Thrombocytopenia at birth in neonates with red cell alloimmune haemolytic disease

Vox Sanguinis

Volumn 102, Issue 3, 2012, Pages 228-233

  Rath, M E A ^a   Smits Wintjens, V E H J ^a   Oepkes, D ^a   van Zwet, E W ^a   van Kamp, I L ^a   Brand, A ^a   Walther, F J ^a   Lopriore, E ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Haemolytic disease of the foetus newborn; Intrauterine transfusion; Red cell alloimmunization; Thrombocytopenia

Indexed keywords

ALLOIMMUNIZATION; ARTICLE; DISEASE SEVERITY; ERYTHROCYTE; ERYTHROCYTE TRANSFUSION; FEMALE; FETUS HYDROPS; GESTATIONAL AGE; HOSPITAL ADMISSION; HUMAN; INCIDENCE; INTRAUTERINE BLOOD TRANSFUSION; MAJOR CLINICAL STUDY; MALE; NEONATAL THROMBOCYTOPENIA; NEWBORN; NEWBORN HEMOLYTIC DISEASE; OBSERVATIONAL STUDY; PREECLAMPSIA; PRIORITY JOURNAL; RED CELL ALLOIMMUNIZATION; RETROSPECTIVE STUDY; RISK FACTOR; SMALL FOR DATE INFANT; THROMBOCYTE COUNT;

BLOOD TRANSFUSION, INTRAUTERINE; ERYTHROBLASTOSIS, FETAL; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; MALE; NETHERLANDS; PLATELET COUNT; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOCYTOPENIA, NEONATAL ALLOIMMUNE;

EID: 84858294823     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2011.01539.x     Document Type: Article

References (23)

1. Saade GR, Moise KJ Jr, Copel JA, et al.: Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization. Obstet Gynecol 1993; 82:987-991
2. Van den Akker ES, de Haan TR, Lopriore E, et al.: Severe fetal thrombocytopenia in Rhesus D alloimmunized pregnancies. Am J Obstet Gynecol 2008; 199:387.e1-4
3. Van den Akker ES, Klumper FJ, Brand A, et al.: Kell alloimmunization in pregnancy: associated with fetal thrombocytopenia? Vox Sang 2008; 95:66-69
4. Koenig JM, Christensen RD: Neutropenia and thrombocytopenia in infants with Rh hemolytic disease. J Pediatr 1989; 1:625-631
5. Chadd MA, Gray OP, Hole DJ: Blood coagulation studies during exchange transfusion. J Obstet Gynaecol Br Commonw 1972; 79:373-376
6. Wagner T, Bernaschek G, Geissler K: Inhibition of megakaryopoiesis by Kell-related antibodies. N Engl J Med 2000; 343:72
7. Murray NA, Roberts IA: Circulating megakaryocytes and their progenitors in early thrombocytopenia in preterm neonates. Pediatr Res 1996; 40:112-119
8. Watts T, Roberts I: Haematological abnormalities in the growth-restricted infant. Semin Neonatol 1999; 4:41-54
9. Rath ME, Smits-Wintjens VE, Lindenburg I, et al.: Top-up transfusions in neonates with Rh hemolytic disease in relation to exchange transfusions. Vox Sang 2010; 99:65-70
10. Rath ME, Smits-Wintjens VE, Lindenburg IT, et al.: Exchange transfusions and top-up transfusions in neonates with Kell haemolytic disease compared to Rh D haemolytic disease. Vox Sang 2010; 100:312-316
11. Smits-Wintjens VE, Walther FJ, Rath ME, et al.: Intravenous immunoglobulin in neonates with rhesus hemolytic disease: a randomized controlled trial. Pediatrics 2011; 127:680-686
12. Kloosterman GJ: Intrauterine growth and intrauterine growth curves. Ned Tijdschr Verloskd Gynaecol 1969; 69:349-365
13. Roberts I, Stanworth S, Murray NA: Thrombocytopenia in the neonate. Blood Rev 2008; 22:173-186
14. Smits-Wintjens VE, Walther FJ, Lopriore E: Rhesus haemolytic disease of the newborn: postnatal management, associated morbidity and long-term outcome. Semin Fetal Neonatal Med 2008; 13:265-271
15. De Boer I, Zeestraten EC, Lopriore E, et al.: Pediatric outcome in Rhesus hemolytic disease treated with and without intrauterine transfusion. Am J Obstet Gynecol 2008; 198:54
16. Viëtor HE, Klumper F, Meerman RJ, et al.: Intrauterine transfusions influence fetal leukocyte counts and subsets. Prenat Diagn 1998; 18:325-331
17. Beiner ME, Simchen MJ, Sivan E, et al.: Risk factors for neonatal thrombocytopenia in preterm infants. Am J Perinatol 2003; 20:49-54
18. Harms K, Rath W, Herting E, et al.: Maternal hemolysis, elevated liver enzymes, low platelet count, and neonatal outcome. Am J Perinatol 1995; 12:1-6
19. Carbonne B, Chereau E, Larsen M, et al.: Concomitant fetal anemia and thrombocytopenia due to anti-D and anti-HPA1a alloimmunization. Prenat Diagn 2005; 25:1172-1174
20. Klüter H, Germer U, Gortner L, et al.: Coincidence of neonatal alloimmune thrombocytopenia and maternal anti-D immunization: case report. Br J Haematol 1998; 102:1383-1384
21. Schild RL, Hoch J, Plath H, et al.: Perinatal management of fetal hemolytic disease due to Rh incompatibility combined with fetal alloimmune thrombocytopenia due to HPA-5b incompatibility. Ultrasound Obstet Gynecol 1999; 14:64-67
22. Yeast JD, Plapp F: Fetal anemia as a response to prophylactic platelet transfusion in the management of alloimmune thrombocytopenia. Am J Obstet Gynecol 2003; 189:874-876
23. Baer VL, Lambert DK, Henry E, et al.: Severe thrombocytopenia in the NICU. Pediatrics 2009; 124:e1095-e1100