Immunohistochemical expression of ki-67 and p53 in colorectal adenomas: A clinicopathological study

Oman Medical Journal

Volumn 26, Issue 4, 2011, Pages 229-234

  Nussrat, Faris Lutfi ^b   Ali, Hussam Hasson ^b   Hussein, Haider Ghazi ^a   Al Ukashi, Raghad Jawad ^b  

^a UNIVERSITY OF BAGHDAD   (Iraq)

^b Al Nahrain University College of Medicine   (Iraq)

Author keywords

Colorectal adenomas; Dysplasia; Immunohistochemical expression; ki 67 expression; p53

Indexed keywords

EID: 84858316615     PISSN: 1999768X     EISSN: 20705204     Source Type: Journal    
DOI: 10.5001/omj.2011.57     Document Type: Article

References (20)

1. Kumar V, Abbas AK, Fausto N. Robbins and Cotran. Pathologic Basis of Disease, 8thed, Elsevier, Philadelephia 2010, USA, 819.
2. Winawer SJ, Zauber AG, Fletcher RH, Stillman JS, O'Brien MJ, Levin B, et al; US Multi-Society Task Force on Colorectal Cancer; American Cancer Society. Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society. Gastroenterology 2006 May;130(6):1872-1885.
3. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000 Mar;182(3):311-322.
4. Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R. Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Blood 2000 Sep;96(6):2037-2044.
5. Gopalakrishna IN, Suet-Feung C, Hilal O, Yataro D, De-En H, Massimiliano C, et al. p300 regulates p53-dependant apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA p21 levels. Proc Natl Acad Sci USA 2002;101(19):7386-7391.
6. Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer. Nat Rev Cancer 2002 May;2(5):331-341.
7. Mirnezami AH, Campbell SJ, Darley M, Primrose JN, Johnson PW, Blaydes JP. Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53- dependent transcription. Curr Biol 2003 Jul;13(14):1234-1239.
8. Vernillo R, Lorenzi B, Banducci T, Minacci C, Vindigni C, Lucenti Fei A, et al. Immunohistochemical expression of p53 and Ki67 in colorectal adenomas and prediction of malignancy and development of new polyps. Int J Biol Markers 2008 Apr-Jun;23(2):89-95.
9. Abbondanzo SL. Paraffin immunohistochemistry as an adjunct to hematopathology. Ann Diagn Pathol 1999 Oct;3(5):318-327.
10. Edilson S, Airlane A, Benedito S. Ki-67 and Bcl-2 Antigen Expression in Adenomatous Colorectal Polyps from Women with Breast Cancer. Society of Surgical Oncology 2010;17(9):2378-2383.
11. Kaklamanis L, Gatter KC, Mortensen N, Baigrie RJ, Heryet A, Lane DP, et al. p53 expression in colorectal adenomas. Am J Pathol 1993 Jan;142(1):87-93.
12. Abdulamir AS, Hafidh R, Mahdi L, Al-jeboori L, Abubaker F, Abbas KA. The Interplay between p53 and p21 Tumor Suppressor Proteins in the Transformation of Colorectal Adenoma to Carcinoma. American Journal of Immunology 2008;4(2):14-22.
13. Atkin WS, Saunders BP; British Society for Gastroenterology; Association of Coloproctology for Great Britain and IrelandBritish Society for GastroenterologyAssociation of Coloproctology for Great Britain and Ireland. Surveillance guidelines after removal of colorectal adenomatous polyps. Gut 2002 Oct;51(5)(Suppl 5):V6-V9.
14. Khatibzadeh N, Ziaee SA, Rahbar N, Molanie S, Arefian L, Fanaie SA. The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps. J Cancer Res Ther 2005 Oct-Dec;1(4):204-207.
15. Andrey B, Alexander D. Peculiarities of Vascular Component of Communicative Systems in Rectal Adenomas. International Journal of Collaborative Research on Internal Medicine & Public Health 2009;1(1):12-21.
16. Quirke P, Fozard JB, Dixon MF, Dyson JE, Giles GR, Bird CC. DNA aneuploidy in colorectal adenomas. Br J Cancer 1986 Apr;53(4):477-481.
17. Giuliani A, Caporale A, Corona M, Ricciardulli T, Di Bari M, Demoro M, et al. Large size, villous content and distal location are associated with severe dysplasia in colorectal adenomas. Anticancer Res 2006 Sep- Oct;26(5B):3717-3722.
18. Yinghao S, Martha S, Reid N, Qiuyin C, Nobuhiko K, Kay W, et al. Immunohistochemical Expressions of Ki-67, Cyclin D1, B-Catenin, Cyclooxygenase-2, and Epidermal Growth Factor Receptor in Human Colorectal Adenoma. Cancer Epidemiol Biomarkers Prev 2006;15(9).
19. Radovanovic-Dinic B, Nagorni A, Katic V, Stamenkovic I, Zlatic A. An immunohistochemical study of Ki-67 in colorectal adenoma. National center for biotechnology information 2009;63(1):16-18.
20. Karamitopoulou E, Perentes E, Diamantis I, Vogt U, Wegmann W. p53 protein expression in colorectal adenomas: an immunohistochemical study using an antigen retrieval system. Histopathology 1995 Dec;27(6):517-523.