. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24: 197-211.
17. Mirra SS. The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: a commentary. Neurobiol Aging 1997; 18: S91-S94.
18. Louis ED, Vonsattel JP, Honig LS, Ross GW, Lyons KE, Pahwa R. Neuropathologic findings in essential tremor. Neurology 2006; 66: 1756-1759.
19. Troost D, van Rossum A, Straks W, Willemse J. Menkes kinky hair disease. II. A clinicopathological report of three cases. Brain Dev 1982; 4: 115-126.
20. Ferrer I, Cusi V, Pineda M, Galorfre E, Vila J. Focal dendritic swellings in Purkinje cells in mucopolysaccharidoses types I, II and III. A Golgi and ultrastructural study. Neuropathol Appl Neurobiol 1988; 14: 315-323.
21. Yang Q, Hashizume Y, Yoshida M, et al. Morphological Purkinje cell changes in spinocerebellar ataxia type 6. Acta Neuropathol 2000; 100: 371-376.
22. Uyematsu S. A study of some peculiar changes found in the oxons and dendrites of the Purkinje cells. Arch Neurol Psychiatry 1921; 5: 231-269.
23. Friede RL. An enzyme histochemical study of torpedoes and dendritic swellings in the cerebellum. Acta Neuropathol 1965; 4: 288-292.